| Budget Amount *help |
¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
Frailty, characterized as declined physiological reserve, is a prognostic factor of heart failure (HF), and has become a target of cardiac rehabilitation. This multicenter prospective study aimed to develop diagnostic criteria of frailty based on HF-specific outcomes.
Conventional frailty items were quantitatively measured (slowness, weakness, exhaustion, physical inactivity, weight loss), and their relationships with the study outcomes (HF-rehospitalization, all-cause mortality) were analyzed using Cox proportional hazards model. As a result, we found a different weight for each domain to predict prognosis after discharge. This suggests that the appropriate score should be assigned to each domain for risk stratification. From the above, we finally developed the frailty criteria considering the weight of each domain rather than just counting the frailty items.
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