マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成
| Project/Area Number |
16F16720
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
|
| Allocation Type | Single-year Grants |
|---|
| Section | 外国 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Okinawa Institute of Science and Technology Graduate University |
|---|
Principal Investigator |
SHEN Amy 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 教授 (70740314)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
LEUNG HEI MAN 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 外国人特別研究員
|
|---|
| Project Period (FY) |
2016-07-27 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Microfluidics / Nanoprecipitation / Nanoparticles / Dynamic light scattering / Curcumin / Drug delivery |
|---|
| Outline of Annual Research Achievements |
The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.
|
| Research Progress Status |
28年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
|
Report
(1 results)
Research Products
(2 results)
