| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2019: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2018: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2017: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Outline of Final Research Achievements |
To elucidate how different types of cells including neural progenitors and their daughter cells collaborate dynamically to efficiently and safely construct the developing brain, live imaging, gene-manipulating experiments, and simulations were combined. This research found that tissue elasticity caused by cell densification supports passive cell-migration, that elongated fiber-like cells were bent by other cells' migration thereby contributing to tissue morphogenesis, and that external forces can also work to prevent over-migration of other cells. These results show that mechanical collaboration through cell-cell interactions facilitate efficient and safe histogenesis in 3D environment. This research also found that embryonic microglia assist neural progenitor cells and neurons in proper differentiation. Together, understanding on the mechanisms of brain development has been deepened.
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