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Early-stage Identification of CTC (Circulating Tumor Cells) by Employing Softcomputing and Dielectrophoretic Phenomenon

Research Project

Project/Area Number 16H01747
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Soft computing
Research InstitutionFuzzy Logic Systems Institute

Principal Investigator

Yamakawa Takeshi  一般財団法人ファジィシステム研究所, 研究部, 所長 (00005547)

Co-Investigator(Kenkyū-buntansha) 田中 文啓  産業医科大学, 医学部, 教授 (10283673)
堀尾 恵一  九州工業大学, 大学院生命体工学研究科, 准教授 (70363413)
Research Collaborator Kuroki Futoshi  一般財団法人 ファジィシステム研究所, 研究部, 主席研究員 (30195581)
Yoneda Kazue  産業医科大学, 医学部, 学内講師 (80724806)
Imasato Hiroko  一般財団法人 ファジィシステム研究所, 研究部, 主任研究員 (70412682)
Eguchi Masanori  一般財団法人 ファジィシステム研究所, 研究部, 主任研究員 (60613594)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2016: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Keywords循環腫瘍細胞(CTC) / 誘電泳動 / ソフトコンピューティング / 自己組織化ファジィシステム / MEMS / 自己組織化マップ / ファジィ理論 / 循環腫瘍細胞(CTC)
Outline of Final Research Achievements

This research aims at detecting CTCs (Circulating Tumor Cells) which circulate in the body with the flow of blood or lymph. The attempt was made by the following three approaches; (1) Physical approach employing dielectrophoresis, (2)Biochemical approach employing an antigen-antibody reaction, (3)Electrical approach employing dielectric parameters specific to a tumor cell.
The research results are; (1) Although the performance of the system is not yet enough at the current moment, around a half number of cells examined were successfully classified to HL60, BALL-1, PC9 and normal cells.(2)The podoplanin-chip employing an antigen-antibody reaction exhibits much higher performance of trapping a specific tumor cell rather than the conventional commercial product CellSearch and it was evaluated clinically. (3) The ring resonator type of electrode with an active circuit (negative impedance) exhibits a high performance of detecting tumor cells.

Academic Significance and Societal Importance of the Research Achievements

我が国の死亡原因の第1位は悪性新生物(癌)によるもので,近年では総死亡の約3割を占めている.「原発巣」(例えば原発性肺癌)から遊離した腫瘍細胞は,血液やリンパ液の流れに乗って体内を循環し,離れた臓器に到着し,「転移巣」(例えば転移性肝臓癌)を形成する.この転移する細胞を循環腫瘍細胞(CTC : Circulating Tumor Cell)という. 従来,臨床現場でCTCを検出するのに使われていた米国Veridex社製のCellSearchは,2015年3月末をもって国内でのメンテナンスのサービスが終了した.この窮状を打開するために,本研究成果のもつ学術的意義は大きいといえよう.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (76 results)

All 2019 2018 2017 2016 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (51 results) (of which Int'l Joint Research: 28 results,  Invited: 4 results) Book (2 results) Remarks (7 results)

  • [Journal Article] Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma2019

    • Author(s)
      Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F.
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 2 Pages: 726-733

    • DOI

      10.1111/cas.13895

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A liquid biopsy in primary lung cancer2019

    • Author(s)
      Yoneda K, Imanishi N, Ichiki Y, Tanaka F.
    • Journal Title

      Surgical Today

      Volume: 49 Issue: 1 Pages: 1563-1569

    • DOI

      10.1007/s00595-018-1659-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune Checkpoint Inhibitors (ICIs) in Non-Small Cell Lung Cancer (NSCLC)2018

    • Author(s)
      Yoneda K, Imanishi N, Ichiki Y, Tanaka F.
    • Journal Title

      Journal of UOEH

      Volume: 40 Issue: 2 Pages: 173-189

    • DOI

      10.7888/juoeh.40.173

    • NAID

      130007398935

    • ISSN
      0387-821X, 2187-2864
    • Year and Date
      2018-06-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive factors of postoperative survival among patients with pulmonary neuroendocrine tumor2018

    • Author(s)
      Ichiki Y, Matsumiya H, Mori M, Kanayama M, Nabe Y, Taira A, Shinohara S, Kuwata T, Takenaka M, Hirai A, Imanishi N, Yoneda K, Noguchi H, Shimajiri S, Fujino Y, Nakayama T, Tanaka F.
    • Journal Title

      Journal of Thoracic Disease

      Volume: 10 Issue: 12 Pages: 6912-6920

    • DOI

      10.21037/jtd.2018.11.115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung2018

    • Author(s)
      Imanishi N, Hirai A, Yoneda K, Shimajiri S, Kuwata T, Tashima Y, Takeuchi M, Iwai Y, Ichiki Y, Tanaka F.
    • Journal Title

      Journal of Surgical Oncology

      Volume: 117 Issue: 7 Pages: 1563-1569

    • DOI

      10.1002/jso.25041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podoplanin - an emerging cancer biomarker and therapeutic target.2018

    • Author(s)
      Krishnan H, Rayes J, Miyashita T, Ishii G, Retzbach EP, Sheehan SA, Takemoto A, Chang YW, Yoneda K, Asai J, Jensen L, Chalise L, Natsume A, Goldberg GS.
    • Journal Title

      Cancer Sci.

      Volume: 印刷中 Issue: 5 Pages: 1292-1299

    • DOI

      10.1111/cas.13580

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer2018

    • Author(s)
      Takeuchi Masahiro、Doi Tomomitsu、Obayashi Kunie、Hirai Ayako、Yoneda Kazue、Tanaka Fumihiro、Iwai Yoshiko
    • Journal Title

      Immunology letters

      Volume: 196 Pages: 155-160

    • DOI

      10.1016/j.imlet.2018.01.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of programmed death-ligand 1 expression in correlation with human leukocyte antigen class I expression status in stage I adenocarcinoma of the lung.2018

    • Author(s)
      Hirai A, Yoneda K, Shimajiri S, Kuroda K, Hanagiri T, Fujino Y, Tanaka F.
    • Journal Title

      J Thorac Cardiovasc Surg.

      Volume: 155 Issue: 1 Pages: 382-392

    • DOI

      10.1016/j.jtcvs.2017.05.106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positive correlation between postoperative tumor recurrence and changes in circulating tumor cell counts in pulmonary venous blood (pvCTC) during surgical manipulation in non-small cell lung cancer2018

    • Author(s)
      Hashimoto Masaki、Tanaka Fumihiro、Yoneda Kazue、Takuwa Teruhisa、Matsumoto Seiji、Okumura Yoshitomo、Kondo Nobuyuki、Tsujimura Tohru、Nakano Takashi、Hasegawa Seiki
    • Journal Title

      Journal of Thoracic Disease

      Volume: 10 Issue: 1 Pages: 298-306

    • DOI

      10.21037/jtd.2017.12.56

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Considerations on Monopulse-Based Antenna System for Security Gates2018

    • Author(s)
      Tomoki Sakogawa, Katsuyoshi Aoki, Futoshi Kuroki, Masanori Eguchi , Takeshi Yamakawa
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 138 Issue: 2 Pages: 100-105

    • DOI

      10.1541/ieejeiss.138.100

    • NAID

      130006329295

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement on Complex Permittivities of Hydrated Soil, Live and Dead Leaves, Woods, and Stones at Frequency Bands from LF to MF for Landslides Prognostication2018

    • Author(s)
      Kousei Kumahara, Kengo Nakajima, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 138 Issue: 2 Pages: 94-99

    • DOI

      10.1541/ieejeiss.138.94

    • NAID

      130006329318

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capture of mesothelioma cells with 'universal' CTC-chip.2018

    • Author(s)
      Yoneda K, Chikaishi Y, Kuwata T, Ohnaga T, Tanaka F
    • Journal Title

      Oncology Letters

      Volume: 5(2) Pages: 2635-2640

    • DOI

      10.3892/ol.2017.7619

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The clinical value of circulating tumour cells (CTCs) in patients undergoing pulmonary metastasectomy for metastatic colorectal cancer.2018

    • Author(s)
      Hashimoto M, Tanaka F, Yoneda K, Takuwa T, Kuroda A, Matsumoto S, Okumura Y, Kondo N, Tsujimura T, Nakano T, Hasegawa S.
    • Journal Title

      J Thorac Dis.

      Volume: 10 Issue: 3 Pages: 1569-1577

    • DOI

      10.21037/jtd.2018.03.05

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates2017

    • Author(s)
      Inoue Takao、Fujii Masami、Kida Hiroyuki、Yamakawa Toshitaka、Maruta Yuichi、Tokiwa Tatsuji、He Yeting、Nomura Sadahiro、Owada Yuji、Yamakawa Takeshi、Suzuki Michiyasu
    • Journal Title

      Neuroscience Research

      Volume: 122 Pages: 35-44

    • DOI

      10.1016/j.neures.2017.04.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EpCAM-independent capture of circulating tumor cells with a 'universal CTC-chip'2017

    • Author(s)
      Chikaishi Y, Yoneda K, Ohnaga T, Tanaka F
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 37.1 Issue: 1 Pages: 77-82

    • DOI

      10.3892/or.2016.5235

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker2016

    • Author(s)
      Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
    • Journal Title

      Oncotarget

      Volume: Dec 31 Issue: 24 Pages: 39711-39726

    • DOI

      10.18632/oncotarget.14410

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] リング共振器型電極を用いた循環腫瘍細胞検出の高分解能化に関する検討2019

    • Author(s)
      空翔太, 熊原 宏征,,江口正徳, 黒木太司,山川烈,,田中 文啓
    • Organizer
      電子情報通信学会マイクロ波研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Numerical and Experimental Investigations on Ring Resonator Type of Electrode for Circulating Tumor Cell Detection2019

    • Author(s)
      Shouta Sora, Kousei Kumahara, Masanori Eguchi, Futoshi Kuroki, Takeshi Yamakawa, Fumihiro Tanaka
    • Organizer
      2019 Radio ans Wireless Week
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ピンセット形電極の共振現象を利用した肺癌部位推定に関する一考察2019

    • Author(s)
      熊原宏征,坂本雅弥,黒木太司,江口正徳,山川烈,田中文啓
    • Organizer
      2019年電子情報通信学会総合大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 負性抵抗素子を用いた循環腫瘍細胞検出リング共振器型電極のQ値改善に関する検討2019

    • Author(s)
      空翔太,熊原宏征,黒木太司,江口正徳,山川烈,田中文啓
    • Organizer
      2019年電子情報通信学会総合大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Detection of circulating tumor cells (CTCs) with polymeric CTC-chip or LiquidBiopsy system in primary lung cancer2019

    • Author(s)
      Kazue Yoneda, Taiji Kuwata, Masataka Mori, Masatoshi Kanayama, Katsuma Yoshimatsu, Yusuke Takeda, Kasumi Kusanagi, Teruaki Ishida, Hiroki Matsumiya, Yusuke Nabe, Akihiro Taira, Shinji Shinohara, Ayako Hirai, Yuko Tashima, Naoko Imanishi, Koji Kuroda, Yoshinobu Ichiki, Takashi Ohnaga, Fumihiro Tanaka
    • Organizer
      AACR-JCA Joint Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effective detection of circulating tumor cells (CTCs) in malignant pleural mesothelioma (MPM) with "universal" CTC-chip and an anti-podoplanin antibody NZ-1.22019

    • Author(s)
      Kazue Yoneda, Taiji Kuwata, Masataka Mori, Masatoshi Kanayama, Koji Kuroda, Yoshinobu Ichiki, Mika K. Kaneko, Yukinari Kato, Fumihiro Tanaka
    • Organizer
      PDPN meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiation Characteristics of EWE Antenna on Actual Ground for Landslides Prediction Based on Bistatic Radar System Using AM Radio Broadcasting2018

    • Author(s)
      Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      12th European Conference on Antennas and Propagation (EuCAP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sensing Performance Evaluation of Landslides Prediction System Based on Bistatic Radar Technology Using Public AM Radio Broadcasting2018

    • Author(s)
      Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      2018 IEEE MTT-S International Microwave Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Consideration of Relationship between Shape and Angular Velocity of Particles under Electrorotation2018

    • Author(s)
      Keiichi Horio, Koya Matsuyama, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      World Automation Congress 2018 (WAC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Pillar Electrode Array for Electrorotation Analysis of Single Cells2018

    • Author(s)
      Masanori Eguchi, Keiichi Horio, Futoshi Kuroki, Hiroko Imasato, Takeshi Yamakawa
    • Organizer
      World Automation Congress 2018 (WAC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Investigation of Circulating Tumor Cell Detection Using Resonant Circuits2018

    • Author(s)
      Shouta Sora, Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa, Fumihiro Tanaka
    • Organizer
      World Automation Congress 2018 (WAC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identifying and Handling a Biological Cell by Employing Dielectrophoresis2018

    • Author(s)
      Takeshi Yamakawa
    • Organizer
      7th International Conference on Informatics, Electronics & Vision (ICIEV2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Orthogonally-Face-to Face Type of Micro-electrode with Ring Resonator for Circulating Tumor Cell Detection2018

    • Author(s)
      Shouta Sora, Kousei Kumahara, Masanori Eguchi, Futoshi Kuroki, Takeshi Yamakawa, Fumihiro Tanaka
    • Organizer
      Asia -Pacific Microwave Conference (APMC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Capture of tumor cells in blood with “universal CTC-chip”2018

    • Author(s)
      Kazue Yoneda, Taiji Kuwata, Yasuhiro Chikaishi, Takashi Ohnaga, Yoshinobu Ichiki, Fumihiro Tanaka
    • Organizer
      American Association for Cancer Research (AACR) Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] “Universal”CTC-chipと抗EGFR抗体(Cetuximab)を用いたEpCAM陰性中皮腫細胞の捕捉2018

    • Author(s)
      米田和恵,田中文啓
    • Organizer
      第22回分子標的治療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circulating Tumor Cells (CTCs): Detection and clinical significance in thoracic malignancies2018

    • Author(s)
      Kazue Yoneda, Fumihiro Tanaka
    • Organizer
      Anti-Cancer Treatment Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Application of a Novel CTC-chip to Detect Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM)2018

    • Author(s)
      Kazue Yoneda, Taiji Kuwata, Yasuhiro Chikaishi, Yoshinobu Ichiki, Takashi Ohnaga, Fumihiro Tanaka
    • Organizer
      6th Japanease Cancer Association (JCA) -American Association for Cancer Research (AACR) Special joint conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性胸膜中皮腫における循環腫瘍細胞(CTC)の臨床的意義2018

    • Author(s)
      米田和恵,田中文啓
    • Organizer
      第28回日本産業衛生学会 職業性呼吸器疾患研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Circulating tumor cells (CTCs) in malignant pleural mesothelioma (MPM) with the novel CTC-chip system2018

    • Author(s)
      米田和恵,大永崇,田中文啓
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫における循環腫瘍細胞 (CTC)の臨床的意義2018

    • Author(s)
      米田 和恵,桒田 泰治,近石泰弘,森將鷹,金山雅俊,吉松克真,武田祐介,草薙佳澄,石田輝明,小山倫太郎,松宮弘喜,有村ゆう子,名部祐介,平良彰浩,篠原伸二,竹中賢,平井文子,田嶋裕子,今西直子,黒田耕志,市来嘉伸,田中文啓
    • Organizer
      第36回産業医科大学学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺癌学会悪性胸膜中皮腫における循環腫瘍細胞:新規CTCチップの開発と臨床応用2018

    • Author(s)
      米田和恵,桒田泰治,近石泰弘,森將鷹,金山雅俊,平良彰浩,名部裕介,篠原伸二,竹中賢,岡壮一,平井文子,田嶋裕子,今西直子,黒田耕志,市来嘉伸,大永崇,田中文啓
    • Organizer
      第59回日本肺癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫における循環腫瘍細胞(CTCs)の分離検出に関する検討2018

    • Author(s)
      米田和恵,桒田泰治,近石泰弘,森將鷹,金山雅俊,吉松克真,武田祐介,草薙佳澄,石田輝明,小山倫太郎,松宮弘喜,有村ゆう子,名部祐介,平良彰浩,篠原伸二,竹中賢,平井文子,田嶋裕子,今西直子,黒田耕志,市来嘉伸,大永崇,田中文啓
    • Organizer
      第3回Liquid Biopsy研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A Consideration on Detection of Circulating Tumor Cells Using Ring Resonator Type of Electrode2018

    • Author(s)
      Shouta Sora, Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Hiroko Imasato, Takeshi Yamakawa, Kazue Yoneda, Fumihiro Tanaka
    • Organizer
      International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting (AP-S/URSI2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 対向型循環腫瘍細胞検出マイクロ電極を構成するマイクロストリップ線路の伝送損失と Q値に関する検討2018

    • Author(s)
      空 翔太,熊原 宏征,江口正徳,黒木太司,山川 烈,,田中 文啓
    • Organizer
      電気情報通信学会ソサイエティ大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Experimental Investigation on Potentiality for Circulating Tumor Cell Detection Using Ring-resonator-shaped Electrode2018

    • Author(s)
      Shouta Sora, Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa, and Fumihiro Tanaka
    • Organizer
      6th Smart City Workshop 2018 in Malaysia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Landslide Prognostication System Based on Bistatic Radar Technology Using AM Radio Waves2018

    • Author(s)
      Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      Radio and Wireless Symposium (RWS2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Consideration on Influence of Interference Waves at Security Gate Using Monopulse System at UHF Band2018

    • Author(s)
      Tomoki Sakogawa, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      Radio and Wireless Symposium (RWS2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸器悪性腫瘍におけるLiquid Biopsy2018

    • Author(s)
      米田和恵、桒田泰治、近石泰弘、大永 崇、田中文啓
    • Organizer
      第2回Liquid Biopsy研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リング共振器を用いた血中循環腫瘍細胞検出電極に関する検討2018

    • Author(s)
      空 翔太,熊原 宏征,黒木 太司,江口 正徳,今里 浩子,山川 烈,堀尾 恵一,米田 和恵,田中 文啓
    • Organizer
      電子情報通信学会マイクロ波研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロアレイ電極への応用を目的としたリング共振器装荷循環腫瘍細胞検出電極に関する検討2018

    • Author(s)
      空 翔太,熊原 宏征,黒木 太司,江口 正徳,今里 浩子,山川 烈,堀尾 恵一,米田 和恵,田中 文啓
    • Organizer
      2018年電子情報通信学会総合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロストリップ線路上に作成した経好電極による循環腫瘍細胞検出に関する一検討2017

    • Author(s)
      空 翔太, 黒木 太司, 江口 正徳, 今里 浩子, 山川 烈, 堀尾 恵一, 米田 和恵, 田中 文啓
    • Organizer
      2017年電子情報通信学会総合大会
    • Place of Presentation
      名城大学 (愛知県・名古屋市)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Consideration on Incidence and Reflection Characteristics of Hydrated Soil for Landslides Prognostication Systems Using Electromagnetic Waves2017

    • Author(s)
      Kohsei Kumahara, Kengo Nakajima, Futoshi Kuroki, Masanori Eguchi and Takeshi Yamakawa
    • Organizer
      11th European Conference on Antennas and Propagation (EuCAP2017)
    • Place of Presentation
      The Congress Center of Paris (France)
    • Year and Date
      2017-03-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Universal CTC-chipによる血液中腫瘍細胞の捕捉2017

    • Author(s)
      米田和恵、桒田泰治、近石泰弘、由良冴希子、小林健一、小山倫太郎、松宮弘喜、金山雅俊、平良彰浩、名部裕介、篠原伸二、竹中 賢、岡 壮一、平井文子、田嶋裕子、今西直子、黒田耕志、大永 崇、田中文啓
    • Organizer
      第1回Liquid Biopsy研究会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2017-01-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of CTCs in thoracic malignant tumors with "universal" CTC-chip.2017

    • Author(s)
      Kazue Yoneda, Taiji Kuwata, Yasuhiro Chikaishi, Kenichi Kobayashi , Sakiko Yura, Hiroki Matsumiya, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Masaru Takenaka, Soichi Oka, Ayako Hirai, Yuko Tashima, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
    • Organizer
      America Association for Cancer Research (AACR) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognostic impact of PD-L1 expression in correlation with HLA class I expression status in stage I adenocarcinoma of the lung.2017

    • Author(s)
      Kazue Yoneda, Ayako Hirai, Shohei Shimajiri, Takeshi Hanagiri, Fumihiro Tanaka
    • Organizer
      American Society of Clinical Oncology (ASCO) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Universal CTC-Chip”と抗ポドプラニン抗体NZ-1を用いた中皮腫細胞の捕捉2017

    • Author(s)
      米田和恵、加藤幸成、田中文啓
    • Organizer
      第21回がん分子標的治療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cryoprobe System with Built-in Thermocouple for Cryosurgery2017

    • Author(s)
      Tatsuji Tokiwa, Lev Zimin, Hiroshi Ishiguro, Takeshi Yamakawa
    • Organizer
      The 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'17)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy of an Exercise Program to Prepare People with Severe Intellectual Disabilities for Physical Fitness Test2017

    • Author(s)
      Mizuki Sakamoto, Ritsuko Imamura, Kiyohisa Natsume and Takeshi Yamakawa
    • Organizer
      12th International Conference on Innovative Computing, Information and Control (ICICIC2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of an Applied Behavior Analysis-Based Intervention on People with Extremely Severe Intellectual Disabilities Displaying Aversion to Exercise2017

    • Author(s)
      Ritsuko Imamura, Takeshi Yamakawa, and Mizuki Sakamoto
    • Organizer
      12th International Conference on Innovative Computing, Information and Control (ICICIC2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リング共振器型電極による循環腫瘍細胞検出に関する検討2017

    • Author(s)
      空 翔太,熊原 宏征,黒木 太司,江口 正徳,今里 浩子,山川 烈,堀尾 恵一,米田 和恵,田中 文啓
    • Organizer
      2017電子情報通信学会ソサイエティ大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] "universal CTC-chip"を用いた胸部悪性腫瘍における循環腫瘍細胞(CTCs)の検出2017

    • Author(s)
      米田和恵、桒田泰治、大永崇、田中文啓
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 独創性を武器に生き残る2017

    • Author(s)
      山川烈
    • Organizer
      第5回Design Expo 2017 くまもとデザイン協議会30周年記念講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] “Universal CTC-chip”による血液中腫瘍細胞の捕捉と検出に関する基礎検討2017

    • Author(s)
      米田和恵、桒田泰治、近石泰弘、大永 崇、田中文啓
    • Organizer
      第35回日本ヒト細胞学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prognostic impact of PD-L1 expression in correlation with HLA class I expression status in adenocarcinoma of the lung. International Association of Study of Lung Cancer (IASLC)2017

    • Author(s)
      Kazue Yoneda, Ayako Hirai, Shohei Shimajiri, Koji Kuroda, Takeshi Hangiri, Fumihiro Tanaka
    • Organizer
      18th World Conference on Lung Cancer (WCLC) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Propagation Modeling of Mountain with Flourishing Forest for Landslide Prognostication Using MF-band2017

    • Author(s)
      Kousei Kumahara, Futoshi Kuroki, Masanori Eguchi, Takeshi Yamakawa
    • Organizer
      Progress In Electromagnetics Research Symposium (PIERS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 誘電泳動下で回転する細胞の形状と角速度の関係性検討及び角速度補正の試み2017

    • Author(s)
      松山公弥, 古賀裕章, 江口正徳, 山川烈, 堀尾恵一
    • Organizer
      第30回バイオメディカル・ファジィ・システム学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 直列スタブ結合循環腫瘍細胞検出電極の検討2017

    • Author(s)
      空 翔太,熊原 宏征,黒木 太司,江口 正徳,今里 浩子,山川 烈,堀尾 恵一,米田 和恵,田中文啓
    • Organizer
      電気学会A部門マグネティックス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sensitive Detection of CTCs in Thoracic Malignant Tumors with "Universal" CTC-Chip2016

    • Author(s)
      K. Yoneda, T. Kuwata, Y. Chikaishi, K. Kobayashi, R. Oyama, S. Yura, H. Matsumiya, A. Taira, Y. Nabe, M. Takenaka, S. Oka, A. Hirai, Y. Tashima, N. Imanishi, K. Kuroda, T. Ohnaga, F. Tanaka
    • Organizer
      IASLC (International Association for the Study of Lung Cancer) 17th World Conference on Lung Cancer
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Capture of tumor cells in blood with "Universal CTC-chip"2016

    • Author(s)
      Kazue Yoneda,Takashi Ohnaga, Fumihiro Tanaka
    • Organizer
      The 75th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Circulating Tumor Cells: A Novel Detection System with “Universal” CTC-chip2016

    • Author(s)
      Kazue Yoneda, Fumihiro Tanaka
    • Organizer
      World Automation Congress 2016 Japan Satellite Session
    • Place of Presentation
      じばさんびる(兵庫県姫路市)
    • Year and Date
      2016-08-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Microwell Array for Dielectric Characterization of Circulating Tumor Cells2016

    • Author(s)
      Masanori Eguchi, Futoshi Kuroki, Hiroko Imasato and Takeshi Yamakawa
    • Organizer
      World Automation Congress 2016 Japan Satellite Session
    • Place of Presentation
      じばさんびる(兵庫県姫路市)
    • Year and Date
      2016-08-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 早期発見・予防に向けた次世代がん検査技術の最前線2019

    • Author(s)
      米田和恵、田中文啓
    • Total Pages
      216
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314051
    • Related Report
      2018 Annual Research Report
  • [Book] Molecular diagnosis and targeting for lung cancer. Molecular diagnosis and targeting for thoracic and gastrointestinal malignancy2018

    • Author(s)
      Kazue Yoneda, Fumihiro Tanaka
    • Total Pages
      156
    • Publisher
      Springer Nature
    • ISBN
      9789811064685
    • Related Report
      2017 Annual Research Report
  • [Remarks] 一般財団法人ファジィシステム研究所

    • URL

      http://flsi.cird.or.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 産業医科大学 医学部 第2外科

    • Related Report
      2018 Annual Research Report
  • [Remarks] 九州工業大学 大学院 生命体工学研究科

    • URL

      http://www.lsse.kyutech.ac.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 呉工業高等専門学校

    • URL

      https://www.kure-nct.ac.jp

    • Related Report
      2018 Annual Research Report
  • [Remarks] 一般財団法人ファジィシステム研究所

    • URL

      http://flsi.cird.or.jp/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 産業医科大学 医学部 第2外科

    • URL

      http://www.kitakyusyu-gan.jp/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州工業大学生命体工学研究科

    • URL

      http://www.lsse.kyutech.ac.jp/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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