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歯科用パノラマX線写真による心血管系疾患の早期スクリーニング支援システムの開発

Research Project

Project/Area Number 16659519
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHiroshima University

Principal Investigator

田口 明  広島大学, 病院, 講師 (70243582)

Co-Investigator(Kenkyū-buntansha) 末井 良和  広島大学, 病院・講師 (10206378)
津田 幹夫  広島大学, 病院・助手 (60335651)
東 幸仁  広島大学, 大学院医歯薬学総合研究科, 講師 (40346490)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsパノラマX線写真 / 閉経 / 女性 / スクリーニング / 自動支援 / 心血管障害
Research Abstract

前年度(16年度)には,パノラマX線写真の指標と心血管障害のリスク因子(総コレステロール,低密度コレステロール,高感度CRP及び酸化LDL)が関係することを解明したが,17年度はこのパノラマの指標を,自動的に抽出する手法の確立を行った.すなわち,パノラマX線写真上の下顎骨下縁皮質骨厚みを,オトガイ孔を手動設定するだけで,自動的に測定するシステムを新たに開発した.この自動システムは,従来の専門医による手動測定に比して,優れた測定能力を有していた.この知見に関する論文は,国際骨粗鬆症財団の機関誌であるOsteoporosis Internationalに受理された.
また,パノラマX線写真における総頸動脈の石灰化所見が,脳梗塞や心筋梗塞とどのような関係にあるのかあるいは,血管の石灰化能力を実際に反映しているのか否かについて検討を行った.結果,(1)総頸動脈の石灰化所見は,日本人における脳梗塞や心筋梗塞の発症と関連を有する可能性があること,及び(2)総頸動脈の石灰化所見を有する女性では,骨形成マーカーが有意に高値を示す(日本歯科骨粗鬆症研究会研究奨励賞受賞)ことが判明した.今後は,これらの知見を基にして,総頸動脈の石灰化所見を自動的に抽出するシステムの構築に取りかかる予定である.

Report

(2 results)
  • 2005 Annual Research Report
  • 2004 Annual Research Report

Research Products

(11 results)

All 2006 2005 2004

All Journal Article (11 results)

  • [Journal Article] Diagnostic performance of general dental practitioners after lecture in identifying postmenopausal women with low bone mineral density by panoramic radiographs2006

    • Author(s)
      Sutthiprapaporn P et al.
    • Journal Title

      Dentomaxillofac Radiol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Use of dental panoramic radiographs in identifying younger postmenopausal women with osteoporosis2006

    • Author(s)
      Taguchi A et al.
    • Journal Title

      Osteoporosis International (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Computer-aided system for measuring the mandibular cortical width on dental panoramic radiographs in identifying postmenopausal women with low bone mineral density2006

    • Author(s)
      Arifin AZ et al.
    • Journal Title

      Osteoporosis International (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis2006

    • Author(s)
      Ishii K et al.
    • Journal Title

      Dentomaxillofac Radiol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Visual estimation of mandibular cortex on panoramic radiographs in identifying postmenopausal women with low bone mineral density2005

    • Author(s)
      Lee et al.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100

      Pages: 226-231

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship between self-reported periodontal status and skeletal bone mineral density in Japanese postmenopausal women2005

    • Author(s)
      Taguchi A, et al.
    • Journal Title

      Menopause-Journal of the North America Menopause Society 12

      Pages: 144-148

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Estrogen receptor alpha gene polymorphism and myocardial infarction2004

    • Author(s)
      Taguchi A
    • Journal Title

      JAMA - Journal of the American Medical Association 292

      Pages: 1683-1683

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Etiology of the metabolic syndrome2004

    • Author(s)
      Taguchi A
    • Journal Title

      JAMA - Journal of the American Medical Association 291

      Pages: 1443-1444

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Forearm endothelial function and bone mineral loss in postmenopausal women2004

    • Author(s)
      Sanada M, et al.
    • Journal Title

      Atherosclerosis 176

      Pages: 387-392

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tooth loss is associated with an increased risk of hypertension in postmenopausal women2004

    • Author(s)
      Taguchi A, et al.
    • Journal Title

      Hypertension 43

      Pages: 1297-1300

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Validation of dental panoramic radiographic measures in identifying postmenopausal women with spinal osteoporosis2004

    • Author(s)
      Taguchi A, et al.
    • Journal Title

      AJR Am J Roentgenol 183

      Pages: 1755-1760

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-03-31   Modified: 2016-04-21  

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