• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Ultrasensitive biological mass sensing by nonlinear mode localized microresonator array

Research Project

Project/Area Number 16H02318
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Dynamics/Control
Research InstitutionUniversity of Tsukuba

Principal Investigator

yabuno hiroshi  筑波大学, システム情報系, 教授 (60241791)

Co-Investigator(Kenkyū-buntansha) 山本 泰之  国立研究開発法人産業技術総合研究所, 計量標準総合センター, 主任研究員 (00398637)
松本 壮平  国立研究開発法人産業技術総合研究所, エレクトロニクス・製造領域, 副研究センター長 (70358050)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥39,910,000 (Direct Cost: ¥30,700,000、Indirect Cost: ¥9,210,000)
Keywords質量計 / MEMS / 連成振動 / 非線形振動 / ナノ・バイオセンシング / 自励振動 / モード局在化 / 弾性計 / mass sensing / microcantilever / coupled resonator / mode coupling / self-excited oacillation / 機械力学・制御 / ナノ・マイクロシステム / 非線形力学 / バイオセンサー / 質量計測 / 自励発振 / フィードバック制御 / 振動
Outline of Final Research Achievements

It is well known that elongation and reaction of DNA are detected by the variation of the mass. High-sensitive mass sensors are required for clarifying the micro/nano-scale constructions of biological samples. To realize such a purpose, the miniaturization of the resonator is necessary in the conventional methods, but is limited in the advanced process for the fabrication. In this research, a new ultrahigh sensitive mass sensing was proposed using weakly coupled resonators. Toward the applications on bio-nano technology, a special control method was applied to produce self-excited oscillation in the resonators for compensating for the viscosity in liquid environments. The theoretically proposed method was verified by conducting experiments using coupled micro cantilevers.

Academic Significance and Societal Importance of the Research Achievements

質量は基本的な物理量の一つであり、それを正確に計測することはいつの時代も重要な科学的な課題である。近年ナノバイオテクノロジーの発展により、微小質量の精密な計測を可能にする技術の開発が喫緊の課題になっている。本研究では従来法では限界があった、超高感度化を実現する全く新しい質量計測法を数学的な裏付けのもとに提案した。さらにその有効性を実際の計測システムを開発することにより実験的に証明した。測定環境を選ばない点も提案手法の特徴である。従来法では高真空な測定環境が必要であったが、自励振動とよばれる特別な振動を利用することにより、そのような特別な環境は必要なく、液中の微小質量計測をも可能にした。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) (of which Int'l Joint Research: 7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Mass Sensing in a Liquid Environment Using Nonlinear Self-Excited Coupled-Microcantilevers2018

    • Author(s)
      Endo, D, Yabuno, H., Yamamoto, Y. Matsumoto, S.
    • Journal Title

      Journal of Microelectromechanical Systems

      Volume: 27 Issue: 5 Pages: 774-779

    • DOI

      10.1109/jmems.2018.2866877

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proposition for sensorless self-excitation by a piezoelectric device2018

    • Author(s)
      Tanaka, Y, Kokubun, Y, and Yabuno H.
    • Journal Title

      Journal of Sound and Vibration

      Volume: 419 Pages: 544-547

    • DOI

      10.1016/j.jsv.2017.11.033

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モード連成を利用した自励発振型マイクロレゾネーターによる超微小質量計測 (解説)2018

    • Author(s)
      藪野浩司
    • Journal Title

      システム/制御/情報

      Volume: 62 Pages: 99-104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Amplitude control of coupled cantilevers with computational coupling2019

    • Author(s)
      Kasai, Y. and Yabuno, H..
    • Organizer
      First International Nonlinear Dynamics Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of nonlinear feedback control on a coupled cantilevers2018

    • Author(s)
      Nakamura, T., Yabuno, H., Yamamoto, Y., and Matsumoto, S.
    • Organizer
      Colloquium 603 Dynamics of micro and nano electromechanical systems: multi-field modelling and analysis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mass sensing of microbeads using a weakly coupled cantilever2017

    • Author(s)
      Nakamura, T. and Yabuno, H.
    • Organizer
      PhysCon2017 8th International Conference on Physics and Control
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the parameters of the Maxwell model using self-excited oscillation2017

    • Author(s)
      Luo, Y. and Yabuno, H.
    • Organizer
      PhysCon2017 8th International Conference on Physics and Control
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-excited oscillation for high-viscosity sensing and self-excited coupled oscillation for ultra-sensitive mass sending2016

    • Author(s)
      Yabuno, H.
    • Organizer
      IUTAM Symposium Nonlinear and Delayed Dynamics of Mechanical Systems
    • Place of Presentation
      Nanjing China
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utilization of self-excited oscillation for mass sensing in liquid2016

    • Author(s)
      Endo, D., Yabuno, H., Yamamoto, Y., and Matsumoto, S.
    • Organizer
      International Congress of Theoretical and Applied Mechanics 2016
    • Place of Presentation
      Montrial Canada
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of fractional order of viscoelastic materials by feedback control2016

    • Author(s)
      Yamane, S. and Yabuno, H.
    • Organizer
      International Congress of Theoretical and Applied Mechanics 2016
    • Place of Presentation
      Montrial Canada
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 計測装置、計測装置用の部品及び計測装置用の演算処理装置2018

    • Inventor(s)
      藪野浩司、山本泰之、松本壮平
    • Industrial Property Rights Holder
      藪野浩司、山本泰之、松本壮平
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-197993
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi