| Budget Amount *help |
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2017: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2016: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Outline of Final Research Achievements |
The increase of the blood flow during local cooling is known as cold-induced vasodilation (CIVD). However, the exact mechanism is still subject to debate. To clear the mechanism, we measured the finger skin blood flow. We showed that endothelial NO-independent activity was significantly higher and neurogenic activity significantly lower at vasoconstriction than at baseline. Additionally, the differences in both activities were significant between vasoconstriction and prior to CIVD, suggesting that the increase of endothelial NO-independent activity and the decrease of neurogenic activity may contribute to CIVD. We also analyzed H2O2 as a NO independent factor using cultured endothelial cells. We showed the increase of H2O2 in lower temperature condition. This increase suggested that H2O2 may be related to CIVD. We further analyzed SNPs using GWAS technique. We showed that PATJ, ROCK2, LGR are considered to be candidate genes for CIVD.
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