| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2017: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2016: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Outline of Final Research Achievements |
Since screening for a peptide that specifically binds to cancer cells among a huge number of peptides has been conventionally performed manually, it took time and effort. In this study, we have developed microfluidic devices that automate peptide screening by devising MEMS devices and using measurement and control technologies. For a screening device against two dimensional-cultured cancer cells, we have developed a device that can remove peptides binding to normal cells. Spheroids, a type of three-dimensional culture, is said to be closer in nature to tumors in the body. We have developed a screening device against spheroids. In addition, a method for targeting cancer cells cultivated under hypoxia and undernutrition is devised.
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