| Budget Amount *help |
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2020: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2019: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
Recently, we have developed a new dehydrative allylation/deallylation catalyst, quinaldic acid (QAH)-CpRu, which improves the usefulness of allylic protecting groups. From this catalysis as a starting point, we have developed a soft Lewis acid/hard Bronsted acid-combined catalyst consisting of a new optically active picolinic acid-type ligand as well as a CpRu complex with a new chiral sp2 nitrogen-based bidentate ligand, combined with a Bronsted acid. These catalysts enabled new Tsuji-Trost (T-T)-type reaction with dehydrative manner. In this work, these two catalytic systems were thoroughly extended to substrate applicability and mechanistic studies were carried out for the estimation of reaction pathways and the origin of the reactive enantioselectivity.
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