| Co-Investigator(Kenkyū-buntansha) |
井関 祥子 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80251544)
山口 聰 東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (00280628)
田村 篤志 東京医科歯科大学, 生体材料工学研究所, 准教授 (80631150)
有坂 慶紀 東京医科歯科大学, 生体材料工学研究所, 助教 (70590115)
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| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2020: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2019: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Outline of Final Research Achievements |
In this research project, we designed polyrotaxane scaffolds with molecular motility and investigated tissue reconstruction and repair in vitro and in vivo by controlling molecular motility. By modulating the molecular motility and chemical composition of the polyrotaxane surface, we succeeded in creating a growth environment suitable for symbiosis of heterologous cells. Furthermore, it was demonstrated that molecular motility regulates the inflammatory response of macrophages and enhances the intercellular adhesion of epithelial cells. Based on these findings, polyrotaxane scaffolds with different molecular motility were implanted in the skull defects of mice, demonstrating that the control of molecular motility affects the rate of tissue regeneration in vivo.
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