| Project/Area Number |
16592058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
IINUMA Mitsuo Asahi University, Dentistry, Associate Professor (70184364)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Senessence accererated mice / masticatory dysfunction / spatial recognition / fos-positive cells / neurons cells / pyramidal cells / hippocampus / 咬合挙上 / 神経細胞 / 加齢変化 / 経管栄養飼育 / 脳幹 / 刺激 / 認知症 / Morris水迷路テスト / Fos陽性細胞数 |
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| Research Abstract |
To investigate the influence of masticatory dysfunction(tube feeding) on the hippocampus, it was conducted an experiment using juvenile (15-week-old after birth) and elderly (35-week-old after birth) Senessence accererated mice (SAMP1). As a behavioral investigation, Morris' water maze test was conducted from 8 days after cube feeding were started. As morphological investigations, the numbers of fos-positive cell, which were linked to the water maze test in the hippocampus, neurons cell and pyramidal cell in the hippocampus were measured after Morris' water maze test.
As results in elderly mice acclimated by tube feeding, spatial recognition was reduced, and the number of fos-positive cells, neurons cells and pyramidal cells in the hippocampus was decreased, but not in the juvenile mice.
The results of these animal experiments suggest that masticatory dysfunction (tube feeding) decreases information input into the hippocampus, reducing spatial recognition and accelerating the process of aging.
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