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Elucidation of exercise performance-related genes by whole genome sequencing of world elite sprinters and long distance runners

Research Project

Project/Area Number 16H01872
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionJuntendo University (2019-2020, 2022)
National Institutes of Biomedical Innovation, Health and Nutrition (2018)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2016-2017)

Principal Investigator

Tanaka Masashi  順天堂大学, 大学院医学研究科, 客員教授 (60155166)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2016: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords全ゲノム塩基配列解析 / 持久走能力 / 骨格筋 / 心機能 / 機能的多型 / 骨強度 / 心筋リモデリング / 骨格筋Z帯形成 / 骨強度に関連する因子 / 長距離走選手 / アスリート / マルチオミクス / 標的遺伝子 / 運動能力 / 遺伝子多型 / 全ゲノム塩基配列決定 / 持久系運動能力 / 瞬発系運動能力 / 筋損傷 / 腱断裂 / 加齢性筋減弱症 / サルコペニア / マルチオミクス研究 / ミトコンドリア / 次世代シークエンサー / 全ゲノム塩基配列 / 持久力 / 瞬発力
Outline of Final Research Achievements

The primary aim of the Athlome Project is to combine resources from individual studies and consortia worldwide to collectively study the genotype and phenotype data available on elite athletes, the adaptation to exercise training (in both human and animal models), and the determinants of exercise-related musculoskeletal injuries. Whole genome analysis of elite athletes is going to reshape our current understanding of the genetic basis of human performance and by association health-related fitness. This knowledge will help generate new solutions to modern-day health problems such as inactivity, obesity, and sarcopenia, all of which are at the opposite spectrum of the elite athlete phenotype. We present preliminary data on the whole genome sequencing analysis of Kenyan elite runners.

Academic Significance and Societal Importance of the Research Achievements

成人における肥満・メタボリック症候群は生活習慣病の予備軍として注目されているが、その予防には個人に適した運動処方と栄養処方が必要である。転倒・骨折は高齢者の生活の質を低下させ、介護負担を上昇させる。転倒・骨折に対する恐怖は、ひきこもり・うつ・認知能低下を誘発する。サルコペニア・フレイルの予防には、個人の特性に応じた適切な運動処方と栄養処方が必要である。運動による微細な筋損傷を修復する過程にも個人差・年齢差が存在するので、それぞれの高齢者の特性に応じた筋強化運動が必要である。これらの課題に対してアスリートの全ゲノム塩基配列解析は解決への道を拓く。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019 2018 2017 2016 Other

All Journal Article (52 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 49 results,  Open Access: 49 results,  Acknowledgement Compliant: 20 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Association Between Serum GDF15 Concentration and Total Mortality in Community-Dwelling Japanese Older Populations: The Involvement of Renal Dysfunction2023

    • Author(s)
      Fujita Yasunori、Shinkai Shoji、Taniguchi Yu、Miura Yuri、Tanaka Masashi、Ohsawa Ikuroh、Kitamura Akihiko、Ito Masafumi
    • Journal Title

      The Journals of Gerontology: Series A

      Volume: in press Issue: 9 Pages: 1701-1707

    • DOI

      10.1093/gerona/glad105

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secondary structure of the human mitochondrial genome affects formation of deletions2023

    • Author(s)
      Shamanskiy Victor、Mikhailova Alina A.、Tanaka Masashi、Khrapko Konstantin、Gunbin Konstantin、Popadin Konstantin, et al.
    • Journal Title

      BMC Biology

      Volume: 21 Issue: 1 Pages: 103-103

    • DOI

      10.1186/s12915-023-01606-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study2022

    • Author(s)
      Fujita Akiko、Ihara Kazushige、Kawai Hisashi、Obuchi Shuichi、Watanabe Yutaka、Hirano Hirohiko、Fujiwara Yoshinori、Takeda Yoichi、Tanaka Masashi、Kato Keiko
    • Journal Title

      Discover Mental Health

      Volume: 2 Issue: 1 Pages: 20-20

    • DOI

      10.1007/s44192-022-00023-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on the heavy strand2022

    • Author(s)
      Mikhailova Alina G、Mikhailova Alina A、Ushakova Kristina、Tanaka Masashi、Khrapko Konstantin、Gunbin Konstantin、Popadin Konstantin et al.
    • Journal Title

      Nucleic Acids Research

      Volume: 50 Issue: 18 Pages: 10264-10277

    • DOI

      10.1093/nar/gkac779

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COL17A1 germline variant p.Ser1029Ala and mucosal malignant melanoma: An autopsy study2021

    • Author(s)
      Tong Daike、Tanaka Masashi、Eguchi Hidetaka、Okazaki Yasushi、Muramatsu Masaaki、Arai Tomio
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 16 Issue: 2 Pages: 32-32

    • DOI

      10.3892/mco.2021.2465

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] D-amino acid oxidase (DAO) rare genetic missense variant p.Pro103Leu and gastric cancer2021

    • Author(s)
      Zong Yuan, Tanaka Masashi, Muramatsu Masaaki, Arai Tomio
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 14 Issue: 3 Pages: 58-58

    • DOI

      10.3892/mco.2021.2220

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ミトコンドリアゲノムと疾患2021

    • Author(s)
      田中雅嗣
    • Journal Title

      医学のあゆみ

      Volume: 278 Pages: 340-346

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Journal Article] ミトコンドリア病の治療と診断のためのバイオマーカーGDF152021

    • Author(s)
      田中雅嗣
    • Journal Title

      小児内科

      Volume: 54 Pages: 663-666

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Sport and Exercise Genomics: The FIMS 2019 Consensus Statement Update2020

    • Author(s)
      Tanisawa K, Wang G, Seto J, Verdouka I, Twycross-Lewis R, Karanikolou A, Tanaka M, Borjesson M, Di Luigi L, Dohi M, Wolfarth B, Swart J, Bilzon JLJ, Badtieva V, Papadopoulou T, Casasco M, Geistlinger M, Bachl N, Pigozzi F, Pitsiladis Y
    • Journal Title

      Br J Sports Med

      Volume: 54(16) Issue: 16 Pages: 969-975

    • DOI

      10.1136/bjsports-2019-101532

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A mitochondrial mutational signature of temperature in ectothermic and endothermic vertebrates2020

    • Author(s)
      Mikhailova Alina G., Iliushchenko Dmitrii, Shamansky Victor, Tanaka Masashi, Popadin Konstantin, et al.
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.07.25.221184

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Werner Syndrome Helicase (WRN) Gene Variants and Cancer in Japanese Elderly: An Autopsy Study2020

    • Author(s)
      Yuan Zong, Masashi Tanaka, Masaaki Muramatsu, Tomio Arai
    • Journal Title

      Journal of Geriatric Medicine and Gerontology

      Volume: 6 Issue: 4 Pages: 103-103

    • DOI

      10.23937/2469-5858/1510103

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease2020

    • Author(s)
      Oba Kazuhito, Ishikawa Joji, Tamura Yoshiaki, Fujita Yasunori, Ito Masafumi, Iizuka Ai, Fujiwara Yoshinori, Kodera Remi, Toba Ayumi, Toyoshima Kenji, Chiba Yuko, Mori Seijiro, Tanaka Masashi, Ito Hideki, Harada Kazumasa, Araki Atsushi
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 10 Pages: 980-987

    • DOI

      10.1111/ggi.14021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19-9 expression occurring in elderly individuals: an autopsy study.2020

    • Author(s)
      145.Wang T, Matsuda Y, Nonaka K, Kakizaki M, Ishiwata T, Kanazawa N, Uegaki S, Muramatsu M, Sawabe M, Mori S, Kitagawa M, Arai T.
    • Journal Title

      Pathology International

      Volume: 70 Issue: 2 Pages: 92-100

    • DOI

      10.1111/pin.12882

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome2019

    • Author(s)
      Mikhailova Alina A., Shamanskiy Viktor, Tanaka Masashi, Khrapko Konstantin, Popadin Konstantin et al.
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/603282

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Olympia Declaration2019

    • Author(s)
      Pitsiladis Yannis P., Abatzis-Papadopoulos Manolis, Tanaka Masashi, Wang Guan, Yang Huanming, et al.
    • Journal Title

      Current Sports Medicine Reports

      Volume: 18 Issue: 12 Pages: 448-451

    • DOI

      10.1249/jsr.0000000000000660

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease2019

    • Author(s)
      Koga Y, Povalko N, Inoue E, Nashiki K, Tanaka M.
    • Journal Title

      Mitochondrion

      Volume: 48 Pages: 11-15

    • DOI

      10.1016/j.mito.2019.02.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer2019

    • Author(s)
      Matsuda Yoko、Tanaka Masashi、Sawabe Motoji、Mori Seijiro、Muramatsu Masaaki、Naka Mieno Makiko、Ishiwata Toshiyuki、Arai Tomio
    • Journal Title

      Oncology Letters

      Volume: 17 Pages: 4647-54

    • DOI

      10.3892/ol.2019.10106

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renormalized Basal Metabolic Rate Describes the Human Aging Process and Longevity2019

    • Author(s)
      Kitazoe Y, Kishino H, Tanisawa K, Udaka K, Tanaka M
    • Journal Title

      Aging Cell

      Volume: 18(4) Issue: 4 Pages: 1-11

    • DOI

      10.1111/acel.12968

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Future of human mitochondrial DNA editing technologies2019

    • Author(s)
      Verechshagina N, Nikitchina N, Yamada Y, Harashima H, Tanaka M, Orishchenko K, Mazunin I
    • Journal Title

      Mitochondrial DNA Part A Mapp Seq Anal

      Volume: 30 Issue: 2 Pages: 214-221

    • DOI

      10.1080/24701394.2018.1472773

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inverse Association Between Height-Increasing Alleles and Extreme Longevity in Japanese Women.2018

    • Author(s)
      Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K, Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Tanaka M.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: 73(5) Issue: 5 Pages: 588-595

    • DOI

      10.1093/gerona/glx155

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation of physical function with the thickness of multiple muscles of the quadriceps femoris in community-dwelling elderly individuals2018

    • Author(s)
      Nishihara Ken、Kawai Hisashi、Kera Takeshi、Hirano Hirohiko、Watanabe Yutaka、Fujiwara Yoshinori、Ihara Kazushige、Kim Hunkyung、Tanaka Masashi、Obuchi Shuichi
    • Journal Title

      Clinical Interventions in Aging

      Volume: Volume 13 Pages: 1945-1951

    • DOI

      10.2147/cia.s177237

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of frailty, cognitive impairment, and sarcopenia in outpatients with cardiometabolic disease in a frailty clinic2018

    • Author(s)
      Tamura Y, Ishikawa J, Fujiwara Y, Tanaka M, Kanazawa N, Chiba Y, Iizuka A, Kaito S, Tanaka J, Sugie M, Nishimura T, Kanemaru A, Shimoji K, Hirano H, Furuta K, Kitamura A, Seino S, Shinkai S, Harada K, Kyo S, Ito H, Araki A
    • Journal Title

      BMC Geriatrics

      Volume: 18 Issue: 1 Pages: 264-264

    • DOI

      10.1186/s12877-018-0955-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients2017

    • Author(s)
      Matsuda Yoko、Tanaka Masashi、Sawabe Motoji、Mori Seijiro、Muramatsu Masaaki、Mieno Makiko Naka、Furukawa Toru、Arai Tomio
    • Journal Title

      Genes, Chromosomes and Cancer

      Volume: 57 Issue: 1 Pages: 12-18

    • DOI

      10.1002/gcc.22479

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of STXBP2 as a novel susceptibility locus for myocardial infarction in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 20 Pages: 33527-33535

    • DOI

      10.18632/oncotarget.16536

    • NAID

      120007129044

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese individuals by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 28 Pages: 45259-45273

    • DOI

      10.18632/oncotarget.16696

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 24 Pages: 39296-39308

    • DOI

      10.18632/oncotarget.16945

    • NAID

      120007128952

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of polymorphisms in 12q24.1, <i>ACAD10</i>, and <i>BRAP</i> as novel genetic determinants of blood pressure in Japanese by exome-wide association studies2017

    • Author(s)
      Yamada Yoshiji、Sakuma Jun、Takeuchi Ichiro、Yasukochi Yoshiki、Kato Kimihiko、Oguri Mitsutoshi、Fujimaki Tetsuo、Horibe Hideki、Muramatsu Masaaki、Sawabe Motoji、Fujiwara Yoshinori、Taniguchi Yu、Obuchi Shuichi、Kawai Hisashi、Shinkai Shoji、Mori Seijiro、Arai Tomio、Tanaka Masashi
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 26 Pages: 43068-43079

    • DOI

      10.18632/oncotarget.17474

    • NAID

      120007128873

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 24 Pages: 38950-38961

    • DOI

      10.18632/oncotarget.17159

    • NAID

      120007128954

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of five genetic variants as novel determinants of type 2 diabetes mellitus in Japanese by exome-wide association studies2017

    • Author(s)
      Yamada Yoshiji、Sakuma Jun、Takeuchi Ichiro、Yasukochi Yoshiki、Kato Kimihiko、Oguri Mitsutoshi、Fujimaki Tetsuo、Horibe Hideki、Muramatsu Masaaki、Sawabe Motoji、Fujiwara Yoshinori、Taniguchi Yu、Obuchi Shuichi、Kawai Hisashi、Shinkai Shoji、Mori Seijiro、Arai Tomio、Tanaka Masashi
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 46 Pages: 80492-80505

    • DOI

      10.18632/oncotarget.19287

    • NAID

      120007134713

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Int J Mol Med

      Volume: 39 Issue: 6 Pages: 1477-1491

    • DOI

      10.3892/ijmm.2017.2972

    • NAID

      120007129063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of EGFLAM, SPATC1L, and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Int J Mol Med

      Volume: 39 Issue: 5 Pages: 1091-1100

    • DOI

      10.3892/ijmm.2017.2927

    • NAID

      120007129065

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome-wide association study2017

    • Author(s)
      Yamada Yoshiji、Sakuma Jun、Takeuchi Ichiro、Yasukochi Yoshiki、Kato Kimihiko、Oguri Mitsutoshi、Fujimaki Tetsuo、Horibe Hideki、Muramatsu Masaaki、Sawabe Motoji、Fujiwara Yoshinori、Taniguchi Yu、Obuchi Shuichi、Kawai Hisashi、Shinkai Shoji、Mori Seijiro、Arai Tomio、Tanaka Masashi
    • Journal Title

      Molecular Medicine Reports

      Volume: 16 Issue: 5 Pages: 5823-5832

    • DOI

      10.3892/mmr.2017.7334

    • NAID

      120007128795

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Macrophage Capping Protein (CAPG) Arg335His Polymorphism and Cancer Susceptibility in the Elderly Japanese2017

    • Author(s)
      Dechamethakun Sariya、Sato Noriko、Ikeda Shinobu、Sawabe Motoji、Mori Seijiro、Yamada Yoshiji、Tanaka Masashi、Muramatsu Masaaki、Arai Tomio
    • Journal Title

      Journal of Gerontology & Geriatric Research

      Volume: 06 Issue: 02 Pages: 417-417

    • DOI

      10.4172/2167-7182.1000417

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017

    • Author(s)
      Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito
    • Journal Title

      BMC Cancer

      Volume: 316 Issue: 1 Pages: 316-316

    • DOI

      10.1186/s12885-017-3301-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids2017

    • Author(s)
      12.Nishi K, Luo H, Nakabayashi K, Doi K, Ishikura S, Iwaihara Y, Yoshida Y, Tanisawa K, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M, Sakata T, Shirasawa S, Tsunoda T
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 7 Pages: 3855-3862

    • DOI

      10.21873/anticanres.11765

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial determinants of mammalian longevity2017

    • Author(s)
      Kitazoe Yasuhiro、Hasegawa Masami、Tanaka Masashi、Futami Midori、Futami Junichiro
    • Journal Title

      Open Biology

      Volume: 7 Issue: 10 Pages: 170083-170083

    • DOI

      10.1098/rsob.170083

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017

    • Author(s)
      Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi, Masafumi Ito
    • Journal Title

      BMC Cancer

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of macrophage capping protein (CAPG) Arg335His polymorphism and cancer susceptibility in the elderly2017

    • Author(s)
      Sariya Dechamethakun, Noriko Sato, Shinobu Ikeda, Motoji Sawabe, Seijiro Mori, Yoshiji Yamada, Masashi Tanaka, Masaaki Muramatsu, Tomio Arai
    • Journal Title

      J Gerontol Geriatr Res

      Volume: 6 Pages: 417-417

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of TNFSF13, SPATC1L, SLC22A25, and SALL4 as novel susceptibility loci for atrial fibrillation by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Mol Med Rep

      Volume: (in press)

    • NAID

      120007128795

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: (in press)

    • NAID

      120007128954

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: (in press)

    • NAID

      120007128873

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Int J Mol Med

      Volume: (in press)

    • NAID

      120007129063

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: (in press)

    • NAID

      120007128952

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese individuals by exome-wide association studies2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: (in press)

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of STXBP2 as a novel susceptibility locus for myocardial infarction in Japanese individuals by an exome-wide association study2017

    • Author(s)
      Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
    • Journal Title

      Oncotarget

      Volume: (in press)

    • NAID

      120007129044

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated with Extreme Longevity in East Asian Populations2016

    • Author(s)
      Kumpei Tanisawa, Masashi Tanaka, et al.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: 00 Pages: 1-10

    • DOI

      10.1093/gerona/glw074

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gene-exercise interactions in the development of cardiometabolic diseases2016

    • Author(s)
      Kumpei Tanisawa, Masashi Tanaka, Higuchi Mitsuru
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 1 Pages: 25-36

    • DOI

      10.7600/jpfsm.5.25

    • NAID

      130005138387

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of non-synonymous variants in WIPF3 and LIPA genes with abdominal aortic aneurysm: an autopsy study2016

    • Author(s)
      Yuko Maeda, Noriko Sato, Makiko Naka-Mieno, Seijiro Mori, Tomio Arai, Masashi Tanaka, Masaaki Muramatsu, Motoji Sawabe
    • Journal Title

      J Geriatr Cardiol

      Volume: 13 Pages: 960-967

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders2016

    • Author(s)
      Yasunori Fujita, Yu Taniguchi, Shoji Shinkai, Masashi Tanaka, Masafumi Ito
    • Journal Title

      Geriatr Gerontol Int

      Volume: 16 (Suppl. 1) Issue: S1 Pages: 17-29

    • DOI

      10.1111/ggi.12724

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Advancing sports and exercise genomics: moving from hypothesis-driven single study approaches to large multi-omics collaborative science2016

    • Author(s)
      Masashi Tanaka, Guan Wang, Yannis P. Pitsiladis
    • Journal Title

      Physiol Genomics

      Volume: 48 Issue: 3 Pages: 173-174

    • DOI

      10.1152/physiolgenomics.00009.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] STED super-resolution imaging of mitochondria labeled with TMRM in living cells2016

    • Author(s)
      Masaya Ishigaki, Masumi Iketani, Maki Sugaya, Mayumi Takahashi, Masashi Tanaka, Seisuke Hattori, Ikuroh Ohsawa
    • Journal Title

      Mitochondrion

      Volume: 28 Pages: 79-87

    • DOI

      10.1016/j.mito.2016.03.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Athlome Project Consortium: a concerted effort to discover genomic and other “omic” markers of athletic performance2016

    • Author(s)
      Yannis P. Pitsiladis, Masashi Tanaka, et al.
    • Journal Title

      Physiol Genomics

      Volume: 48 Issue: 3 Pages: 183-190

    • DOI

      10.1152/physiolgenomics.00105.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Whole genome sequence analysis of legendary Kenyan endurance runners2023

    • Author(s)
      Masashi Tanaka
    • Organizer
      The 18th International Conference on Genomics (ICG-18)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The 1000 Athlomes Project: An Initiative for Whole Genome Sequencing of Elite Athletes2016

    • Author(s)
      Masashi Tanaka
    • Organizer
      International Convention on Science, Education and Medicine in Sport (ICSEMIS)
    • Place of Presentation
      Santos, Brazil
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] An Initiative for Whole Genome Sequencing of Elite Athletes2016

    • Author(s)
      Masashi Tanaka
    • Organizer
      International Federation of Sports Medicine 34th WORLD CONGRESS OF SPORTS MEDICINE
    • Place of Presentation
      Ljubljana, Slovenia
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] テキスト健康科学 「遺伝と健康」2017

    • Author(s)
      田中雅嗣
    • Publisher
      南江堂
    • Related Report
      2016 Annual Research Report
  • [Remarks] Human Mitochondrial Genome Polymorphism Database

    • URL

      http://mtsnp.tmig.or.jp/mtsnp/index_e.shtml

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report 2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2024-01-30  

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