Elucidation of species differences and adaptive evolution of chemical sensitivity in mammal and bird species
Project/Area Number |
16H01779
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
池中 良徳 北海道大学, 獣医学研究院, 准教授 (40543509)
中山 翔太 北海道大学, 獣医学研究院, 助教 (90647629)
水川 葉月 北海道大学, 獣医学研究院, 博士研究員 (60612661)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
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Keywords | シトクロムP450 / グルクロン酸抱合 / 硫酸抱合 / 環境化学物質 / 種差 / 異物代謝 / 毒性学 / 遺物代謝 |
Outline of Final Research Achievements |
We cloned P450 and UGT, the major pathways of xenobiotic metabolism in the liver, in mammals and birds, and characterized them enzymatically, identifying species in which UGT and ST are deficient or extremely inactive and the causes. In addition, anticoagulant rodenticides are currently used primarily for the control of exotic small mammals worldwide. Therefore, we evaluated the susceptibility of a wide range of animal species to rodenticides and clarified the differences in the metabolic capacity of P450 and UGT.
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Academic Significance and Societal Importance of the Research Achievements |
高次捕食者の動物種について、環境化学物質を中心に外来性化学物質の代謝能を明らかにし、低活性の動物種についてはその原因を同定した。これにより、対象動物種だけではなく、近縁種へのリスク評価の展開を可能とした。本研究では環境化学物質についてその感受性の高い動物種を明らかにしており、今後の生態系保全のデータ基盤となるほか、実際に、小笠原諸島などにおける殺鼠剤など科学的防除の際のアセスメントに必要なデータを提供した。
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Report
(5 results)
Research Products
(172 results)
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[Journal Article] Avian interspecific differences in VKOR activity and inhibition: insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1.2020
Author(s)
Nakayama SMM, Morita A, Ikenaka Y, Kawai YK, Watanabe KP, Ishii C, Mizukawa H, Yohannes YB, Saito K, Watanabe Y, Ito M, Ohsawa N, Ishizuka M.
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Journal Title
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.
Volume: 228
Pages: 108635-108635
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure2019
Author(s)
Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Darwish WS, Takiguchi M, Tanabe S, Ishizuka M
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Journal Title
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
Volume: 226
Pages: 108613-108613
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios2017
Author(s)
Chihiro Ishii, Shouta M.M.Nakayama, Yoshinori Ikenaka, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Mayumi Ishizuka
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Journal Title
Chemosphere
Volume: 186
Pages: 367-373
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats.2017
Author(s)
Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution).
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Journal Title
Int. J. Environ. Res. Public Health
Volume: in press
Issue: 1
Pages: 56-56
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats2016
Author(s)
Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M.
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Journal Title
Journal of Veterinary Medical Science
Volume: 78
Issue: 4
Pages: 675-680
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances?2016
Author(s)
Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama M.M.S, Kunisue T, Tanabe S
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Journal Title
Environmental Science & Technology
Volume: 50
Issue: 1
Pages: 444-452
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Characteristics of CYP450 expression in cat exposed PCBs: Estimating the potential toxicity2018
Author(s)
Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka,
Organizer
第27回環境化学討論会
Related Report
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[Presentation] Tissue distribution and CYP expression related-PCBs exposure in cats. 38th International Symposium on Halogenated Persistent Organic Pollutants (POPs)2018
Author(s)
Kraisiri Khidkan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M. M. Nakayama, Wageh Sobhy Darwish, Kei Nomiyama, Mitsuyoshi Takiguchi, Nozomu Yokoyama, Osamu Ichii, Shinsuke Tanabe, Mayumi Ishizuka.
Organizer
DIOXIN 2018
Related Report
Int'l Joint Research
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[Presentation] 代謝酵素の動物種差2017
Author(s)
石塚真由美、中山翔太、水川葉月、池中良徳
Organizer
日本薬学会第137年会シンポジウム
Place of Presentation
仙台国際センター、仙台市
Year and Date
2017-03-24
Related Report
Invited
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[Presentation] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population2017
Author(s)
Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
Organizer
第26回環境化学討論会
Related Report
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[Presentation] Inveatigation of biochemical changes in cat exposed organohalogen compounds2017
Author(s)
Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
Organizer
the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
Related Report
Int'l Joint Research
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[Presentation] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis2017
Author(s)
Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
Organizer
37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
Related Report
Int'l Joint Research
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[Presentation] 鳥類医学の発展に向けた新規腎障害マーカーの探索2017
Author(s)
石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美
Organizer
日本鳥学会2017年度大会
Related Report
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[Presentation] Effect of DDTs on gallinacins in the avian immune system2017
Author(s)
Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
Organizer
The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
Related Report
Int'l Joint Research
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[Presentation] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats2017
Author(s)
Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
Organizer
" SETAC North America 38th Annual Meeting"
Related Report
Int'l Joint Research
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[Presentation] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia2017
Author(s)
Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka
Organizer
" SETAC North America 38th Annual Meeting"
Related Report
Int'l Joint Research
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[Presentation] Lead levels in eggs in Kabwe, Zambia: implication of human exposure2017
Author(s)
Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
Organizer
Society of Toxicology’s 57th Annual Meeting and ToxExpo
Related Report
Int'l Joint Research
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[Presentation] Monitoring of blood lead levels (BLLs) in dogs and chickens from lead pollution area, Kabwe, Zambia.2016
Author(s)
Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
Organizer
International Doctoral Symposium on Sustainable Management of Resources and Environment in the 21st Century
Place of Presentation
Hokkaido University, Hokkaido, Japan
Year and Date
2016-11-09
Related Report
Int'l Joint Research
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[Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats.2016
Author(s)
Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
Organizer
The 7th SETAC World Congress/37th SETAC North America Annual Meeting
Place of Presentation
Rosen Shingle Creek, Orlando, FL, USA
Year and Date
2016-11-06
Related Report
Int'l Joint Research
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[Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis.2016
Author(s)
Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe.
Organizer
The 7th SETAC World Congress/37th SETAC North America Annual Meeting
Place of Presentation
Rosen Shingle Creek, Orlando, FL, USA
Year and Date
2016-11-06
Related Report
Int'l Joint Research
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[Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats.2016
Author(s)
Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka.
Organizer
The 9th International PCB Workshop
Place of Presentation
Kobe International Conference Center, Kobe, Japan
Year and Date
2016-10-09
Related Report
Int'l Joint Research
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[Presentation] A glycomics approach to renal biomarkers in birds.2016
Author(s)
Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka
Organizer
The 4th Sapporo Summer Seminar for One Health (SaSSOH)
Place of Presentation
Sapporo, Japan
Year and Date
2016-09-20
Related Report
Int'l Joint Research
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[Presentation] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~.2016
Author(s)
Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka.
Organizer
The 4th Sapporo Summer Seminar for One Health (SaSSOH)
Place of Presentation
Sapporo, Japan
Year and Date
2016-09-20
Related Report
Int'l Joint Research
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[Presentation] Kabwe childhood lead poisoning: past, present and future2016
Author(s)
John Yabe, Shouta MM Nakayama, Yoshinori Ikenaka, Yared B. Yohannes, Haruya Toyomaki, Kennedy Choongo, Kaampwe Muzandu and Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Risk Assessment of Heavy Metals via Consumption of Muscle and Offal of Free-Range Animals from Benin City2016
Author(s)
Emmanuel Temiotan Ogbomida, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Isioma Tongo, Alex Ajeh Enuneku, Ogbeide Ozekeke, Martins Oshioriamhe Ainerua, Iriagbonse Priscillia Fasipe, Lawrence Ikechukwu Ezemonye, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Creating a model of renal damage in chicken and glycomic approach to identify novel biomarkers for kidney injury in birds2016
Author(s)
Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Cytochrome P450 expression in the rabbit2016
Author(s)
Walaa Fathy Saad Eldin, Wageh S. Darwish, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Pb levels and isotope ratio profiles in kidneys of Japanese wild rats2016
Author(s)
Shouta M.M. Nakayama, Hokuto Nakata, Balazs Oroszlany, Yoshinori Ikenaka, Hazuki Mizukawa, Kazuyuki Tanaka, Tsunehito Harunari, Tsutomu Tanikawa, Yared B. Yohannes, Aksorn Saengtienchai, Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs2016
Author(s)
Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] Is there species difference of biological variation of lead (Pb) isotopic composition between livestock and poultry?2016
Author(s)
Masao Togao, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yoshinori Ikenaka, Chihiro Ishii, Yared B. Yohannes, Hazuki Mizukawa, Wageh Sobhy Darwish, Aksorn Saengtienchai, Mayumi Ishizuka
Organizer
8th International Toxicology Symposium in Africa
Place of Presentation
Giza, Egypt
Year and Date
2016-08-29
Related Report
Int'l Joint Research / Invited
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[Presentation] N-glycans as potential novel biomarkers for kidney injury in avian species.2016
Author(s)
Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama,Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka,Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka.
Organizer
65th International Conference of the Wildlife Disease Association,
Place of Presentation
Greek Peak Mountain Resort, Cortland, New York, USA
Year and Date
2016-07-31
Related Report
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[Presentation] Kabwe Mining Pollution Amelioration Initiative Project2016
Author(s)
Mayumi Ishizuka
Organizer
Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
Place of Presentation
CRESTA Golfview Hotel, Lusaka, Zambia
Year and Date
2016-07-14
Related Report
Int'l Joint Research
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[Presentation] KAMPAI -Team 2, PAST, PRESENT and FUTURE-2016
Author(s)
Shouta M.M. Nakayama, John Yabe, Yared Beyene, Haruya Toyomaki, Kaampwe Muzandu, Kennedy Choongo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
Organizer
Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
Place of Presentation
CRESTA Golfview Hotel, Lusaka, Zambia
Year and Date
2016-07-14
Related Report
Int'l Joint Research
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[Presentation] UGTの動物種差2016
Author(s)
石塚 真由美、中山 翔太、水川 葉月、池中 良徳
Organizer
第43回日本毒性学会学術年会
Place of Presentation
ウインクあいち、愛知
Year and Date
2016-06-29
Related Report
Invited
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[Presentation] Plasma essential trace element concentrations in dogs with chronic enteropathy.2016
Author(s)
Nozomu Yokoyama, Hiroshi Ohta, Hazuki Mizukawa, Yumiko Kagawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi.
Organizer
American College of Veterinary Internal Medicine Forum 2016
Place of Presentation
Colorado convention center, Colorado, U.S.A
Year and Date
2016-06-08
Related Report
Int'l Joint Research
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[Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites.2016
Author(s)
Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Kwadwo A. Asante, Christian Obirikorang, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
Organizer
SETAC Europe 26th Annual Meeting
Place of Presentation
La Cite Nantes Congress Center, Nantes, France
Year and Date
2016-05-22
Related Report
Int'l Joint Research
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