| Project/Area Number |
16F16724
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|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Research Field |
Neurophysiology / General neuroscience
|
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| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Moore Adrian 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30442932)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TRAN HEIDI 国立研究開発法人理化学研究所, 脳科学総合研究センター, 外国人特別研究員
|
|---|
| Project Period (FY) |
2016-07-27 – 2017-03-31
|
| Project Status |
Discontinued (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2016: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
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| Keywords | Microtubule / Neuron / Dendrite |
|---|
| Outline of Annual Research Achievements |
Dr Tran characterized final dendrite shape in augmin mutants.
Her preliminary studies of RNAi knock-down dgt4 neurons labeled for EB1 suggested a simplified dendrite arbor shape compared to controls.
Dr Tran performed in vivo time-lapse imaging of EB1::GFP (to label MTs) and Fascin:: KO (to mark actin) in developing augmin mutant neurons. dgt4 RNAi growth cones showed reduced MT nucleation and track extension.
Furthermore Dr Tran generated endogenously tagged wac and dgt4 Drosophila flies using CRISPR.
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| Research Progress Status |
28年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
|
