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Research and development of a sheet-type autonomic function monitoring system

Research Project

Project/Area Number 16H01857
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionOsaka University

Principal Investigator

Sekitani Tsuyoshi  大阪大学, 産業科学研究所, 教授 (80372407)

Research Collaborator Uemura Takafumi  国立大学法人大阪大学, 産業科学研究所, 特任准教授 (30448097)
Izumi Shintaro  国立大学法人大阪大学, 産業科学研究所, 特任准教授 (60621646)
Araki Teppei  国立大学法人大阪大学, 産業科学研究所, 助教 (10749518)
Noda Yuki  国立大学法人大阪大学, 産業科学研究所, 特任助教 (30784748)
Yoshimoto Shusuke  国立大学法人大阪大学, 産業科学研究所, 招へい教員 (80755463)
Mochizuki Hideki  大阪大学, 医学部精神内科, 教授
Murase Shou  大阪大学, 医学部精神内科脳卒中科
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2018: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Keywordsフレキシブルエレクトロニクス / 遠隔医療 / ヘルスケア / シート型生体計測システム / 生体BIG DATA / シート型センサシステム / 生体情報取得 / 信号アルゴリズム / 生体計測 / 電子デバイス・機器 / 有機薄膜トランジスタ / プリンテッドトランジスタ / フレキシブルセンサシステム / 生体信号計測 / ワイヤレスシステム / 医工学研究
Outline of Final Research Achievements

We have successfully developed sheet-type sensor systems for monitoring functions of autonomic nervous system. This system consists of sheet-type electroencephalogram (EEG), electrocardiogram (ECG), electromyogram (EMG), and sweat sensors. For the realization of imperceptible electronic system, almost all the component has been manufactured on flexible and stretchable substrates, so that it can spread over arbitrary curved surfaces including human skins. With integrating the ultrafsoft gel electrodes, ultraflexible amplifier, Si-LSI platform consisting of wireless data-transmission module and analog-to-digital converter, Li-ion-based thin-film battery, and information engineering.The collaboration with medical doctors in Osaka University Medical Hospital, we have successful monitored the functions of autonomic nervous system using the developed systems, demonstrating the excellent feasibility of the newly-developed sheet-type system.

Academic Significance and Societal Importance of the Research Achievements

自律神経の乱れに伴う疾患は極めて多く患者がいる。その一方で、自律神経の機能を定量的に計測できる技術は皆無であり、開発が期待されていた。本研究では、脳波、心電、体動、発汗を包括的に計測できるシート型センサの開発を行い、その有用性を医師とともに確認した。将来の家庭内でのヘルスケアや遠隔医療に資する取り組みである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (38 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (25 results) (of which Invited: 4 results) Remarks (1 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 4 results)

  • [Int'l Joint Research] ヨハネスケプラー大学リンツ校(オーストリア)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Raman Spectroscopic Studies of Dinaphthothienothiophene (DNTT)2019

    • Author(s)
      B.S. Bhardwaj, T. Sugiyama, N. Namba, T. Umakoshi, T. Uemura, T. Sekitani, P. Verma.
    • Journal Title

      Materials

      Volume: 12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core-Shell Nanowires2019

    • Author(s)
      Teppei Araki, Fumiaki Yoshida, Takafumi Uemura, Yuki Noda, Shusuke Yoshimoto, Taro Kaiju, Takafumi Suzuki, Hiroki Hamanaka, Kousuke Baba, Hideki Hayakawa, Taiki Yabumoto, Hideki Mochizuki, Shingo Kobayashi, Masaru Tanaka, Masayuki Hirata, Tsuyoshi Sekitani
    • Journal Title

      Advanced Healthcare Materials

      Volume: 1900130 Pages: 1900130-1900130

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A few-layer molecular film on polymer substrates to enhance the performance of organic devices2018

    • Author(s)
      T. Yokota, T. Kajitani, R. Shidachi, T. Tokuhara, M. Kaltenbrunner, Y. Shoji, F. Ishiwari, T. Sekitani, T. Fukushima, T. Someya
    • Journal Title

      Nature Nanotech.

      Volume: 13 Issue: 2 Pages: 139-144

    • DOI

      10.1038/s41565-017-0018-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ultraflexible organic amplifier with biocompatible gel electrodes2016

    • Author(s)
      Tsuyoshi Sekitani, Tomoyuki Yokota, Kazunori Kuribara, Martin Kaltenbrunner, Takanori Fukushima, Yusuke Inoue, Masaki Sekino, Takashi Isoyama, Yusuke Abe Hiroshi, Onodera and Takao Someya
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11425-11425

    • DOI

      10.1038/ncomms11425

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Electric resistivity modulation by proton control using an electric field effect in HVO2-FET structures2019

    • Author(s)
      Keita Muraoka,Teruo Kanki,Takafumi Uemura,Tsuyoshi Sekitani,Hidekazu Tanaka
    • Organizer
      The 22nd SANKEN International Symposium The 17th SANKEN Nanotechnology International Symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] A Contact Resistance and Noise Amount Evaluation Method for Wearable EEG Sensors2019

    • Author(s)
      M. Inaoka, S. Izumi, S. Yoshimoto, T. Nezu, Y. Noda, T. Araki, T. Uemura, T. Sekitani
    • Organizer
      The 22nd SANKEN International Symposium, The 17th SANKEN Nanotechnology International Symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] Enhancement of resistive modulation in nano-convex VO2 FET2019

    • Author(s)
      Yoshihide Tsuji,Teruo Kanki,Takafumi Uemura,Tsuyoshi Sekitani,Hidekazu Tanaka
    • Organizer
      The 22nd SANKEN International Symposium, The 17th SANKEN Nanotechnology International Symposiu
    • Related Report
      2018 Annual Research Report
  • [Presentation] Raman Spectroscopic Investigation of Dinaphthothienothiophene in a Transistor Devic2019

    • Author(s)
      B. S. Bhardwaj, T. Sugiyama, N. Namba, T. Umakoshi, T. Uemura, T. Sekitani, P. Verma
    • Organizer
      第66回応用物理学会春期学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Magnetic Resonance Wireless Power Transmission System for an Implantable Sensor in the Common Marmoset2018

    • Author(s)
      M. Fujii, S. Yoshimoto, T. Nezu, H. Ohta, H. Hamanaka, T. Araki, Y. Noda, T. Uemura, M. Hirata, T. Sekitani
    • Organizer
      40th International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Design of Ultraflexible Organic Differential Amplifier Circuits for Wearable Sensor Technologies2018

    • Author(s)
      Masaya Kondo, Takafumi Uemura, Mihoko Akiyama, Naoko Namba, Masahiro Sugiyama, Yuki Noda, Teppei Araki, Shusuke Yoshimoto,Tsuyoshi Sekitani
    • Organizer
      International Conference on Microelectronics Test Structures (ICMTS)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Patch-Type Brain Wave Measurement System Using Flexible Electronic2018

    • Author(s)
      T. Uemura and T. Sekitan
    • Organizer
      ECUST -OU Symposium 2018 East-China University of Science and Technology
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ultraflexible Organic Differential Amplifier for Biosignal Monitoring Systems2018

    • Author(s)
      T. Uemura and T. Sekitani
    • Organizer
      The 18th International Meeting on Information Display (IMID 2018)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Low-Noise Signal Amplification Circuits Based on Organic Thin-Film Transistors2018

    • Author(s)
      T. Uemura and T. Sekitani
    • Organizer
      Collaborative Conference on Materials Research (CCMR) 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Printable strain gauge of high sensitivity and wide range for simple structural health monitoring implemented with wireless measurement syste2018

    • Author(s)
      Teppei Araki, Shisuke Yoshimoto, Yuki Noda, Takafumi Uemura, Yuko Kasai, Shintaro Izumi, Tsuyoshi Sekitani
    • Organizer
      MRS2018 Fall Symposium PM02, Conductive Materials Reliability in Flexible Electronics
    • Related Report
      2018 Annual Research Report
  • [Presentation] Design of Conductive Gel for Sensing Weak Biosignals with High S/N Ratio2018

    • Author(s)
      Y. Noda, N. Toyoshima, T. Araki, S. Yoshimoto, T. Uemura, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Fall meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Biocompatible Gel for Measuring the Biosignal with Low Noise2018

    • Author(s)
      Y. Noda, N. Toyoshima, T. Araki, S. Yoshimoto, I. Hirokazu, T. Uemura, T. Sekitani
    • Organizer
      67th Symposium on Macromolecules
    • Related Report
      2018 Annual Research Report
  • [Presentation] A High-Resolution Printing Technique of Ag-Nanowire-Based Electrodes for Transparent Flexible Organic Transistors on a 1-μm-Thick Polymer Fil2018

    • Author(s)
      A. Takemoto, T. Araki, Y. Noda, S. Yoshimoto, T. Uemura, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Threshold-Voltage Controls in Organic Transistors by the Gate Electrode Modification2018

    • Author(s)
      K. Sakaguchi, T. Uemura, M. Kondo, T. Araki, S. Yoshimoto, Y. Noda, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bio-Conformable Organic Differential Amplifier on Ultraflexible Polymer Substrate for Low-Noise Biosignal Monitorin2018

    • Author(s)
      M. Sugiyama, T. Uemura, S. Yoshimoto, M. Akiyama, M. Kondo, T. Araki, Y. Noda, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Two-Months-Implantable Neural Interface Integrated with Transparent and Stretchable Metal-Nanowire-Based Tracks2018

    • Author(s)
      T. Araki, F. Yoshida, Y. Noda, T. Uemura, S. Yoshimoto, T. Kaiju, T. Suzuki, H. Hamanaka, M. Hirata, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular Orientation Analysis in Organic Thin-Film Transistor Device by Polarized Raman Microscopy2018

    • Author(s)
      T. Sugiyama, B. S. Bhardwaj, T. Umakoshi, N. Namba, T. Uemura, T. Sekitani, P. Verma
    • Organizer
      SPIE Optics + Photonics 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Highly-uniform Triptycene Modifier Layer Based on Blade Coating for Ultraflexible Organic Circuits2018

    • Author(s)
      M. Kondo, T. Uemura, T. Kajitani, Y. Noda, F. Ishiwari, Y. Shoji, M. Akiyama, N. Namba, M. Sugiyama, S. Yoshimoto, T. Araki, T. Fukushima, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Fall meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] Wireless Ultraflexible Magnetic Sensor Matrix System Integrated with Organic Driver and Amplifier Circuits2018

    • Author(s)
      M. Kondo, M. Melzer, T. Uemura, D. Karnaushenko, S. Yoshimoto, M. Akiyama, N. Yuki, T. Araki, O. Schmidt, T. Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit
    • Related Report
      2018 Annual Research Report
  • [Presentation] フレキシブルエレクトロニクスによる 高感度バイオセンシング技術2018

    • Author(s)
      植村隆文, 関谷毅
    • Organizer
      M&BE新分野開拓研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 有機トランジスタを用いたフレキシブル生体信号計測回路の設計・開発2018

    • Author(s)
      杉山真弘, 植村隆文, 近藤雅哉, 秋山実邦子, 難波直子, 吉本秀輔, 野田祐樹, 荒木徹平, 関谷毅
    • Organizer
      第13回 有機デバイス・物性院生研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 低電圧駆動有機トランジスタの開発とフレキシブルセンサ回路への応用2018

    • Author(s)
      近藤 雅哉, 植村隆文, 杉山 真弘, 秋山実邦子, 吉本秀輔, 荒木徹平, 野田 祐樹, Michael Melzer, Daniil Karnaushenko, Oliver Schmidt, 関谷毅
    • Organizer
      第13回 有機デバイス・物性院生研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体埋込センサを用いた微小信号モニタリングに向けた低ノイズ計測技術の開発2018

    • Author(s)
      稲岡美咲, 吉本秀輔, 根津俊一, 関谷毅
    • Organizer
      大阪大学 産業科学研究所 第74回学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] インフラ構造物モニタリングに向けたコンクリート内塩化物イオン濃度の電気的計測に関する検討2018

    • Author(s)
      田邊史夏, 吉本秀輔, 植村隆文, 根津俊一, 秋山実邦子, 大田裕, 荒木徹平, 野田祐樹, 関谷毅
    • Organizer
      第35回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] コモンマーモセットへの埋込センサに向けた無線給電システムの開発2018

    • Author(s)
      藤井麻祐子,吉本秀輔,根津俊一,大田裕,濱中裕喜,荒木徹平,野田祐樹,植村隆文,平田雅之,関谷毅
    • Organizer
      LSIとシステムのワークショップ2018
    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/aed/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 電極シート2018

    • Inventor(s)
      関谷毅、吉本秀輔
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 有機薄膜トランジスタ用の電極形成方法および電極形成装置、有機薄膜トランジスタの製造方法ならびに有機薄膜トランジスタ2018

    • Inventor(s)
      関谷毅、植村隆文他
    • Industrial Property Rights Holder
      国立大学法人大阪大学他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 振動センサおよび圧電素子2018

    • Inventor(s)
      関谷毅、植村隆文、吉本秀輔他
    • Industrial Property Rights Holder
      国立大学法人大阪大学他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 振動センサおよび圧電素子2018

    • Inventor(s)
      関谷毅、植村隆文、吉本秀輔他
    • Industrial Property Rights Holder
      国立大学法人大阪大学他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体信号計測装置2018

    • Inventor(s)
      関谷毅、植村隆文、荒木徹平、吉本秀輔
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 測定装置2018

    • Inventor(s)
      関谷毅、荒木徹平、吉本秀輔、植村隆文
    • Industrial Property Rights Holder
      関谷毅、荒木徹平、吉本秀輔、植村隆文
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 電極シート2017

    • Inventor(s)
      関谷毅、荒木徹平、吉本秀輔、植村隆文
    • Industrial Property Rights Holder
      関谷毅、荒木徹平、吉本秀輔、植村隆文
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2016-04-21   Modified: 2020-03-30  

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