| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Outline of Final Research Achievements |
We investigated injectable polymer (IP) systems, which can form hydrogels in response to temperature after injection into the body, and their application as biomedical materials. Especially, we succeeded in preparing an IP system, which can form partially covalent cross-linking via thiol-ene reaction and show a longer duration of gel state in vivo and variable mechanical properties. We also succeeded in controlling the pH region where the IP shows temperature-responsive sol-gel transition provided by introducing functional groups at the termini of the IP molecules. We evaluated the application of the IP system as a drug delivery device showing the sustained release of drugs, post-operative antiadhesives, scaffold for tissue regeneration against ischemic heart using stem cells, and embolization materials in blood vessels. Then, positive results were obtained.
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