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Development of genome montage technology for predicting facial morphology

Research Project

Project/Area Number 16H01752
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionTokai University

Principal Investigator

IMANISHI Tadashi  東海大学, 医学部, 教授 (80270461)

Co-Investigator(Kenkyū-buntansha) 木村 亮介  琉球大学, 医学(系)研究科(研究院), 准教授 (00453712)
瀧 靖之  東北大学, スマート・エイジング学際重点研究センター, 教授 (10375115)
安藤 寿康  慶應義塾大学, 文学部(三田), 教授 (30193105)
中川 草  東海大学, 医学部, 講師 (70510014)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywordsゲノム多型 / 顔形状 / モンタージュ / 人類学 / 情報システム / 双生児 / 遺伝率 / ゲノム / 画像
Outline of Final Research Achievements

Because most identical twins have similar looks, there seems to be strong genetic factors contributing to the human facial morphology. In this study, we aimed to reveal the genetic factors that determine the personal variation of faces by collecting and analyzing morphological and genetic data. We held events for measuring facial morphology by a 3D scanner and collecting DNA samples from Japanese volunteers including twins and siblings. Using the data for 186 individuals, we predicted heritability of various parts of faces. We also examined genetic polymorphisms for 380 volunteers collected by IDAC of Tohoku University, and are carrying out the genome-wide association study of head MRI data. In this way, we succeeded in developing infrastructure for the study of genome montage technology.

Academic Significance and Societal Importance of the Research Achievements

本研究では双生児およびきょうだいの調査に基づく顔形状の遺伝率推定を行ったが、これは日本人集団については初めての試みであり、学術的な意義がある。また、現在進行中の顔形状に関するゲノムワイド関連解析の結果を使えば、個人のゲノム配列から顔形状を推定するソフトウエアである「ゲノム・モンタージュ」を作成することが可能であり、将来は法医学分野をはじめとする社会の各方面での応用が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (20 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (2 results)

  • [Journal Article] Interferon regulatory factor 6 variants affect nasolabial morphology in East Asian populations2018

    • Author(s)
      Tomita Daisuke、Yamaguchi Tetsutaro、Nakawaki Takatoshi、Hikita Yu、Adel Mohamed、Kim Yong-Il、Haga Shugo、Takahashi Masahiro、Kawaguchi Akira、Isa Mutsumi、Park Soo-Byung、Ishida Hajime、Maki Koutaro、Kimura Ryosuke
    • Journal Title

      Archives of Oral Biology

      Volume: 85 Pages: 142-147

    • DOI

      10.1016/j.archoralbio.2017.10.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of FGFR1 Variants to Craniofacial Variations in East Asians2017

    • Author(s)
      Adel Mohamed、Yamaguchi Tetsutaro、Tomita Daisuke、Nakawaki Takatoshi、Kim Yong-Il、Hikita Yu、Haga Shugo、Takahashi Masahiro、Nadim Mohamed A.、Kawaguchi Akira、Isa Mutsumi、El-Kenany Walid H.、El-Kadi Abbadi A.、Park Soo-Byung、Ishida Hajime、Maki Koutaro、Kimura Ryosuke
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 1 Pages: e0170645-e0170645

    • DOI

      10.1371/journal.pone.0170645

    • NAID

      120006891154

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Growth hormone receptor gene variant and three-dimensional mandibular morphology.2016

    • Author(s)
      Nakawaki, T., T. Yamaguchi, M. Isa, A. Kawaguchi, D. Tomita, Y. Hikita, Y. Suzuki-Tomoyasu, M. Adel, H. Ishida, K. Maki, and R. Kimura
    • Journal Title

      The Angle Orthodontist

      Volume: 87(1) Issue: 1 Pages: 68-73

    • DOI

      10.2319/02316-154.1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 個人ゲノム情報に基づくヒト顔形状の予測をめざして2018

    • Author(s)
      今西 規、中川 草、木村 亮介、瀧 靖之、安藤 寿康
    • Organizer
      第7回生命医薬情報学連合大会(IIBMP2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 個人ゲノム情報に基づくヒト顔形状の予測2018

    • Author(s)
      今西 規、中川 草、木村 亮介、瀧 靖之、安藤 寿康
    • Organizer
      遺伝研研究会・理論分子進化学の新機軸
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 日本人における三次元顔面形態解析と関連遺伝子多型探索2017

    • Author(s)
      木村亮介
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Interpopulation differentiation and neutrality in the human face.2017

    • Author(s)
      Kimura, R.
    • Organizer
      Workshop Human evolution in Eurasia elucidated through Genetics, Archeology, and Linguistics
    • Place of Presentation
      National Institute of Genetics(Mishima, Shizuoka)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム情報に基づく個人の表現型予測と医療への応用2017

    • Author(s)
      今西規
    • Organizer
      基盤研究(S)「人種化のプロセスとメカニズムに関する複合的研究」研究会
    • Place of Presentation
      KKRホテル金沢(石川県金沢市)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒト頭蓋顔面形態の多様性とその遺伝的基盤2017

    • Author(s)
      木村亮介
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒトの表現型を規定するゲノム変異の進化的起源を探る2017

    • Author(s)
      今西規
    • Organizer
      日本進化学会第19回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 個人ゲノム情報はどこまで解き明かされたか -疾患リスク予測と個人同定-2017

    • Author(s)
      今西規
    • Organizer
      生物学史分科会シンポジウム「生命科学とビッグデータ」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 日本におけるツインリサーチのこれまで・これから ふたごが拓く予防医学の未来:ツインリサーチの可能性2016

    • Author(s)
      安藤寿康
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 行動の遺伝学-ふたご研究のエビデンスから2016

    • Author(s)
      安藤寿康
    • Organizer
      日本生理人類学会第74回大会
    • Place of Presentation
      和倉温泉観光会館(石川県七尾市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] FST-QST 解析による琉球-本土間三次元顔面形態の中立性検定2016

    • Author(s)
      木村亮介, 渡辺千晶, 宮里絵理, 山口今日子, 佐藤丈寛, 伊藤毅, 山本健, 石田肇
    • Organizer
      第70回日本人類学会大会
    • Place of Presentation
      学生総合プラザSTEP(新潟県新潟市)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 琉球-本土間における三次元顔面形態比較:FST-QST 解析による中立性検定2016

    • Author(s)
      木村亮介, 渡辺千晶, 宮里絵理, 山口今日子, 佐藤丈寛, 川口亮, 山本健, 石田肇
    • Organizer
      日本進化学会第18回大会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都目黒区)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Longitudinal effect of Executive Function (EF) on general factor of cognition (g) and personality (GFP).2016

    • Author(s)
      Ando, J.
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      PACIFICO Yokohama(Yokohama, Kanagawa)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficiency of functional brain networks and intellectual performance in discordant monozygotic twins.2016

    • Author(s)
      Ando, J. and Someya, Y.
    • Organizer
      The 22nd Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Palexpo Exhibition and Congress Center(Geneve, Switzerland)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] History of twin research in Japan and Keio Twin Registry.2016

    • Author(s)
      Ando, J.
    • Organizer
      The 16th International Congress on Twin Studies
    • Place of Presentation
      QIMR Berghofer Medical Research Institute(Brisbane, Australia)
    • Year and Date
      2016-06-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 日本人の9割が知らない遺伝の真実2016

    • Author(s)
      安藤寿康
    • Total Pages
      224
    • Publisher
      SB新書
    • Related Report
      2016 Annual Research Report
  • [Book] Evolutionary Locus of the Neanderthal Between Chimpanzees and Modern Humans: A Working Memory, Theory of Mind, and Brain Developmental, Piagetian Perspective. In: "Social Learning and Innovation in Contemporary Hunter-Gatherers."2016

    • Author(s)
      Ando, J
    • Total Pages
      17
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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