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Elucidation of species differences and adaptive evolution of chemical sensitivity in mammal and bird species

Research Project

Project/Area Number 16H01779
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionHokkaido University

Principal Investigator

Ishizuka Mayumi  北海道大学, 獣医学研究院, 教授 (50332474)

Co-Investigator(Kenkyū-buntansha) 池中 良徳  北海道大学, 獣医学研究院, 准教授 (40543509)
中山 翔太  北海道大学, 獣医学研究院, 助教 (90647629)
水川 葉月  北海道大学, 獣医学研究院, 博士研究員 (60612661)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
KeywordsシトクロムP450 / グルクロン酸抱合 / 硫酸抱合 / 環境化学物質 / 種差 / 異物代謝 / 毒性学 / 遺物代謝
Outline of Final Research Achievements

We cloned P450 and UGT, the major pathways of xenobiotic metabolism in the liver, in mammals and birds, and characterized them enzymatically, identifying species in which UGT and ST are deficient or extremely inactive and the causes. In addition, anticoagulant rodenticides are currently used primarily for the control of exotic small mammals worldwide. Therefore, we evaluated the susceptibility of a wide range of animal species to rodenticides and clarified the differences in the metabolic capacity of P450 and UGT.

Academic Significance and Societal Importance of the Research Achievements

高次捕食者の動物種について、環境化学物質を中心に外来性化学物質の代謝能を明らかにし、低活性の動物種についてはその原因を同定した。これにより、対象動物種だけではなく、近縁種へのリスク評価の展開を可能とした。本研究では環境化学物質についてその感受性の高い動物種を明らかにしており、今後の生態系保全のデータ基盤となるほか、実際に、小笠原諸島などにおける殺鼠剤など科学的防除の際のアセスメントに必要なデータを提供した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (172 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (16 results) Journal Article (40 results) (of which Int'l Joint Research: 29 results,  Peer Reviewed: 40 results,  Open Access: 38 results,  Acknowledgement Compliant: 17 results) Presentation (110 results) (of which Int'l Joint Research: 39 results,  Invited: 18 results) Book (1 results) Remarks (2 results) Funded Workshop (3 results)

  • [Int'l Joint Research] Kasetsert University(タイ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] North-West University(南アフリカ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ザンビア大学(ザンビア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ノースウェスト大学(南アフリカ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Zagazig University(エジプト)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Benin University(ナイジェリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Zambia(ザンビア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] North West University(南アフリカ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] KNUST(ガーナ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Zagazig University(Egypt)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] North West University/University of Johannesburg(South Africa)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Gondar University(Ethiopia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Zambia(Zambia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] KNUST(Ghana)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Comparison of two reducing agents dithiothreitol and tris(3-hydroxypropyl)phosphine for in vitro kinetic assay of vitamin K epoxide reductase.2020

    • Author(s)
      Kazuki Takeda, Ayuko Morita, Yoshinori Ikenaka, Shouta M.M.Nakayama, Mayumi Ishizuka.
    • Journal Title

      Veterinary and Animal Science.

      Volume: 9 Pages: 100095-100095

    • DOI

      10.1016/j.vas.2020.100095

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In?Vivo Accumulation of Plastic-Derived Chemicals into Seabird Tissues2020

    • Author(s)
      Tanaka Kosuke、Watanuki Yutaka、Takada Hideshige、Ishizuka Mayumi、Yamashita Rei、Kazama Mami、Hiki Nagako、Kashiwada Fumika、Mizukawa Kaoruko、Mizukawa Hazuki、Hyrenbach David、Hester Michelle、Ikenaka Yoshinori、Nakayama Shouta M.M.
    • Journal Title

      Current Biology

      Volume: 30 Issue: 4 Pages: 106-106

    • DOI

      10.1016/j.cub.2019.12.037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Avian interspecific differences in VKOR activity and inhibition: insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1.2020

    • Author(s)
      Nakayama SMM, Morita A, Ikenaka Y, Kawai YK, Watanabe KP, Ishii C, Mizukawa H, Yohannes YB, Saito K, Watanabe Y, Ito M, Ohsawa N, Ishizuka M.
    • Journal Title

      Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.

      Volume: 228 Pages: 108635-108635

    • DOI

      10.1016/j.cbpc.2019.108635

    • NAID

      120006955194

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry2020

    • Author(s)
      Togao Masao、Nakayama Shouta M.M.、Ikenaka Yoshinori、Mizukawa Hazuki、Makino Yoshiki、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Hirata Takafumi、Ishizuka Mayumi
    • Journal Title

      Chemosphere

      Volume: 238 Pages: 124581-124581

    • DOI

      10.1016/j.chemosphere.2019.124581

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dichlorodiphenyltrichloroethane (DDT) levels in rat livers collected from a malaria vector control region2019

    • Author(s)
      MOTOHIRA Kodai、IKENAKA Yoshinori、YOHANNES Yared Beyene、NAKAYAMA Shouta M. M.、WEPENER Victor、SMIT Nico J.、VAN VUREN Johan H. J.、SOUSA Ana Catarina、ENUNEKU Alex Ajeh、OGBOMIDA Emmanuel Temiotan、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 11 Pages: 1575-1579

    • DOI

      10.1292/jvms.19-0168

    • NAID

      130007744347

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure2019

    • Author(s)
      Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Darwish WS, Takiguchi M, Tanabe S, Ishizuka M
    • Journal Title

      Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

      Volume: 226 Pages: 108613-108613

    • DOI

      10.1016/j.cbpc.2019.108613

    • NAID

      120006937043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the organochlorine p,p’-DDT on MCF-7 cells: Investigating metabolic and immune modulatory transcriptomic changes2019

    • Author(s)
      Thompson Lesa A.、Ikenaka Yoshinori、Sobhy Darwish Wageh、Nakayama Shouta M.M.、Mizukawa Hazuki、Ishizuka Mayumi
    • Journal Title

      Environmental Toxicology and Pharmacology

      Volume: 72 Pages: 103249-103249

    • DOI

      10.1016/j.etap.2019.103249

    • NAID

      120006941695

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A review: poisoning by anticoagulant rodenticides in non-target animals globally2019

    • Author(s)
      Nakayama SMM, Morita A, Ikenaka Y, Mizukawa H, Ishizuka M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 2 Pages: 298-313

    • DOI

      10.1292/jvms.17-0717

    • NAID

      130007605094

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human Health Risk from Consumption of Marine Fish Contaminated with DDT and Its Metabolites in Maputo Bay, Mozambique2018

    • Author(s)
      Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、Ichise T.、Ito G.、Bortey-Sam N.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M.
    • Journal Title

      Bulletin of Environmental Contamination and Toxicology

      Volume: 100 Issue: 5 Pages: 672-676

    • DOI

      10.1007/s00128-018-2323-7

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia2018

    • Author(s)
      Yabe John、Nakayama Shouta M.M.、Ikenaka Yoshinori、Yohannes Yared B.、Bortey-Sam Nesta、Kabalo Abel Nketani、Ntapisha John、Mizukawa Hazuki、Umemura Takashi、Ishizuka Mayumi
    • Journal Title

      Chemosphere

      Volume: 202 Pages: 48-55

    • DOI

      10.1016/j.chemosphere.2018.03.079

    • NAID

      120006864479

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens2018

    • Author(s)
      Ishii C、Ikenaka Y、Ichii O、Nakayama S M M、Nishimura S-I、Ohashi T、Tanaka M、Mizukawa H、Ishizuka M
    • Journal Title

      Poultry Science

      Volume: 97 Issue: 5 Pages: 1722-1729

    • DOI

      10.3382/ps/pey016

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species2018

    • Author(s)
      Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M.
    • Journal Title

      CBP

      Volume: 214 Pages: 28-35

    • DOI

      10.1016/j.cbpc.2018.08.007

    • NAID

      120006769940

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats ( Rattus rattus ) in Tokyo by in situ liver perfusion2018

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D.Tanaka, Shouta M.M .Nakayama, Tsutomu Tanikawa, Hazuki Mizukawa, Mayumi Ishizuka
    • Journal Title

      Pesticide Biochemistry and Physiology

      Volume: in press Pages: 42-49

    • DOI

      10.1016/j.pestbp.2018.03.018

    • NAID

      120006636185

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomarkers in tigerfish ( Hydrocynus vittatus ) as indicators of metal and organic pollution in ecologically sensitive subtropical rivers2018

    • Author(s)
      Gerber R.、Smit N.J.、van Vuren Johan H.J.、Ikenaka Y.、Wepener Victor
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 157 Pages: 307-317

    • DOI

      10.1016/j.ecoenv.2018.03.091

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana2018

    • Author(s)
      Bortey-Sam Nesta、Ikenaka Yoshinori、Akoto Osei、Nakayama Shouta M.M.、Asante Kwadwo A.、Baidoo Elvis、Obirikorang Christian、Mizukawa Hazuki、Ishizuka Mayumi
    • Journal Title

      Environ Pollut.

      Volume: 235 Pages: 163-170

    • DOI

      10.1016/j.envpol.2017.12.005

    • NAID

      120006820161

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accumulation patterns and risk assessment of metals and metalloid in muscle and offal of free-range chickens, cattle and goat in Benin City, Nigeria2018

    • Author(s)
      Ogbomida Emmanuel Temiotan、Nakayama Shouta M.M.、Bortey-Sam Nesta、Oroszlany Balazs、Tongo Isioma、Enuneku Alex Ajeh、Ozekeke Ogbeide、Ainerua Martins Oshioriamhe、Fasipe Iriagbonse Priscillia、Ezemonye Lawrence Ikechukwu、Mizukawa Hazuki、Ikenaka Yoshinori、Ishizuka Mayumi
    • Journal Title

      Ecotoxicol Environ Saf

      Volume: 151 Pages: 98-108

    • DOI

      10.1016/j.ecoenv.2017.12.069

    • NAID

      120006842182

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle2018

    • Author(s)
      BORTEY-SAM Nesta、IKENAKA Yoshinori、AKOTO Osei、NAKAYAMA Shouta M.M.、MARFO Jemima T.、SAENGTIENCHAI Aksorn、MIZUKAWA Hazuki、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 375-381

    • DOI

      10.1292/jvms.17-0410

    • NAID

      130006410766

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Species Differences in Xenobiotic Metabolism in Non-experimental Animals2017

    • Author(s)
      水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 3 Pages: 257-263

    • DOI

      10.1248/yakushi.16-00230-2

    • NAID

      130005396880

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line2017

    • Author(s)
      Darwish Wageh Sobhy、Ikenaka Yoshinori、Nakayama Shouta、Mizukawa Hazuki、Thompson Lesa A、Ishizuka Mayumi
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 25 Issue: 7 Pages: 6320-6328

    • DOI

      10.1007/s11356-017-0977-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios2017

    • Author(s)
      Chihiro Ishii, Shouta M.M.Nakayama, Yoshinori Ikenaka, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Mayumi Ishizuka
    • Journal Title

      Chemosphere

      Volume: 186 Pages: 367-373

    • DOI

      10.1016/j.chemosphere.2017.07.143

    • NAID

      120006477493

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores2017

    • Author(s)
      Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
    • Journal Title

      Toxicological Sciences

      Volume: 158 Issue: 1 Pages: 90-100

    • DOI

      10.1093/toxsci/kfx072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa2017

    • Author(s)
      Yohannes Yared Beyene、Ikenaka Yoshinori、Ito Gengo、Nakayama Shouta M. M.、Mizukawa Hazuki、Wepener Victor、Smit Nico J.、Van Vuren Johan H. J.、Ishizuka Mayumi
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 24 Issue: 30 Pages: 23763-23770

    • DOI

      10.1007/s11356-017-9911-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea2017

    • Author(s)
      Chihiro Ishii, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Yutaka Watanuki, Masaaki Fukuwaka, and Mayumi Ishizuka
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 4 Pages: 807-814

    • DOI

      10.1292/jvms.16-0441

    • NAID

      130007331465

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Organochlorine pesticide contamination of foods in Africa: incidence and public health significance2017

    • Author(s)
      L. A. Thompson, W. S. Darwish, Y. Ikenaka, S. M. Nakayama, H. Mizukawa and M. Ishizuka
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 4 Pages: 751-764

    • DOI

      10.1292/jvms.16-0214

    • NAID

      130005568160

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats.2017

    • Author(s)
      Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution).
    • Journal Title

      Int. J. Environ. Res. Public Health

      Volume: in press Issue: 1 Pages: 56-56

    • DOI

      10.3390/ijerph14010056

    • NAID

      120005981457

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia.2017

    • Author(s)
      Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
    • Journal Title

      BECT

      Volume: 98 Issue: 2 Pages: 172-177

    • DOI

      10.1007/s00128-016-2011-4

    • NAID

      120006377485

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia.2017

    • Author(s)
      Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
    • Journal Title

      Sci. Total. Environ.

      Volume: 574 Pages: 1389-1395

    • DOI

      10.1016/j.scitotenv.2016.08.056

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis.2016

    • Author(s)
      Takeda K*, Ikenaka Y*, Tanikawa T, Tanaka KD, Nakayama SMM, Mizukawa H, Ishizuka M (*Equal contribution).
    • Journal Title

      Pestic Biochem Physiol.

      Volume: in press Pages: 1-7

    • DOI

      10.1016/j.pestbp.2016.04.004

    • NAID

      120006360062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities.2016

    • Author(s)
      Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M.
    • Journal Title

      Comp Biochem Physiol C Pharmacol Toxicol.

      Volume: 190 Pages: 38-47

    • DOI

      10.1016/j.cbpc.2016.08.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana.2016

    • Author(s)
      Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo J, Saengtienchai A, Mizukawa H, Ishizuka, M.
    • Journal Title

      Environmental Pollution

      Volume: 218 Pages: 331-337

    • DOI

      10.1016/j.envpol.2016.07.008

    • NAID

      120006539246

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heavy metals and metalloid accumulation in livers and kidneys of wild rats around gold-mining communities in Tarkwa, Ghana.2016

    • Author(s)
      Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution).
    • Journal Title

      Journal of Environmental Chemistry and Ecotoxicology,

      Volume: 8 Issue: 7 Pages: 58-68

    • DOI

      10.5897/jece2016.0374

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam2016

    • Author(s)
      Nakayama SMM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M
    • Journal Title

      Journal of Veterinary Pharmacology and Therapeutics

      Volume: in press Issue: 5 Pages: 478-87

    • DOI

      10.1111/jvp.12303

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Feather mercury concentration in streaked shearwaters wintering in separate areas of southeast Asia2016

    • Author(s)
      Watanuki Y, Yamashita A, Ishizuka M, Ikenaka Y, Nakayama SMM, Ishii C, Yamamoto T, Ito M, Kuwae T, Trathan PN
    • Journal Title

      Marine Ecology Progress Series

      Volume: 546 Pages: 263-269

    • DOI

      10.3354/meps11669

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells.2016

    • Author(s)
      Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
    • Journal Title

      J. Food. Sci.

      Volume: 81 Issue: 1

    • DOI

      10.1111/1750-3841.13162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area.2016

    • Author(s)
      Gerber R, Smit NJ, Van Vuren JH, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V.
    • Journal Title

      Sci. Total. Environ.

      Volume: 550 Pages: 522-533

    • DOI

      10.1016/j.scitotenv.2016.01.129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats2016

    • Author(s)
      Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 4 Pages: 675-680

    • DOI

      10.1292/jvms.15-0299

    • NAID

      130007331491

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances?2016

    • Author(s)
      Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
    • Journal Title

      Environmental Science & Technology

      Volume: 50 Issue: 1 Pages: 444-452

    • DOI

      10.1021/acs.est.5b04216

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens.2016

    • Author(s)
      Nakata H, Nakayama SMM, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M
    • Journal Title

      Environ Pollut.

      Volume: 208 Pages: 395-403

    • DOI

      10.1016/j.envpol.2015.10.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue.2016

    • Author(s)
      Mahmoud AFA, IkenakaY, YohannesYB, DarwishWS, Eldaly EA, Morshdy AE, Nakayama SMM, MizukawaH, Ishizuka M.
    • Journal Title

      Chemosphere

      Volume: 144 Pages: 1365-1371

    • DOI

      10.1016/j.chemosphere.2015.10.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance2016

    • Author(s)
      Darwish WS, Ikenaka Y, Morshdy AE, Eldesoky KI, Nakayama SMM, MizukawaH, Ishizuka M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 2 Pages: 351-354

    • DOI

      10.1292/jvms.15-0287

    • NAID

      130005131329

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Species differences in xenobiotic metabolism by phase I and II enzymes of companion animals and wildlife.2019

    • Author(s)
      Mayumi Ishizuka, Yoshinori Ikenaka, Shouta MM Nakayam
    • Organizer
      The 2nd Joint Meeting of Veterinary Science in East Asia.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] LC/MSを用いたイヌ血清中ステロイドホルモンの分析法の確立と副腎疾患モデルを用いた実測2019

    • Author(s)
      白尾大樹、池中良徳、一瀬貴大、中山翔太、佐々木東、永田矩之、水川葉月、滝口満善、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 摂食プラスチックから海鳥への化学物質の移行の検証2019

    • Author(s)
      田中厚資、綿貫豊、高田秀重、石塚真由美、山下麗、水川薫子、水川葉月、池中良徳、中山翔太
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In Vivo Pharmacokinetic/pharmacodynamic analysis of first generation anticoagulant rodenticide warfarin with Egyptian fruit bats ( Rousettus aegyptiacus ) for risk assessment of Bonin fruit bats Pteropus pselaphon2019

    • Author(s)
      Shouta M.M. Nakayama, Kosuke Manago, Kazuki Takeda, Ayuko Morita, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characterization and differentiation of xenobiotic metabolism in mammalian animals through glucuronidation and sulfation profiling2019

    • Author(s)
      Aksorn Saengtienchai, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネオニコチノイドの母子間移行の実態と移行メカニズムの解明2019

    • Author(s)
      池中良徳、一瀬貴大、ニマコ・コリンズ、市川剛、野見山桂、長谷川浩、中山翔太、星信彦、平久美子、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PCBs 曝露によるネコ肝トランスクリプトームへの影響2019

    • Author(s)
      水川葉月、Hoa Thanh Ngyuen、岩田久人、野見山桂 、池中良徳、中山翔太、横山望 、市居修 、滝口満喜、Kraisiri Khidkhan、田辺信介、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鳥類の鉛暴露の実態とその毒性2019

    • Author(s)
      石塚真由美、池中良徳、中山翔太
    • Organizer
      希少な鳥を守るには ―野鳥の鳥インフルエンザと鉛汚染対策に向けて―
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Ryo Yamazaki, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      SETAC-Australasia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of mechanism of rodenticide resistance with closed colonies of rodenticide resistant rats from Tokyo2019

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Tsutomu Tanikawa and Mayumi Ishizuka
    • Organizer
      the 15th International Congress of Toxicology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 東京都小笠原諸島における殺鼠剤散布のアオウミガメへのリスク評価2019

    • Author(s)
      山村快哉、武田一貴、中山翔太、川合佑典、森田鮎子、小松謙之、北山知代、近藤理美、池中良徳、石塚真由美
    • Organizer
      第25回日本野生動物医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 体内動態および行動毒性試験から見た動物用医薬品フィプロニルの影響評価2019

    • Author(s)
      鈴木智裕、池中良徳、武田一貴、中山翔太、水川葉月、一瀬貴大、佐々木東、笹岡一慶、滝口満喜、石塚真由美
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LC-MS/MSを用いたイヌ血清中ステロイドホルモンの分析法の確立と内分泌疾患モデルを用いた実測2019

    • Author(s)
      白尾 大樹、池中 良徳、一瀬 貴大、中山 翔太、佐々木 東、永田 矩之、 水川 葉月、滝口 満善、石塚 真由美
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗凝血系殺鼠剤が小笠原諸島在来固有種に与える影響の評価2019

    • Author(s)
      真砂皓大、武田 一貴、中山 翔太、森田 鮎子、池中 良徳、石塚 真由美
    • Organizer
      第25回日本環境毒性学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 単回投与試験によるコウモリの抗凝血系殺鼠剤リスクアセスメントの実施2019

    • Author(s)
      真砂皓大、武田 一貴、中山 翔太、森田 鮎子、池中 良徳、石塚 真由美
    • Organizer
      第25回日本環境毒性学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pharmacokinetic/pharmacodynamic analysis of first-generation anticoagulant rodenticide warfarin with Egyptian fruit bats (Rousettus aegyptiacus)2019

    • Author(s)
      Shouta MM NAKAYAMA, Kosuke MANAGO, Kazuki TAKEDA, Ayuko MORITA, Yoshinori IKENAKA, Mayumi ISHIZUKA
    • Organizer
      SETAC North America 40th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 基質結合部位からも活性残基からも離れたアミノ酸変異はどのように殺鼠剤抵抗性に寄与するのか?2019

    • Author(s)
      武田一貴、池中良徳、フルシュデニス、田中和之、中山翔太、谷川力、トリキドハ、シンハオリー、石塚真由美
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DDTによる異物代謝酵素の遺伝子発現撹乱と健康影響評価2019

    • Author(s)
      本平 航大, 池中 良徳, Yared Beyene, 中山 翔太, 江口 哲史, 武田 一貴, Victor Wepener, Nico Smit, Johan Van Vuren, 石塚 真由美
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Experimental evidence of accumulation of plastic-derived chemicals into seabirds’ tissue2019

    • Author(s)
      Kosuke Tanaka, Yutaka Watanuki, Hideshige Takada, Yoshinori Ikenaka, Shouta M.M. Nakayama, Rei Yamashita, Mayumi Ishizuka
    • Organizer
      Pacific Seabird Group 46th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鉛鉱床地域における野生トカゲ亜目の生体内金属類濃度に影響を与える環境要因の解析2018

    • Author(s)
      谷理緒、中山翔太、中田北斗、豊巻治也、Yabe John、Muzandu Kaampwe、Beyene Yared、Kataba Andrew、Zyambo Golden、水川 葉月、池中 良徳、石塚 真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] HPLC-APCI-MSを用いたビタミンKの網羅的検出とin vitroビタミンKエポキシド還元酵素活性の評価2018

    • Author(s)
      武田一貴、池中良徳、田中和之、中山翔太、谷川力、水川葉月、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characteristics of CYP450 expression in cat exposed PCBs: Estimating the potential toxicity2018

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka,
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 有機ハロゲン化合物曝露によるネコの生化学マーカーの変化および甲状腺機能に及ぼす影響評価2018

    • Author(s)
      水川葉月、Kraisiri Khidkhan、高口倖暉、横山望、市居修、滝口満喜、笹岡一慶、池中良徳、中山翔太、野見山桂、田辺信介、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 野生哺乳類における硫酸転移酵素の動物種差解明2018

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、三谷曜子、田辺信介 、野見山桂、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スーパーラットは何が「スーパー」なのか? ~東京の殺鼠剤抵抗性クマネズミにおける抵抗性獲得機序の探索~2018

    • Author(s)
      武田 一貴、池中 良徳、田中 和之、中山 翔太、谷川 力、水川 葉月、石塚 真由美
    • Organizer
      第45回 日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食肉目動物での第II 相抱合酵素の遺伝的性状および酵素学的性状の解明2018

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、三谷曜子、田辺信介 、野見山桂、石塚真由美
    • Organizer
      第45回 日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネオニコチノイド系殺虫剤の日本人における曝露実態2018

    • Author(s)
      石塚真由美
    • Organizer
      第45回 日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Tissue distribution and CYP expression related-PCBs exposure in cats. 38th International Symposium on Halogenated Persistent Organic Pollutants (POPs)2018

    • Author(s)
      Kraisiri Khidkan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M. M. Nakayama, Wageh Sobhy Darwish, Kei Nomiyama, Mitsuyoshi Takiguchi, Nozomu Yokoyama, Osamu Ichii, Shinsuke Tanabe, Mayumi Ishizuka.
    • Organizer
      DIOXIN 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 殺鼠剤に弱い野生動物種を探る:標的分子ビタミンKエポキシド還元酵素(VKOR)の鳥類における特徴および種差2018

    • Author(s)
      中山翔太、森田鮎子、池中良徳、石井千尋、水川葉月、武田一貴、川合佑典、齊藤慶輔、渡邊有希子、大澤夏生、伊藤真輝、石塚真由美
    • Organizer
      第24回日本野生動物医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 鰭脚類を中心とした食肉目の薬物代謝酵素である硫酸転移酵素の種差解明2018

    • Author(s)
      近藤 誉充、池中 良徳、中山 翔太、水川 葉月、三谷 曜子、田辺 信介、野見山 桂、石塚 真由美
    • Organizer
      第24回日本野生動物医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 代謝酵素の動物種差2017

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      日本薬学会第137年会シンポジウム
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Comparison of Food Products Contaminated by DDTs in South Africa and Mozambique2017

    • Author(s)
      Lesa A. Thompson, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
    • Organizer
      19th International Conference on One Health
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イエネコのin vivo長期曝露試験:デカブロモジフェニルエーテル(BDE209)は甲状腺機能亢進症を引き起こすのか?2017

    • Author(s)
      水川葉月、野見山桂、池中良徳、中山翔太、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、笹岡一慶、市居修、Kraisiri Khidkhan、高居名菜、滝口満喜、田辺信介、石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価2017

    • Author(s)
      野見山桂、西川 博之、水川葉月、髙口倖暉、Tsend-ayush Sainnoxoi、横山 望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イエネコのin vivo長期曝露試験:デカブロモジフェニルエーテル(BDE209)の生体内変化2017

    • Author(s)
      田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia2017

    • Author(s)
      Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト生体試料を用いたネオニコチノイドおよびネオニコチノイド代謝物の分析方法2017

    • Author(s)
      一瀬貴大,池中良徳,藤岡一俊,平久美子,中山翔太,水川葉月,八木橋美緒,有薗幸司,加藤恵介,高橋圭介,石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population2017

    • Author(s)
      Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In situ肝灌流試験によるワルファリン抵抗性クマネズミでのワルファリン代謝能の解明2017

    • Author(s)
      武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 幼児における尿中ネオニコチノイド濃度とその曝露実態の解明2017

    • Author(s)
      池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、遠山千春、石塚真由美
    • Organizer
      第26回環境化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高次栄養段階生物への化学物質の感受性の種差2017

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      第31回環境ホルモン学会講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] UDP-glucuronosyltransferase (UGT) among Pinnipedia and other carnivores2017

    • Author(s)
      Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomiyama, Shinsuke Tanabe, and Mayumi Ishizuka
    • Organizer
      the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inveatigation of biochemical changes in cat exposed organohalogen compounds2017

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ塩化ビフェニル(PCBs)のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価2017

    • Author(s)
      水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Studies on polycyclic aromatic hydrocarbons formation in heat-treated meat2017

    • Author(s)
      Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝灌流試験、in vitro酵素活性試験による東京由来ワルファリン抵抗性クマネズミのワルファリン代謝能の解明2017

    • Author(s)
      武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 幼児のネオニコチノイド系農薬の曝露評価に関する研究2017

    • Author(s)
      池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、平久美子、有薗幸司、高橋圭介、加藤恵介、遠山千春、石塚真由美
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Utility evaluation for stable Pb isotopes analysis using potential sentinel animals to identify Pb pollution sources2017

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      International Conference on Geology, Mining, Mineral and Groundwater Resources of the Sub-Saharan Africa
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis2017

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] "エストロジェン類高感度分析法の開発と野生動物におけるスクリーニング "2017

    • Author(s)
      新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、伊藤真輝、高江洲昇、大澤夏生、綿貫豊、石塚 真由美
    • Organizer
      第23回日本野生動物医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 全国規模での鳥類への鉛曝露:曝露指標として骨の利用の可能性2017

    • Author(s)
      石井千尋,中山翔太,池中良徳,Kataba Andrew,齊藤慶輔,渡辺有希子,槇納好岐,松川岳久,久保田章乃,横山和仁,水川葉月,平田岳史,石塚真由美
    • Organizer
      第23回日本野生動物医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] "東京由来殺鼠剤抵抗性ラットを用いた新規抵抗性獲得機序の解明 ペントースリン酸経路の亢進による殺鼠剤代謝能の活性化"2017

    • Author(s)
      武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
    • Organizer
      第160回日本獣医学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鳥類医学の発展に向けた新規腎障害マーカーの探索2017

    • Author(s)
      石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美
    • Organizer
      日本鳥学会2017年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] "鳥類におけるグルクロン酸抱合能の種差の解明と化学物質感受性の推定 "2017

    • Author(s)
      新屋惣、池中良徳、中山翔太、水川葉月、伊藤真輝、高江洲昇、齊藤 慶輔、渡邊 有希子、石塚 真由美
    • Organizer
      日本鳥学会2017年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 海鳥を介した汚染物質輸送2017

    • Author(s)
      庄子晶子、K. Elliott, S. Aris-Brosou、水 川葉月、中山翔太、池中良徳、石塚真由美、桑江朝比呂、渡辺謙太、綿貫豊
    • Organizer
      日本鳥学会2017年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of DDTs on gallinacins in the avian immune system2017

    • Author(s)
      Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] "Discovery of renal biomarkers in birds by transcriptome analysis and glycomics analysis following kidney injury in chicken model "2017

    • Author(s)
      Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of utility for stable lead isotope ratios to identify lead sources and verifying biological fractionation of lead isotopes in goats and chickens2017

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      " SETAC North America 38th Annual Meeting"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats2017

    • Author(s)
      Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      " SETAC North America 38th Annual Meeting"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia2017

    • Author(s)
      Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka
    • Organizer
      " SETAC North America 38th Annual Meeting"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ塩化ビフェニル(PCBs)がネコの甲状腺機能に及ぼす影響2017

    • Author(s)
      水川葉月、高居名菜、野見山桂、高口倖暉、横山望、市居修、滝口満喜、池中良徳、中山翔太、石塚真由美
    • Organizer
      環境ホルモン学会第20回研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of indoor residual spraying DDT for mosquito control: Tissue distribution and gene expression profiling in rat tissues2017

    • Author(s)
      Emmanuel Temiotan Ogbomida, Alex Ajeh Enuneku, Yoshinori Ikenaka, Yared Beyene Yohannes, Wageh Sobhy Darwish, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      環境ホルモン学会第20回研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 幼児および新生児におけるネオニコチノイド系殺虫剤の曝露実態2017

    • Author(s)
      池中良徳、宮原裕一、一瀬貴大、中山翔太、水川葉月、市川剛、遠山千春、石塚真由美
    • Organizer
      環境ホルモン学会第20回研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lead levels in eggs in Kabwe, Zambia: implication of human exposure2017

    • Author(s)
      Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
    • Organizer
      Society of Toxicology’s 57th Annual Meeting and ToxExpo
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Mechanism of Rodenticide (warfarin) Resistance of Wild Rats in Tokyo ~ Enhanced Pentose Phosphate Pathway Causes Rapid Metabolism of Warfarin ~2017

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      Society of Toxicology’s 57th Annual Meeting and ToxExpo
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In situ肝灌流モデルによる殺鼠剤抵抗性野生クマネズミにおけるワルファリン代謝能の解明2016

    • Author(s)
      武田一貴、池中良徳、田中和之、中山翔太、谷川力、水川葉月、石塚真由美
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化学物質の汚染環境に生きる野生動物の適応戦略2016

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      一般社団法人日本環境化学会25周年記念講演会:「環境化学の今、そして未来へ-環境化学からの提言-」
    • Place of Presentation
      発明会館地下ホール、東京都
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Monitoring of blood lead levels (BLLs) in dogs and chickens from lead pollution area, Kabwe, Zambia.2016

    • Author(s)
      Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      International Doctoral Symposium on Sustainable Management of Resources and Environment in the 21st Century
    • Place of Presentation
      Hokkaido University, Hokkaido, Japan
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats.2016

    • Author(s)
      Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
    • Organizer
      The 7th SETAC World Congress/37th SETAC North America Annual Meeting
    • Place of Presentation
      Rosen Shingle Creek, Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis.2016

    • Author(s)
      Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe.
    • Organizer
      The 7th SETAC World Congress/37th SETAC North America Annual Meeting
    • Place of Presentation
      Rosen Shingle Creek, Orlando, FL, USA
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats.2016

    • Author(s)
      Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka.
    • Organizer
      The 9th International PCB Workshop
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 野生げっ歯類の殺鼠剤の抵抗性メカニズムと非対象動物に対する毒性メカニズム2016

    • Author(s)
      石塚真由美、中山翔太、水川葉月、池中良徳
    • Organizer
      日本哺乳類学会2016年度大会「企画シンポジウム:野生動物が関わる問題にどのように対応するか?~基礎研究を応用した解決への取り組み~」
    • Place of Presentation
      筑波大学、つくば市、茨城県
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Investigation of Warfarin Metabolic Ability of Warfarin Resistant Roof Rats by in situ Liver Perfusion.2016

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      The 4th Sapporo Summer Seminar for One Health (SaSSOH)
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lead exposure on human samples in African countries and lead pollution in Kabwe, Zambia.2016

    • Author(s)
      Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
    • Organizer
      The 4th Sapporo Summer Seminar for One Health (SaSSOH)
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A glycomics approach to renal biomarkers in birds.2016

    • Author(s)
      Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka
    • Organizer
      The 4th Sapporo Summer Seminar for One Health (SaSSOH)
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~.2016

    • Author(s)
      Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka.
    • Organizer
      The 4th Sapporo Summer Seminar for One Health (SaSSOH)
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] UGT2Bサブファミリーに着目した食肉目におけるグルクロン酸抱合能の動物種差解明2016

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
    • Organizer
      平成28年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      静岡県立大学薬学部、静岡市、静岡県
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鳥類における新規腎障害マーカーの探索2016

    • Author(s)
      石井千尋、池中良徳、市居修、中山翔太、西村紳一郎、大橋哲、田中誠一、齊藤慶輔、渡邊有希子、水川葉月、石塚真由美
    • Organizer
      第22回日本野生動物医学会
    • Place of Presentation
      宮崎市民プラザ、宮崎
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鳥類におけるグルクロン酸抱合酵素による薬物代謝2016

    • Author(s)
      新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、齊藤慶輔、渡邉有希子、伊藤真輝、高江洲昇、坂本健太郎、石塚真由美
    • Organizer
      第22回日本野生動物医学会
    • Place of Presentation
      宮崎市民プラザ、宮崎
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 野生動物及び実験動物におけるグルクロン酸抱合酵素の動物種差解明2016

    • Author(s)
      近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部、藤沢市、神奈川県
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 家畜・家禽の鉛安定同位体生体内分別の種差および歩哨動物としての有用性評価2016

    • Author(s)
      栂尾正雄、中山翔太、John Yabe、池中良徳、中田北斗、石井千尋、水川葉月、Yared B. Yohannes、 Aksorn Saengtienchai、石塚真由美
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部、藤沢市、神奈川県
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] X線照射したヒト子宮頸がん由来HeLa細胞におけるミトコンドリア機能を中心としたエネルギー代謝応答の解析2016

    • Author(s)
      山本久美子、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山盛徹、 稲波修
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部、藤沢市、神奈川県
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト子宮頚部がんHeLa細胞における放射線照射後のミトコンドリア応答2016

    • Author(s)
      稲波修、山本久美子、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山盛徹
    • Organizer
      第69回日本酸化ストレス学会学術年会
    • Place of Presentation
      仙台国際センター会議 棟、仙台市、宮城県
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Kabwe childhood lead poisoning: past, present and future2016

    • Author(s)
      John Yabe, Shouta MM Nakayama, Yoshinori Ikenaka, Yared B. Yohannes, Haruya Toyomaki, Kennedy Choongo, Kaampwe Muzandu and Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lead exposure on human samples in African countries: a mini review2016

    • Author(s)
      Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Risk Assessment of Heavy Metals via Consumption of Muscle and Offal of Free-Range Animals from Benin City2016

    • Author(s)
      Emmanuel Temiotan Ogbomida, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Isioma Tongo, Alex Ajeh Enuneku, Ogbeide Ozekeke, Martins Oshioriamhe Ainerua, Iriagbonse Priscillia Fasipe, Lawrence Ikechukwu Ezemonye, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Creating a model of renal damage in chicken and glycomic approach to identify novel biomarkers for kidney injury in birds2016

    • Author(s)
      Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cytochrome P450 expression in the rabbit2016

    • Author(s)
      Walaa Fathy Saad Eldin, Wageh S. Darwish, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pb levels and isotope ratio profiles in kidneys of Japanese wild rats2016

    • Author(s)
      Shouta M.M. Nakayama, Hokuto Nakata, Balazs Oroszlany, Yoshinori Ikenaka, Hazuki Mizukawa, Kazuyuki Tanaka, Tsunehito Harunari, Tsutomu Tanikawa, Yared B. Yohannes, Aksorn Saengtienchai, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs2016

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Is there species difference of biological variation of lead (Pb) isotopic composition between livestock and poultry?2016

    • Author(s)
      Masao Togao, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yoshinori Ikenaka, Chihiro Ishii, Yared B. Yohannes, Hazuki Mizukawa, Wageh Sobhy Darwish, Aksorn Saengtienchai, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pharmacokinetic analysis of warfarin resistant roof rats (Rattus rattus) in Tokyo2016

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
    • Organizer
      8th International Toxicology Symposium in Africa
    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites.2016

    • Author(s)
      Nesta Bortey-Sam, Yoshinori Ikenaka, Shouta M.M. Nakayama, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
    • Organizer
      第30回北海道薬物作用談話会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] N-glycans as potential novel biomarkers for kidney injury in avian species.2016

    • Author(s)
      Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama,Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka,Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka.
    • Organizer
      65th International Conference of the Wildlife Disease Association,
    • Place of Presentation
      Greek Peak Mountain Resort, Cortland, New York, USA
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト子宮頸がんHeLa細 胞における放射線照射後のエネルギー生産とその意義2016

    • Author(s)
      稲波 修、山本久美子、西村英里、房 知輝、酒井友里、鈴木基史、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山田健一、山崎俊栄、山盛 徹
    • Organizer
      第54回日本放射線腫瘍学会生物部会学術大会
    • Place of Presentation
      I-siteなんば、大阪市、大阪府
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Kabwe Mining Pollution Amelioration Initiative Project2016

    • Author(s)
      Mayumi Ishizuka
    • Organizer
      Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
    • Place of Presentation
      CRESTA Golfview Hotel, Lusaka, Zambia
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KAMPAI -Team 2, PAST, PRESENT and FUTURE-2016

    • Author(s)
      Shouta M.M. Nakayama, John Yabe, Yared Beyene, Haruya Toyomaki, Kaampwe Muzandu, Kennedy Choongo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
    • Place of Presentation
      CRESTA Golfview Hotel, Lusaka, Zambia
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂肪組織における芳香族炭化水素受容体(AhR)の機能解明2016

    • Author(s)
      本平 航大、池中 良徳、ワギ ダルウィシュ、中山 翔太、水川 葉月、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 東京由来ワルファリン抵抗性クマネズミクローズドコロニーでのワルファリン体内動態の解明2016

    • Author(s)
      武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] ハリネズミは化学物質高感受性種? African hedgehog (Atalerix albiventris)で観察された低薬物代謝能2016

    • Author(s)
      アクソルン サエンティエンチャイ、池中 良徳、ネスタ サム、ウスマ ジャムナーク、水川 葉月、中山 翔太、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川 葉月、前原 美咲、横山 望、市居 修、滝口 満喜、野見山 桂、西川 博之、池中 良徳、中山 翔太、高口 倖暉、田辺 信介、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト尿中ネオニコチノイドおよびその代謝産物の高感度分析による暴露実態の解明2016

    • Author(s)
      池中 良徳、石塚 真由美
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] UGTの動物種差2016

    • Author(s)
      石塚 真由美、中山 翔太、水川 葉月、池中 良徳
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち、愛知
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Plasma essential trace element concentrations in dogs with chronic enteropathy.2016

    • Author(s)
      Nozomu Yokoyama, Hiroshi Ohta, Hazuki Mizukawa, Yumiko Kagawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi.
    • Organizer
      American College of Veterinary Internal Medicine Forum 2016
    • Place of Presentation
      Colorado convention center, Colorado, U.S.A
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ネコにおけるポリ塩化ビフェニル(PCBs)の異物代謝機構解明と甲状腺ホルモンへの影響評価2016

    • Author(s)
      水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト尿中のネオニコチノイドおよびその代謝産物の分析法の確立とヒトへの曝露評価2016

    • Author(s)
      池中 良徳、藤岡 一俊、平 久美子、中山 翔太、水川 葉月、一瀬 貴大、Jemima Tiwaa Marfo、有薗 幸司、加藤 恵介、石坂 真澄、馬場 浩司、川上 智規、石塚 真由美
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価2016

    • Author(s)
      野見山 桂、山本 恭央、水川 葉月、江口 哲史、滝口 満喜、中山 翔太、池中 良徳、石塚 真由美、国末 達也、田辺 信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタボローム解析を用いたPCBsによるイエネコの毒性影響評価2016

    • Author(s)
      西川博之、野見山桂、水川葉月、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites.2016

    • Author(s)
      Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Kwadwo A. Asante, Christian Obirikorang, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
    • Organizer
      SETAC Europe 26th Annual Meeting
    • Place of Presentation
      La Cite Nantes Congress Center, Nantes, France
    • Year and Date
      2016-05-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 地球をめぐる不都合な物質 拡散する化学物質がもたらすもの2019

    • Author(s)
      日本環境化学会(石塚真由美、他)
    • Total Pages
      272
    • Publisher
      講談社
    • ISBN
      9784065163931
    • Related Report
      2019 Annual Research Report
  • [Remarks] 北大獣医毒性学教室

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院毒性学教室

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] International Symposium on Chemical Hazard in Wildlife.2020

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 9th International Toxicology Symposium in Africa2017

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 8th International Toxicology Symposium in Africa2016

    • Place of Presentation
      Giza, Egypt
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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