| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2019: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2018: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2016: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Highly reproducible animal development is achieved by robust, time-dependent morphogenesis. To study the mechanisms underlying morphogenetic robustness, we analyzed the developmental process of Drosophila Minute/+ mutants heterozygous for a ribosomal protein gene. We found that both cell death and compensatory cell proliferation are dramatically increased in the wing imaginal epithelium of Minute/+ animals. This massive ‘cell-turnover’ plays an essential role in normal wing morphogenesis. We elucidated the mechanism underlying cell-turnover, which is induced by the morphogen Wg and developmental delay.
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