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Longitudinal follow up of the functional status in life of the early stage dementia patients

Research Project

Project/Area Number 16615003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 臨床疫学
Research InstitutionKyoto University

Principal Investigator

TAKECHI Hajime  Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (10314197)

Co-Investigator(Kenkyū-buntansha) YAMADA Hiroko  Dosisha University, Faculty of Social studies, Associate Professor, 社会学部, 助教授 (80278457)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsdementia / caregiver burden / activities of daily living / behavioral and psychological symptoms of dementia (BPSD) / cognitive function / Alzheimer's disease / アルツハイマー型認知 / 痴呆症 / アルツハイマー型痴呆症
Research Abstract

In this research project, we investigated the longitudinal change of quality of life of early stage dementia patients in order to establish an effective support technique. First of all, to know the present status of patients, we explored, cross sectionally, the relationship among caregiver burden, activities of daily living, behavioral and psychological symptoms of dementia (BPSD), and cognitive function. The caregiver burden was highly correlated with BPSD. However, the relationship was varied depending on the kind of BPSD. We also showed the relationship between BPSD and cognitive function.
Then we investigated longitudinal change of cognitive function of Alzheimer's disease patients treated with donepezil chloride. The scores of MMSE in average were 22.9±4.2(before treatment),22.7±3.9(6 month),21.6±4.2(12 month),19.7±5.3(24 month).
Two years after treatment, almost half of patients still stay improved or no change. We also showed that the profile of cognitive impairment before the treatment predicts the rate of cognitive decline during 2 years follow up period.
Finally, we also investigated functional status of dementia patients according to the hierarchical classification of ADL ; basic ADL, instrumental ADL and advanced ADL including hobbies. Our results showed that advanced ADL is relatively preserved, by means of various supports provided by family caregivers.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005 2004 Other

All Journal Article (18 results)

  • [Journal Article] もの忘れ外来通院中のアルツハイマー型痴呆症患者における行動・心理学的症候と認知機能障害、介護負担感の関連について2006

    • Author(s)
      武地 一, 山田裕子, 杉原百合子, 北 徹
    • Journal Title

      日本老年医学会雑誌 43(2)

      Pages: 207-216

    • NAID

      10018178992

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Usefulness of measuring serum markers in addition to comprehensive geriatric assessment for cognitive impairment and depressive mood in the elderly2006

    • Author(s)
      Arai H, Takechi H, Wada T et al.
    • Journal Title

      Geriat Gerontol Int. 6

      Pages: 7-14

    • NAID

      10017615791

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Behavioral and psychological symptoms, cognitive impairment and caregiver burden related to Alzheimer's disease patients treated in an outpatient memory clinic.2006

    • Author(s)
      Hajime Takechi, Hiroko Yamada, Yuriko Sugihara, Toru Kita
    • Journal Title

      Japanese Journal of Geriatrics Society 43

      Pages: 207-216

    • NAID

      10018178992

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Usefulness of measuring serum markers in addition to comprehensive geriatric assessment for cognitive impairment and depressive mood in the elderly.2006

    • Author(s)
      Arai H, Takechi H, Wada T et al.
    • Journal Title

      Geriat Gerontol Int. 6

      Pages: 7-14

    • NAID

      10017615791

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 一般高齢者のもつアルツハイマー型痴呆症についての知識量と関連要因の検討2005

    • Author(s)
      杉原百合子, 山田裕子, 武地 一
    • Journal Title

      日本認知症ケア学会誌 4

      Pages: 9-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] センター方式の評価と今後の課題-医療の立場から-2005

    • Author(s)
      武地 一
    • Journal Title

      介護支援専門員 7巻5号

      Pages: 39-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 高齢者医療における総合的機能評価(CGA)2005

    • Author(s)
      武地 一
    • Journal Title

      ファルマシア 41巻10号

      Pages: 937-941

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Examining older adult's knowledge and images about dementia of Alzheimer's type and their relation with other factors.2005

    • Author(s)
      Yuriko Sugihara, Hiroko Yamada, Hajime Takechi
    • Journal Title

      Journal of Japanese Society for Dementia Care 4

      Pages: 9-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Appraisals and future issues of newly developed assessment sheet for dementia patients.2005

    • Author(s)
      Hajime Takechi
    • Journal Title

      Care manager 7

      Pages: 39-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comprehensive geriatric assessment in geriatrics.2005

    • Author(s)
      Hajime Takechi
    • Journal Title

      Pharmacia 41

      Pages: 937-941

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 一般高齢者のもつアルツハイマー型痴呆症についての知識量と関連要因の検討2005

    • Author(s)
      杉原百合子, 山田裕子, 武地_一
    • Journal Title

      日本認知症ケア学会誌 4

      Pages: 9-16

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 一般高齢者のもつアルツハイマー型痴呆症についての知識量と関連要因の検討2005

    • Author(s)
      杉原百合子, 山田裕子, 武地 一
    • Journal Title

      日本痴呆ケア学会誌 (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 高齢者のケアに関する社会体制2004

    • Author(s)
      山田裕子, 武地 一
    • Journal Title

      治療学 38巻7号

      Pages: 803-806

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comprehensive geriatric assessment for outpatients is important for the detection of functional disabilities and depressive symptoms associated with sensory impairment as well as for the screening of cognitive impairment.

    • Author(s)
      Sumi E, Takechi H, Wada T, et al.
    • Journal Title

      Geriat Gerontol Int. (In press)

    • NAID

      10017616174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comprehensive geriatric assessment for outpatients is important for the detection of functional disabilities and depressive symptoms associated with sensory impairment as well as for the screening of cognitive impairment.

    • Author(s)
      Sumi E, Takechi H, Wada T et al.
    • Journal Title

      Geriat Gerontol Int. (in press)

    • NAID

      10017616174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] もの忘れ外来通院中のアルツハイマー型痴呆症患者における行動・心理学的症候と認知機能障害、介護負担感の関連について

    • Author(s)
      武地 一, 山田裕子, 杉原百合子, 北 徹
    • Journal Title

      日本老年医学会雑誌 (印刷中)

    • NAID

      10018178992

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Usefulness of measuring serum markers in addition to comprehensive geriatric assessment for cognitive impairment and depressive mood in the elderly.

    • Author(s)
      Arai H, Takechi H, Wada T, Ishine M, Wakatsuki Y, Horiuchi H, Murayama T, Yokode M, Tanaka M, Kita T, Matsubayashi K, Kume N
    • Journal Title

      Geriat Gerontol Int (in press)

    • NAID

      10017615791

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comprehensive geriatric assessment for outpatients is important for the detection of functional disabilities and depressive symptoms associated with sensory impairment as well as for the screening of cognitive impairment.

    • Author(s)
      Sumi E, Takechi H, Wada T, Ishine M, Wakatsuki Y, Murayama T, Yokode M, Tanaka M, Kita T, Matsubayashi K, Arai H
    • Journal Title

      Geriat Gerontol Int (in press)

    • NAID

      10017616174

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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