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Study of the onset of gametogenesis at the beginning of puberty

Research Project

Project/Area Number 16H02514
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphology/Structure
Research InstitutionNagoya University

Principal Investigator

TANAKA MINORU  名古屋大学, 理学研究科, 教授 (80202175)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2016: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Keywords性決定 / 配偶子形成 / 性転換 / メダカ / 配偶子形成開始 / 第二次性徴 / 性分化 / 生殖細胞 / 思春期 / 精子形成開始 / 生殖腺
Outline of Final Research Achievements

A series of studies have successfully revealed the presence of factors that regulate initiation of spermatogenesis at the timing of secondary sex characteristics. These include lhx8b and figla, which have been recognized as folliculogenic factors in mammals, and fbxo47, a component of ubiquitin ligase complex, and function downstream of sexual switch gene of germ cells, foxl3. Loss of these factors allowed spermatogenesis before onset of secondary sex characteristics. Regulations of chromosomal structures and membrane trafficking are involved in this mechanism. In addition, we are getting evidences that these factors are under control of somatic signal downstream of dmrt1.
The initiation of gametogenesis has been studied in terms of endocrinological regulation in the brain. However, these studies, for the first time, reveal that the initiation of spermatogenesis is associated with the mechanism of sex differentiation in the gonad.

Academic Significance and Societal Importance of the Research Achievements

配偶子形成開始は脳ホルモンによる第二次性徴制御の研究がほとんどであり、その明確な開始機構は未だ不明であった。今回の一連の研究により、配偶子形成開始が生殖腺の性決定分化と関わることが分子レベルで初めて示され、脳ホルモン以外の分子機構の存在を初めて明らかにした。
研究はメダカを用いて行われたが、同定された因子は脊椎動物に共通であり、哺乳類生殖腺でも発現が報告されている。第二次性徴は社会的医学的にさまざまな問題を包含する現象である。この研究は第二次性徴研究の新たな分野を拓き、人間を含めた哺乳類の第二次性徴そして配偶子形成の理解を前進させる成果と理解する。

Report

(5 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (72 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (9 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (44 results) (of which Int'l Joint Research: 12 results,  Invited: 15 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] College de France(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Heidelberg/Wurzburg University(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KIST(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] College de France(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Heidelberg(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] College de France(France)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(Taiwan)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Institut Curie(France)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Academina Sinica(Taiwan)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka.2020

    • Author(s)
      Kikuchi, M., Nishimura, T., Ishishita, S., Matsuda, Y. and Tanaka, M. (in press)
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 117 Issue: 22 Pages: 12174-12181

    • DOI

      10.1073/pnas.1918556117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)2020

    • Author(s)
      Sakae Yuta、Oikawa Akira、Sugiura Yuki、Mita Masatoshi、Nakamura Shuhei、Nishimura Toshiya、Suematsu Makoto、Tanaka Minoru
    • Journal Title

      Biology Open

      Volume: 9 Issue: 4 Pages: 1-12

    • DOI

      10.1242/bio.050054

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase of cortisol levels after temperature stress activates dmrt1a causing female-male sex reversal and reduced germ cell number in medaka2019

    • Author(s)
      Adolfi M.C., Fischer, P., Herpin, A., Regensburger, M., Kikuchi, M., Tanaka, M. and Schartl, M
    • Journal Title

      Mol. Reprod. Dev.

      Volume: 86 Issue: 10 Pages: 1405-1417

    • DOI

      10.1002/mrd.23177

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel components of germline sex determination acting downstream of foxl3 in medaka2019

    • Author(s)
      Kikuchi Mariko、Nishimura Toshiya、Saito Daisuke、Shigenobu Shuji、Takada Ritsuko、Gutierrez-Triana Jos? Arturo、Cerd?n Juan Luis Mateo、Takada Shinji、Wittbrodt Joachim、Suyama Mikita、Tanaka Minoru
    • Journal Title

      Developmental Biology

      Volume: 445 Issue: 1 Pages: 80-89

    • DOI

      10.1016/j.ydbio.2018.10.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seasonally regulation of the lncRNA LDAIR modulates self-protective behaviors during the breeding season.2019

    • Author(s)
      Nakayama T., Shimmura, T., Shinomiya, A., Okimura, K., Takehana,Y., Furukawa, Y., Shimo, T., Senga, T., Nakatsukasa, M., Nishimura, T., Tanaka, M., Okubo, K., Kamei, Y., Naruse, K. and Yoshimura, T.
    • Journal Title

      Nature Eco. Evol.

      Volume: 3 Issue: 5 Pages: 845-852

    • DOI

      10.1038/s41559-019-0866-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of germline cell sex identity in medaka2019

    • Author(s)
      Tanaka, M.
    • Journal Title

      Curr. Top. Dev. Biol.

      Volume: 134 Pages: 151-165

    • DOI

      10.1016/bs.ctdb.2019.01.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germ cells in the teleost fish medaka have an inherent feminizing effect2018

    • Author(s)
      Nishimura Toshiya、Yamada Kazuki、Fujimori Chika、Kikuchi Mariko、Kawasaki Toshihiro、Siegfried Kellee R.、Sakai Noriyoshi、Tanaka Minoru
    • Journal Title

      PLOS Genetics

      Volume: 14 Issue: 3 Pages: 1-18

    • DOI

      10.1371/journal.pgen.1007259

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic plasticity in phototransduction regulates seasonal changes in color perception2017

    • Author(s)
      Shimmura Tsuyoshi、Nakayama Tomoya、Shinomiya Ai、Fukamachi Shoji、Yasugi Masaki、Watanabe Eiji、Shimo Takayuki、Senga Takumi、Nishimura Toshiya、Tanaka Minoru、Kamei Yasuhiro、Naruse Kiyoshi、Yoshimura Takashi
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 412-412

    • DOI

      10.1038/s41467-017-00432-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Germline stem cells are critical for sexual fate decision of germ cells.2016

    • Author(s)
      Tanaka, M.
    • Journal Title

      BioEssays

      Volume: 38 Issue: 12 Pages: 1227-1233

    • DOI

      10.1002/bies.201600045

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A structurally and functionally common unit in testes and ovaries of medaka (Oryzias latipes), a teleost fish.2016

    • Author(s)
      Nishimura, T. Nakamura, S. and Tanaka, M.
    • Journal Title

      Sexual Development

      Volume: 10 Issue: 3 Pages: 159-165

    • DOI

      10.1159/000447313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Mechanism of Germline Sex Determination in Vertebrates2016

    • Author(s)
      Toshiya Nishimura and Minoru Tanaka
    • Journal Title

      Biology of Reproduction

      Volume: in press Issue: 1 Pages: 1-6

    • DOI

      10.1095/biolreprod.115.138271

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] メダカのメスとオスはどう決まるか2019

    • Author(s)
      田中実
    • Organizer
      あいちサイエンス・コミュニケーション・ネットワーク事業
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 性の不思議 - 女と男2019

    • Author(s)
      田中実
    • Organizer
      愛知県 高校生公開講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生殖細胞の性、生殖細胞が決める性2019

    • Author(s)
      田中実
    • Organizer
      日本遺伝学会第91回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生殖細胞と性2019

    • Author(s)
      田中実
    • Organizer
      遺伝研研究会「有性生殖にかかわる染色体、クロマチン・核動態に関する研究会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] メダカ性分化におけるパントテン酸代謝の関与2019

    • Author(s)
      榮雄大, 杉浦悠毅, 及川彰, 三田雅敏, 西村俊哉, 田中実
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Metabolic regulation of sex differentiation under starvation in medaka.2019

    • Author(s)
      Sakae, Y., Sugiura, Y., Oikawa, A., Mita, M., Nishimura, T., and Tanaka, M.
    • Organizer
      Annual Meeting of Society of Reproduction USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 卵形成コミットメントの分子機構2019

    • Author(s)
      菊地真理子、田中実
    • Organizer
      遺伝研研究会「有性生殖にかかわる染色体、クロマチン・核動態に関する研究会」
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spermatogenestic process and heat stress2019

    • Author(s)
      Sumita R, Nishimura T, Yoshimura T, Tanaka M.
    • Organizer
      8th meeting on HP Axis and Gonad Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Steroidogenic genes during early oogenesis2019

    • Author(s)
      Yamada, K., Sakae, Y., Nishimura, T. and Tanaka, M.
    • Organizer
      8th meeting on HP Axis and Gonad Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How do germ cells determine their sexual fate?2018

    • Author(s)
      TANAKA M.
    • Organizer
      The 9th International Symposium on Fish Endocrinology (9ISFE2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Germ Cells - more than gametogenesis2018

    • Author(s)
      TANAKA M.
    • Organizer
      4th Medaka Strategic PI meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 性のゆらぎ:分子機構から見えてきた性の特徴 - 幹細胞が生み出す性のフレキシブルさと頑強さ-2018

    • Author(s)
      田中実
    • Organizer
      公益財団法人 大隅基礎科学創成財団 第4回 創発セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生殖腺研究最前線 性決定における生殖幹細胞機能と代謝制御2018

    • Author(s)
      田中実
    • Organizer
      日本アンドロロジー学会 第37回学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Gonadal Sex Differentiation in two Oryzias species2018

    • Author(s)
      Carranza, J. Takehana, Y. Nishimura, T. Tanaka, M.
    • Organizer
      日本動物学会中部支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 熱ストレス環境下でのnanos2の機能解析2018

    • Author(s)
      住田流香、西村 俊哉、吉村泰河、田中 実
    • Organizer
      日本動物学会中部支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メダカのオスの生殖細胞における遺伝子発現誘導の系の開発と卵の運命を決定する因子の探索2018

    • Author(s)
      吉村泰河、菊地真理子、西村俊哉、竹内秀明、田中 実
    • Organizer
      日本動物学会中部支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生殖細胞の性決定機構 - メダカfoxl3下流で働く新規因子の同定-2018

    • Author(s)
      菊地 真理子、西村 俊哉、斎藤 大助、重信 秀治、髙田 律子、Jose; Arturo Gutierrez-Triana、Juan Luis Mateo Cerdan、高田 慎治、Joachim Wittbrodt、須山 幹太、田中 実
    • Organizer
      日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The regulation mechanism of medaka sex differentiation by the metabolic change2018

    • Author(s)
      Sakae, Y., Oikawa, A., Sugiura, Y., Mita, M., Nishimura, T. and Tanaka, M
    • Organizer
      日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Labeling Germ Cells in Medaka-Related Species for Sex Determination Studies2018

    • Author(s)
      Carranza, J. Takehana, Y. Nishimura, T. Tanaka, M.
    • Organizer
      The 9th International Symposium on Fish Endocrinology (9ISFE2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Germline sex determination by nanos3, a component of germ plasm2018

    • Author(s)
      Nishimura T. and Tanaka, M.
    • Organizer
      4th Medaka Strategic PI meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of foxl3-downstream genes2018

    • Author(s)
      Kikuchi M, Saito D, Shigenobu S., Suyama M, Nishimura T and Tanaka, M.
    • Organizer
      Seminar in College de France
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Germline stem cells and ovarian structure2018

    • Author(s)
      Tanaka, M.
    • Organizer
      Seminar in Shanghai Ocean University
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A feminizing power is an innate nature of germ cells in medaka2017

    • Author(s)
      Tanaka, M.
    • Organizer
      18th International Congress of Comaprative Endocrinology (ICCE18)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 雌雄のどちらかになることを保障する性のコアメカニズム - 生殖細胞がもたらす性決定機構 -2017

    • Author(s)
      田中実
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 哺乳類の生殖幹細胞と生殖腺の組織構造の原型2017

    • Author(s)
      田中実
    • Organizer
      第16回東海不妊内分泌研究会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] foxl3 制御から見えた、生殖細胞の性決定機構について2017

    • Author(s)
      菊地真理子、津田弥与、重信秀治、須山幹太、西村俊哉、田中実
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 栄養源飢餓によるメダカの性転換と代謝変化2017

    • Author(s)
      榮雄大、及川彰、杉浦悠毅、田中実
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカ生殖腺におけるRNA新規合成の雌雄差の解析2017

    • Author(s)
      山田一輝・西村俊哉・田中実
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生殖質の構成因子nanos3によるメダカ生殖細胞の性の運命決定2017

    • Author(s)
      西村俊哉・田中実
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Medaka sex differentiation under the starvation2017

    • Author(s)
      Sakae, Y. and Tanaka, M.
    • Organizer
      Asian Sex Differentiation Network
    • Related Report
      2017 Annual Research Report
  • [Presentation] How does the germline sex determinant regulate the downstream genes?2017

    • Author(s)
      Kikuchi, M. and Tanaka, M.
    • Organizer
      Asian Sex Differentiation Network
    • Related Report
      2017 Annual Research Report
  • [Presentation] Germ cells have an inherent property feminizing the gonad in medaka2017

    • Author(s)
      Nishimura, T. and Tanaka, M.
    • Organizer
      Asian Sex Differentiation Network
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカ配偶子形成において雌雄差を示すpiRNAの網羅的同定2017

    • Author(s)
      山本耕裕・大竹規仁・齋藤大介・西村俊哉・田中実
    • Organizer
      第88回日本動物学会 富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカにおける生殖腺組織構築の解析2017

    • Author(s)
      尾崎湧馬, 西村俊哉, 田中実
    • Organizer
      第88回日本動物学会 富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メダカの生殖細胞は身体をメス化する能力を元々持っているのか?2017

    • Author(s)
      西村俊哉、河崎敏広、酒井則良、田中実
    • Organizer
      第88回日本動物学会 富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] An inherent feminizing power of germ cells - independent of sex and development2017

    • Author(s)
      Tanaka, M.
    • Organizer
      SSR
    • Related Report
      2017 Annual Research Report
  • [Presentation] 栄養制限時におけるメダカの性制御と代謝2017

    • Author(s)
      栄雄大、及川彰、田中実
    • Organizer
      第4回発生において代謝を考える会
    • Place of Presentation
      京都大学医学部
    • Related Report
      2016 Annual Research Report
  • [Presentation] メダカ卵巣由来の生殖細胞培養2017

    • Author(s)
      藤森千加、田中実
    • Organizer
      性と生殖の懇談会
    • Place of Presentation
      名古屋大学 理学南館
    • Related Report
      2016 Annual Research Report
  • [Presentation] Follicles are not required for feminization of gonads in medaka.2016

    • Author(s)
      Nishimura, T. and Tanaka, M.
    • Organizer
      Cold Spring Harbor Laboratory Meeting: GERM CELLS
    • Place of Presentation
      New Yolk, USA
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An intrinsic mechanism of sexual fate decision in germ cells - Commitment to Femaleness Independent of Estrogenic Action2016

    • Author(s)
      Tanaka, M.
    • Organizer
      The 8th International Symposium on Fish Endocrinology
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sex of Germline Stem Cells2016

    • Author(s)
      Tanaka, M.
    • Organizer
      3rd Macau Symposium on Biomedical Sciences
    • Place of Presentation
      University of Macau (澳門大学), (China)
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 卵巣・精巣の配偶子幹細胞と性決定機構2016

    • Author(s)
      田中実
    • Organizer
      第61回 日本生殖医学学会 特別招請シンポジウム
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生殖細胞の性決定機構~FOXL3制御因子の探索~2016

    • Author(s)
      菊地真理子、西村俊哉、齋藤大助、須山幹太、重信秀治、田中実
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2016 Annual Research Report
  • [Presentation] メダカにおいて卵胞は生殖腺のメス化に必要ない2016

    • Author(s)
      西村俊哉、田中実
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2016 Annual Research Report
  • [Book] 遺伝子から解き明かす性の不思議な世界2019

    • Author(s)
      田中実(編著)
    • Total Pages
      542
    • Publisher
      一色出版
    • ISBN
      9784909383068
    • Related Report
      2018 Annual Research Report
  • [Book] Regulation of germline stem cells in the Teleost: Gametogenesis, Sex, and Fecundity2018

    • Author(s)
      Tanaka, M.
    • Total Pages
      9
    • Publisher
      Springer Japan
    • ISBN
      9784431566076
    • Related Report
      2018 Annual Research Report
  • [Remarks] 名古屋大学 大学院理学研究科 生命理学専攻 生殖生物学グループ

    • URL

      http://www.medaka.bio.nagoya-u.ac.jp

    • Related Report
      2019 Annual Research Report
  • [Remarks] 名古屋大学 研究教育成果情報 プレスリリース

    • URL

      https://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20200408_sci1.pdf

    • Related Report
      2019 Annual Research Report
  • [Remarks] 名古屋大学大学院理学研究科 生命理学専攻 生殖生物学グループ

    • URL

      http://www.medaka.bio.nagoya-u.ac.jp/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 名古屋大学理学研究科 生命理学 生殖生物学グループ

    • URL

      http://www.bio.nagoya-u.ac.jp/laboratory/rb.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] ゲノム編集技術2018

    • Inventor(s)
      田中実、西村俊哉
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Asian Sex Differentiation Network2017

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-08-26  

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