| Budget Amount *help |
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Outline of Final Research Achievements |
The operational dynamics of the astrocyte in relation to memory and learning have been investigated. We found a hippocampal sharp wave ripple phenotype in IP3R2-KO mice that were reared in isolation. In addition to astrocytes, we showed that microglia are affected by tDCS in mice. We found that Ca2+ and cAMP are elevated in astrocytic soma and processes during fear conditioning learning. To understand how GPCR signaling in astrocytes contributes to memory, we made a transgenic mouse that express an optogenetic Gq-GPCR in astrocytes. Using this mouse, we demonstrated that astrocytic Gq activation promotes the maintenance of remote memory.
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