| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2017: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2016: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Outline of Final Research Achievements |
Germ cells inherit genetic information to the next generation. Although it was implicated that only a fraction of germ cells generated during development give rise to mature sperm or oocytes, little is known about this important process. In this study, the process of selection and/or competition of germ cells have been analyzed during postnatal puberty and sexually matured adulthood. During puberty, when primitive progenitors give rise to stem cells, we identified prospectively a cell population that directly differentiate to sperm without experiencing the stem cells, barely contributing to the next generation. During adulthood, we found a novel mechanism of stem cell competition for limited extracellular factors to achieve the constant stem cell number.
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