| Project/Area Number |
16GS0311
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyoto University |
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Principal Investigator |
NODA Makoto Kyoto University, 医学研究科, 教授 (30146708)
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| Co-Investigator(Kenkyū-buntansha) |
KITAYAMA Hitoshi 京都大学, 医学研究科, 助教授 (30231286)
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Tomoko 京都大学, 医学研究科, 助教 (50402855)
YOSHIDA Yoko 京都大学, 医学研究科, 助教 (60130324)
IMAMURA Yukio 京都大学, 医学研究科, 助教 (90447954)
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| Project Period (FY) |
2004 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥602,810,000 (Direct Cost: ¥463,700,000、Indirect Cost: ¥139,110,000)
Fiscal Year 2008: ¥125,320,000 (Direct Cost: ¥96,400,000、Indirect Cost: ¥28,920,000)
Fiscal Year 2007: ¥125,320,000 (Direct Cost: ¥96,400,000、Indirect Cost: ¥28,920,000)
Fiscal Year 2006: ¥125,320,000 (Direct Cost: ¥96,400,000、Indirect Cost: ¥28,920,000)
Fiscal Year 2005: ¥129,090,000 (Direct Cost: ¥99,300,000、Indirect Cost: ¥29,790,000)
Fiscal Year 2004: ¥97,760,000 (Direct Cost: ¥75,200,000、Indirect Cost: ¥22,560,000)
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| Keywords | がん / 発生 / マウス遺伝学 / MMP / ADAM / Notch / シグナル伝達 / RECK / 細胞マトリックス / fibronectin / 細胞移動 / 細胞密度 / 血清濃度 / 酸素濃度 / 条件的遺伝子欠損マウス / Ras / 発現遺伝子プロファイリング / 軟骨分化 / MT1-MMP / CD13 / Rg13 / profilin II / MMP-2 / Sept4 / MRF / 筋肉発生 / Rb / N-Ras / 甲状腺腫瘍 / septin / 精子形成 / Rap1 / C3G / endomucin |
|---|
| Research Abstract |
RECK, first isolated as a transformation suppressor gene, encodes a membrane-anchored glycoprotein essential for mouse embryogenesis and down-regulated in various type of human cancer. Our studies at the molecular, cellular, and whole animal levels revealed that RECK forms cowbell-shaped dimer, regulates a wide spectrum of extracellular metalloproteases, and protects cell surface molecules as well as extracellular matrix components. We also found that RECK expression is under dynamic regulations by various external stimuli, including growth factors, cell density, and oxygen concentration.
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