『機能リズム障害としての自閉症』仮説検証

• Project/Area Number: 16H01880
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Childhood science (childhood environment science)
• Research Institution: Doshisha University
• Principal Investigator: 小西 行郎 同志社大学, 研究開発推進機構, 教授 (40135588)
• Co-Investigator(Kenkyū-buntansha): 板倉 昭二 京都大学, 文学研究科, 教授 (50211735) ; 諸隈 誠一 九州大学, 医学研究院, 教授 (50380639) ; 松石 豊次郎 久留米大学, 付置研究所, 教授 (60157237) ; 八木田 和弘 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90324920) ; 松田 佳尚 同志社大学, 付置研究所, 准教授 (60342854)
• Project Period (FY): 2016 – 2020
• Project Status: Discontinued (Fiscal Year 2019)
• Budget Amount: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
• Keywords: 自閉スペクトラム障害 / 睡眠リズム / 胎児 / 共同注意 / 自閉症スペクトラム障害 / ASD / 生体機能リズム / 睡眠 / 自閉症 / 生体リズム

Outline of Annual Research Achievements

ヒトの自閉スペクトラム障害(ASD)の新規遺伝子異常の探索的研究を共同で行い、多数の新規の遺伝子異常を報告した。ASD症状を呈し、MECP2遺伝子変異によっておこる発達障害の代表疾患であるレット症候群の睡眠障害機序を解明中である。MeCP2欠損マウスの視床下部領域の解析から、概日リズムの統合や睡眠制御に関わるいくつかの遺伝子の発現異常を見出しており、睡眠リズムや睡眠・覚醒の制御に関わる「X遺伝子」異常と睡眠障害の関係に着目した研究を展開中である(松石グループ)。また、胎児の顔面を超音波断層法により描出することで、妊娠後期頃より規則的な口唇の動きを観察することができる。新生児においても、満期産近くの週齢になると静睡眠期に規則的な口唇運動(RMMs : Regular mouthing movements)がクラスターを形成して認められることが知られている。胎児のRMMsクラスターの形成様式についてこれまで知られておらず、本年度、正常単体妊娠症例90例(妊娠24-39週)を対象としてRMMsクラスターの変化およびnon-eye movement (NEM)期との関連性を検討した。超音波断層法を用いて胎児の口唇運動と眼球運動を60分間観察し保存した動画データを用いて、眼球運動と口唇運動の時系列データを作成し、有効観察時間内の単位時間当たりのRMMsクラスター数、NEM期の単位時間当たりのRMMsクラスター数を算出し、折れ線回帰分析を用いて解析した。その結果、単位時間当たりのRMMsクラスター数とNEM期の単位時間当たりのRMMsクラスター数とも、32-33週、36-37週の2か所で変曲点が検出され、32-33週から36-37週にかけて増加していた。この変化は胎児期の睡眠発達および中枢神経系の発達を表していると考えられた。本研究結果は現在投稿中である(諸隈グループ)。乳児(10ヵ月～12ヵ月齢)を対象に、始発的共同注意および応答的共同注意の効果を比較した。その結果、始発的共同注意は、物体情報の処理過程に影響を与えることがわかった。また、両方の共同注意の条件で、共同注意を示す顔の人物に対する選好が認められた(板倉グループ)。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] ミュンスター大学/ベルリン大学(ドイツ)
• [Int'l Joint Research] ミュンヘン大学(ドイツ)
• [Journal Article] 生体機能リズムの発達と自閉症スペクトラム障害 (2019)
  • Author(s): 小西行郎、豊浦麻記子、小西行彦、三池輝久
  • Journal Title: JOHNS Volume: 35 Issue: 7 Pages: 782-786
• [Journal Article] 自閉症スペクトラム障害にあたらしい展開を (2019)
  • Author(s): 小西行郎、豊浦麻記子、小西行彦、三池輝久
  • Journal Title: 病児保育研究 Issue: 10 Pages: 14-21
  • NAID: 40021971522
• [Journal Article] It Does Not Matter Who You Are: Fairness in Pre-schoolers Interacting with Human and Robotic Partners. (2019)
  • Author(s): Di Dio, C., Manzi, F., Itakura, S., Kanda, T., Ishiguro, H., Massaro, D., & Marchetti, A
  • Journal Title: International Journal of Social Robotics Volume: 11 Issue: 5 Pages: 1-15
  • DOI: 10.1007/s12369-019-00528-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sensitivity to register selection errors amongst 5- and 7-year-old children. (2019)
  • Author(s): Ikeda Ayaka、Kobayashi Tessei、Itakura Shoji
  • Journal Title: Developmental Psychology Volume: 55 Issue: 7 Pages: 1380-1388
  • DOI: 10.1037/dev0000725
  • Peer Reviewed
• [Journal Article] High frequency of vitamin D deficiency in current pregnant Japanese woman associated with UV avoidance and hypo-vitamin D diet (2019)
  • Author(s): Kumiko T Kanatani, Takeo Nakayama, Yuichi Adachi, Kei Hamazaki, Kazunari Onishi, Yukuo Konishi, Yasuyuki Kawanishi, Tohshin Go, Keiko Sato, Youichi Kurozawa, Hidekuni Inadera, Ikuo Konishi, Satoshi Sasaki, Hiroshi Oyama, Japan Environment and Children's Study Group.
  • Journal Title: PLOS ONE Volume: 14(3) Issue: 3 Pages: 0213264-0213264
  • DOI: 10.1371/journal.pone.0213264
  • Peer Reviewed / Open Access
• [Journal Article] Causal Information Over Facial Expression: Modulation of Facial Expression Processing by Congruency and Causal Factor of the Linguistic Cues in 5-Year-Old Japanese Children (2019)
  • Author(s): Park, YH & Itakura, S.
  • Journal Title: Journal of Psycholinguistic Research Volume: Online Issue: 5 Pages: 1-18
  • DOI: 10.1007/s10936-019-09643-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of attentional behaviours on infant visual preferences and object choice (2019)
  • Author(s): Ishikawa, M., Yoshimura, M., Sato, H., & Itakura, S.
  • Journal Title: Cognitive Processing Volume: Online Issue: 3 Pages: 317-324
  • DOI: 10.1007/s10339-019-00918-x
  • Peer Reviewed / Open Access
• [Journal Article] Physiological arousal predicts gaze following in infants (2019)
  • Author(s): Ishikawa Mitsuhiko、Itakura Shoji
  • Journal Title: Proceedings of the Royal Society B: Biological Sciences Volume: 286 Issue: 1896 Pages: 20182746-20182746
  • DOI: 10.1098/rspb.2018.2746
  • Peer Reviewed / Open Access
• [Journal Article] From understanding others' needs to prosocial action: Motor and social abilities promote infants' helping (2019)
  • Author(s): Koaster, M. Itakura, S., Omori, M., & Kartner, J.
  • Journal Title: Developmental Science Volume: e12804 Issue: 6 Pages: 43480-43480
  • DOI: 10.1111/desc.12804
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early motor signs of autism spectrum disorder in spontaneous position and movement of the head (2018)
  • Author(s): Gima H, Kihara H, Watanabe H, Nakano H, Nakano J, Konishi Y, Nakamura T, Taga G
  • Journal Title: Exp Brain Res. Volume: 4 Issue: 4 Pages: 1139-1148
  • DOI: 10.1007/s00221-018-5202-x
  • Peer Reviewed / Open Access
• [Journal Article] Task Difficulty Makes ‘No’ Response Different From ‘Yes’ Response in Detection of Fragmented Object Contours (2018)
  • Author(s): Taniguchi Kosuke、Kuraguchi Kana、Konishi Yukuo
  • Journal Title: Perception Volume: 47 Issue: 9 Pages: 943-965
  • DOI: 10.1177/0301006618787395
  • Peer Reviewed / Open Access
• [Journal Article] Multi-Scopeでいきましょう！時間生物学 (2018)
  • Author(s): 八木田和弘
  • Journal Title: 時間生物学 Volume: 24 Pages: 90-91
• [Journal Article] Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study: A cohort study (2018)
  • Author(s): Morokuma Seiichi、Michikawa Takehiro、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 15853-15853
  • DOI: 10.1038/s41598-018-34231-y
  • Peer Reviewed / Open Access
• [Journal Article] De novo HDAC8 mutation causes Rett-related disorder with distinctive facial features and multiple congenital anomalies (2018)
  • Author(s): Saikusa Tomoko、Hara Munetsugu、Iwama Kazuhiro、Yuge Kotaro、Ohba Chihiro、Okada Jun-ichiro、Hisano Tadashi、Yamashita Yushiro、Okamoto Nobuhiko、Saitsu Hirotomo、Matsumoto Naomichi、Matsuishi Toyojiro
  • Journal Title: Brain and Development Volume: 40 Issue: 5 Pages: 406-409
  • DOI: 10.1016/j.braindev.2017.12.013
  • Peer Reviewed / Open Access
• [Journal Article] A novel STXBP1 mutation causes typical Rett syndrome in a Japanese girl (2018)
  • Author(s): Yuge K, Iwama K, Yonee C,--Matsuishi T
  • Journal Title: Brain Dev Volume: 40 Issue: 6 Pages: 493-497
  • DOI: 10.1016/j.braindev.2018.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder (2018)
  • Author(s): Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, ...Matsumoto N.
  • Journal Title: Cell Reports Volume: 22(3) Issue: 3 Pages: 734-747
  • DOI: 10.1016/j.celrep.2017.12.074
  • Peer Reviewed / Open Access
• [Journal Article] レット症候群の病態とMeCP2の多様な役割 (2018)
  • Author(s): 高橋知之，弓削康太郎，松石豊次郎，山下裕史朗
  • Journal Title: 久留米医学会雑誌 Volume: 81 Pages: 1-8
  • Peer Reviewed / Open Access
• [Journal Article] Chronic inflammation in mice exposed to the long-term un-entrainable light-dark cycles (2018)
  • Author(s): Minami Y, Ohashi M, Hotta E, Hisatomi M, Okada N, Konishi E, Teramukai S, Inokawa H, Yagita K.
  • Journal Title: Sleep Biol Rhythm Volume: 16 Issue: 1 Pages: 63-68
  • DOI: 10.1007/s41105-017-0127-5
  • NAID: 40021436060
  • Peer Reviewed
• [Journal Article] Selective learning and teaching among Japanese and German children. (2018)
  • Author(s): Kim Sunae、Paulus Markus、Sodian Beate、Itakura Shoji、Ueno Mika、Senju Atsushi、Proust Jolle
  • Journal Title: Developmental Psychology Volume: 54 Issue: 3 Pages: 536-542
  • DOI: 10.1037/dev0000441
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Species-specific Posture of Human Foetus in Late First Trimester (2018)
  • Author(s): Ohmura Yoshiyuki、Morokuma Seiichi、Kato Kiyoko、Kuniyoshi Yasuo
  • Journal Title: Scientific reports Volume: 8 Issue: 1
  • DOI: 10.1038/s41598-017-18384-w
  • Peer Reviewed / Open Access
• [Journal Article] Disruption of circadian clockwork in in vivo reprogramming-induced mouse kidney tumors (2017)
  • Author(s): Ohashi Munehiro、Umemura Yasuhiro、Koike Nobuya、Tsuchiya Yoshiki、Inada Yutaka、Watanabe Hitomi、Tanaka Tomoko、Minami Yoichi、Ukimura Osamu、Miki Tsuneharu、Tajiri Tatsuro、Kondoh Gen、Yamada Yasuhiro、Yagita Kazuhiro
  • Journal Title: Genes to Cells Volume: 23 Issue: 2 Pages: 60-69
  • DOI: 10.1111/gtc.12552
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome. (2017)
  • Author(s): Hiroshi Kida, Tomoyuki Takahashi, Yuki Nakamura, Takashi Kinoshita, Munetsugu Hara, Masaki Okamoto, Satoko Okayama, Keiichiro Nakamura, Ken-ichiro Kosai, Takayuki Taniwaki, Yushiro Yamashita, Toyojiro Matsuishi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12293-12298
  • DOI: 10.1038/s41598-017-12293-8
  • Peer Reviewed / Open Access
• [Journal Article] Ghrelin improves dystonia and tremor in patients with Rett syndrome: a pilot study (2017)
  • Author(s): Yuge K, Hara M, Okabe R, Nakamura Y, Okamura H, Nagamitsu S, Yamashita Y, Orimoto K, Kojima M, Matsuishi T
  • Journal Title: J Neurol Sci Volume: 377 Pages: 219-223
  • Peer Reviewed
• [Journal Article] Involvement of posttranscriptional regulation ofClockin the emergence of circadian clock oscillation during mouse development (2017)
  • Author(s): Umemura Yasuhiro、Koike Nobuya、Ohashi Munehiro、Tsuchiya Yoshiki、Meng Qing Jun、Minami Yoichi、Hara Masayuki、Hisatomi Moe、Yagita Kazuhiro
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 114 Issue: 36
  • DOI: 10.1073/pnas.1703170114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robust circadian clock oscillation and osmotic rhythms in inner medulla reflecting cortico-medullary osmotic gradient rhythm in rodent kidney (2017)
  • Author(s): Hara Masayuki、Minami Yoichi、Ohashi Munehiro、Tsuchiya Yoshiki、Kusaba Tetsuro、Tamagaki Keiichi、Koike Nobuya、Umemura Yasuhiro、Inokawa Hitoshi、Yagita Kazuhiro
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 2045-2322
  • DOI: 10.1038/s41598-017-07767-8
  • Peer Reviewed / Open Access
• [Journal Article] Period23′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation (2017)
  • Author(s): Yoo Seung-Hee、Kojima Shihoko、Shimomura Kazuhiro、Koike Nobuya、Buhr Ethan D.、Furukawa Tadashi、Ko Caroline H.、Gloston Gabrielle、Ayoub Christopher、Nohara Kazunari、Reyes Bryan A.、Tsuchiya Yoshiki、Yoo Ook-Joon、Yagita Kazuhiro、Lee Choogon、Chen Zheng、Yamazaki Shin、Green Carla B.、Takahashi Joseph S.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 114 Issue: 42
  • DOI: 10.1073/pnas.1706611114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Individual differences in object-processing explain the relationship between early gaze-following and later language development (2017)
  • Author(s): Okumura, Y., Kanakogi,Y., Kobayashi, T., & Itakura, S.
  • Journal Title: Cognition Volume: 166 Pages: 418-426
  • DOI: 10.1016/j.cognition.2017.06.005
  • Peer Reviewed / Open Access
• [Journal Article] Social information affects adults’ evaluation of fairness in distributions: An ERP approach (2017)
  • Author(s): Ishikawa, M., Park, Y-h., Kitazaki, M., and Itakura, S.
  • Journal Title: PLoS ONE Volume: 12 Issue: 2 Pages: 1-13
  • DOI: 10.1371/journal.pone.0172974
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Familiarity of actors affects eye gaze processing during observation of goal-directed actions. (2017)
  • Author(s): Ishikawa, M. & Itakura, S.
  • Journal Title: Psychology and Behavioral Science. Volume: 2 Issue: 4 Pages: 1-4
  • DOI: 10.19080/pbsij.2017.02.555592
  • Peer Reviewed / Open Access
• [Journal Article] Eye movement activity in normal human fetuses between 24 and 39 weeks of gestation (2017)
  • Author(s): 33.Okawa H, Morokuma S, Maehara K, Horinouchi T, Arata A, Konishi Y, Kato K.
  • Journal Title: PLoS One Volume: 12;12(7) Issue: 7 Pages: 178722-178722
  • DOI: 10.1371/journal.pone.0178722
  • Peer Reviewed / Open Access
• [Journal Article] NICU・GCUの低出生体重児における音楽暴露時の生理的影響と アクチグラフによる身体活動量・睡眠の質についての検討 (2017)
  • Author(s): 光武玲子, 長谷川泰代, 荒田弘樹, 上野ふじ美, 新小田春美, 諸隈誠一
  • Journal Title: 日本新生児看護学会誌 Volume: 23(1) Pages: 6-22
  • Peer Reviewed
• [Journal Article] Association between exposure to air pollution during pregnancy and false positives in fetal heart rate monitoring (2017)
  • Author(s): Morokuma Seiichi、Michikawa Takehiro、Yamazaki Shin、Nitta Hiroshi、Kato Kiyoko
  • Journal Title: Scientific Reports Volume: 7 Issue: 1
  • DOI: 10.1038/s41598-017-12663-2
  • Peer Reviewed / Open Access
• [Journal Article] Increased cortisol awakening response after completing the summer treatment program in children with ADHD (2017)
  • Author(s): Okabe R, Okamura H, Egami C, Tada Y, Anai C, Mukasa A, Iemura A, Nagamitsu S, Furusho J, Matsuishi T, Yamashita Y
  • Journal Title: Brain Dev Volume: 39 Pages: 583-592
  • Peer Reviewed
• [Journal Article] Assessment of Autistic Traits in Children Aged 2 to 4.5 Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan. (2017)
  • Author(s): Stickley A, Tachibana Y, Hashimoto K, Haraguchi H, Miyake A, Morokuma S, Nitta H, Oda M, Ohya Y, Senju A, Takahashi H, Yamagata T, Kamio Y.
  • Journal Title: Autism Res. Volume: 3 Issue: 5 Pages: 852-865
  • DOI: 10.1002/aur.1742
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus. (2017)
  • Author(s): Morokuma S, Tsukimori K, Hori T, Kato K, Furue M.
  • Journal Title: Sci Rep. Volume: 7(1) Issue: 1 Pages: 739-739
  • DOI: 10.1038/s41598-017-00863-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autistic traits affect P300 response to unexpected events, regardless of mental state inferences (2017)
  • Author(s): Ishikawa, M., Itakura, S., & Tanabe, H.
  • Journal Title: Autism Research and Treatment Volume: 2
  • Peer Reviewed
• [Journal Article] Constant light exposure impairs immune tolerance development in mice. (2017)
  • Author(s): Mizutani H, Tamagawa-Mineoka R, Minami Y, Yagita K, Katoh N
  • Journal Title: J Darmatol. Sci. Volume: 86 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Analysis of antenatal-onset cerebral palsy secondary to transient ischemia in utero using a national database in Japan (2016)
  • Author(s): Fukushima K, Morokuma S, Kitadai Y, Tazaki Y, Sumie M, Nakanami N, Ushiro S, Matsuda Y, Tsukimori K.
  • Journal Title: J Obstet Gynaecol Res Volume: 42(10) Issue: 10 Pages: 1297-1303
  • DOI: 10.1111/jog.13046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Influence of sleep-onset time on the development of 18-month-old infants: Japan Children's cohort study (2016)
  • Author(s): Iemura A, Iwasaki M, Yamakawa N, Tomiwa K, Anji Y, Sakakihara Y, Kakuma T, Nagamitsu S, Matsuishi T.
  • Journal Title: Brain Dev Volume: 38 Issue: 4 Pages: 364-72
  • DOI: 10.1016/j.braindev.2015.10.003
  • Peer Reviewed
• [Journal Article] Acute encephalopathy with biphasic seizures and late reduced diffusion aasociated with staphylococcal toxic shock syndrome by burns (2016)
  • Author(s): Yokochi T, Sakanishi S, Ishidou Y, Kawano G, Matsuishi T, Akita Y, Obu K
  • Journal Title: Brain Dev Volume: 38 Pages: 875-879
  • Peer Reviewed
• [Journal Article] Altered SPECT (123)I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa (2016)
  • Author(s): Nagamitsu S, Sakurai R, Matsuoka M et al.
  • Journal Title: Front Psychiatry Volume: 7 Pages: 16-16
  • DOI: 10.3389/fpsyt.2016.00016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 典型的なけいれん重積型二相性脳症とは異なる経過でbright tree appearanceを呈した2症例 (2016)
  • Author(s): 横地賢興、竹内孝仁、向井純平、石堂雄毅、松石豊次郎、秋田幸大、大部敬三
  • Journal Title: 日本小児救急医学会誌 Volume: 15 Pages: 61-65
  • Peer Reviewed
• [Journal Article] 小児の摂食障害における転帰評価因子の検討 (2016)
  • Author(s): 千葉比呂美、永光信一郎、櫻井利恵子、日吉佑介、松岡美智子、山下裕史朗、角間辰之、内村直尚、松石豊次郎
  • Journal Title: 子どもの心とからだ Volume: 25 Pages: 212-218
  • Peer Reviewed
• [Journal Article] Cross cultural differences in response to social feedback during metacognitive evaluations: An electromyographic study (2016)
  • Author(s): 4.Jacquot, A., Eskenazi, T., Itakura, S., Sales-Wuillemin, E., Senju, A., Proust, J., Conty, L.
  • Journal Title: International Journal of Psychophysiology Volume: 108 Pages: 153-154
  • DOI: 10.1016/j.ijpsycho.2016.07.444
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site (2016)
  • Author(s): Tatsuya Kunimoto, Naoki Okubo, Yoichi Minami, Hiroyoshi Fujiwara, Toshihiro Hosokawa, Maki Asada, Ryo Oda, Toshikazu Kubo, Kazuhiro Yagita
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 22409-22409
  • DOI: 10.1038/srep22409
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of Multiple clock gene ablations on the circadian period-length and temperature compensation in mammalian cells. (2016)
  • Author(s): Tsuchiya Y., Umemura Y., Minami Y., Koike N., Hosokawa T., Hara M., Ito H., Inokawa H. & Yagita K.
  • Journal Title: Journal of Biological Rhythms Volume: 31 Issue: 1 Pages: 48-56
  • DOI: 10.1177/0748730415613888
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Familiar face + novel face = familiar face? Representational bias in the perception of morphed faces in chimpanzees (2016)
  • Author(s): Matsuda Y, Myowa-Yamakoshi M, Hirata S
  • Journal Title: PeerJ Volume: 4 Pages: e2304-e2304
  • DOI: 10.7717/peerj.2304
  • NAID: 120005973258
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autism spectrum disorder as a disorder of biological and behavioral rhythms (2016)
  • Author(s): 小西 行郎
  • Journal Title: Pediatric Otorhinolaryngology Japan Volume: 37 Issue: 3 Pages: 231-235
  • DOI: 10.11374/shonijibi.37.231
  • NAID: 130005467154
  • ISSN: 0919-5858, 2186-5957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 体内時計形成と発達障害 (2018)
  • Author(s): 小西 行郎
  • Organizer: 第121回日本小児科学会学術集会
• [Presentation] 新生児、乳幼児の睡眠障害は発達障害の有効な予測因子 (2018)
  • Author(s): 小西 行郎
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] オープンサイエンスから見た自閉症 (2018)
  • Author(s): 小西 行郎
  • Organizer: 第37回日本思春期学会総会・学術集会
  • Invited
• [Presentation] 胎児期の睡眠と発達障害 (2018)
  • Author(s): 小西 行郎
  • Organizer: 第27回日本睡眠環境学会学術大会
  • Invited
• [Presentation] 睡眠から紐解く子どもの発達 (2018)
  • Author(s): 小西 行郎
  • Organizer: 平成30年度埼玉県作業療法士会学術部第１回研修会
  • Invited
• [Presentation] 赤ちゃんの心を知り育てる～その手法と活用～ (2018)
  • Author(s): 小西 行郎
  • Organizer: けいはんなイノベーション共創シンポジウム
  • Invited
• [Presentation] 睡眠から紐解く子どもの発達 (2018)
  • Author(s): 小西 行郎
  • Organizer: 平成30年度京都市地域リハビリテーション推進研修
  • Invited
• [Presentation] Regulation and mis-regulation of cellular differentiation-coupled circadian clock functionality in mammals. (2018)
  • Author(s): Kazuhiro Yagita
  • Organizer: Matrix Biology Europe 2018
  • Int'l Joint Research / Invited
• [Presentation] Plasticity of Mammalian Circadian Clock: from cellular to organismal levels (2018)
  • Author(s): Kazuhiro Yagita
  • Organizer: Sapporo Symposium on Biological Rhythm in 2018
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiological Insights of Circadian Rhythm Disorder and Stress: A report of “Mouse-Cohort” Study. (2018)
  • Author(s): Kazuhiro Yagita
  • Organizer: Summer School on Stress
  • Int'l Joint Research / Invited
• [Presentation] 胎児期の体内時計と睡眠発達 (2018)
  • Author(s): 諸隈誠一
  • Organizer: 第121回日本小児科学会学術集会
• [Presentation] 妊娠期の環境が周産期予後・次世代に与える影響に関する研究 (2018)
  • Author(s): 諸隈誠一
  • Organizer: 第70回日本産科婦人科学会学術講演会
• [Presentation] Ghrelin improves dystonia/behavioral dysfunctions with an atypical form of Rett syndrome patient (2018)
  • Author(s): Orimoto K, Matsuishi T, Yuge K, Horike S, Meguro M
  • Organizer: 59th Annual Meeting of the Japanese Society of Neurology
  • Int'l Joint Research / Invited
• [Presentation] グレリンはレット症候群の症状を改善する -新規治療法開発の未来への扉- (2018)
  • Author(s): 松石豊次郎
  • Organizer: Bio JAPAN
• [Presentation] An atypical form of Rett syndrome (RTT) patient exhibited dystonia and characteristic psychological/behavioral dysfunction (2017)
  • Author(s): Orimoto K, Matsuishi T, Yuge K
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 「レット症候群の新規治療法開発」グレリンの実用化に向けた取り組みと課題 (2017)
  • Author(s): 松石豊次郎
  • Organizer: 第1回「レット症候群とMECP2重複症候群」合同シンポジウム
• [Presentation] Disruption of Circadian Clockwork in Dysdifferentiation-mediated Cancers (2017)
  • Author(s): Yagita, K
  • Organizer: 15th Congress of the European Biological Rhythm Society
  • Int'l Joint Research
• [Presentation] Circadian Clock Ontogeny in Mammals (2017)
  • Author(s): Yagita, K
  • Organizer: JSSR International Forum on Somnology
  • Int'l Joint Research
• [Presentation] From whom do infants learn?-Developmental Cybernetics view- (2017)
  • Author(s): Itakura,S.
  • Organizer: British Psychological Society- Developmental Section Conference
  • Int'l Joint Research
• [Presentation] Pro-social behavior in young infants: Fairness, helping, and empathy. (2017)
  • Author(s): Itakura, S.
  • Organizer: The 3rd International Symposium on Child Developmental Science.
  • Int'l Joint Research / Invited
• [Presentation] 胎児の生体周期から見た脳の発達 (2017)
  • Author(s): 諸隈誠一
  • Organizer: 第59回 日本小児神経学会学術集会
• [Presentation] Temporal and spatial perspective taking with autism spectrum disorders (2017)
  • Author(s): Hidetsugu Komeda, Yoko Mano, Yoshi-Taka Matsuda, Hidekazu Osanai, Masahiro Kawasaki., Takashi Kusumi, Toshihiko Aso, & Yasuko Funabiki
  • Organizer: Neurodevelopmental Disorders Annual Seminar 2017
  • Int'l Joint Research
• [Presentation] 自閉症スペクトラム症のおけるResting-state fMRI解析 (2017)
  • Author(s): 松田佳尚、麻生俊彦、米田英嗣、小西行郎、村井俊哉、船曳康子
  • Organizer: 日本赤ちゃん学会第17回学術集会
• [Presentation] 生体リズム異常と発達障害 (2017)
  • Author(s): 小西行郎
  • Organizer: 日本赤ちゃん学会第17回学術集会
  • Invited
• [Presentation] 生体機能リズムの障害としての自閉スペクトラム症 (2017)
  • Author(s): 小西行郎
  • Organizer: 生理学研究所所長招聘セミナー
  • Invited
• [Presentation] 胎児期にはじまる発達障害の先制医療 (2017)
  • Author(s): 小西行郎
  • Organizer: 関西健康・医療創生会議セミナー
  • Invited
• [Presentation] 表情知覚の発達：選好注視のふるまいから脳内基盤を探る (2017)
  • Author(s): 松田佳尚、谷口康祐、小西行郎
  • Organizer: 第28回 日本発達心理学会
  • Place of Presentation: 広島市
• [Presentation] 自閉症スペクトラム特性をもつ子どもの保育を考える―生涯にわたるWell-beingの礎となる乳幼児期の発達保障のあり方とは― (2017)
  • Author(s): 高橋翠、遠藤利彦、三隅輝見子、淀川裕美、野澤祥子、関智弘、小西行郎、萩原拓
  • Organizer: 日本発達心理学会第28回大会シンポジウム
  • Place of Presentation: 広島市
• [Presentation] Developmental Cybernetics: Infant Perceptions of Nonhuman Agents (2016)
  • Author(s): Itakura, S.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan, PACIFICO Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] The cognitive studies of eye gaze (2016)
  • Author(s): Itakura S.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan, PACIFICO Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Building blocks of moral competence: Do infants link the domains of harm and fairness? (2016)
  • Author(s): Surian, L., Meristo, M., Ueno, M., & Itakura, S
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan, PACIFICO Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Understanding violations of Gricean maxims in typically developing preshoolers and adults (2016)
  • Author(s): Okanda, M., & Itakura, S.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan, PACIFICO Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Do infants refer the social evaluation by others? (2016)
  • Author(s): Suk, Y., Zhao, W., Hamlin, K., & Itakura, S.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan, PACIFICO Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] East-West cultural differences in context-sensitivity are evident in early childhood (2016)
  • Author(s): Itakura, S., Imada, T., & Carlson, S.
  • Organizer: 24th Biennial Meeting of the International Society for the Study of Behavioural Development
  • Place of Presentation: Vilnius, Lithuania
  • Year and Date: 2016-07-10
  • Int'l Joint Research / Invited
• [Presentation] Nonverbal theory of mind: Evidence in Japanese children (2016)
  • Author(s): Itakura, S.
  • Organizer: DAVIDNORM Workshop
  • Place of Presentation: Ecole Normale Superieure, Paris
  • Year and Date: 2016-05-31
  • Int'l Joint Research / Invited
• [Presentation] Infants expect helpers but not hinderers to carry out fair distributions of resources. (2016)
  • Author(s): Surian, L., Merist, M., Ueno, M., & Itakura, S.
  • Organizer: 2016 International Conference of Infant Study
  • Place of Presentation: New Orleans, USA, Hilton riverside
  • Year and Date: 2016-05-26
  • Int'l Joint Research
• [Presentation] The role of maternal scaffolding during task assignment in the early ontogeny of helping behavior: A cross-cultural perspective. (2016)
  • Author(s): Koster, M., Itakura, S., & Kartner, J.
  • Organizer: 2016 International Conference of Infant Study
  • Place of Presentation: New Orleans, USA, Hilton riverside
  • Year and Date: 2016-05-26
  • Int'l Joint Research
• [Presentation] Infants understanding of other's needs as a universal precoursor of early helping behavior (2016)
  • Author(s): Koster, M., Itakura, S., & Kartner, J.
  • Organizer: 2016 International Conference of Infant Study
  • Place of Presentation: New Orleans, USA, Hilton riverside
  • Year and Date: 2016-05-26
  • Int'l Joint Research
• [Presentation] Shyness in early infancy: Approach-avoidance conflicts in temperaments and hypersensitivity to eyes (2016)
  • Author(s): Yoshi-Taka Matsuda, Kazuo Okanoya, Masako Myowa-Yamakoshi, Yukuo Konishi
  • Organizer: 2016 International Conference of Infant Study
  • Place of Presentation: New Orleans, USA, Hilton riverside
  • Year and Date: 2016-05-26
  • Int'l Joint Research
• [Presentation] はじまりとしての赤ちゃん～胎児 (2016)
  • Author(s): 諸隈誠一
  • Organizer: 第16回 日本赤ちゃん学会学術集会
  • Place of Presentation: 同志社大学今出川キャンパス 京都
• [Presentation] 胎児期からのハイリスク児の臨床観察による発達障害理解と包括的診断法 (2016)
  • Author(s): 諸隈誠一
  • Organizer: 日本発達神経科学学会 第5 回学術集会
  • Place of Presentation: 東京
• [Presentation] 神経科学からみた発達障害 (2016)
  • Author(s): 松石豊次郎
  • Organizer: 第18回「子どもの心」研修科医
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 新生児～学童期の睡眠は発達障害予測の指標になるか？ (2016)
  • Author(s): 松石豊次郎
  • Organizer: 日本赤ちゃん学会 第16回学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 筑後地区における聖マリア病院小児神経の役割 (2016)
  • Author(s): 松石豊次郎
  • Organizer: 第3回聖マリア医師同門会総会特別講演
  • Place of Presentation: 久留米市
  • Invited
• [Presentation] Rett症候群の謎に挑戦する (2016)
  • Author(s): 松石豊次郎
  • Organizer: 小児神経学クリニック 瀬川塾講演
  • Place of Presentation: 東京
  • Invited
• [Presentation] レット症候群のグレリン治療について (2016)
  • Author(s): 松石豊次郎、弓削康太郎、児島将康
  • Organizer: 小児神経学クリニック 瀬川塾講演
  • Place of Presentation: 東京
  • Invited
• [Presentation] Japanese Rett Syndrome Database Consortium (2016)
  • Author(s): Itoh M, Saikusa T, Ikenaga T, Hirayama S, Nabatame S, Matsuishi T
  • Organizer: RTT 50.1 The 50th Anniversary of the First Publication Wienon Rett Syndrome
  • Place of Presentation: Wien, Austria
  • Int'l Joint Research
• [Presentation] Development of the therapeutic strategies for Rett syndrome (2016)
  • Author(s): Orimoto K, Matsuishi T, Yuge K
  • Organizer: 第39回日本分子生物学会総会
  • Place of Presentation: 横浜市
• [Presentation] バルプロ酸(VPA)投与後、遷延する嘔吐が軽快した錯乱型片頭痛の1例 (2016)
  • Author(s): 中村美彩、三宅 淳、寺澤藍子、松下美由紀、中嶋洋介、横地賢興、岡本陽子、石本和久、工藤嘉公、河野 剛、秋田幸大、松石豊次郎、大部敬三
  • Organizer: 第484回日本小児科学会福岡地方会
  • Place of Presentation: 福岡市
• [Presentation] Histone deacetylation 8（HDAC8）遺伝子変異により非典型的Rett 症候群をきたした女児の1 例 (2016)
  • Author(s): 七種朋子、下村 豪、弓削康太郎、原 宗嗣、永光信一郎、山下裕史朗、松石豊次郎、松本直道
  • Organizer: 第58回日本小児神経学会学術集会
  • Place of Presentation: 東京
• [Presentation] 過去11年間における一過性の神経症状に可逆性脳梁膨大部病変を伴った14例の検討 (2016)
  • Author(s): 加藤 健、島さほ、中村美彩、屋宮清仁、寺澤藍子、松下美由紀、八戸由佳子、横地賢興、岡本陽子、工藤嘉公、河野 剛、秋田幸大、松石豊次郎、大部敬三
  • Organizer: 第485回日本小児科学会福岡地方会
  • Place of Presentation: 福岡市
• [Presentation] 急性脳症との鑑別を有した錯乱型片頭痛の1例 (2016)
  • Author(s): 横地賢興、松下美由紀、河野 剛、秋田幸大、松石豊次郎、大部敬三
  • Organizer: 第30回日本小児救急医学会学術集会
  • Place of Presentation: 仙台市
• [Presentation] ベッドと壁の間に転落し心肺停止状態で発見された４か月男児の1例 (2016)
  • Author(s): 井手水紀、山内良賢、加藤 健、島さほ、中村美彩、屋宮清仁、寺澤藍子、松下美由紀、八戸由佳子、倉田悟子、横地賢興、工藤嘉公、河野 剛、秋田幸大、松石豊次郎、大部敬三
  • Organizer: 第486回日本小児科学会福岡地方会
  • Place of Presentation: 福岡市
• [Presentation] Children’s Eating Attitudes Test: Reliability and Validation in Japanese Adolecents (2016)
  • Author(s): Nagamitsu S, Chiba H, Sakurai R, Mukai T, Shintou H, Yamashita Y, Kakuma T, Matsuishi T
  • Organizer: The 12th Asian Society for Pediatric Research (ASPR)
  • Place of Presentation: Bangkok, Thai
  • Int'l Joint Research
• [Presentation] 胃瘻チューブ交換後に消化管穿孔をきたしショック状態となり搬送された5歳男児の1例 (2016)
  • Author(s): 島 さほ、山内良賢、日吉佑介、荒木潤一郎、屋宮清仁、寺澤藍子、松下美由紀、八戸由佳子、倉田悟子、横地賢興、工藤嘉公、河野 剛、秋田幸大、松石豊次郎、大部敬三
  • Organizer: 第492回日本小児科学会福岡地方会例会
  • Place of Presentation: 福岡市
• [Presentation] Impaired Glucose Tolerance among Children, Adolescents, and Young adults with Circadian Rhythm Sleep Disorders (2016)
  • Author(s): Makiko Toyoura
  • Organizer: 第58回日本小児神経学会学術集会
  • Place of Presentation: 東京
• [Presentation] 自閉症スペクトラム症におけるResting-state fMRI解析 (2016)
  • Author(s): 松田佳尚、麻生俊彦、米田英嗣、小西行郎、村井俊哉、福山秀直、船曳康子
  • Organizer: 第5回 日本発達神経科学学会
  • Place of Presentation: 東京
• [Presentation] Microscopic- and Macroscopic-Bioluminescence Imaging for Understanding the Integrative Circadian Physiology in Organ Level (2016)
  • Author(s): Yagita K.
  • Organizer: 16th International Symposium of Biolumiescence and Chemiluminescence in 2016
  • Place of Presentation: つくば市
  • Int'l Joint Research / Invited
• [Presentation] Suppression of circadian molecular clockwork in dysdifferentiation-mediated cancers (2016)
  • Author(s): Yagita K.
  • Organizer: The 29th Conference of the International Society for Chronobiology
  • Place of Presentation: Suzhou, China
  • Int'l Joint Research / Invited
• [Presentation] 体内時計と発達障害：動物モデルの研究から (2016)
  • Author(s): 八木田和弘
  • Organizer: 日本赤ちゃん学会第１６回学術集会
  • Place of Presentation: 京都市
  • Int'l Joint Research
• [Presentation] circadian clock and cancer: molecular mechanism of circadian clock disruption in in vivo reprograming induced mouse Wilms Tumor model (2016)
  • Author(s): 八木田和弘
  • Organizer: 第８９回日本生化学会
  • Place of Presentation: 仙台市
  • Int'l Joint Research
• [Presentation] 概日時計の根本原理から紐解く疾患理解 (2016)
  • Author(s): 八木田和弘
  • Organizer: 第２３回日本時間生物学会学術集会
  • Place of Presentation: 名古屋市
  • Int'l Joint Research
• [Presentation] お腹の赤ちゃんのチカラ－赤ちゃん学最前線 (2016)
  • Author(s): 小西行郎
  • Organizer: 生命尊重全国研修会
  • Place of Presentation: 東京
  • Int'l Joint Research
• [Presentation] 子どもの発達を理解する～赤ちゃん学からのメッセージ～ (2016)
  • Author(s): 小西行郎
  • Organizer: 平成28年度障害児保育担当職員研修
  • Place of Presentation: 山口市
  • Int'l Joint Research
• [Presentation] はじまりとしての赤ちゃん (2016)
  • Author(s): 小西行郎
  • Organizer: 第107回「子ども学」講演会公開シンポジウム
  • Place of Presentation: 神戸市
  • Int'l Joint Research
• [Book] 稀少てんかんの診療指標 (2017)
  • Author(s): 井上有史，小国弘量，須貝研司，永井利三郎，松石豊次郎，石井敦士，廣瀬伸一，岡本伸彦，酒井規夫，加藤光弘，川合謙介，高橋幸利，大松泰生，柿田明美，小林勝弘，今井克美，池田浩子，青天目信，浜野晋一郎，村井智彦ほか
  • Total Pages: 276
  • Publisher: 診断と治療社
  • ISBN: 9784787823090
• [Book] 赤ちゃんの脳と心で何が起こっているの？ (2017)
  • Author(s): リザ・エリオット、小西 行郎、福岡 洋一
  • Total Pages: 691
  • Publisher: 楽工社
  • ISBN: 9784903063799
• [Book] 16．Rett症候群．稀少難治てんかん診療マニュアル．第2章 疾患の特徴と診療指針 (2017)
  • Author(s): 松石豊次郎
  • Publisher: 診断と治療社
• [Book] 時間の風景920 出会いのありがたさと忘れられない患者さん (2017)
  • Author(s): 松石豊次郎
  • Total Pages: 22
  • Publisher: Medical Tribune
• [Book] 実験医学 (2017)
  • Author(s): 桜田一洋、望月敦史、小西行郎、唐﨑隆弘、垣見和宏、川崎洋、川上英良、天谷雅行、古閑明彦、中津川雅彦、種石慶、奥野恭史、shannon M.Rego，Michael P.Snyder他
  • Total Pages: 138
  • Publisher: 羊土社
• [Book] 慢性疾患児の一生を診る．・神経疾患 Rett症候群 (2016)
  • Author(s): 松石豊次郎
  • Total Pages: 3
  • Publisher: 小児内科
• [Book] 赤ちゃん学で理解する乳児の発達と保育 第1巻 睡眠・食事・生活の基本 (2016)
  • Author(s): 三池輝久、上野有理、小西行郎
  • Total Pages: 137
  • Publisher: 中央法規出版株式会社
• [Book] 乳幼児の音楽表現 ―赤ちゃんから始まる音環境の創造（保育士・幼稚園教諭要請課程） (2016)
  • Author(s): 小西行郎、志村洋子、今川恭子、坂井康子
  • Total Pages: 155
  • Publisher: 中央法規出版株式会社
• [Book] ママ、わたしこんなこと思ってるよ (2016)
  • Author(s): 小西行郎
  • Total Pages: 175
  • Publisher: 株式会社ＰＨＰ研究所
• [Patent(Industrial Property Rights)] グレリンを有効成分として含有するレット症候群(RTT)の予防・治療剤 (2018)
  • Inventor(s): 松石豊次郎、弓削康太郎、児島将康、原宗嗣、山下裕史朗
  • Industrial Property Rights Holder: 学校法人久留米大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] Prophylactic and therapeutic agent for Rett syndrome (RTT) comprising ghrelin as active ingredient (2018)
  • Inventor(s): Toyojiro Matsuishi,etc
  • Industrial Property Rights Holder: 学校法人久留米大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas