| Project/Area Number |
16591990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TANAKA Hideo Hamamatsu University School of Medicine, University Hospital, Department of Oral and Maxillofacial Surgery, Assistant Professor, 医学部附属病院, 助手 (30362205)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Kenji Hamamatsu University School of Medicine, Department of Oral and Maxillofacial Surgery, Professor, 医学部, 教授 (60094166)
KATOU Fuminori Hamamatsu University School of Medicine, Department of Oral and Maxillofacial Surgery, Associate Professor, 医学部, 助教授 (60204492)
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| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Photodynamic therapy / 5-aminolevulinic acid / Oral precancerous lesions |
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| Research Abstract |
5-aminorevulinic acid was administered topically to the tongue of rabbit. Even when medicine was washed away about 10 minutes after topical application, protoporfirin IX accumulated to almost same degree with conventional application methods. Fluorescence micrography to evaluate drug localization revealed that protoporfirin accumulate mucosal basal layer. The result suggest that 5-aminorevulinic acid mediated photodynamic therapy will be efficient therapy for oral leukoplakia.
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