Elucidation of the structure and function of the primate cerebral oculomotor control system by means of cutting-edge neural network analyses

• Project/Area Number: 16H02454
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Kyoto University
• Principal Investigator: Takada Masahiko 京都大学, 霊長類研究所, 教授 (00236233)
• Research Collaborator: MATSUMOTO masayuki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000); Fiscal Year 2018: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2017: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
• Keywords: 大脳皮質 / 前頭葉 / 大脳基底核 / 線条体 / 黒質 / 眼球運動制御 / ウイルスベクター / 霊長類 / 眼球運動系

Outline of Final Research Achievements

The present research project aims at elucidating the fundamental framework of the cortico-basal ganglia link that is involved in the execution and control of behavioral actions. To this end, we employed a wide variety of cutting-edge techniques, including input-output analyses with rabies viral vectors, network dynamics analyses through multiple (multi-area and multi-site) simultaneous activity recordings, and pathway-selective activity manipulation by means of diverse viral vector systems, and then performed comprehensive research plans for investigating the architecture and information processing mechanism of neural networks achieving oculomotor control in primates. Consequently, we not only have analyzed the distribution patterns of multisynaptic inputs to the oculomotor-related cortical areas in macaque monkeys and the dynamics of the oculomotor-related neural networks, but also have established optogenetic/chemogenetic methods for pathway-selective activity manipulation.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、狂犬病ウイルスベクターを利用した入出力トレーシング、神経ネットワークを構成する異なる部位からの多領域多点同時記録、神経路選択的活動操作を組み合わせて、複雑なネットワークをコンポーネント毎に分離、解析するとともに、ネットワーク全体の機能的意義を検証できるという点で極めて画期的かつ重要である。また、眼球運動は学習・認知機能などヒトを含む霊長類で特に発達した高次機能が関与し、多くの精神疾患においてその障害が特徴的に認められるため、関係する神経ネットワークの動作原理を解明する意義は極めて大きい。

Research Products

• [Journal Article] Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E. (2019)
  • Author(s): Kato S; Sugawara M; Kobayashi K; Kimura K; Inoue K; Takada M; Kobayashi K
  • Journal Title: J Neurosci Methods Volume: 311 Pages: 147-155
  • DOI: 10.1016/j.jneumeth.2018.10.023
  • Peer Reviewed
• [Journal Article] A note on retrograde gene transfer efficiency and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins. (2019)
  • Author(s): Tanabe S; Uezono S; Tsuge H; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 3567-3567
  • DOI: 10.1038/s41598-019-39535-1
  • NAID: 120006818701
  • Peer Reviewed / Open Access
• [Journal Article] Multisynaptic projections from the amygdala to the ventral premotor cortex in macaque monkeys: Anatomical substrate for feeding behavior. (2018)
  • Author(s): Ishida H; Inoue K; Takada M
  • Journal Title: Front Neuroanat Volume: 12 Pages: 3-3
  • DOI: 10.3389/fnana.2018.00003
  • Peer Reviewed / Open Access
• [Journal Article] Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition (2018)
  • Author(s): Ogasawara Takaya、Nejime Masafumi、Takada Masahiko、Matsumoto Masayuki
  • Journal Title: Neuron Volume: 100 Issue: 6 Pages: 1513-1526.e4
  • DOI: 10.1016/j.neuron.2018.10.025
  • Peer Reviewed
• [Journal Article] Recruitment of calbindin into nigral dopamine neurons protects against drug-induced parkinsonism. Mov Disord [Epub ahead of print] doi: 10.1002/mds.107 (2018)
  • Author(s): Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M
  • Journal Title: Mov Disord Volume: － Issue: 2 Pages: 200-209
  • DOI: 10.1002/mds.107
  • Peer Reviewed
• [Journal Article] Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury (2018)
  • Author(s): Nakagawa H, Ninomiya T, Yamashita T, Takada M
  • Journal Title: Cereb Cortex Volume: 印刷中 Issue: 2 Pages: 561-572
  • DOI: 10.1093/cercor/bhx338
  • NAID: 120006377720
  • Peer Reviewed / Open Access
• [Journal Article] Preferential representation of past outcome information and future choice behavior by putative inhibitory interneurons rather than putative pyramidal neurons in the primate dorsal anterior cingulate cortex (2018)
  • Author(s): Takashi Kawai, Hiroshi Yamada, Nobuya Sato, Masahiko Takada, Masayuki Matsumoto
  • Journal Title: Cerebral Cortex Volume: 印刷中 Issue: 6 Pages: 2339-2352
  • DOI: 10.1093/cercor/bhy103
  • Peer Reviewed
• [Journal Article] Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease. (2018)
  • Author(s): Ichinose H; Inoue K; Arakawa S; Watanabe Y; Kurosaki H; Koshiba S; Hustad E; Takada M; Aasly JO
  • Journal Title: J Neural Transm Volume: 125 Issue: 1 Pages: 45-52
  • DOI: 10.1007/s00702-017-1784-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-speed and scalable whole-brain imaging in rodents and primates (2017)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H
  • Journal Title: Neuron Volume: 94 Issue: 6 Pages: 1085-1100
  • DOI: 10.1016/j.neuron.2017.05.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pseudotyped lentiviral vectors for retrograde gene delivery into target brain regions. (2017)
  • Author(s): Kobayashi K; Inoue K; Tanabe S; Kato S; Takada M; Kobayashi K
  • Journal Title: Front Neuroanat Volume: 11 Pages: 65-65
  • DOI: 10.3389/fnana.2017.00065
  • Peer Reviewed / Open Access
• [Journal Article] Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus. (2017)
  • Author(s): Saga Y, Nakayama Y, Inoue K, Yamagata T, Hashimoto M, Tremblay L, Takada M, Hoshi E
  • Journal Title: Eur J Neurosci Volume: 印刷中 Issue: 9 Pages: 1186-1199
  • DOI: 10.1111/ejn.13421
  • NAID: 120006305932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain. (2017)
  • Author(s): Tanabe S, Inoue K, Tsuge H, Uezono S, Nagaya K, Fijiwara M, Kato S, Kobayashi K, Takada M
  • Journal Title: Neurosci Res Volume: 印刷中 Pages: 45-52
  • DOI: 10.1016/j.neures.2017.02.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaque. (2016)
  • Author(s): Kimura K,Inoue K, Kuroiwa Y, Tanaka F, Takada M
  • Journal Title: PLoS ONE Volume: 11 Issue: 11 Pages: e0166861-e0166861
  • DOI: 10.1371/journal.pone.0166861
  • NAID: 120005954462
  • Peer Reviewed / Open Access
• [Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. (2016)
  • Author(s): Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 13605-13605
  • DOI: 10.1038/ncomms13605
  • NAID: 120005898960
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations. (2016)
  • Author(s): Oh Y-M, Karube F, Takahashi S, Kobayashi K, Takada M, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, *Fujiyama F
  • Journal Title: Brain Struct Funct Volume: 印刷中 Issue: 5 Pages: 2359-2378
  • DOI: 10.1007/s00429-016-1346-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 融合糖タンパク質E型変異体を用いた神経特異的逆行性ウイルスベクターによるマーモセット脳内への遺伝子導入効率の向上. (2019)
  • Author(s): 菅原正晃、加藤成樹、木村 慧、井上 謙一、高田 昌彦、小林 和人
  • Organizer: 第8回日本マーモセット研究会大会
• [Presentation] Retrograde gene transfer efficacy and inflammatory response of HiRet vs. NeuRet lentiviral vectors in the motor cortical input system of nonhuman primates and rodents. (2019)
  • Author(s): Otsuka Y, Tsuge H, Uezono S, Tanabe S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: 第8回日本マーモセット研究会大会
• [Presentation] Retrograde gene transfer efficacy and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins in the striatal input system of primates and rodents. (2019)
  • Author(s): Tanabe S, Uezono S, Tsuge H, Fujiwara M, Nagaya K, Nagaya N, Sugawara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: 第8回日本マーモセット研究会大会
• [Presentation] Deep brain stimulation of the ventral midbrain facilitates the output to forelimb muscles via the primary motor cortex in monkeys. (2019)
  • Author(s): Suzuki M, Inoue K, Nakagawa H, Isa T, Takada M, Nishimura Y
  • Organizer: 3rd International Brain Stimulation Conference
  • Int'l Joint Research
• [Presentation] 霊長類脳への神経細胞特異的かつ高効率な遺伝子導入を実現する改変AAVベクターの開発. (2019)
  • Author(s): 木村 慧、永井 裕司、田辺 創思、Zheng Andi、Oh Jungmin、藤原 真紀、中野 真由子、南本 敬史、井上 謙一、高田 昌彦
  • Organizer: 第8回 生理研-霊長研-新潟脳研 合同シンポジウム
• [Presentation] Morphological differences of large layer V pyramidal neurons in the cortical motor-related areas of the primate models of spinal cord injury. (2019)
  • Author(s): 高田裕生、中川浩、山中創、高田昌彦
  • Organizer: 第8回 生理研-霊長研-新潟脳研 合同シンポジウム
• [Presentation] Recruitment of calbindin into nigral dopamine neurons protects against drug-induced parkinsonism. (2019)
  • Author(s): Takada M
  • Organizer: AD/PD 2019
  • Int'l Joint Research
• [Presentation] Automatic time-recording test apparatus for marmoset using Raspberry pi. (2018)
  • Author(s): Oishi T, Ueno L, Takada M
  • Organizer: 第41回日本神経科学大会
• [Presentation] Semaphorins and their transcriptional regulators limit axonal regeneration after spinal cord injury. (2018)
  • Author(s): Nakamura Y, Ueno M, Nakagawa H, Niehaus J, Takebayashi H, Lu Q.R, Takada M, Yoshida Y
  • Organizer: 第41回日本神経科学大会
• [Presentation] Morphological changes of large layer V pyramidal neurons in the monkey motor-related areas after spinal cord injury. (2018)
  • Author(s): Takata Y, Nakagawa H, Yamanaka H, Takada M
  • Organizer: 第41回日本神経科学大会
• [Presentation] A test battery to assess depression-like behaviors in common marmosets. (2018)
  • Author(s): Yamanaka H, Ishibashi H, Takada M, Nakamura K
  • Organizer: 第41回日本神経科学大会
• [Presentation] Neuron-specific efficient gene transduction in the primate brain with modified AAV vectors. (2018)
  • Author(s): Kimura K, Tanabe S, Fujiwara M, Nakano M, Nagai Y, Minamimoto T, Inoue K, Takada M
  • Organizer: 第41回日本神経科学大会
• [Presentation] Lentiviral vectors pseudotyped with FuG-E and FuG-E2 glycoprotein suitable for retrograde gene transfer into neural networks involving cerebral cortical areas in nonhuman primates and rodents. (2018)
  • Author(s): Otsuka Y, Tsuge H, Uezono S, Tanabe S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: 第41回日本神経科学大会
• [Presentation] Using PET imaging to monitor chemogenetic manipulation of nigrostriatal dopamine system in common marmoset (2018)
  • Author(s): Mimura K, Nagai Y, Inoue K, Suhara T, Takada M, Minamimoto T
  • Organizer: 第41回日本神経科学大会
• [Presentation] PET imaging of selective control of neural activity with a novel DREADD agonist (2018)
  • Author(s): Nagai Y, Miyakawa N, Huang X, Slocum S, Ono M, Inoue K, Yan X, Liu J, English J, Shimojo M, Mimura K, Hirabayashi T, Bin J, Kumata K, Higuchi M, Zhang M, Takada M, Jin J, Roth B, Minamimoto T
  • Organizer: 第41回日本神経科学大会
• [Presentation] Enhanced gene transfer efficiency of neuron-specific retrograde lentiviral vector with variants of fusion glycoprotein type E into the mouse and common marmoset brains. (2018)
  • Author(s): Sugawara M, Kato S, Kimuta K, Inoue K, Takada M, Kobayashi K
  • Organizer: 第41回日本神経科学大会
• [Presentation] Pathway-selective optogenetic modulation of value-biased saccade circuits in the monkey basal ganglia. (2018)
  • Author(s): Amita H, Hikosaka O, Hyoung F.K, Inoue K, Takada M
  • Organizer: 第41回日本神経科学大会
• [Presentation] Microarchitecture of binocular disparity processing in V2: combined use of intrinsic optical imaging and 2-photon Ca2+ imaging. (2018)
  • Author(s): Fang Y, Hatanaka G, Inagaki M, Inoue K, Takada M, Fujita I
  • Organizer: International Workshop "Monitoring and manipulating brain function in non-human primates"
  • Int'l Joint Research
• [Presentation] High-resolution imaging of primate brains using FAST. (2018)
  • Author(s): Hashimoto H, Seiriki K, Kasai A, Nakazawa T, Inoue K, Takada M
  • Organizer: International Workshop "Monitoring and manipulating brain function in non-human primates"
  • Int'l Joint Research
• [Presentation] Using PET imaging to monitor chemogenetic manipulation of nigrostriatal dopamine system in common marmoset. (2018)
  • Author(s): Mimura K, Nagai Y, Inoue K, Matsumoto J, Suhara T, Nishijo H, Takada M, Minamimoto T
  • Organizer: International Workshop "Monitoring and manipulating brain function in non-human primates"
  • Int'l Joint Research
• [Presentation] Neuron-specific efficient gene transduction in the primate brain with modified AAV vectors. (2018)
  • Author(s): Kimura K, Tanabe S, Fujiwara M, Nagai Y, Minamimoto T, Inoue K, Takada M
  • Organizer: International Workshop "Monitoring and manipulating brain function in non-human primates"
  • Int'l Joint Research
• [Presentation] Differences in retrograde gene transfer efficiency and cytotoxicity between lentiviral vectors pseudotyped with FuG-E, FuG-E2, and FuG-B2 glycoprotein in primate brains. (2018)
  • Author(s): Otsuka Y, Tanabe S, Tsuge H, Uezono S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: International Workshop "Monitoring and manipulating brain function in non-human primates"
  • Int'l Joint Research
• [Presentation] マーモセットの帯状皮質を巡る基底核連関構築様式 (2018)
  • Author(s): 上園志織、田辺創思、藤原真紀、柘植仁美、中村克樹、井上謙一、高田昌彦
  • Organizer: 第33回 日本大脳基底核研究会
• [Presentation] 高精細全脳イメージング技術FASTの開発と精神疾患モデルマウスの病態解析 (2018)
  • Author(s): 勢力薫、笠井淳司、丹生光咲、田沼将人、五十嵐久人、中澤敬信、山口瞬、井上謙一、高田昌彦、橋本均
  • Organizer: 第68回日本薬学会近畿支部総会・大会
• [Presentation] Optogenetic activation of cutaneous and proprioceptive afferent in the rat sciatic nerve. (2018)
  • Author(s): Kubota S, Sidikejiang W, Kudoh M, Inoue K, Umeda T, Takada M, Seki K
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Morphological changes of layer-V pyramidal cells in motor-related areas in a primate model of spinal cord injury. (2018)
  • Author(s): Takata Y, Nakagawa H, Yamanaka H, Takada M
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with anti-RGMa antibody treatment in a monkey model of spinal cord injury. (2018)
  • Author(s): Yamanaka H, Takata Y, Nakagawa H, Yamashita T, Takada M
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] サル脊髄損傷モデルにおける運動機能変化と運動関連領野５層巨大錐体細胞の形態学変化の関係について. (2018)
  • Author(s): 高田裕生、中川浩、山中創、高田昌彦
  • Organizer: 第23回 日本基礎理学療法学会
• [Presentation] サル腹側中脳は一次運動野を介して筋出力を促通する. (2018)
  • Author(s): 鈴木迪諒、井上謙一、中川浩、伊佐正、高田昌彦、西村幸男
  • Organizer: 次世代脳プロジェクト冬のシンポジウム
• [Presentation] 光学センサーと小型コンピュータを用いた可搬型行動実験装置の開発 (2018)
  • Author(s): 大石高生、上野瑠惟、高田昌彦
  • Organizer: 第7回日本マーモセット研究会大会
• [Presentation] マーモセットにおける大脳基底核および小脳から前部・後部帯状皮質への多シナプス性入力様式 (2018)
  • Author(s): 上園志織、田辺創思、藤原真紀、柘植仁美、中村克樹、井上謙一、高田昌彦
  • Organizer: 第7回日本マーモセット研究会大会
• [Presentation] 化学遺伝学とPET イメージングの融合による黒質線条体ドーパミン神経活動制御 (2018)
  • Author(s): 南本敬史、三村喬生、永井裕司、井上謙一、須原哲也、高田昌彦
  • Organizer: 第7回日本マーモセット研究会大会
• [Presentation] 光遺伝学による脳神経系へのアプローチ：霊長類 (2017)
  • Author(s): 高田昌彦
  • Organizer: 第64回日本実験動物学会総会
  • Invited
• [Presentation] 第58回日本神経病理学会総会学術研究会 (2017)
  • Author(s): 高田昌彦
  • Organizer: マカクサルモデルの脳病態：多系統萎縮症、パーキンソン病、老化
  • Invited
• [Presentation] Cells of origin of multisynaptic projections from amygdala to ventral premotor cortex in macaques (2017)
  • Author(s): Ishida H, Inoue K, Hoshi E, Takada M
  • Organizer: Different elements of Primate Neural Networks in the Connectome Era
  • Int'l Joint Research
• [Presentation] Organization of multisynaptic inputs from the basal ganglia to the premotor cortex in macaque monkeys - Retrograde transneuronal dual tracing using rabies viral vectors (2017)
  • Author(s): Inoue K, Fujiwara M, Uezono S, Tanabe S, Ishida H, Hoshi E, Takada M
  • Organizer: Cold Spring Harbor Asia Conference: Primate Neuroscience
  • Int'l Joint Research
• [Presentation] 霊長類および齧歯類の線条体入力系におけるFuGシュードタイプレンチウイルス (2017)
  • Author(s): 田辺 創思、井上 謙一、上園 志織、柘植 仁美、中村 克樹、小林 和人、高田 昌彦
  • Organizer: 第32回 日本大脳基底核研究会
• [Presentation] マーモセットにおける大脳基底核から帯状皮質への多シナプス性入力様式 (2017)
  • Author(s): 上園 志織、田辺 創思、藤原 真紀、柘植 仁美、中村 克樹、井上 謙一、高田 昌彦
  • Organizer: 第32回 日本大脳基底核研究会
• [Presentation] Raspberry Piを用いたマーモセット運動機能解析装置の開発 (2017)
  • Author(s): 大石高生、福冨憲司、上野瑠惟、高田昌彦
  • Organizer: 第33回日本霊長類学会
• [Presentation] Differences in retrograde gene transfer efficiency and cytotoxicity between lentiviral vectors pseudotyped with FuG-E and FuG-B2 glycoprotein in the striatal input system of rodents and primates (2017)
  • Author(s): Tanabe S, Uezono S, Tsuge H, Fujiwara M, Nagaya K, Nagaya N, Sugawara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayasi K, Inoue K, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Improvement of a sucrose preference test for evaluating depression-like behavior in macaque monkeys (2017)
  • Author(s): Yamanaka H, Hosaka N, Takada M, Onoe H
  • Organizer: 第40回日本神経科学大会
• [Presentation] GABAergic modulation of striatal neuron activity in behaving macaque monkeys (2017)
  • Author(s): Hatanaka N, Takara S, Kaneko N, Takada M, Nambu A
  • Organizer: 第40回日本神経科学大会
• [Presentation] Phase-amplitude coupling in cerebro-basal ganglia-cerebellar networks: A new model of hypo- and hyperkinetic movement disorders (2017)
  • Author(s): Ninomiya T, Nagai Y, Inoue K, Hori Y, Kikuchi E, Lee J, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M, Mccairn K.W.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Organization of multisynaptic inputs from the basal ganglia to the dorsal and ventral premotor cortices in macaque monkeys: retrograde transneuronal dual tracing with fluorescent rabies viral vectors (2017)
  • Author(s): Inoue K, Fujiwara M, Uezono S, Tanabe S, Tsuge H, Nagaya N, Nagaya K, Ishida H, Hoshi E, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] The lentiviral vector pseudotyped with FuG-E glycoprotein is more suitable, compared with the FuG-B2 type, for retrograde gene transfer into the cortical input system of primates (2017)
  • Author(s): Tsuge H, Uezono S, Tanabe S, Fujiwara M, Nagaya K, Nagaya N, Sugawara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Morphological differences of large layer V pyramidal neurons among the cortical motor-related areas of macaques (2017)
  • Author(s): Takata Y, Nakagawa H, Yamanaka H, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Primate dopamine neurons in the substantia nigra transmit a stop signal to the caudate nucleus during the performance of a saccadic countermanding task (2017)
  • Author(s): Ogasawara T, Takada M, Matsumoto M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Predicted reward value in the rostromedial caudate and the ventral pallidum for goal-directed action in monkeys (2017)
  • Author(s): Fujimoto A, Hori Y, Nagai Y, Mccairn K.W. Hirabayashi T, Takada M, Suhara T, Minamimoto T.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Nucleus Accumbens Dysregulation and Deep Brain Stimulation: Evidence for Disruption of Normal and Abnormal Behavioral Profiles and Neurophysiological Activity in Monkeys and Humans (2017)
  • Author(s): Mccairn K.W., Ninomiya T, Min P.H., Lim, Park, Bennet K.E., Lee K.H., Isoda M, Paek S, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Organization of multisynaptic inputs from the basal ganglia and cerebellum to the cingulate cortex in common marmosets as revealed by retrograde transneuronal labeling with rabies virus (2017)
  • Author(s): Uezono S, Tsuge H, Tanabe S, Fujiwara M, Nagaya N, Nagaya K, Inoue K, Takada M
  • Organizer: 第40回日本神経科学大会
• [Presentation] Involvement of the store operated calcium entry in the long-lasting calcium transient in the striatal GABAergic neuron (2017)
  • Author(s): Kikuta S, Yanagawa Y, Homma N, Takada M, Osanai M
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] A sucrose preference test modified for evaluation of depression-like behavior in macaque monkeys (2017)
  • Author(s): Yamanaka H, Hosaka N, Takada M, Onoe H
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Arrangement of multisynaptic inputs from the basal ganglia to the dorsal and ventral premotor cortical areas in macaques: retrograde transneuronal double labeling with fluorescent rabies viral vectors (2017)
  • Author(s): Inoue K, Fujiwara M, Uezono S, Tanabe S, Ishida H, Hoshi E, Takada M
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] The nigrostriatal dopamine pathway transmits a stop signal during the performance of a saccadic countermanding task in monkeys (2017)
  • Author(s): Ogasawara T, Takada M, Matsumoto M
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] FAST, High-speed serial-sectioning imaging for whole brain analysis with high scalability (2017)
  • Author(s): Kasai A, Seiriki K, Hashimoto T, Niu M, Yamaguchi S, Naka Y, Igarashi H, Tamura M, Nakazawa T, Inoue K, Takada M, Fujita K, Hashimoto H
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Encoding expected reward value for formulating goal-directed decision in the rostro-medial caudate and the ventral pallidum (2017)
  • Author(s): Fujimoto A, Hori Y, Nagai Y, McCairn K.W, Hirabayashi T, Kikuchi E, Takada M, Suhara T, Minamimoto T
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Organization of multisynaptic inputs from the basal ganglia and cerebellum to the anterior and posterior cingulate cortical areas in common marmosets: Retrograde transneuronal double labeling with fluorescent rabies viral vectors (2017)
  • Author(s): Uezono S, Tanabe S, Fujiwara M, Tsuge H, Nakamura K, Inoue K, Takada M
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Optogenetic modulation of saccade-controlling circuits in the monkey basal ganglia (2017)
  • Author(s): Amita H, Kim H.F, Inoue K, Takada M, Hikosaka O
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Differences in retrograde gene transfer efficiency and cytotoxicity between lentiviral vectors pseudotyped with FuG-E and FuG-B2 glycoprotein in rodent and primate brains (2017)
  • Author(s): Tanabe S, Tsuge H, Uezono S, Fujiwara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Cells of origin of multisynaptic projections from amygdala to ventral premotor cortex in macaques (2017)
  • Author(s): Ishida H, Inoue K, Hoshi E, Takada M
  • Organizer: 平成29年度生理研研究会 第7回社会神経科学研究会
• [Presentation] Prevention of MPTP-induced parkinsonism by recruitment of calbindin into nigral dopamine neurons. (2017)
  • Author(s): Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M
  • Organizer: the 12th International Basal Ganglia Society Meeting ; IBAGS 2017.
  • Place of Presentation: Merida、Mexico
  • Int'l Joint Research
• [Presentation] Motivation center in the ventral midbrain directly activates the descending motor pathways via the primary motor cortex. (2016)
  • Author(s): Suzuki M, Inoue K, Nakagawa H, Takada M, Isa T, Nishimura Y
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Origin of multisynaptic projections from the amygdala to the forelimb region of the ventral premotor cortex in macaque monkeys. (2016)
  • Author(s): Ishida M, Inoue K, Takada M, Hoshi E
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Investigations of spontaneously naturally emerging parkinsonism-cerebellar syndromein an aged Japanese macaque (Macaca fuscata yakui): a potential analogue of multiplesystem atrophy. (2016)
  • Author(s): K.W. McCairn, Ninomiya T, Nagai Y, Go Y, Inoue K, Kimura K, Matsumoto M, Minamimoto M, Isoda M, Takada M
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Comparison of efficiency of retrograde gene transfer between lentiviral vectors pseudotyped with FuG-E and FuG-B2 glycoprotein in primate brains: Cortical input system. (2016)
  • Author(s): Tsuge H, Uezono S, Tanabe S, Fujiwara M, Nagaya K, Sugawara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Comparison of the efficiency of retrograde gene transfer between lentiviral vectors pseudotyped with FuG-E and FuG-B2 glycoprotein in primate brains: Striatal input system. (2016)
  • Author(s): Tanabe S, Uezono S, Tsuge H, Fujiwara M, Nagaya K, Sugawara M, Miwa M, Konoike N, Kato S, Nakamura K, Kobayashi K, Inoue K,
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Use of an optimized chimeric envelope glycoprotein for enhancement of the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain. (2016)
  • Author(s): Inoue K, Tanabe S, Tsuge H, Ueno T, Nagaya K, Fujiwara M, Sugawara M, Kato S, Kobayashi K, Takada M
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] In vivo electrophysiological evaluation of chanelrhodopsin-2-expressed dorsal root ganglion neurons in adults rats. (2016)
  • Author(s): Seki K, S Wupuer, Umeda T, Inoue K, Kudo M, Takada M
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] Differential adeno-associated virus mediated gene transfer to dorsal root ganglion neurons with different size in common marmosets. (2016)
  • Author(s): Kudo M, S Wupuer, Inoue K, Takada M, Seki K
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
• [Presentation] αシヌクレイン過剰発現によるパーキンソン病霊長類モデルの開発 (2016)
  • Author(s): 高田昌彦
  • Organizer: 第2回α-Synuclein研究会
  • Place of Presentation: 大阪万博公園 迎賓館(大阪府・吹田市）
  • Invited
• [Presentation] Multisynaptic projections from the basal nucleus of the amygdala to the ventral premotor cortex in macaque monkeys. (2016)
  • Author(s): Ishida H, Inoue K, Takada M, Hoshi E
  • Organizer: Neuroscience 2016
  • Place of Presentation: Sun Diego、USA
  • Int'l Joint Research
• [Presentation] Nigrostriatal signal inhibits saccadic eye movement during countermanding task in monkeys. (2016)
  • Author(s): Ogasawara T, Takada M, Matsumoto M
  • Organizer: Neuroscience 2016
  • Place of Presentation: Sun Diego、USA
  • Int'l Joint Research
• [Presentation] Prominent phase-amplitude cross-frequency coupling between alpha and gamma oscillations underlies motor-tic encoding in cerebro-basal ganglia-cerebellar networks. (2016)
  • Author(s): Ninomiya T, Nagai Y, Suhara T, Minamimoto T, Takada M, Matsumoto M, Isoda M, K.W.McCairn
  • Organizer: Neuroscience 2016
  • Place of Presentation: Sun Diego、USA
  • Int'l Joint Research
• [Presentation] Use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain. (2016)
  • Author(s): Fujiwara M, Tanabe S, Tsuge H, Uezono S, Nagaya K, Sugawara M, Kato S, Kobayashi K, Inoue K, Takada M
  • Organizer: Neuroscience 2016
  • Place of Presentation: Sun Diego、USA
  • Int'l Joint Research
• [Presentation] Protection against parkinsonism by calbindin recruitment into nigral dopamine neurons. (2016)
  • Author(s): Takada M
  • Organizer: Mini Symposium on Non-Human Primate Biology
  • Place of Presentation: Shanghai、 China
  • Int'l Joint Research / Invited
• [Book] Gene Therapy for Neurological Disorders: Methods and Protocols, Methods in Molecular Biology, vol 1382 (Manfredsson FP, ed) (2016)
  • Author(s): Kobayashi K, Kato S, Inoue K, Takada M, Kobayashi K
  • Total Pages: 493
  • Publisher: Springer
• [Remarks] 京都大学霊長類研究所 統合脳システム分野 ホームページ
  • URL: http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/index.html