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Psychoneuroimmunological evaluation of chronic muscle pain and joint pain in TMD patients

Research Project

Project/Area Number 16591943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOsaka University

Principal Investigator

ISHIGAKI Shoichi  Osaka University, Dental Hospital, Assistant Professor, 歯学部附属病院, 講師 (40212865)

Co-Investigator(Kenkyū-buntansha) YATANI Hirofumi  Osaka University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (80174530)
TODA Masahiro  Osaka University, Graduate School of Medicine, Assistant, 大学院・医学系研究科, 助手 (90362714)
MORIMOTO Kanehisa  Osaka University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20143414)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsTMD / chronic pain / joint pain / mood profile / cortisol / Chromogranin A
Research Abstract

Chronic muscle pain is enhanced by psychological and physical stressor such as fatigue, anxiety, neurosis, and chronic oral parafunction.
However, the relation between these stresses and the manifestation of clinical symptoms is not clear in TMD patients.
In addition, masticatory muscles' pain tends to follows chronic course not only because of local factors but also general factors such as psychological status.
In a two-year period, two journal articles, 21 oral presentations (seven of which were presented at the international meeting), and one publication were presented. The followings are the brief summary of this research.
1.In the management of symptoms of TMD, a biopsychosocial factor played an important role, and symptoms of about 85% patients improved in two months with no dental intervention.
2.To evaluate pain quantitatively and qualitatively, Multidimensional Pain Inventory (MPI) was translated into Japanese and sufficient internal, theoretical, criterion-related, and constructive validities were confirmed.
3.The perception and pain thresholds of trigeminal nerve area were influenced by physical factor, and that the psychological character of each TMD subgroup affects the manifestation of clinical symptoms. The cortisol was evaluated as the stress marker that reflect psychoimmunological status and it was revealed that the cortisol concentration in saliva showed higher value in order of joint disorder group, masticatory disorder group, and masticatory/joint disorder group.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (5 results)

All 2006 2005

All Journal Article (4 results) Book (1 results)

  • [Journal Article] Clinical effectiveness of cognitive behavior therapy in the management of TMD2006

    • Author(s)
      Morishige E, Ishigaki S, Yatani H, Hirokawa M
    • Journal Title

      International Journal of Prosthodontics 19・1

      Pages: 31-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical effectiveness of cognitive behavior therapy in the management of TMD2006

    • Author(s)
      Morishige E, Ishigaki S, Yatani H, Hirokawa M
    • Journal Title

      International Journal of Prosthodontics 19

      Pages: 31-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical effectiveness of cognitive behavior therapy in the management of TMD2006

    • Author(s)
      Morishige E, Ishigaki S, Yatani H, Hirokawa M
    • Journal Title

      International Journal of Prosthodontics (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Significance of biopsychosocial interface in the management of TMD & orofacial pain2005

    • Author(s)
      Ishigaki S, Morishige E, Egusa H, Yatani H
    • Journal Title

      International Congress Series 1284

      Pages: 71-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Book] 顎関節症患者の細病態別にみた気分プロフィールの特徴(POMS短縮版 手引きと事例解説,横山和仁編著)2005

    • Author(s)
      矢谷博文, 石垣尚一, 森重恵美子, 中江佳代, 戸田雅裕, 森本兼曩
    • Total Pages
      11
    • Publisher
      金子書房
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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