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Non-invasive visualization of immune dynamizm by magnetic resonance

Research Project

Project/Area Number 16H01849
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

Yoshioka Yoshichika  大阪大学, 生命機能研究科, 特任教授(常勤) (00174897)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsバイオイメージング / 超高磁場MRI / 磁気共鳴スペクトロスコピー / タイムラプスMRI / 磁性粒子 / 免疫反応イメージング / 免疫ダイナミズム / 免疫細胞トラッキング / 磁気共鳴イメージング / 免疫細胞 / 炎症 / 脳内温度 / ultra high field MRI / MR spectroscopy / immune system / inflammation / immune dynamism / MRI / MRS / 貪食細胞 / ステルス性磁性粒子 / 造影剤 / リポポリサッカリド / 免疫イメージング / 非侵襲
Outline of Final Research Achievements

We had developed the visualizing technique for immune dynamism with ultra high-field MRI. Some model mice were used for the analysis. Labeled immune cells of the mice could be tracked three dimensionally at the single cell level. We also applied our technique for inflammation and chronic pain. Our MRI showed that immune cells involve in the formation of chronic pain. We tried to provide a broad-ranging analysis of the immune dynamism with several information obtained by MRI such as anatomical, functional, metabolic, and physiological changes.

Academic Significance and Societal Importance of the Research Achievements

磁気共鳴法により、いくつかのモデル実験動物を対象として、1細胞レベルでのダイナミックな免疫現象を捉えることに成功した。対象にできる免疫現象はまだ限られるが、我々の手法により、生体内で起こっている真の免疫現象を1細胞レベルで可視化できるようになったと考えられる。ダイナミックな免疫現象の追跡は、現在深刻な状況にある新型コロナウイルスのような免疫系が重要な役割を果たす疾患の対処や克服のための評価技術にもなるものである。磁気共鳴法は、既に臨床診断でも不可欠な手法であり、磁気共鳴法による免疫現象イメージングはヒトへの応用が容易と考えられ、本研究成果は、学術的にも社会的に大きな意義がある。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (66 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (21 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 20 results,  Open Access: 19 results,  Acknowledgement Compliant: 1 results) Presentation (45 results) (of which Int'l Joint Research: 14 results,  Invited: 3 results)

  • [Journal Article] Original experimental rat model of blast-induced mild traumatic brain injury: a pilot study.2021

    • Author(s)
      Matsuura H, Ohnishi M, Yoshioka Y, Togami Y, Hosomi S, Umemura Y, Ebihara T, Shimizu K, Ogura H, Shimazu T.
    • Journal Title

      Brain Injury

      Volume: 16 Issue: 3 Pages: 1-14

    • DOI

      10.1080/02699052.2020.1861653

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats.2020

    • Author(s)
      Fujiwara S., *Mori Y., **de la Mora D.M., Akamatsu Y., Yoshida K., *Shibata Y., Masuda T., Ogasawara K., *Yoshioka Y.
    • Journal Title

      SCIENTIFIC REPORTS.

      Volume: 10(1) Issue: 1 Pages: 8404-8404

    • DOI

      10.1038/s41598-020-65310-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurate Estimation of the Duration of Testicular Ischemia Using Creatine Chemical Exchange Saturation Transfer ( CrCEST ) Imaging2020

    • Author(s)
      Takahashi Yusuke、Kioka Hidetaka、Saito Shigeyoshi、Fukuhara Shinichiro、Asano Yoshihiro、Takashima Seiji、Yoshioka Yoshichika、Sakata Yasushi
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 53 Issue: 5 Pages: 1559-1567

    • DOI

      10.1002/jmri.27456

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 磁気共鳴法によるヒトの脳内温度の非侵襲的測定と脳内温度の活用2020

    • Author(s)
      吉岡芳親
    • Journal Title

      Netsu Sokutei

      Volume: 47 Pages: 135-141

    • NAID

      40022423743

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amide proton transfer imaging of glioblastoma, neuroblastoma, and breast cancer cells on a 11.7?T magnetic resonance imaging system2019

    • Author(s)
      Tanoue Minori、Saito Shigeyoshi、Takahashi Yusuke、Araki Rikita、Hashido Takashi、Kioka Hidetaka、Sakata Yasushi、Yoshioka Yoshichika
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 62 Pages: 181-190

    • DOI

      10.1016/j.mri.2019.07.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulatory roles of epithelial-mesenchymal interaction (EMI) during early and androgen dependent external genitalia development2019

    • Author(s)
      Hyuga T, Suzuki K, Acebedo AR, Hashimoto D, Kajimoto M, Miyagawa S, Enmi JI, Yoshioka Y, Yamada G.
    • Journal Title

      Differentiation

      Volume: 110 Pages: 29-35

    • DOI

      10.1016/j.diff.2019.08.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7T MRI2019

    • Author(s)
      Takahashi Yusuke、Saito Shigeyoshi、Kioka Hidetaka、Araki Rikita、Asano Yoshihiro、Takashima Seiji、Sakata Yasushi、Yoshioka Yoshichika
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 51 Issue: 2 Pages: 563-570

    • DOI

      10.1002/jmri.26844

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Female child with hematidrosis of the palm: Case report and published work review2019

    • Author(s)
      Murota Hiroyuki、Kotobuki Yorihisa、Yamaga Kosuke、Yoshioka Yoshichika
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 2 Pages: 166-168

    • DOI

      10.1111/1346-8138.15179

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment2018

    • Author(s)
      Ono E,Murota H,Mori Y,Yoshioka Y,Nomura Y,Munetsugu T,Yokozeki H,Katayama I
    • Journal Title

      PLoS One

      Volume: 13 Issue: 4 Pages: 0195960-0195960

    • DOI

      10.1371/journal.pone.0195960

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder2018

    • Author(s)
      Yamashita Kazuya、Kinoshita Makoto、Miyamoto Katsuichi、Namba Akiko、Shimizu Mikito、Koda Toru、Sugimoto Tomoyuki、Mori Yuki、Yoshioka Yoshichika、Nakatsuji Yuji、Kumanogoh Atsushi、Kusunoki Susumu、Mochizuki Hideki、Okuno Tatsusada
    • Journal Title

      Journal of Neuroinflammation

      Volume: 15 Issue: 1 Pages: 125-125

    • DOI

      10.1186/s12974-018-1162-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018

    • Author(s)
      Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
    • Journal Title

      iScience

      Volume: 6 Pages: 306-318

    • DOI

      10.1016/j.isci.2018.08.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice2018

    • Author(s)
      Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T.
    • Journal Title

      NeuroImage: clinical

      Volume: 20 Pages: 946-954

    • DOI

      10.1016/j.nicl.2018.09.031

    • NAID

      120006543327

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 超高磁場MRIと磁性粒子を用いた細胞可視化と細胞トラッキング2018

    • Author(s)
      吉岡芳親, 小林竜馬, 圓見純一郎, 木下学
    • Journal Title

      まぐね

      Volume: 13 Pages: 181-186

    • Related Report
      2018 Annual Research Report
  • [Journal Article] BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation2018

    • Author(s)
      Kaito Takashi、Morimoto Tokimitsu、Mori Yuki、Kanayama Sadaaki、Makino Takahiro、Takenaka Shota、Sakai Yusuke、Otsuru Satoru、Yoshioka Yoshichika、Yoshikawa Hideki
    • Journal Title

      The Spine Journal

      Volume: 18 Issue: 1 Pages: 139-146

    • DOI

      10.1016/j.spinee.2017.07.171

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.2018

    • Author(s)
      Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.
    • Journal Title

      Sci Transl Med.

      Volume: -- Issue: 429 Pages: 264-273

    • DOI

      10.1126/scitranslmed.aan0333

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit.2017

    • Author(s)
      Arima, Y., T. Ohki, N. Nishikawa, K. Higuchi, M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, M. Murakami.
    • Journal Title

      eLife

      Volume: 6:e25517 Pages: 1-27

    • DOI

      10.7554/elife.25517

    • NAID

      120006360081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal observations of progressive cardiac dysfunction in a cardiomyopathic animal model by self-gated cine imaging based on 11.7-T magnetic resonance imaging2017

    • Author(s)
      Saito Shigeyoshi、Tanoue Minori、Masuda Kasumi、Mori Yuki、Nakatani Satoshi、Yoshioka Yoshichika、Murase Kenya
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 9106-9106

    • DOI

      10.1038/s41598-017-09755-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 11.7 T MR Imaging Revealed Dilatation of Virchow–Robin Spaces within Hippocampus in Maternally Lipopolysaccharide-exposed Rats2017

    • Author(s)
      Ooi Y, Inui-Yamamoto C, Yoshioka Y, Seiyama Y, Seki J
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 16 Issue: 1 Pages: 54-60

    • DOI

      10.2463/mrms.mp.2015-0090

    • NAID

      130005286873

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping of left ventricle wall thickness in mice using 11.7 T magnetic resonance imaging.2017

    • Author(s)
      Saito S, Masuda K, Mori Y, Nakatani S, Yoshioka Y, Murase K.
    • Journal Title

      Magn Reson Imaging

      Volume: 36 Pages: 128-134

    • DOI

      10.1016/j.mri.2016.10.030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an atypical monocyte and committed progenitor involved in fibrosis.2017

    • Author(s)
      Satoh T, Nakagawa K, Sugihara F, Kuwahara R, Ashihara M, Yamane F, Minowa Y, Fukushima K, Ebina I, Yoshioka Y, Kumanogoh A, Akira S
    • Journal Title

      Nature

      Volume: 541 Issue: 7635 Pages: 96-101

    • DOI

      10.1038/nature20611

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polymer-brush-afforded SPIO Nanoparticles Show a Unique Biodistribution and MR Imaging Contrast in Mouse Organs2017

    • Author(s)
      Chen T, Mori Y, Inui-Yamamoto C, Komai Y, Tago Y, Yoshida S, Takabatake Y, Isaka Y, Ohno K, Yoshioka Y
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 16 Issue: 4 Pages: 275-283

    • DOI

      10.2463/mrms.mp.2016-0067

    • NAID

      130006163849

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 磁気共鳴法で引き出す多様な生体情報:分子・細胞レベルから個体レベルまで2020

    • Author(s)
      吉岡芳親
    • Organizer
      マグネティックス マイクロマシン・センサシステム 合同研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Triplet-DNP法を用いた新規MRIによるマウス撮像2020

    • Author(s)
      小林竜馬, 松本和也, 阿曽沼智明, 圓見純一郎, 根来誠, 香川晃徳, 北川勝浩, 吉岡芳親
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 動物用 11.7 T MRI による IVIM パラメータを用いた段階的両側総頚動脈閉塞ラット脳虚血部位の推定2020

    • Author(s)
      藤原俊朗, 森勇樹, 赤松陽介, 吉田研二, 柴田雄二, 増田友行, 小笠原邦明, 吉岡芳親
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 11.7 T における ex vivo MRI によるマウス腓腹筋内微細血管構築の描出2020

    • Author(s)
      圓見純一郎, 佐藤照, 嶋谷憲一郎, 笹井雅夫, 吉岡芳親
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Distribution pattern of neurotransmitters and antioxidants in human brain: a 1H-MRS study at 7 T.2019

    • Author(s)
      Enmi J, Kida I, Itoi S, Shimokawa T, Hattori N, Yoshioka Y.
    • Organizer
      The 27th Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intravoxel incoherent motion perfusion magnetic resonance imaging of water molecules in the rat cortex after common carotid artery occlusion at 11.7T.2019

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y.
    • Organizer
      Computer Assisted Radiology and Surgery 2019 (CARS2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of ischemic changes in the rat cortex after common carotid artery occulusion using intravoxel incoherent motion diffusion-weighted magnetic resonance imaging at 11.7T.2019

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Yoshida K, Ogasawara K, Yoshioka Y.
    • Organizer
      Brain & Brain PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Data Driven Quantification of the Effects of different doses of Gabapentin for Pain in Chronic Phase in Mice using Manganese-Enhanced MRI with AI based analyses.2019

    • Author(s)
      Nakae A, Nakai K, Yoshioka Y, Kato H, Kishimoto C, Nomura K, Nakanishi M, Miyamae M, Urabe R, Enmi J, Yanagida T.
    • Organizer
      The 11th Congress of the European Pain Fedearation (EFIC 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of using apparent brain temperature map on proton magnetic resonance spectroscopy to detect hemodynamic abnormalities in patients with unilateral chronic major cerebral artery steno-occlusive disease.2019

    • Author(s)
      Namba T, Ogasawara K, Yoshioka Y, Sasaki M, Uwano I, Ishigaki D, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K.
    • Organizer
      The 10th Annual Scientific Symposium of Ultrahigh Field Magnetic Resonance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨格筋病変の全身分布の把握における超高磁場磁気共鳴イメージングの有用性.2019

    • Author(s)
      上総勝之,高橋美和,渡辺雄大,坪田健次郎,栗原博司,圓見純一郎,吉岡芳親.
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 11.7T 1H-Magnetic Resonance Spectroscopyを用いた脂肪肝モデルラットにおける肝脂肪蓄積量の定量.2019

    • Author(s)
      吉野有香, 藤井雄太, 吉沢佑基, 上松泰明, 中江文, 圓見純一郎, 吉岡芳親, 宮脇出.
    • Organizer
      第46回日本毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 11.7T-MRI装置を用いたマウス下肢骨格筋CrCESTイメージングの確立.2019

    • Author(s)
      高橋佑典, 齋藤茂芳, 木岡秀隆, 荒木力太, 高島成二, 坂田泰史, 吉岡芳親.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Triplet-DNP法を用いた新規MRIの開発.2019

    • Author(s)
      松本和也, 小林竜馬, 圓見純一郎, 根来誠, 香川晃徳, 一条直樹, 北川勝浩, 吉岡芳親.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 11.7T-MRIを用いたマウス下肢虚血モデルにおけるCrCESTイメージング.2019

    • Author(s)
      高橋佑典, 齋藤茂芳, 木岡秀隆, 荒木力太, 高島成二, 坂田泰史, 吉岡芳親.
    • Organizer
      第63回日本放射線技術学会近畿支部学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 複数固定標本のマイクロイメージングを可能とするソレノイド型コイルの開発.2019

    • Author(s)
      齋藤茂芳, 川畑義彦, 高橋孝一郎, 荒木力太, 吉岡芳親.
    • Organizer
      第63回日本放射線技術学会近畿支部学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Assessment of cerebral ischemic changes in rats using different diffusion-weighted signal models for intravoxel incoherent motion analysis at 11.7T.2018

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Yoshida K, Ogasawara K, Yoshioka Y.
    • Organizer
      The 32nd International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS 2018).
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of outcome in bilateral common carotid artery occlusion rats by intravoxel incoherent motion analysis at 11.7 Tesla.2018

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y.
    • Organizer
      European Stroke Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Objective methods for evaluating chronic orofacial pain using high resolution brain MRI.2018

    • Author(s)
      Nakae A, Nakai K, Kato H, Mori Y, Yoshioka Y.
    • Organizer
      World Congress of Pain 2018,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高解像MRIを用いた顔面の神経障害性疼痛モデルの自発痛の評価.2018

    • Author(s)
      中江文, 中井國博, 加藤弘樹, 畑澤順, 吉岡芳親, 柳田敏雄.
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生殖発生毒性試験における磁気共鳴画像診断(MRI)によるラット胎児の内臓検査能力の向上と課題.2018

    • Author(s)
      坂井祐子, 青木嘉信, 藤原道夫, 藤川昭彦, 圓見純一郎, 吉岡芳親.
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 7Tにおけるヒト脳1H-MRSについての検討.2018

    • Author(s)
      圓見純一郎, 李欣洋, 黄田育宏, 吉岡芳親.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 11.7T-MRI を用いた神経膠芽腫・乳癌細胞及び神経芽細胞腫のAmide proton transfer (APT) イメージングについての検討.2018

    • Author(s)
      田上穗, 齋藤茂芳, 高橋佑典, 木岡秀隆, 坂田泰史, 吉岡芳親.
    • Organizer
      第3回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In-vivo Creatine Chemical Exchange Saturation transfer (CrCEST) Imaging in a Mouse Model of Hindlimb Ischemia at 11.7 T-MRI.2018

    • Author(s)
      Takahashi Y, Saito S, Kioka H, Takashima S, Sakata Y, Yoshioka Y.
    • Organizer
      第3回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超高磁場MRI におけるマウス大脳皮質バレル野の描出.2018

    • Author(s)
      田上穂, Daniela Martinez de la Mora, 森勇樹, 黄田育宏, 藤原俊朗, 小笠原邦昭, 吉岡芳親.
    • Organizer
      第二回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 老化促進モデルにおける11.7T-MRI を用いた脳代謝物評価.2018

    • Author(s)
      泉早紀, 齋藤茂芳, 吉岡芳親.
    • Organizer
      第二回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス下肢骨格筋における温度とpH の同時計測.2018

    • Author(s)
      圓見純一郎, 吉岡芳親.
    • Organizer
      第二回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ナノ磁性粒子を用いた多発性硬化症モデルマウスの評価.2017

    • Author(s)
      陳挺, 森勇樹, 乾千珠子, 大野工司, 吉岡芳親
    • Organizer
      第一回国際磁気共鳴医学会日本支部学術集会
    • Place of Presentation
      脳情報通信融合研究センター、吹田市、大阪府
    • Year and Date
      2017-02-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小動物用11.7T MRIを用いた非侵襲的4次元細胞追跡.2017

    • Author(s)
      森勇樹, 黄田育宏, 小橋昌司, 畑豊, 吉岡芳親
    • Organizer
      第一回国際磁気共鳴医学会日本支部学術集会
    • Place of Presentation
      脳情報通信融合研究センター、吹田市、大阪府
    • Year and Date
      2017-02-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Brain temperature depends on degree of cerebral white matter damage in patients with subacute carbon monoxide poisoning.2017

    • Author(s)
      Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Ogawa A, Ogasawara K, Beppu T.
    • Organizer
      BRAIN & BRAIN PET 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of outcome in bilateral common carotid artery occlusion (BCCAO) rats by intravoxel incoherent motion (IVIM) analysis at 11.7 Tesla.2017

    • Author(s)
      Shunrou Fujiwara, Yuki Mori, Daniela Martinez de la Mora, Kuniaki Ogasawara, Yoshichika Yoshioka.
    • Organizer
      The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation Between Brain Temperature and Cerebral Perfusion and Metabolism in Human Brain.2017

    • Author(s)
      Fujiwara S, Beppu T, Ogasawara K, Yoshioka Y.
    • Organizer
      The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of 1H-MRS brain temperature map to detect hemodynamic abnormality in patients with unilateral chronic major cerebral artery steno-occlusive disease.2017

    • Author(s)
      Takamasa Namba, Kuniaki Ogasawara, Hideaki Nishimoto, Daiya Ishigaki, Yoshichika Yoshioka, Toshiyuki Murakami, Makoto Sasaki, Masakazu Kobayashi, Kenji Yoshida, Ikuko Uwano, Shunrou Fujiwara, Kazunori Terasaki, Akira Ogawa.
    • Organizer
      The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative four-dimensional motility tracking of individual immune cells in living mouse brain.2017

    • Author(s)
      Yuki Mori, Daniela Martinez de la Mora, Atsuki Tashita, Syoji Kobashi, Ikuhiro Kida, Yutaka Hata, Yoshichika Yoshioka.
    • Organizer
      The 25th Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative four-dimensional tracking of individual immune cells in living mouse brain with 11.7T preclinical MRI scanner.2017

    • Author(s)
      Mori Y, de la Mora DM, Jin T, Yoshioka Y.
    • Organizer
      The 8th Annual Scientific Symposium of Ultrahigh Field Magnetic Resonance
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association of autoregulation and intravoxel incoherent motion in the brain with outcome of bilateral common carotid artery occlusion rats.2017

    • Author(s)
      Fujiwara S, Mori Y, Daniela Martinez de la Mora, Ogasawara K, Yoshioka Y.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optimization of gadolinium-enhanced MR histological imaging for the visualization of mouse barrel cortex.2017

    • Author(s)
      Tanoue M, Daniela Martinez de la Mora, Mori Y, Kida I, Fujiwara S, Ogasawara K, Yoshioka Y.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of experimental autoimmune encephalomyelitis by using SPIO.2017

    • Author(s)
      Chen T, Mori Y, Inui C, Ohno K, Yoshioka Y.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 11.7 T MRI revealed the cerebrospinal fluid channel within trigeminal nerve between the locus coeruleus and the periodontal tissue in rats.2017

    • Author(s)
      Ooi Y, Inui-Yamamoto C, Sasai T, Yoshioka Y, Seki J.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 両側総頸動脈閉塞ラットの予後予測因子は? ~動物用11.7TMRIを用いたIVIM-DWI計測~.2017

    • Author(s)
      藤原俊朗、吉田研二、小笠原邦昭、森勇樹、Daniela Martinez de la Mora、吉岡芳親.
    • Organizer
      第24回東北脳循環カンファランス
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小動物MRIで見えてきたダイナミックな構造変化と1細胞レベルでの細胞の動き.2017

    • Author(s)
      吉岡芳親
    • Organizer
      第13回小動物インビボイメージング研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 小動物用超高磁場MRIの活用.2017

    • Author(s)
      吉岡芳親
    • Organizer
      第1回ヒト脳イメージング研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neuronal activities induced by conditioned solution in the retrieval of the conditioned taste aversion paired with lipopolysaccharide.2017

    • Author(s)
      Inui-Yamamoto C, Sugihara F, Chen T, Wakisaka S, Yoshioka Y
    • Organizer
      第一回国際磁気共鳴医学会日本支部学術集会
    • Place of Presentation
      脳情報通信融合研究センター、吹田市、大阪府
    • Related Report
      2016 Annual Research Report
  • [Presentation] Four-dimensional in vivo MRI imaging for tracking individual immune cells in mouse brain.2016

    • Author(s)
      Mori Y, de la Mora DM, Tashita A, Kobashi S, Kida I, Hata Y, Yoshioka Y
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、さいたま市、埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gd-enhancement differences between mouse strains as shown by 3D MR Histology (MRH).2016

    • Author(s)
      Mori Y, Osugi K, de la Mora DM, Yoshioka Y
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、さいたま市、埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Labeled peripheral macrophages were found in the spinal cord of chronic constriction injury model mice by MRI.2016

    • Author(s)
      Yoshida Y, Mori Y, Chen T, Yoshioka Y
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、さいたま市、埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-01-27  

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