| Project/Area Number |
16614007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
|
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| Research Institution | Kyoto University |
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Principal Investigator |
KADOTANI Hiroshi Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (90362516)
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| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Sleep / Sleep Apnea Syndrome / Sleep-disordered Breathing / Metabolic Syndrome / Brain Machine Interface / 睡眠障害 / 高血圧 / マウス / 概日リズム |
|---|
| Research Abstract |
Hypoxia and hypercapnia may cause arousal from sleep and sleep fragmentation in human obstructive sleep apnea syndrome. Recently, several reports presented chronic repetitive ambient hypoxia as a rodent model of sleep-disordered breathing. However, with such a model, it is not possible to elucidate the relative roles of hypercapnia as well as hypoxia on sleep and vigilance. Thus, we made a mouse model of sleep-induced hypercapnia and/or hypoxia to assess this question.
With our model, we disrupted mouse from sleep for a week. As a result, not only sleep rebound, but also hypertension and hyperglycemia were induced in the mouse. This model may be very useful to elucidate interaction between sleep-disordered breathing and metabolic syndrome.
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