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Contribution of particulate air pollution to increasing in childhood asthma.

Research Project

Project/Area Number 16616006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field アレルギー
Research InstitutionNara Medical University

Principal Investigator

HAMADA Kaoru  Nara Medical university, Department of Medicine, Assistant Professor, 医学部, 助教授 (80228535)

Co-Investigator(Kenkyū-buntansha) KIMURA Hiroshi  Nara Medical university, Department of Medicine, Professor, 医学部, 教授 (20195374)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsBronchial asthma / Air pollution / oil fly ash / Th1 / Th2 balance / Mouse model / angiogenic factor / 大気汚染粉塵
Research Abstract

[Background] Air pollution contributes to both exacerbation and development of bronchial asthma. We have reported that co-exposure to air pollution directly promotes sensitization to inhaled allergen in neonatal mice.
[Objective] We investigated whether prenatal exposure to air pollution could also increase susceptibility to development of asthma in early life.
[Method] Pregnant female BALB/c mice were exposed to aerosolised leachate of residual oil fly ash (ROFA, 50mg/ml, 30 min) at 5, 3 and 1 days before delivery. Offspring were treated once at 3-day of life with ovalbumin (OVA 5 ug) and alum (i.p.), an intentionally sub-optimal dose for sensitization, exposed to aerosolised OVA (1%, 10 min) at 12 - 14 days or 32 - 35 days of age, and evaluated two days after the final exposure.
[Result] The offspring of ROFA-exposed mothers (ROFA group ) revealed increasing airway hyperresponsiveness (higher Penh value to methacholine challenge) and had substantial numbers of eosinophils in the BALF (ROFA group vs. control : 0.66 +/- 0.17 vs. 0.06 +/- 0.02 (x 10^5/ml, mean +/- S.E., 2-week-old mice), p < 0.01). Histopathology revealed prominent inflammation in the lungs of ROFA group and they showed increased allergen-specific IgE and IgG1 levels. Their cultured splenocytes showed an increased IL-4/IFN-gamma cytokine, indicating Th2 skewed immunity.
[Conclusion] The data indicated that exposure of pregnant female mice to an air pollutant aerosol increased asthma susceptibility of their offspring.
[Further study] Clinical studies suggest a role for angiogenesis in the development and persistence of chronic asthma. We investigated a role of vascular endothelial growth factor (VEGF), a major angiogenic and proinflammatory mediator, in allergen-induced acute asthma and to determine whether endostatin/Fc, a potent anti-angiogenic factor can attenuate allergic airway responses.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (5 results)

All 2005 Other

All Journal Article (5 results)

  • [Journal Article] A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model2005

    • Author(s)
      Suzaki Y
    • Journal Title

      Journal of Allergy and Clinical Immunology 116(6)

      Pages: 1220-1227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model2005

    • Author(s)
      Suzaki Y, Hamada K et al.
    • Journal Title

      Journal of Allergy and Clinical Immunology 116(6)

      Pages: 1220-1227

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring

    • Author(s)
      Hamada K
    • Journal Title

      Journal of Toxicology and Environmental Health (revised)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring

    • Author(s)
      Hamada K, Suzaki Y, et al.
    • Journal Title

      Journal of Toxicology and Environmental Health. (revised)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring

    • Author(s)
      Hamada K
    • Journal Title

      Journal of Toxicology and Environmental Health (accepted)

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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