| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2019: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2018: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
Based on our previous resources, we analyzed the mechanism of cancer cell metastasis focusing on galectin-3. We found that suppression of galactin-3 induces integrins on cancer cells and promotes cell aggregation with platelets, resulting in enhancement of cancer cell metastasis. In terms of Tie1 tyrosine kinase receptor expressed on endothelial cells in which physiological ligands have not been identified, we found that soluble extra-cellular domain Tie1 receptor which is generated on the onset of angiogenesis, associates with maturation of tumor vasculature. Moreover, by establishing the new co-culture system using cancer cells and endothelial cells, we isolated a novel molecule that can inhibits epithelial to mesenchymal transition.
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