Creation of Mechanobiology Based on Mechanosensitive Channels

• Project/Area Number: 16GS0308
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Nagoya University
• Principal Investigator: SOKABE Masahiro Nagoya University, 大学院・医学系研究科, 教授 (10093428)
• Co-Investigator(Kenkyū-buntansha): TATSUMI Hitoshi 名古屋大学, 大学院・医学系研究科, 准教授 (20171720) ; 吉村 建二郎 (吉村 健二郎) 筑波大学, 大学院・生命環境科学科, 教授 (10230806) ; 成瀬 恵治 岡山大学, 大学院・生命環境科学科, 教授 (40252233)
• Co-Investigator(Renkei-kenkyūsha): NARUSE Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40252233) ; YOSHIMURA Kenjiro 筑波大学, 大学院・生命環境科学科, 教授 (10230806)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥497,640,000 (Direct Cost: ¥382,800,000、Indirect Cost: ¥114,840,000); Fiscal Year 2008: ¥88,920,000 (Direct Cost: ¥68,400,000、Indirect Cost: ¥20,520,000); Fiscal Year 2007: ¥91,130,000 (Direct Cost: ¥70,100,000、Indirect Cost: ¥21,030,000); Fiscal Year 2006: ¥98,930,000 (Direct Cost: ¥76,100,000、Indirect Cost: ¥22,830,000); Fiscal Year 2005: ¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000); Fiscal Year 2004: ¥109,460,000 (Direct Cost: ¥84,200,000、Indirect Cost: ¥25,260,000)
• Keywords: メカノバイオロジー / 細菌SAチャネル / メカノセンサー / 細胞骨格 / チャネルブロッカー / 蜘蛛毒 / 接着斑 / 心房細動 / SAチャネル / zyxin / クラミドモナス / シロイヌナズナ / 血管内皮細胞 / 心筋SAチャネル

Research Abstract

細胞の機械刺激受容・応答能は生命現象を支える根幹機能であるが、その分子機構は全く未解明であった。本研究では、(1)変異体を用いた実験とシミュレーションにより、機械刺激受容チャネルである細菌Mscの張力感知部位を同定し、活性化過程における膜脂質との相互作用・張力感知とチャネル開閉の連関の詳細を明らかにした。(2)細胞骨格であるストレス繊維が、チャネルや接着斑と分子複合体を形成し機械刺激の伝達・収斂といった役割を担うこと、さらに、それ自体が機械刺激感知のセンサーであること、を見出した。(3)応用研究として新規機械刺激受容チャネルブロッカーの探索を行い、心臓の不整脈治療薬の候補を見出した。

Research Products

• [Journal Article] Differential effect of double-pulse TMS applied to dorsal premotor cortex and precuneus during internal operation of visuospatial information (2010)
  • Author(s): Oshio R, 他5名
  • Journal Title: Neuroimage 49 Pages: 1108-1115
  • Peer Reviewed
• [Journal Article] Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes (2010)
  • Author(s): Sasai N, 他6名
  • Journal Title: Muscle Nerve 41 Pages: 100-106
  • Peer Reviewed
• [Journal Article] Treatment with progesterone after focal cerebral ischemia suppresses proliferation of progenitor cells but enhances survival of newborn neurons in adult male mice (2010)
  • Author(s): Zhang Z, 他5名
  • Journal Title: Neuropharmacology (印刷中)
  • Peer Reviewed
• [Journal Article] DMXB(GTS-21)ameliorates the cognitive deficits in beta amyloid(25-35(-))injected mice through preventing the dysfunction of alpha7 nicotinic receptor (2010)
  • Author(s): Chen L, 他6名
  • Journal Title: J Neurosci Res. (印刷中)
  • Peer Reviewed
• [Journal Article] DHEA prevents Abeta(25-35)-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI(3)K-Akt-mTOR signaling (2010)
  • Author(s): Li L, 他5名
  • Journal Title: Neuropharmacology (印刷中)
  • Peer Reviewed
• [Journal Article] Structural changes in the cytoplasmic domain of the mechanosensitive channel MscS during opening. (2009)
  • Author(s): Machiyama H, Tatsumi H, Sokabe M.
  • Journal Title: Biophys J 97 Pages: 1048-1057
  • Peer Reviewed
• [Journal Article] Chlamydomonas PPR2 encodes a voltage-dependent calcium channel required for the flagellar waveform conversion. (2009)
  • Author(s): Fujiu K, Nakayama Y, Yanagisawa A, Sokabe M, Yoshimura K.
  • Journal Title: Curr Biol 19 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Chlamydomonas CAV2 encodes a voltage- dependent calcium channel required for the flagellar waveform conversion (2009)
  • Author(s): Fujiu K, Nakayama Y, Yanagisawa A, Sokabe M, Yoshimura K.
  • Journal Title: Curr Biol. 19 Pages: 133-139
  • Peer Reviewed
• [Journal Article] DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats (2009)
  • Author(s): Zhou R, 他5名
  • Journal Title: Neuroscience 159 Pages: 287-296
  • Peer Reviewed
• [Journal Article] Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells (2009)
  • Author(s): Iwata S, 他8名
  • Journal Title: Eur J Pharmacol 605 Pages: 15-22
  • Peer Reviewed
• [Journal Article] Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice (2009)
  • Author(s): Zhang Z, 他5名
  • Journal Title: Hippocampus 20 Pages: 402-412
  • Peer Reviewed
• [Journal Article] Repetitive stretch suppresses denervation-induced atrophy of soleus muscle in rats (2009)
  • Author(s): Agata N, 他6名
  • Journal Title: Muscle Nerve. 39 Pages: 456-462
  • Peer Reviewed
• [Journal Article] Structural changes in the cytoplasmic domain of the mechanosensitive channel MscS during opening (2009)
  • Author(s): Machiyama H, Tatsumi H, Sokabe M.
  • Journal Title: Biophys J. 97 Pages: 1048-57
  • Peer Reviewed
• [Journal Article] Stress-Axis Regulated Exon(STREX)in the C terminus of BK(Ca)channels is responsible for the stretch sensitivity (2009)
  • Author(s): Naruse K, Tang QY, Sokabe M.
  • Journal Title: Biochem Biophys Res Commun 385 Pages: 634-639
  • Peer Reviewed
• [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus (2009)
  • Author(s): Enomoto A, 他18名
  • Journal Title: Neuron. 63 Pages: 774-787
  • Peer Reviewed
• [Journal Article] Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells (2009)
  • Author(s): Iwaki M, 他10名
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 531-536
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 曽我部正博
  • Journal Title: 細胞膜の透過性と物質輸送、In「標準細胞生物学第2版」(近藤、柴田、藤本、溝口編)(医学書院) Pages: 90-98
• [Journal Article] (2009)
  • Author(s): 曽我部正博
  • Journal Title: 動物の思考と意識、In「動物は何を考えているのか?:学習と記憶の比較生物学」(曽我部編)(共立出版) Pages: 1-15
• [Journal Article] Mechanical Forces Facilitate Actin Polymerization at Focal Adhesions in a Zyxin-Dependent Manner. (2008)
  • Author(s): Hirata H, Tatsumi H, Sokabe M
  • Journal Title: J Cell Sci 121 Pages: 2795-2804
  • Peer Reviewed
• [Journal Article] Stress fiber acts as a force-transmitting and-focusing structure to activate MS channels in endothelial cells. (2008)
  • Author(s): Hayakawa K, Tatsumi H, Sokabe M
  • Journal Title: J Cell Sci 121 Pages: 496-503
  • Peer Reviewed
• [Journal Article] Interaction between the cytoplasmic and transmembrane domains of the mechanosensitive channel (2008)
  • Author(s): Nomura T, Sokabe M, Yoshimura K
  • Journal Title: MscS. Biophys J 94 Pages: 1638-45
  • Peer Reviewed
• [Journal Article] Gating-associated conformational changes in the mechanosensitive channel (2008)
  • Author(s): Yoshimura K, Usukura J, Sokabe M
  • Journal Title: MscL. PNAS 105 Pages: 4033-4038
  • Peer Reviewed
• [Journal Article] Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss (2008)
  • Author(s): Mizoguchi F, 他10名
  • Journal Title: J.Cell Physiol 216 Pages: 47-53
  • Peer Reviewed
• [Journal Article] A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells (2008)
  • Author(s): Ito S, 他7名
  • Journal Title: Am J Respir Cell Mol Biol. 38 Pages: 407-413
  • Peer Reviewed
• [Journal Article] Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage (2008)
  • Author(s): Cai W, 他5名
  • Journal Title: Neuropharmacology 55 Pages: 127-138
  • Peer Reviewed
• [Journal Article] Tuning the mechanosensitivity of a BK channel by changing the linker length (2008)
  • Author(s): Zhao H, Sokabe M
  • Journal Title: Cell Res. 18 Pages: 871-878
  • Peer Reviewed
• [Journal Article] Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner (2008)
  • Author(s): Hirata H, Tatsumi H, Sokabe M.
  • Journal Title: J.Cell Sci. 121 Pages: 2795-2804
  • Peer Reviewed
• [Journal Article] Nitric oxide(NO)increase at fertilization in sea urchin eggs upregulates fertilization envelope hardening (2008)
  • Author(s): Mohri T, Sokabe M, Kyozuka K.
  • Journal Title: Dev Biol 322 Pages: 251-262
  • Peer Reviewed
• [Journal Article] Gating-associated conformational changes in the mechanosensitive channel, MscL (2008)
  • Author(s): Yoshimura K, Usukura J, Sokabe M
  • Journal Title: PNAS 105(10) Pages: 4033-4038
  • Peer Reviewed
• [Journal Article] Mechanosensitive channel with a latch mechanism is present in the cytoplasm and chloroplast of Chlamydomonas (2007)
  • Author(s): Nakayama Y, Fujiu K, Sokabe M, Yoshimura K
  • Journal Title: PNAS 104(14) Pages: 5883-5888
  • Peer Reviewed
• [Journal Article] Dynamics of Actin Filaments during Tension-Dependent Formation of Actin Bundles (2007)
  • Author(s): Hirata H, Tatsumi H, Sokabe M.
  • Journal Title: Biochim Biophys Acta 1770 Pages: 1115-1127
  • Peer Reviewed
• [Journal Article] Mechanosensitive channel with a latch mechanism is present in the cytoplasm and chloroplast of Chlamydomonas (2007)
  • Author(s): Nakayama Y, Fujiu K, Sokabe M, Yoshimura K.
  • Journal Title: PNAS (in press)
• [Journal Article] Quantitative estimation of Na^+ K^+ ATPase activity in the Endolymphati Sac Epithelial Cells of Guinea-Pig. (2007)
  • Author(s): Miyashita T, Tatsumi H, Hayakawa K, Mori N, Sokabe M.
  • Journal Title: Pflugers Arch-Eur J Physiol 453(6) Pages: 905-913
• [Journal Article] Lipid-protein interaction of the MscS mechanosensitive channel examined by scanning mutagenesis. (2006)
  • Author(s): Nomura T, Yoshimura K, Sokabe M
  • Journal Title: Biophys J 91 Pages: 2874-81
  • Peer Reviewed
• [Journal Article] Lipid-protein interaction of the MscS mechanosensitive channel examined by scanning mutagenesis. (2006)
  • Author(s): Nomura T, Yoshimur K, Sokabe M
  • Journal Title: Biophys J 91(8) Pages: 2874-2881
• [Journal Article] Bi-pasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs (2006)
  • Author(s): Takeda H, Komori K, Nishikimi N, Nimura Y, Sokabe M, Naruse K.
  • Journal Title: Life Sci 79(3) Pages: 233-239
• [Journal Article] Bipahsic activation of liver regeneration associated signals at an eraly stage after potal vein branch ligation. (2006)
  • Author(s): Yokoyama S, Yokoyama Y, Kawai T, Kobayashi S, Nagimo M, Oda K, Nimura Y, Sokabe M.
  • Journal Title: Biochem Biophys Res Comm. 349(2) Pages: 732-739
• [Journal Article] Chronic Application of DHEAS Enhances Long-Term Potentiation in Rat Hippocampal CA1 via sigma 1 receptor. (2006)
  • Author(s): Chen L, Dai XN, Sokabe M
  • Journal Title: Neuropharmacol 50(2) Pages: 254-268
• [Journal Article] Mechanosensitive BK Channel Activated by Membrane Stress Created by Amphipaths (2005)
  • Author(s): Qu Z, Chi S, Su X, Naruse K, Sokabe M
  • Journal Title: Mol Membr Biol. 22(6) Pages: 519-527
• [Journal Article] Pregnenolone sulfate enhances presynaptic glutamate releases in rat hippocampal slices as studied by optical recordings (2005)
  • Author(s): Chen L, Sokabe M.
  • Journal Title: J Neurophysiol 94(6) Pages: 4131-4144
• [Journal Article] Characteristics of Subepithelial Fibroblasts as a Mechano-Sensor in the Intestine : Cell-Shape Dependent ATP Release and P2Y1 Signaling. (2005)
  • Author(s): Furuya K, Sokabe M, Furuya S
  • Journal Title: J Cell Sci 118(15) Pages: 3289-3304
• [Journal Article] Involvement of reactive oxygen species in cyclic stretch induced NF-κB activation in human fibroblast cells. (2005)
  • Author(s): Amma H, Naruse K, Ishiguro N, Sokabe M
  • Journal Title: Br J Pharmacol 145(3) Pages: 364-373
• [Journal Article] Mechanotransduction by integrin is essential for interleukin-6 secretion from human umbilical vein endothelial cells in response to uni-axial continuous stretch. (2005)
  • Author(s): Sasamoto A, Nagino M, Kobayashi S, Naruse K, Nimura Y, Sokabe M
  • Journal Title: Am J Physiol : Cell Physiol 288(5) Pages: 1012-1022
• [Journal Article] Identification of functional domains of Mid1, a stretch-activated channel component, necessary for localization to the plasma membrane and Ca~<2+> permeation (2005)
  • Author(s): Ozeki-Miyawaki C, Moriya Y, Tatsumi H, Iida H, Sokabe M
  • Journal Title: Exp Cell Res 311(1) Pages: 84-95
• [Journal Article] Characteristics of cultured subepithelial fibroblasts in the rat small intestine. II. Localization and functional analysis of endothelin receptors and cell-shape-independent gap junction permeability. (2005)
  • Author(s): Furuya S, Furuya K, Sokabe M, Hiroe T, Ozaki T
  • Journal Title: Cell Tissue Res 319(1) Pages: 103-119
• [Journal Article] Mechanosenstive Anion Channel in Arabidopsis Thaliana Mesophyll Cells. (2004)
  • Author(s): Qi Z, Kishigami A, Nakagawa Y, Iida H, Sokabe M.
  • Journal Title: Plant Cell Physiol. 45(11) Pages: 1704-1708
• [Journal Article] Tension-Dependent Formation of Stress Fibers in Fibroblasts : a Study Using Semi-Intact Cells. (2004)
  • Author(s): Hirata H, Tatsumi H, Sokabe M.
  • Journal Title: JSME Int J. 47(4) Pages: 962-969
  • NAID: 110004820824
• [Journal Article] Loss-of-function mutations at the rim of the funnel of mechanosensitive channel MscL. (2004)
  • Author(s): Yoshimura K, Nomura T, Sokabe M.
  • Journal Title: Biophys J 86(4) Pages: 2113-2120
• [Journal Article] 新規MSチャネルSAKCAと新規MSチャネルブロッカーGsMTx-4 (2004)
  • Author(s): 曽我部正博, 成瀬恵治, 唐涼瑶
  • Journal Title: 日本薬理学雑誌 123(6) Pages: 397-402
  • NAID: 10014384969
• [Journal Article] Mechanotransduction at integrin is essential for interleukin-6 secretion from human umbilical vein endothelial cells in response to uni-axial continuous stretch.
  • Author(s): Sasamoto A, Nagino M, Kobayashi S, Naruse K, Nimura Y, Sokabe M.
  • Journal Title: Am J Physiol : Cell Physiol. (印刷中)
• [Presentation] Introduction to Mechanobiology : Biophysics and Physiology of Cell Mechanosensing (2010)
  • Author(s): 曽我部正博
  • Organizer: Physiology Seminar at University of Pennsylvania
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2010-03-25
• [Presentation] Overview of Cell Mechanosensing Project "Mechanotransduction by supra-molecular complex" (2010)
  • Author(s): 曽我部正博
  • Organizer: 13^<th> International Membrane Research Forum
  • Place of Presentation: Kyoto, Japan
• [Presentation] Gating mechanisms of mechanosensitive ion channel : roles of water (2010)
  • Author(s): 曽我部正博
  • Organizer: International Symposium on Hydration and ATP Energy
  • Place of Presentation: Sendai, Japan
• [Presentation] Roles of actin filaments in cell mechanotransduction (2010)
  • Author(s): 曽我部正博
  • Organizer: Fifty Years of Biophysics Research at Nagoya University
  • Place of Presentation: Nagoya, Japan
• [Presentation] 機械受容チャネルの膜張力感知とゲーティングの物理化学的本質 (2009)
  • Author(s): 曽我部正博, 澤田康之
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] ATP-releases via multiple pathways in mammary epithelial cells revealed by ATP imaging (2009)
  • Author(s): 古家喜四夫, 原田京子, 曽我部正博
  • Organizer: 40th NIPS International Symposium
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-08-04
• [Presentation] Role of cytoskeleton in mechanotransduction. (2009)
  • Author(s): Sokabe M
  • Organizer: Gordon Research Conference: Cellular Osmoregulation & Mechanotransduction.
  • Place of Presentation: Biddeford, ME USA(invited)
• [Presentation] Molecular Biophysics of mechanosensitive ion channels. (2009)
  • Author(s): Sokabe M
  • Organizer: ymposium on Single molecules Physiology of ion channel and motor proteins, IUPS Congress 2009
  • Place of Presentation: Kyoto, Japan(organizer)
• [Presentation] Nanobiology of cell mechanotransduction. (2009)
  • Author(s): Sokabe M
  • Organizer: First World Congress of International Academy of Nanomedicine (IANM)
  • Place of Presentation: Sanya, Hainan, China(invited)
• [Presentation] Molecular dynamics simulations on the mechanosensitive ion channel. (2009)
  • Author(s): Sokabe M
  • Organizer: Phuket, Thailand
  • Place of Presentation: invited
• [Presentation] Frontier research on cell-mechanosensing : Ms channel and cytoskeleton (2009)
  • Author(s): 曽我部正博
  • Organizer: 6th Asian Biophysics Association(ABA)Symposium
  • Place of Presentation: Hong Kong
• [Presentation] Molecular mechanisms of neuroprotection by neurosteroids against ischemic brain damages (2009)
  • Author(s): 曽我部正博
  • Organizer: The 11th meeting Hirosaki International Forum of Medical Science : Emerging Frontiers in Brain Research-Crossroads of metabolic regulation, stress response and disease
  • Place of Presentation: Hirosaki, Japan
• [Presentation] Molecular dynamics simulations on the mechanosensitive ion channel (2009)
  • Author(s): 曽我部正博
  • Organizer: Computaional Biology and Robotics 2009
  • Place of Presentation: Phuket, Thailand
• [Presentation] Nanobiology of cell mechanotransduction (2009)
  • Author(s): 曽我部正博
  • Organizer: First World Congress of International Academy of Nanomedicine(IANM)
  • Place of Presentation: Sanya, Hainan, China
• [Presentation] Role of cytoskeleton in mechanotransduction (2009)
  • Author(s): 曽我部正博
  • Organizer: Gordon Research Conference : Cellular Osmoregul ation & Mechanotransduction
  • Place of Presentation: Biddeford, ME USA
• [Presentation] Molecular Biophysics of mechanosensitive ion channels (2009)
  • Author(s): 曽我部正博
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] ANTI-CHOLESTEROL DRUG STATINS AFFECT STRETCH-INDUCED CALCIUM INFLUX IN THE CARDIOMYOCYTE CELL LINE H9c2 (2009)
  • Author(s): Takahashi K, Omori M, Sokabe M
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] ACTIVATION MECHANISM OF BACTERIAL MECHANOSENSITIVE CHANNEL MscL BY CHLORPROMAZINE (2009)
  • Author(s): Nomura T, Yoshimura K, Sokabe M
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] MULTI PATHWAYS OF ATP-RELEASE IN MAMMARY EPITHELIAL CELLS REVEALED BY ATP IMAGING (2009)
  • Author(s): 古家喜四夫, 原田京子, 曽我部正博
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] A ROLE OF NITRIC OXIDE(NO)AND ITS CELL SIGNALLING AT FERTILIZATION IN SEA URCHIN EGGS. (2009)
  • Author(s): Mohri T, Sokabe M, Kyozuka K
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] STRETCH-ACTIVATED CALCIUM RESPONSE OF A RAT CARDIOM YOCYTE CELL LINE H9c2 (2009)
  • Author(s): Takahashi K, Hattori M, Sokabe M
  • Organizer: IUPS Congress2009
  • Place of Presentation: Kyoto, Japan
• [Presentation] Time-dependent differential roles of actin cytoskeleton under mechanical stress (2009)
  • Author(s): 曽我部正博
  • Organizer: The 3^<rd> Mechanobiology Workshop
  • Place of Presentation: NUS, Singapore
• [Presentation] アクチンは張力センサーである (2009)
  • Author(s): 辰己仁史, 早川公英, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] アクチンフィラメントの力学的ふるまい:分子動力学シミュレーション (2009)
  • Author(s): 安達泰治, 松下慎二, 井上康博, 北條正樹, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] 非機械感受性イオンチャネルは本当に機械刺激によって開かないか?-粗視化分子動力学シミュレーション研究- (2009)
  • Author(s): 高橋賢, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] アクチン調節タンパク質 zyxin のストレスファイバーへの張力依存的会合 (2009)
  • Author(s): 平田宏聡, 辰己仁史, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] アクチンフィラメントの運動自由度の制限はコフィリンの結合頻度を低下させる (2009)
  • Author(s): 早川公英, 船戸雄介, 辰己仁史, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] 異なったキネティクスを持った経路が乳腺におけるATP放出に関わっている (2009)
  • Author(s): 古家喜四夫, 原田京子, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] 張力がアクチンフィラメントの力学特性に及ぼす影響 (2009)
  • Author(s): 松下慎二, 安達泰治, 井上康博, 北條正樹, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] 大腸菌機械受容チャネルMscLのメカノゲーティングにおける水の浸潤と透過の役割 (2009)
  • Author(s): 澤田康之, 村瀬雅樹, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] 試験管再構成モデルを用いた力刺激による接着関連タンパク質の集積 (2009)
  • Author(s): 清島大資, 平田宏聡, 辰己仁史, 曽我部正博
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: アスティ徳島(徳島県)
• [Presentation] Biophysics of cell mechanosensor at work: structure function of an MS channel protein. (2008)
  • Author(s): Sokabe M
  • Organizer: 5th Structural Biology & Functional Genomics and 1st Biological Physics International Conference
  • Place of Presentation: Singapore(invited)
• [Presentation] Biophysics of Cell Mechanosensors : from channel to cytoskeleton (2008)
  • Author(s): 曽我部正博
  • Organizer: The 2^<nd> Workshop on Mechanobiology
  • Place of Presentation: Singapore
• [Presentation] Gating mechanisms of mechanosensitive ion channels : interactions aniong lipid, protein and water (2008)
  • Author(s): 曽我部正博
  • Organizer: Workshop on Water and Cell Physilogy
  • Place of Presentation: Kyoto, Japan
• [Presentation] Biophysics of cell mechanosensor at work : structure function of an MS channel protein (2008)
  • Author(s): 曽我部正博
  • Organizer: 5th Structural Biology & Functional Genomics and 1st Biological Physics International Conference
  • Place of Presentation: Singapore
• [Presentation] Nanobiology of mechanotransduction in cells: basics and applications. (2007)
  • Author(s): Sokabe M
  • Organizer: World Congress on Bioengineering
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-07-11
• [Presentation] Molecular and cellular biophysics of mechanotransduction. (2007)
  • Author(s): Sokabe M
  • Organizer: National Symposium on "Biophysics in Medicine and Biology". Ann Meeting of Ind Biophys Soc.
  • Place of Presentation: Chandigar, India(invited)
• [Presentation] Overview. Molecular physiology of mechanosignaling in the cell. (2007)
  • Author(s): Sokabe M
  • Organizer: Symposium on "Comparative aspects of mechanobiology" 7th ICCPB
  • Place of Presentation: Salvador, Brazil(Organizer, invited)
• [Presentation] Plenary Lecture, Nanobiology of mechanotransduction in cells: basics and applications. (2007)
  • Author(s): Sokabe M
  • Organizer: World Congr Bio Eng 2007
  • Place of Presentation: Bangkok, Thailand(invited)
• [Book] Nanotechnology in mechanobiology: mechanical manipulation of cells and organelle while monitoring intra-cellular signaling.(Mechanosensing Biology) (2010)
  • Author(s): Tatsumi H, Hayakawa K, Sokabe M
  • Publisher: Springer(in press)
• [Book] Biophysical mechanisms of tesion-dependent formation of stress fibers from actin meshwork. In "Biomechanics at Micro-and Nanoscale Levels, Volume IV" ed.(Wada H. ) (2007)
  • Author(s): Hirata H, Tatsumi H, Sokabe M.
  • Publisher: World Scientific Publishing
• [Book] 機械刺激受容チャネル、In「生物物理学ハンドブック」 (2007)
  • Author(s): 曽我部正博, 石渡, 他編
  • Publisher: 朝倉書店
• [Book] Roles of Ion Channels in Environmental Responses of Plants In "Sensing with Ion Channels" ed. Martinac B. (2007)
  • Author(s): Furuichi T, Kawano T, Tatsumi H, Sokabe M.
  • Publisher: Springer Verlag
• [Book] Effects of mechanical stresses on the migrating behavior of endothelial cells., In "Biomechanics at Micro - and Nanoscale Levels, Volume II " (ed. H. Wada) (2006)
  • Author(s): Furuya K, Furuya S, Sokabe M
  • Total Pages: 168
  • Publisher: World Scientific Publishing
• [Book] Analysis of micro-and nano-mechanisms in the activation of cell mechanosensors. In“Biomechanics at Micro-and Nanoscale Levels: Introduction of The Project" (2005)
  • Author(s): Sokabe M
  • Publisher: Sanko Printing
• [Book] Effects of mechanical stresses on the migrating behavior of endothelial cells.,In "Biomechanics at Micro-and Nanoscale Levels,Volune I"(ed.H.Wada) (2005)
  • Author(s): Tanaka K, Naruse K, Sokabe M.
  • Total Pages: 173
  • Publisher: World Scientific Publishing
• [Book] Effects of mechanical stresses on the migrating behavior of endothelial cells., In "Biomechanics at Micro and Nanoscale Levels, Volume I" (ed.H.Wada) (2004)
  • Author(s): Tanaka K, Naruse K, Sokabe M.
  • Total Pages: 173
  • Publisher: World Scientific Publishing
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/physiol2
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/physiol2
• [Patent(Industrial Property Rights)] 細胞培養方法 (2010)
  • Inventor(s): 曽我部正博・古家喜四夫・田崎剛・鶴田仁志・福田始弘
  • Industrial Property Rights Holder: 名古屋大学・株式会社クラレ
  • Filing Date: 2010-02-05
• [Patent(Industrial Property Rights)] 細胞培養方法 (2009)
  • Inventor(s): 曽我部正博・古家喜四夫・田崎剛・鶴田仁志・福田始弘
  • Industrial Property Rights Holder: 名古屋大学・株式会社クラレ
  • Industrial Property Number: 2008-026385
  • Filing Date: 2009-02-06
• [Patent(Industrial Property Rights)] 細胞培養方法 (2008)
  • Inventor(s): 曽我部正博, 古家喜四夫, 田崎剛, 鶴田仁志, 福田始弘
  • Industrial Property Rights Holder: 名古屋大学(株)クラレ
  • Filing Date: 2008-02-08
• [Patent(Industrial Property Rights)] 機械受容(Stretch Activated)チャネルの活性化抑制剤 (2004)
  • Inventor(s): 成瀬 恵治, 曽我部 正博
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2004-032916
  • Filing Date: 2004-11-08