Dynamic study of the specific bone metabolism marker in the synovial fluid of patient with TMJ internal derangement
| Project/Area Number |
16592029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
KURITA Kenichi Aichi-Gakuin University, Scho. of Dent., The 1^<th> Department of Oral and Maxillofacial Surgery, Professor, 歯学部, 教授 (40133483)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Hiroaki Aichi-Gakuin Unviersity, Scho.of Dent., The 1^<th> Department of Oral and Maxillofacial Surgery, Assistant Professor, 歯学部, 非常勤講師 (20329618)
MOGI Makio Aichi-Gakuin Unviersity, Scho.of Pharma., Medical Biochemistry, Associate Professor, 歯学部, 助教授 (00174334)
TOGARI Akifumi Aichi-Gakuin Unviersity, Sch.of Dent., Pharmacology, Professor, 歯学部, 教授 (80126325)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | TMJ internal derangement / synovial fluid / RANKL / OPG / Fas / NO / osteoclast / osteoprotegerin |
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| Research Abstract |
A recent study suggests the involvement of receptor activator for NF-κB ligand (RANKL) and the RANKL decoy receptor osteoprotegerin (OPG) in the pathogenesis of bone-destructive disease, rheumatoid arthritis and periodontitis. However, no one has examined the level of RANKL and OPG in the synovial fluid of patients with tempomandibular joint (TMJ) disorder and focused on RANKL : OPG ratio for osteoclastogenesis. This communication reports on the in vivo concentrations of RANKL, OPG, Fas and NO in synovial fluid from osteoarthritis, disk displacement with reduction, and disk displacement without reduction of TMJ. In contrast with an unchanged concentration of RANKL, a potent decreased concentration of OPG were detected in synovial fluid from patients with TMJ disorder (***p < 0.005 vs. control subjects). A potent increased concentration of Fas were detected in synovial fluid from patients with disk displacement without reduction (*p < 0.05 vs. control subjects). A potent increased concentration of NO were detected in synovial fluid from patients with osteoarthritis and disk displacement without reduction (***p < 0.005, *p < 0.05 vs. control subjects). The ratio of the concentration of RANKL to that of OPG in the synovial fluid was significantly higher for TMJ disorder patients than for healthy subjects (*p < 0.05). The artificial sample containing RANKL and OPG of the same level as those in synovial fluid of osteoarthritis resulted in the potent production of osteoclast-like cells from peripheral blood mononuclear cells with macrophage-colony stimulating factor (M-CSF) and pit
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Report
(4 results)
Research Products
(3 results)
