| Budget Amount *help |
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
|---|
| Outline of Final Research Achievements |
In biomolecules and liquids, conformations fluctuate and change over a wide range of spatiotemporal scales. In this project, we conducted theoretical studies on how chemical reactions and conformational changes proceed in biomolecular systems and how biomolecular functions are brought about under fluctuations. As a result, we revealed the presence of heterogeneous conformational changes and important prepared structures before reaction. We have also clarified the molecular mechanism of efficient excitation energy transfer in photosynthetic bacteria. In addition, we conducted theoretical studies on the dynamics of water and ionic aqueous solutions. As a result, we found a new dynamical transition at a very low temperature and revealed the low glass transition temperature of water. Furthermore, we investigated the molecular mechanism of ion and concentration dependence of collective orientation relaxation of water in aqueous solutions.
|
| Academic Significance and Societal Importance of the Research Achievements |
反応に関して、タンパク質の折れ畳みを例に構造変化の時間分布が従来の一次元理論では記述できないこと、異性化反応を例に反応前に構造変化に重要な構造励起状態の存在等を明らかにした。生体機能に関しては、光合成細菌における効率的励起エネルギー移動の分子機構を解明した。さらに、水に関する研究において、これまで見出されていなかった状態変化や低いガラス転移温度の起源等を解明した。これらの成果として、2018, 2019年におけるJ. Chem. Phys.のLiquids, Glasses, and Crystals分野のベスト論文に2報の論文が選ばれる等、国際的にも本研究課題の学術的意義が認知されている。
|
