Level of human lactoferrin in whole saliva, research for risk factors for periodontal disease

Research Project

Project/Area Number	16592084
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Social dentistry
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KANEHIRA Takashi Hokkaido Univ., Hokkaido Univ. Hospital, Lecturer, 大学病院, 講師 (90194935)
Co-Investigator(Kenkyū-buntansha)	MORITA Manabu Hokkaido Univ., Grad.School of Dental Medicine., Prof., 大学院歯学研究科, 教授 (40157904) TAKAHASHI Dairo Hokkaido Univ., Grad.School of Dental Medicine., Assist., 大学院歯学研究科, 助手 (80312370)
Project Period (FY)	2004 – 2006
Project Status	Completed (Fiscal Year 2006)
Budget Amount *help	¥2,700,000 (Direct Cost: ¥2,700,000) Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000) Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000) Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords	Whole Saliva / Lactoferrin / Periodontal Disease / 個人差
Research Abstract	The purpose of this study was to measure the levels of human lactoferrin in whole saliva among various age groups and examine the relationship between levels of lactoferrin and periodontal status. Whole saliva sample from donors (n=351) were collected by gum stimulation in ten minutes. The levels of lactoferrin were determined by the enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody. The results were as follows: 1)The levels of lactoferrin in 60's and 70's year old group increased significantly than those under 30's year old groups. 2) Relationships between the levels of lactoferrin and periodontal status were unclear.