| Project/Area Number |
16591993
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
NISHIDA Mitsuo KYOTO UNIVERSITY, Graduate School of Medicine, Associate Professor, 医学研究科, 講師 (50154620)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Akira KYOTO UNIVERSITY, Graduate School of Medicine, Professor, 医学研究科, 教授 (00162694)
KOSUGI Shinzi KYOTO UNIVERSITY, Graduate School of Medicine, Professor, 医学研究科, 教授 (50252432)
TAKAHASHI Katsu KYOTO UNIVERSITY, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (90314202)
SUGAI Manabu KYOTO UNIVERSITY, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (90303891)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | ameloblastoma / CTNNB1 / PTCH1 / polymorphism / PTCH / β-カテニン / 体細胞突然変異 |
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| Research Abstract |
Ameloblastoma is the most common odontogenic tumor, but the genetic nature of the changes in the tumor cells has been unclear. Mutations of the CTNNB1 or PTCH1 are observed in many human tumors. Both CTNNB1 and PTCH1 are important in tooth development and are expressed in ameloblastoma. The aim of this study was to investigate whether genetic alterations of CTNNB1 and PTCH1 are present in ameloblastoma. We investigated 14 cases of ameloblastoma. The polymorphisms found in the ameloblastoma patients were further examined in a subsequent case-control study. We found CTNNB1 mutation in one case of plexiform type ameloblastoma. CGG triplet repeat number polymorphism (CGG7/CGG8) in the 5'-untranslated region of PTCH1 was observed. The proportion of CGG8 alleles was significantly higher in the ameloblastoma group. The results of this study indicate a possible relationship between the CGG8 allele in PTCH1 and the risk for ameloblastoma.
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