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A research on the quantitative analysis of brain lesions caused by hypertension and diabetes mellitus with MRI.

Research Project

Project/Area Number 16615007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 臨床疫学
Research InstitutionInstitute of Biomedical Research and Innovation

Principal Investigator

OKADA Tomohisa  Institute of Biomedical Research and Innovation, Department of Molecular Biology, Investigator, 分子イメージング研究グループ, 客員研究員 (30321607)

Co-Investigator(Kenkyū-buntansha) SENDA Michio  Institute of Biomedical Research and Innovation, Department of Molecular Biology, Leader, 分子イメージング研究グループ, グループリーダー (00216558)
SAKAMOTO Setsu  Institute of Biomedical Research and Innovation, Department of Molecular Biology, Principal Investigator, 分子イメージング研究グループ, 客員研究員 (40344402)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMagnetic Resonance Imaging / Hypertension / Diabetes Mellitus
Research Abstract

1.Brain anatomical changes
We reported a result of quantitative analysis of gray and white matter changes found in patients of chronic fatigue syndrome compared with age-matched normal controls (see Bibliography). Based on this method, the analysis of the changes in patients of hypertension and diabetes mellitus were analyzed. Owing to ischemic brain changes in these patients, however, the analysis method is not directly applicable. Hence, we are now analyzing brain images of patients with cerebrovascular stenosis or occlusion, who have mild ischemic changes and are preparing a manuscript for publication.
2.Brain metabolitic changes
We firstly investigated the reproducibility of metabolite measurements of the brain with MR spectroscopy. We found a linear relationship in myoinositol between reproducibility and signal-to-noise ratio. This result was reported at the American Society of Neuroradiology 43^<rd> Annual Meeting at Toronto, Canada. This is a novel result and a paper was written and is under submission.
3.Brain perfusion changes
In the analysis of brain perfusion, the method itself is of large importance. We had been researched on the brain perfusion with the analysis software, Dr.View 2.0/Linux (AsahiKasei Jyoho System, Inc.). This software was revised at early 2006 and enabled fully automatic analysis, that enables more objective analysis. With this newly introduced system, we are reanalyzing test-retest brain perfusion data and preparing a paper for submission. We are also making a comparative study of the brain perfusion measurement with MRI vs.PET for the evaluation of the accuracy.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (5 results)

All 2004

All Journal Article (5 results)

  • [Journal Article] Mechanisms underlying fatigue : a voxel-based morphometric study of chronic fatigue syndrome.2004

    • Author(s)
      Tomohisa Okada, et al.
    • Journal Title

      BMC Neurology 4・1

      Pages: 14-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] クリニカルfunctional MRI2004

    • Author(s)
      岡田 知久, 他
    • Journal Title

      映像情報メディカル 36・10

      Pages: 1069-1073

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical functional MRI2004

    • Author(s)
      Tomohisa Okada, et al.
    • Journal Title

      Eizojyoho Medical 36・10

      Pages: 1069-1073

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanisms underlying fatigue : a voxel-based morphometric study of chronic fatigue syndrome.2004

    • Author(s)
      Okada T, Tanaka M, Kuratsune H
    • Journal Title

      BMC Neurology 4・1

      Pages: 14-14

    • Related Report
      2004 Annual Research Report
  • [Journal Article] クリニカル functional MRI2004

    • Author(s)
      岡田 知久, 松尾 香弥子, 中尾 哲, 中井 敏晴
    • Journal Title

      映像情報メディカル 36・10

      Pages: 1069-1073

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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