| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2019: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Outline of Final Research Achievements |
In recent years, it has been recognized that one antibody has various kinds of structures. Namely, an antibody has the structural diversity, which has important meaning regarding how to produce the bio products such as antibody drugs possessing a uniform structure. In the first half of the research, we addressed the structural diversity problem of antibodies and solved this problem by using copper ions appropriately. This review article is read by a lot of scientists and engineers in the world.
Then, in the latter half of the research period, we focused on how to make antibodies having an enzymatic action. As a result, we found the epoch-making algorism, in which the antibody light chain can be converted to the catalytic antibody by deleting Pro95 (Kabat numbering) in the hypervariable region (CDR)-3 of the antibody light chain. We also established that this can be applied as a universal technology, and we were able to achieve the goal planned initially, completely.
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