| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2016: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
|
|---|
| Outline of Final Research Achievements |
A series of studies have successfully revealed the presence of factors that regulate initiation of spermatogenesis at the timing of secondary sex characteristics. These include lhx8b and figla, which have been recognized as folliculogenic factors in mammals, and fbxo47, a component of ubiquitin ligase complex, and function downstream of sexual switch gene of germ cells, foxl3. Loss of these factors allowed spermatogenesis before onset of secondary sex characteristics. Regulations of chromosomal structures and membrane trafficking are involved in this mechanism. In addition, we are getting evidences that these factors are under control of somatic signal downstream of dmrt1.
The initiation of gametogenesis has been studied in terms of endocrinological regulation in the brain. However, these studies, for the first time, reveal that the initiation of spermatogenesis is associated with the mechanism of sex differentiation in the gonad.
|
