| Project/Area Number |
16592025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
IMAMURA Yoshiki Nihon University, School of Dentistry, Professor, 歯学部, 教授 (90176503)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWATA Koichi Nihon University, School of Dentistry, Professor, 歯学部, 教授 (60160115)
|
|---|
| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | Trigeminal Nerve / Cervical Nerve / Referred Pain / Spinal Trigeminal Nucleus / Upper Cervical Spine / Sympathetic Nerve / Fos-like Immunoreactivity / Convergence / ニューロパチー / 感作 / 口腔顔面痛 / 頸部疾患 / カプサイシン / ボンフレイ / C-fos |
|---|
| Research Abstract |
Patients occasionally present with a complaint of orofacial pain originating from cervical structures. The mechanisms of orofacial pain with cervical origin are not well known. We studied the etiology of this type of pain on a cervical nerve injury model. 6 SD rats underwent two ligation s on C2-C5 cervical nerves followed by section between them (CN group). 6 SD rats received sham-operation (SO group). Another 6 rats received cervical sympathectomy before nerve injury (SE group). Escape behavior was observed before and after operation (POD14) in all rats. Expression of fos-like immunoreactive protein in cells (Fos-LI cells) was observed with tactile stimulation on ipsilateral preauricular skin on POD14. The results were as follows. 1. Cervical nerve injury resulted in allodynia in trigeminal territory. 2. Fos-LI cell expression was observed not only Vi/Vc and Vc/C levels but also middle Vc and C3. 3. Cervical sympathectomy led to no significant behavioral changes. 4. Sympathectomy resulted in significant expression of Fos-LI cells Vi/Vc and Vc/C levels. These results revealed that cervical nerve injury may elicit hypersensitization of secondary neurons in wide area from Vi/Vc to upper cervical spine. This central sensitization may be due to convergence of the trigeminal nerve and cervical nerves. Cervical sympathectomy may modulate signal transduction in nociceptive neurons in uppercervical spine.
|
