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Empirical studies on physiological and biological factors of the helping behavior by autistic individuals and autistic-like monkeys

Research Project

Project/Area Number 16H02058
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionNagoya University

Principal Investigator

KAWAI Nobuyuki  名古屋大学, 情報学研究科, 教授 (30335062)

Co-Investigator(Kenkyū-buntansha) 神尾 陽子  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 児童・予防精神医学研究部, 客員研究員 (00252445)
香田 啓貴  京都大学, 霊長類研究所, 助教 (70418763)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥39,650,000 (Direct Cost: ¥30,500,000、Indirect Cost: ¥9,150,000)
Fiscal Year 2019: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2018: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywords自閉症 / 援助行動 / マーモセット / オキシトシン / 自閉症モデル動物 / 不公平忌避 / 第三者社会交渉 / 進化
Outline of Final Research Achievements

This study explores the helping behaviors of autistic individuals and autistic-like common marmosets, as marmosets are a rare species that help non-kin conspecifics. An initial study revealed that marmosets do not respond when other marmosets could receive food while they did not. This behavior is considered as exemplifying inequity aversion, which is the preference for fairness and resistance to inequalities. We investigate inequity aversion in marmosets who were prenatally exposed to valproic acid (VPA) in the womb and unexposed marmosets. We found that the latter show inequity aversion while the former do not. As prenatal exposure to VPA is a well-known procedure in inducing ASD-like behaviors in rodents, the lack of inequity aversion in the VPA marmosets could be attributed to weak social motivations or interest towards others.
Social skill training, including helping behaviors, lead to desirable behaviors by elementary school children, including high risk children with autism

Academic Significance and Societal Importance of the Research Achievements

援助行動は嫉妬や不公平感の裏返しであることが、霊長類の研究で示された。援助を促進するためには、これらのネガティブな気持ちを取り除くことが重要であることが示唆される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (50 results)

All 2019 2018 2017 2016

All Journal Article (18 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 16 results,  Open Access: 14 results,  Acknowledgement Compliant: 1 results) Presentation (28 results) (of which Int'l Joint Research: 6 results,  Invited: 11 results) Book (4 results)

  • [Journal Article] Humans detect snakes more accurately and quickly than other animals under natural visual scenes: a flicker paradigm study.2019

    • Author(s)
      Kawai, N., & Qiu, H.
    • Journal Title

      Cognition and Emotion

      Volume: 34 Issue: 3 Pages: 614-620

    • DOI

      10.1080/02699931.2019.1657799

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者は凶暴か?2019

    • Author(s)
      川合 伸幸
    • Journal Title

      心と社会

      Volume: 50 Pages: 22-26

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Common marmosets (Callithrix jacchus) evaluate third-party social interactions of human actors but Japanese monkeys (Macaca fuscata) do not.2019

    • Author(s)
      Kawai Nobuyuki、Nakagami Akiko、Yasue Miyuki、Koda Hiroki、Ichinohe Noritaka
    • Journal Title

      Journal of Comparative Psychology

      Volume: 133 Issue: 4 Pages: 488-495

    • DOI

      10.1037/com0000182

    • NAID

      120006786249

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 社会的な存在-他者-をプロジェクションする2019

    • Author(s)
      中田龍三郎・川合伸幸
    • Journal Title

      認知科学

      Volume: 26 Pages: 86-97

    • NAID

      130007699972

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 研究者の職人魂と夏の道場2018

    • Author(s)
      川合 伸幸
    • Journal Title

      認知科学

      Volume: 25 Pages: 365-366

    • NAID

      130007657530

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid.2018

    • Author(s)
      Yasue M, Nakagami A, Nakagaki K, Ichinohe N, Kawai N
    • Journal Title

      Behav Brain Res.

      Volume: 234 Pages: 36-40

    • DOI

      10.1016/j.bbr.2018.01.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of temperament and autistic traits on psychopathology in Japanese children: A nationwide cross-sectional study.2018

    • Author(s)
      Y. Kamio, R. Takei, A. Stickley, A. Saito, A. Nakagawa
    • Journal Title

      Personality and Individual Differences

      Volume: 124 Pages: 1-7

    • DOI

      10.1016/j.paid.2017.11.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nasalization by Nasalis larvatus : Larger noses audiovisually advertise conspecifics in proboscis monkeys2018

    • Author(s)
      Koda, H., Murai, T., Tuuga, A., Goossens, B., Nathan, S., Stark, D. J., Ramirez, D. A. R., Sha, J. C. M., Osman, I., Sipangkui, R., Seino, S., & Matsuda, I.
    • Journal Title

      Science Advances

      Volume: 4 Issue: 2

    • DOI

      10.1126/sciadv.aaq0250

    • NAID

      120006401710

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A systematic review and meta-analysis of comprehensive interventions for pre-school children with autism spectrum disorder (ASD).2017

    • Author(s)
      Y. Tachibana, C. Miyazaki, E. Ota, R. Mori, Y. Hwang, E. Kobayashi, A. Terasaka, J. Tang, Y. Kamio
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 12 Pages: e0186502-e0186502

    • DOI

      10.1371/journal.pone.0186502

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alpha band event-related desynchronization underlying social situational context processing during irony comprehension: class FormattedString { value: A magnetoencephalography source localization study }2017

    • Author(s)
      Yoritaka Akimoto, Hidetoshi Takahashi, Atsuko Gunji, Yuu Kaneko, Michiko Asano, Junko Matsuo, Miho Ota, Hiroshi Kunugi, Takashi Hanakawa, Reiko Mazuka, Yoko Kamio
    • Journal Title

      Brain and Language

      Volume: 175 Pages: 42

    • DOI

      10.1016/j.bandl.2017.09.002

    • URL

      https://localhost/en/publications/7ec6b865-d13c-49c8-914c-36091f0a8402

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attention-deficit/hyperactivity disorder and physical multimorbidity: A population-based study.2017

    • Author(s)
      A. Stickley, A. Koyanagi, H. Takahashi, V. Ruchkin, Y. Inoue, Y. Kamio
    • Journal Title

      European Psychiatry

      Volume: 45 Pages: 227-234

    • DOI

      10.1016/j.eurpsy.2017.07.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between autistic traits in preschool children and later emotional/behavioral outcomes.2017

    • Author(s)
      A. Saito, A. Stickey, H. Haraguchi, H. Takahashi, M. Ishitobi, Y. Kamio
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: 47 Issue: 11 Pages: 3333-3346

    • DOI

      10.1007/s10803-017-3245-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessment of Autistic Traits in Children Aged 2 to 4.5 Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan.2017

    • Author(s)
      Stickley A, Tachibana Y, Hashimoto K, Haraguchi H, Miyake A, Morokuma S, Nitta H, Oda M, Ohya Y, Senju A, Takahashi H, Yamagata T, Kamio Y.
    • Journal Title

      Autism Res.

      Volume: 3 Issue: 5 Pages: 852-865

    • DOI

      10.1002/aur.1742

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Attention-deficit/hyperactivity disorder symptoms and loneliness among adults in the general population.2017

    • Author(s)
      A. Stickley, A. Koyanagi, H. Takahashi, V. Ruchkin, Y. Kamio
    • Journal Title

      Research in Developmental Disabilities

      Volume: 62 Pages: 115-123

    • DOI

      10.1016/j.ridd.2017.01.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Examining cross-cultural differences in autism spectrum disorder: A multinational comparison from Greece, Italy, Japan, Poland, and the United States.2017

    • Author(s)
      J. L. Matson, M. Matheis, C. O. Burns, G. Esposito, P. Venuti, E. Pisula, A. Misiak, E. Kalyva, V. Tsakiris, Y. Kamio, M. Ishitobi, R. L. Goldin
    • Journal Title

      European Psychiatry

      Volume: 42 Pages: 70-76

    • DOI

      10.1016/j.eurpsy.2016.10.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Breaking snake camouflage: Humans detect snakes more accurately than other animals under less discernible visual conditions.2016

    • Author(s)
      N. Kawai, & H. He
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 10 Pages: e0164342-e0164342

    • DOI

      10.1371/journal.pone.0164342

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Japanese monkeys (Macaca fuscata) quickly detect snakes but not spiders: evolutionary origins of fear-relevant animals2016

    • Author(s)
      Kawai N, Koda H
    • Journal Title

      Journal of Comparative Psychology

      Volume: 130 Issue: 3 Pages: 299-303

    • DOI

      10.1037/com0000032

    • NAID

      120005855939

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conserved evolutionary history for quick detection of threatening faces2016

    • Author(s)
      Kawai, N., Kubo, K., Masataka, N. & Hayakawa, S.
    • Journal Title

      Animal Cognition

      Volume: 19(3) Issue: 3 Pages: 655-60

    • DOI

      10.1007/s10071-015-0949-y

    • NAID

      120005868224

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 交通渋滞場面での怒りの接近動機づけ(攻撃性)における加齢の影響 ー近赤外線分光法(NIRS)・心拍出量・唾液中コルチゾールを用いた検討 ー2019

    • Author(s)
      中田龍三郎, 久保(川合) 南海子, 川合伸幸
    • Organizer
      HCS(ヒューマンコミュニケーション基礎研究会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 誰かと対戦しているとの思い込みがビデオゲームを楽しくさせる:事象関連電位(P300)による検討2019

    • Author(s)
      川合伸幸, 中田龍三郎, 久保賢太
    • Organizer
      人工知能学会全国大会(第33回)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Elucidation of biological rhythms in a non-human primate model of autism using a collar-worn accelerometer2019

    • Author(s)
      Nakamura, M., Nakagami, A., Nakagaki, K., Kawai, N., & Ichinohe, N.
    • Organizer
      NEURO2019(The 42nd Annual Meeting of the Japan Neuroscience Society)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 実環境に存在しない他者をプロジェクションする -他者が実在しなくても,プロジェクションによって社会的変化が生じる-2019

    • Author(s)
      中田龍三郎,川合伸幸
    • Organizer
      日本認知科学会第36回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コモン・マーモセットの第三者互恵性認識の再現性について2019

    • Author(s)
      中神明子, 安江みゆき,一戸紀孝,川合伸幸
    • Organizer
      日本心理学会第83回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hyperactivity in the valproic acid-induced marmoset model of autism2019

    • Author(s)
      Nakamura, M., Nakagami, A., Nakagaki, K., Ichinohe, N., & Kawai, N.
    • Organizer
      日本動物心理学会第79回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hyperactivity in the valproic acid-induced marmoset model of autism2019

    • Author(s)
      Nakamura, M., Nakagami, A., Yasue, M., Nakagaki, K., Kawai, N., & Ichinohe, N.
    • Organizer
      Society for Social Neuroscience 10th Anniversary Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 対戦相手の存在はVRゲームの熱中度を高めるー事象関連電位(P300)による検討ー2018

    • Author(s)
      中田龍三郎,川合伸幸
    • Organizer
      HCS(ヒューマンコミュニケーション基礎研究会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自分の食事中の静止画を正立で見ると食事への注意が高まるー事象関連電位(P300)による検討ー2018

    • Author(s)
      中田龍三郎,川合伸幸
    • Organizer
      日本認知科学会第35回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 発話能力の進化史の推定2017

    • Author(s)
      香田啓貴
    • Organizer
      第47回ホミニゼーション研究会「言語の生物学と進化」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児期から乳幼児期の学習と記憶2017

    • Author(s)
      川合伸幸
    • Organizer
      第5回新胎児学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Why does snakes draw our attention more strongly than other animals?2017

    • Author(s)
      Nobuyuki Kawai
    • Organizer
      Evolution of Brain, Cognition, and Emotion
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マーモセットのコルチゾール分泌機能にバルプロ酸が与える影響2017

    • Author(s)
      中神明子, 安江みゆき,中垣慶子,一戸紀孝, 川合伸幸
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マーモセットにおける胎生期バルプロ酸暴露と不公平忌避2017

    • Author(s)
      安江みゆき,中神明子,中垣慶子,一戸紀孝, 川合伸幸
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 発達障害支援をめぐる教育と医療、福祉、労働との連携:医療の立場から. 学会企画シンポジウム 発達障害支援をめぐる教育と医療、福祉、労働との連携.2017

    • Author(s)
      神尾陽子
    • Organizer
      日本発達障害学会第52回研究大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 最適な精神医学的・心理的治療を提供する際のバリアを克服する. 委員会シンポジウム2017

    • Author(s)
      神尾陽子
    • Organizer
      第113回日本精神神経学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 自閉症治療の確立に向けて研究はどこを目指すべきか? シンポジウム3 精神疾患はここまでわかった-疾患解明への最後の一歩は何を行うべきか?2017

    • Author(s)
      神尾陽子
    • Organizer
      第113回日本精神神経学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 児童期の内在化障害の予測要因. シンポジウム48(日本神経精神薬理学会推薦)不安障害の診断と治療の新しい流れ2017

    • Author(s)
      神尾陽子
    • Organizer
      第113回日本精神神経学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Autism-like behaviors in common marmosets treated prenatally with valproic acid.2017

    • Author(s)
      Nobuyuki Kawai
    • Organizer
      New Era of Preclinical Research for Human Diseases using Marmoset (2017 Asia-oceania Regional Meeting for Marmoset Research)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 霊長類の行動の性差および養育関連行動の研究2017

    • Author(s)
      香田啓貴
    • Organizer
      第46回ホミニゼーション研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 産業革命以前のイノベーションとそれを生み出したヒトの性質2017

    • Author(s)
      川合伸幸
    • Organizer
      国際ナノテクノロジー総合展・技術会議 nano tech 2017 特別シンポジウム
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 霊長類の自閉症モデルの行動評価2016

    • Author(s)
      川合伸幸,中神明子,安江みゆき,坂野拓,中垣慶子,一戸紀孝
    • Organizer
      第6回日本マーモセット研究会大会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Do primate models of autism care other individuals when they receive less valuable reward than other individuals?2016

    • Author(s)
      M. Yasue, A. Nakagami, K. Nakagaki, N. Ichinohe, N. Kawai
    • Organizer
      日本動物心理学会第76回大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new non-invasive method to measure cortisol levels from marmoset saliva.2016

    • Author(s)
      A. Nakagami, M. Yasue, K. Nakagaki, N. Ichinohe, N. Kawai
    • Organizer
      日本動物心理学会第76回大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳幼児期からの発達支援2016

    • Author(s)
      神尾陽子
    • Organizer
      日本発達障害学会第51回研究大会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A primate model for autism with common marmosets show behavioral deficits in the three major symptoms of autism.2016

    • Author(s)
      A. Nakagami, M. Yasue, T. Banno, K. Nakagaki, N. Ichinohe, N. Kawai
    • Organizer
      The 31st International Congress of Psychology ICP2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Marmosets with fetal exposure to valproic acid fail to recognize third-party non-reciprocal interactions.2016

    • Author(s)
      N. Kawai, M. Yasue, A. Nakagami, T. Banno, N. Ichinohe
    • Organizer
      The 31st International Congress of Psychology ICP2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトの知性の進化2016

    • Author(s)
      川合伸幸
    • Organizer
      第15回全脳アーキテクチャ勉強会~知能における進化・発達・学習~
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] The fear of snakes: Evolutionary and psychobiological perspectives on our innate fear.2019

    • Author(s)
      Kawai Nobuyuki
    • Total Pages
      187
    • Publisher
      Springer Nature
    • Related Report
      2019 Annual Research Report
  • [Book] 発達障害. 最新医学別冊: 診断と治療のABC130.2018

    • Author(s)
      神尾陽子 企画
    • Total Pages
      216
    • Publisher
      最新医学社
    • Related Report
      2017 Annual Research Report
  • [Book] 科学の知恵 怒りを鎮める うまく謝る2017

    • Author(s)
      川合伸幸
    • Total Pages
      224
    • Publisher
      講談社
    • Related Report
      2017 Annual Research Report
  • [Book] 子どもの健康を育むために-医療と教育のギャップを克服する-学術会議叢書232017

    • Author(s)
      神尾陽子, 桃井眞里子, 児玉浩子, 山中龍宏, 高田ゆり子, 衞藤隆, 原寿郎, 水田祥代 編集執筆
    • Total Pages
      304
    • Publisher
      日本学術協力財団
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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