| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2018: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2016: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Outline of Final Research Achievements |
In order to study when and where synaptic plasticity occurs during memory consolidation, we established a system that allows erasure of NMDA-receptor mediated synaptic memory. For this purpose, we established a method to optically inactivate cofilin, a protein that accumulates at the synapse after the induction of synaptic plasticity and stabilizes actin cytoskeleton. By using this method, we can optically erase synaptic potentiation within 30 min after induction. When we tested when synaptic plasticity occurs in an intact animal, we found that it occurs while an animal is at asleep. This indicates that reactivation of hippocampal neurons during sleep induces synaptic plasticity, which is required for memory consolidation.
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