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Higher visual areas responsible for shape recognition in mice

Research Project

Project/Area Number 16H01892
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Brain biometrics
Research InstitutionNiigata University

Principal Investigator

Shibuki Katsuei  新潟大学, 脳研究所, 非常勤講師 (40146163)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2017: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2016: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Keywords高次視覚野 / 図形認知 / マウス / 皮質盲 / 視覚的意識 / 聴覚野 / 視覚野 / 連想記憶 / フラビン蛋白蛍光イメージング / 短期記憶 / 遅延見本合わせ / イメージング / 一次視覚野 / 上丘 / 長期増強 / 自動学習実験
Outline of Final Research Achievements

We investigated the responses in the higher visual cortex of conscious mice. The posterior-ventral cortical areas adjacent to the auditory cortex responded to moving object stimuli. Visual object recognition can be performed in wide cortical regions including these areas. Analysis of associative auditory responses to visual stimuli revealed that the associative responses were observed in diffuse auditory areas including the anterior auditory field. The formation of associative memory required stimulus complexity, which may be essential for characterizing stimuli. Visual object recognition is related to visual consciousness. Damages to the primary visual cortex (V1) impair visual consciousness. We investigated a male patient with the damaged V1. Repeated presentation of dynamic visual stimuli to him resulted in long-term potentiation in the probability of detection of visual stimuli, and after this potentiation, he could read hiragana letters presented in the impaired visual field.

Academic Significance and Societal Importance of the Research Achievements

我々は覚醒マウスの高次視覚野応答を解析し、高次視覚野が聴覚野の腹側まで広がっているという新知見を得た。またその部位の性質は一次視覚野の性質と大きく異なることが判った。これらの成果は、図形認知機能の分子機構解明に有用である。図形認知機能は、視覚的意識にかかわるが、視覚的意識を調べるためには、言語による報告が可能な人間を解析対象とする必要がある。我々は一次視覚野が脳梗塞によって障害された被検者の文字を読む図形認知機能について解析し、これらが動的視覚刺激の繰り返し提示によって回復することを示した。本研究の成果は、皮質盲の診断や治療といった臨床医学的観点からも有用であると考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017 2016

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 12 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction2020

    • Author(s)
      Shibuki Katsuei、Wakui Ichiro、Fujimura Takeo、Tomikawa Masaru、Hasegawa Shin
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 1-7

    • DOI

      10.3389/fneur.2020.00069

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reciprocal connectivity between secondary auditory cortical field and amygdala in mice.2019

    • Author(s)
      Tsukano H, Hou X, Horie M, Kitaura H, Nishio N, Hishida R, Takahashi K, Kakita A, Takebayashi H, Sugiyama S, Shibuki K
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 19610-19610

    • DOI

      10.1038/s41598-019-56092-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associative responses to visual shape stimuli in the mouse auditory cortex.2019

    • Author(s)
      Ogi M, Yamagishi T, Tsukano H, Nishio N, Hishida R, Takahashi K, Horii A, Shibuki K
    • Journal Title

      PLoS One

      Volume: 14 Issue: 10 Pages: 1-13

    • DOI

      10.1371/journal.pone.0223242

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feedback inhibition derived from the posterior parietal cortex regulates the neural properties of the mouse visual cortex.2019

    • Author(s)
      Hishida R, Horie M, Tsukano H, Tohmi M, Yoshitake K, Meguro R, Takebayashi H, Yanagawa Y, Shibuki K
    • Journal Title

      Eur J Neurosci

      Volume: 50 Issue: 6 Pages: 2970-2987

    • DOI

      10.1111/ejn.14424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice.2019

    • Author(s)
      Onishi T, Watanabe T, Sasaki M, Kamiya Y, Horie M, Tsukano H, Hishida R, Kohno T, Takebayashi H, Baba H, Shibuki K
    • Journal Title

      J Physiol.

      Volume: 597 Issue: 13 Pages: 3441-3455

    • DOI

      10.1113/jp277615

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Relay Pathways from Lemniscal Auditory Thalamus to Secondary Auditory Field in Mice.2018

    • Author(s)
      Ohga S, Tsukano H, Horie M, Terashima H, Nishio N, Kubota Y, Takahashi K, Hishida R, Takebayashi H, Shibuki K.
    • Journal Title

      Cereb Cortex

      Volume: 28 Issue: 12 Pages: 4424-4439

    • DOI

      10.1093/cercor/bhy234

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher visual responses in the temporal cortex of mice2018

    • Author(s)
      Nishio Nana、Tsukano Hiroaki、Hishida Ryuichi、Abe Manabu、Nakai Junichi、Kawamura Meiko、Aiba Atsushi、Sakimura Kenji、Shibuki Katsuei
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11136-11136

    • DOI

      10.1038/s41598-018-29530-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice.2018

    • Author(s)
      Yamagishi T, Yoshitake K, Kamatani D, Watanabe K, Tsukano H, Hishida R, Takahashi K, Takahashi S, Horii A, Yagi T, Shibuki K.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 9616-9616

    • DOI

      10.1038/s41598-018-28034-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tomographic optical imaging of cortical responses after crossing nerve transfer in mice2018

    • Author(s)
      Maniwa K, Yamashita H, Tsukano H, Hishida R, Endo N, Shibata M, Shibuki K
    • Journal Title

      PLoS One

      Volume: 13 Issue: 2 Pages: e0193017-e0193017

    • DOI

      10.1371/journal.pone.0193017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex2017

    • Author(s)
      Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12646-12646

    • DOI

      10.1038/s41598-017-04007-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice.2017

    • Author(s)
      1.Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K
    • Journal Title

      Front Neural Circuits

      Volume: 11 Pages: 14-14

    • DOI

      10.3389/fncir.2017.00014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice.2017

    • Author(s)
      2.Tsukano H, Horie M, Takahashi K, Hishida R, Takebayashi H, Shibuki K
    • Journal Title

      Neurosci Lett

      Volume: 637 Pages: 26-30

    • DOI

      10.1016/j.neulet.2016.11.062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Auditory cortical field coding long-lasting tonal offsets in mice.2016

    • Author(s)
      3.Baba H, Tsukano H, Hishida R, Takahashi K, Horii A, Takahashi S, Shibuki K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 34421-34421

    • DOI

      10.1038/srep34421

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Feasibility of forward genetic analysis of consciousness using mouse models2017

    • Author(s)
      Shibuki K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Tonotopic properties in the secondary auditory field are derived from structural organization of the ventral medial geniculate body and thalamocortical projections in mice2017

    • Author(s)
      塚野浩明、大賀慎平、堀江正男、寺島裕貴、竹林浩秀、澁木克栄
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plastic changes of visual responses in the primary visual cortex are induced selectively by inhibitory projection from posterior parietal cortex in mice2017

    • Author(s)
      菱田竜一、堀江正男、塚野浩明、任海学、澁木克栄
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Complexity of sound stimuli required for sound-shape associative responses in the mouse auditory cortex2017

    • Author(s)
      小木学、山岸達矢、塚野浩明、西尾奈々、菱田竜一、堀井新、八木健、澁木克栄
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optical imaging of temporal cortical areas involved in audiovisual integration in awake mice2017

    • Author(s)
      西尾奈々、小木学、山岸達矢、塚野浩明、菱田竜一、八木健、澁木克栄
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of prediction error responses in the posterior parietal cortex of awake mice2017

    • Author(s)
      吉武講平、塚野浩明、菱田竜一、八木健、澁木克栄
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional footprints of impaired consciousness in mice with reduced molecular diversity of clustered protocadherin-α2016

    • Author(s)
      Yamagishi T, Kamatani D, Yoshitake K, Tsukano H, Watanabe K, Hishida R, Takahashi K, Takahashi S, Horii A, Yagi T, Shibuki K
    • Organizer
      Neuroscience 2016 Annual Meeting
    • Place of Presentation
      San Diego(アメリカ合衆国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular approach to neural mechanisms of consciousness using mouse models.2016

    • Author(s)
      Shibuki K
    • Organizer
      本神経科学大会サテライトシンポジウム:The Origin of Consciousness
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neural correlates of visual awareness organized by short-term memory in mice2016

    • Author(s)
      Shibuki K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] マウス用学習装置、マウス用学習システム及びマウス用学習プログラム2018

    • Inventor(s)
      澁木克栄
    • Industrial Property Rights Holder
      新潟大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マウス用学習装置、マウス用学習システム及びマウス用学習プログラム2017

    • Inventor(s)
      澁木 克栄
    • Industrial Property Rights Holder
      新潟大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-034171
    • Filing Date
      2017-02-24
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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