| Project/Area Number |
16592019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
SHIROTA Tatsuo Showa University, School of Dentistry, Assistant Professor, 歯学部, 講師 (60235760)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Masanori Showa University, School of Dentistry, Professor, 歯学部, 教授 (50180394)
SHIBATA Yo Showa University, School of Dentistry, Lecture, 歯学部, 助手 (30327936)
MATSUURA Mitsuhiro Showa University, School of Dentistry, Lecture, 歯学部, 助手 (00297037)
大野 康亮 昭和大学, 歯学部, 教授 (30112725)
松井 義郎 昭和大学, 歯学部, 講師 (10181687)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | oral and Maxillofacial Implant / antibacterial titanium / tissue reaction / diabetes / oral reconstruction / bone graft / bone argumentation / artificial bone / 植皮 |
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| Research Abstract |
This study was to investigate the application of antibacterial titanium to the Oral and Maxillofacial Implants. The results are as follows.
Clinical research
1. A clinical study on alveolar bone ridge augmentation with autogenous particulate bone graft and titanium mesh.
2. The clinical study of bone augmentation for alveolar ridge using of titanium mesh.
3. Clinical study on dental occlusion with endosseous implants in grafted alveolar clefts
Experimental research
1. The effects of the hyperglycemia on tissue reaction around the antibacterial titanium
The animals were 20 female Wistar rats (10 weeks old) used in this study. These animals were divided in two groups as follows : a group that received streptzotocin (STZ) and a control group. A titanium screw implants 2mm in diameter and 5mm in length were placed into the tibia, and the animals were killed at 4 weeks after implantation. The tissue reactions were investigated with histological and immuno-histochemistrical study.
There was a significantly neutrophil infiltration around the implants in the diabetic rat compare with the control rats. The results suggest that the inflammatory reactions around the implants in the diabetic patients might be remarkable compare with normal patients.
2. The tissue reactions around the implant placed into the mandible reconstructed with split-thickness skin graft.
The animals were 10 beagle dogs were used in this study. The implant were commercially available titanium screw types. The bilateral mandibular premolar were extracted and split-thickness skin graft were performed into the alveolar ridge of the mandible. Implant surgery was then performed 3 months after the skin grafts. The animals were killed 3 months after the implant The tissue reactions were investigated with histological and immuno-histochemistrical study.
The inflammatory reactions around the implants placed into the mandible with skin graft was remarkable compare with normal mandible.
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