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Basic research on vaccine development for protozoan infectious disease treatment using polyvalent virus-like particles with high immune response

Research Project

Project/Area Number 16H02544
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionShizuoka University

Principal Investigator

PARK Enoch Y.  静岡大学, グリーン科学技術研究所, 教授 (90238246)

Co-Investigator(Kenkyū-buntansha) 加藤 竜也  静岡大学, 農学部, 准教授 (00397366)
宮崎 剛亜  静岡大学, グリーン科学技術研究所, 助教 (30775721)
Deo VipinKumar  静岡大学, 国際連携推進機構, 助教 (80569806)
池 和憲  日本獣医生命科学大学, 獣医学部, 教授 (50159597)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2019: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywordsウイルス様粒子 / バイオテクノロジー / カイコ / ワクチン / 原虫 / 昆虫 / Neospora caninum
Outline of Final Research Achievements

In this study, we succeeded in the expression of virus-like particles (VLPs), which are expected to be used as vaccine materials, and production of highly immune-responsive multivalent VLPs that display two kinds of antigens on the surface of VLPs using silkworm expression system. As a result of an animal test using a divalent VLP prepared for Neosporosis, which is one of the intractable protozoal infections, as a vaccine, a significant survival rate was shown, and lung tissue damage was also small compared to those of a control group. We also applied the SpyTag-SpyCatcher chemical binding method to the silkworm expression system to improve the heterogeneity of antigen-displaying on VLPs and succeeded in producing a non-envelope VLP. This has made it possible to uniformly displaying multiple antigens on VLPs and established a multivalent VLPs expression in silkworms ahead of all other researches in the world.

Academic Significance and Societal Importance of the Research Achievements

古くから家畜化された昆虫で、非常に安全なタンパク質発現系として認められているカイコを用いたワクチン開発であり、特に、VLPの表面に複数の抗原を提示して、より免疫高化を高めたものである。この手法はネオスポラ感染症に限定することなく、世界3大感染症の1つであるマラリア原虫に対しても適応できる極めて挑戦的なものである。また、ウイルス由来のVLPを用いることでアジュバントを必要としないVLPワクチンの開発は、副作用軽減の面で医療産業へのインパクトは大きい。毎年のように発生する新興ウイルスによる感染症との戦いは続いており、本研究成果は、安心・安全な社会作りに大いに貢献できるものである。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (57 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 5 results) Presentation (28 results) (of which Int'l Joint Research: 13 results,  Invited: 5 results) Book (3 results) Remarks (5 results)

  • [Int'l Joint Research] Technical University of Braunschweig(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A systematic and methodical approach for the efficient purification of recombinant protein from silkworm larval hemolymph2020

    • Author(s)
      Minkner Robert、Xu Jian、Zagst Holger、Watzig Hermann、Kato Tatsuya、Oltmann-Norden Imke、Park Enoch Y.
    • Journal Title

      Journal of Chromatography B

      Volume: 1138 Pages: 121964-121964

    • DOI

      10.1016/j.jchromb.2019.121964

    • NAID

      120006777506

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of secretion domain of Neospora caninum profilin2020

    • Author(s)
      Suhaimi Hamizah、Xu Jian、Kato Tatsuya、Setyo Utumo Doddy Irawan、Sekiguchi Tomofumi、Park Enoch Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 522 Issue: 1 Pages: 8-13

    • DOI

      10.1016/j.bbrc.2019.11.056

    • NAID

      120006776430

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of virus-like particle mimetic nanovesicles displaying the S protein of Middle East respiratory syndrome coronavirus using insect cells2019

    • Author(s)
      Kato Tatsuya、Takami Yoshihiro、Kumar Deo Vipin、Park Enoch Y.
    • Journal Title

      Journal of Biotechnology

      Volume: 306 Pages: 177-184

    • DOI

      10.1016/j.jbiotec.2019.10.007

    • NAID

      120006732617

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of virus-like particles of the dengue virus serotype 2 expressed in silkworm larvae2019

    • Author(s)
      Doddy Irawan Setyo Utomo, Ichikawa Hirono, Tatsuya Kato, Enoch Y Park
    • Journal Title

      Molecular Biotechnology

      Volume: 61 Issue: 11 Pages: 852-859

    • DOI

      10.1007/s12033-019-00210-5

    • NAID

      120006716011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neospora caninum antigens displaying virus-like particles as a bivalent vaccine candidate against neosporosis2019

    • Author(s)
      Jian Xu, Rikito Hiramatsu, Hamizah Suhaimi, Tatsuya Kato, Akari Fujimoto, Toshihiro Tokiwa, Kazunori Ike, Enoch Y. Park
    • Journal Title

      Vaccine

      Volume: 37 Issue: 43 Pages: 6426-6434

    • DOI

      10.1016/j.vaccine.2019.09.002

    • NAID

      120006725302

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of SpyTag/SpyCatcher-Bacmid Expression Vector System (SpyBEVS) for Protein Bioconjugations Inside of Silkworms2019

    • Author(s)
      Xu Jian、Kato Tatsuya、Park Enoch Y.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 17 Pages: 4228-4228

    • DOI

      10.3390/ijms20174228

    • NAID

      120006714474

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sero-diagnostic potential of Plasmodium falciparum recombinant merozoite surface protein (MSP)-3 expressed in silkworm2019

    • Author(s)
      Deo Vipin Kumar、Inagaki Yu、Murhandarwati Elsa Herdiana、Asmara Widya、Miyazaki Takatsugu、Kato Tatsuya、Park Enoch Y.
    • Journal Title

      Parasitology International

      Volume: 72 Pages: 101938-101938

    • DOI

      10.1016/j.parint.2019.101938

    • NAID

      120006648611

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Secretory nanoparticles of Neospora caninum profilin-fused with the transmembrane domain of GP64 from silkworm hemolymph2019

    • Author(s)
      Hamizah Suhaimi, Rikito Hiramatsu, Jian Xu, Tatsuya Kato, Enoch Y. Park
    • Journal Title

      Nanomaterials

      Volume: 9 Issue: 4 Pages: 593-593

    • DOI

      10.3390/nano9040593

    • NAID

      120006603027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression and characterization of silkworm Bombyx mori β-1,2-N-acetylglucosaminyltransferase II, a key enzyme for complex-type N-glycan biosynthesis2019

    • Author(s)
      Takatsugu Miyazaki, Ryunosuke Miyashita, Sota Mori, Tatsuya Kato, and Enoch Y. Park
    • Journal Title

      J. Biosci. Bioeng.

      Volume: 127 Issue: 3 Pages: 273-280

    • DOI

      10.1016/j.jbiosc.2018.08.014

    • NAID

      120006555492

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification of human papillomavirus-like particles expressed in silkworm using a Bombyx mori nucleopolyhedrovirus bacmid expression system2018

    • Author(s)
      Robert Minkner, Rina Baba, Yae Kurosawa, Shinichiro Suzuki, Tatsuya Kato, Shintaro Kobayashi, Enoch Y. Park
    • Journal Title

      J. Chromatogra. B

      Volume: 1096 Pages: 39-47

    • DOI

      10.1016/j.jchromb.2018.08.007

    • NAID

      120006549587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterologous expression, purification and characterization of human β-1,2-N-acetylglucosaminyltransferase II using a silkworm-BmNPV bacmid system.2018

    • Author(s)
      Takatsugu Miyazaki, Tatsuya Kato, and Enoch Y. Park
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 印刷中 Issue: 1 Pages: 15-22

    • DOI

      10.1016/j.jbiosc.2018.01.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a functional intrabody against hepatitis C virus core protein in Escherichia coli and silkworm pupae2018

    • Author(s)
      Kato Tatsuya、Hasegawa Moeko、Yamamoto Takeshi、Miyazaki Takatsugu、Suzuki Ryosuke、Wakita Takaji、Suzuki Tetsuro、Park Enoch Y.
    • Journal Title

      Protein Expression and Purification

      Volume: 150 Pages: 61-66

    • DOI

      10.1016/j.pep.2018.05.009

    • NAID

      120006543634

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification of virus-like particles (VLPs) expressed in the silkworm Bombyx mori2018

    • Author(s)
      Minkner Robert、Park Enoch Y.
    • Journal Title

      Biotechnology Letters

      Volume: 40 Issue: 4 Pages: 659-666

    • DOI

      10.1007/s10529-018-2516-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity2017

    • Author(s)
      Miyazaki Takatsugu、Ishizaki Masaaki、Dohra Hideo、Park Sungjo、Terzic Andre、Kato Tatsuya、Kohsaka Tetsuya、Park Enoch Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17339-17339

    • DOI

      10.1038/s41598-017-17707-1

    • NAID

      120006371042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transduction of a Neospora caninum antigen gene into mammalian cells using a modified Bombyx mori nucleopolyhedrovirus for antibody production2017

    • Author(s)
      Kato Tatsuya、Itagaki Kohei、Yoshimoto Mai、Hiramatsu Rikito、Suhaimi Hamizah、Kohsaka Tetsuya、Park Enoch Y.
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 124 Issue: 6 Pages: 606-610

    • DOI

      10.1016/j.jbiosc.2017.06.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conventional and unconventional secretory proteins expressed with silkworm bombyxin signal peptide display functional fidelity2017

    • Author(s)
      Park Sungjo、Arrell D. Kent、Reyes Santiago、Park Enoch Y.、Terzic Andre
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14499-14499

    • DOI

      10.1038/s41598-017-14833-8

    • Related Report
      2017 Annual Research Report
  • [Journal Article] N-Glycan Modification of a Recombinant Protein via Coexpression of Human Glycosyltransferases in Silkworm Pupae2017

    • Author(s)
      Tatsuya Kato, Natsumi Kako, Kotaro Kikuta, Takatsugu Miyazaki, Sachiko Kondo, Hirokazu Yagi, Koichi Kato and Enoch Y. Park
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 1409-1409

    • DOI

      10.1038/s41598-017-01630-6

    • NAID

      120006228195

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene transduction in mammalian cells using Bombyx mori nucleopolyhedrovirus assisted by glycoprotein 64 of Autographa californica multiple nucleopolyhedrovirus2016

    • Author(s)
      Tatsuya Kato, Saki Sugioka, Kohei Itagaki, Enoch Y. Park
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 32283-32283

    • DOI

      10.1038/srep32283

    • NAID

      120005838622

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Versatility of chitosan/BmNPV bacmid nanocomplex as transfection reagent in recombinant protein expression in silkworm larvae2016

    • Author(s)
      Tatsuya Kato, Sho Arai, Hirono Ichikawa, Enoch Y. Park
    • Journal Title

      Biotechnol. Lett.

      Volume: 38 Issue: 9 Pages: 1449-1457

    • DOI

      10.1007/s10529-016-2144-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virus-Like Particles Displaying Recombinant Short-Chain Fragment Region and Interleukin 2 for Targeting Colon Cancer Tumors and Attracting Macrophages2016

    • Author(s)
      VIPIN KUMAR DEO, Tatsuya Kato
    • Journal Title

      J. Pharma. Sci.

      Volume: 105 Issue: 5 Pages: 1614-1622

    • DOI

      10.1016/j.xphs.2016.02.011

    • NAID

      120006228214

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Silkworm biofactory as life science platform2019

    • Author(s)
      Enoch Y. Park
    • Organizer
      2019 Joint International symposium of Korea Society of Life Science and Interdisciplinary Society of Genetic Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Methodical investigations for the efficient purification of recombinant proteins from silkworm compounds2019

    • Author(s)
      Robert Minkner, Jian Xu, Holger Zagst, Imke Oltmann-Norden, Hermann Watzig. Tatsuya Kato and Enoch Y. Park
    • Organizer
      第71回日本生物工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 昆虫細胞を用いたMERSコロナウイルス様ナノ粒子の調製2019

    • Author(s)
      高見 佳宏、町田 佑樹、Vipin Kumar Deo、加藤 竜也、朴 龍洙
    • Organizer
      第71回日本生物工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Silkworm biofactory2019

    • Author(s)
      Enoch Y. Park
    • Organizer
      2nd INTERNATIONAL POSTGRADUATE SYMPOSIUM IN BIOTECHNOLOGY 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neospora caninum profilin: Screening the truncation domain and its identification of secretion in silkworm larvae2019

    • Author(s)
      Hamizah Suhaimi, Jian Xu, Tatsuya Kato, Doddy Irawan Setyo Utumo, Enoch Y. Park
    • Organizer
      2nd INTERNATIONAL POSTGRADUATE SYMPOSIUM IN BIOTECHNOLOGY 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purification of Recombinant Proteins from the Haemolymph and Fat Body of the Silkworm Bombyx Mori Aiming for Industrial Usage2019

    • Author(s)
      Robert Minkner, Tatsuya Kato, Enoch Y. Park
    • Organizer
      2nd INTERNATIONAL POSTGRADUATE SYMPOSIUM IN BIOTECHNOLOGY 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neospora caninum: Expression of Profilin and Recognition to Antigen-Specific Responses, Toll like Receptor 11 Ligand2019

    • Author(s)
      Hamizah Suhaimi, Rikito Hiramatsu, Jian Xu, Tatsuya Kato, Enoch Y. Park
    • Organizer
      The 5th International Symposium toward the Future of Advanced Researches in Shizuoka University 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on efficient purification of recombinant protein from the silkworm larval haemolymph2019

    • Author(s)
      Robert Minkner, Jian Xu, Tatsuya Kato, Enoch Y. Park
    • Organizer
      The 5th International Symposium toward the Future of Advanced Researches in Shizuoka University 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カイコでの単一BmNPVバクミドによるNeospora caninum抗原タンパク質提示ウイルス様粒子発現2019

    • Author(s)
      町田 佑樹、平松 利輝人、徐 剣、加藤 竜也、朴 龍洙
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of antigen-displaying virus-like particle vaccines by SpyTag/SpyCatcher superglue in the silkworm-bacmid expression system2019

    • Author(s)
      Jian Xu, Hamizah Suhaimi, Mikiko Hayashidani, Tatsuya Kato, Enoch Y. Park
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Study on efficient purification of recombinant protein from the silkworm larval haemolymph targeting pharmaceutical grade2019

    • Author(s)
      Robert Minkner and Enoch Y. Park
    • Organizer
      5th International Conference on Biotechnology and Agriculture Engineering (ICBAE 2019)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Displaying Hemagglutinin of H5N1 (A/Vietnam/1194/2004) and Hemagglutinin of H1N1 (A/New Caledonia/20/99) on Rous Sarcoma gag-577 Protein VLPs2019

    • Author(s)
      Muzajjad Gozal Goffar, Deo Vipin Kumar, Tatsuya Kato, Park Y. Enoch
    • Organizer
      Sakura-Bio Meeting 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カイコおよびヒト由来N-アセチルグルコサミン転移酵素IIのカイコ発現系構築と性質の比較2018

    • Author(s)
      宮崎 剛亜、宮下 龍之介、加藤 竜也、朴 龍洙
    • Organizer
      日本応用糖質科学会平成30年度大会(第67回) 応用糖質科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neospora canimum antigens displaying-virus-like particles as a vaccine candidate against neosporosis2018

    • Author(s)
      Jian Xu、平松 利輝人、Hamizah Suhaimi, 加藤竜也, Mayuko Kobayashi、Akari Fujimoto, 池和 憲、朴 龍洙
    • Organizer
      第70回日本生物工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gag protein displaying different rHA mutants in silkworm2018

    • Author(s)
      Muzajjad Gozal Goffa, Vipin Kumar Deo、加藤竜也, 朴 龍洙
    • Organizer
      第70回日本生物工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Study on efficient purificarion of recombinant protein from the silkworm larval hemolymph targeting pharmaceutical grade2018

    • Author(s)
      Robert Minkner, 朴 龍洙
    • Organizer
      第70回日本生物工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] かいこは素晴らしいバイオファクトリー2018

    • Author(s)
      朴 龍洙
    • Organizer
      静岡大学・中日新聞連携講座2018第5回「静岡大学の現在」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Silkworm biotechnology based sustainable prosperity of humankind2018

    • Author(s)
      Enoch Y. Park
    • Organizer
      International symposium on bio-fusion food technology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Construction of Neospora caninum vaccine candidate based on Rous sarcoma virus like particle2018

    • Author(s)
      Rikito Hiramatsu, Tatsuya Kato, Enoch Y Park
    • Organizer
      International symposium on bio-fusion food technology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of recombinant Neospora caninum profilin in silkworm larvae2018

    • Author(s)
      Hamizah Suhaimi, Rikkito Hiramatsu,Tatsuya Kato, Enoch Y Park
    • Organizer
      The 4th International Symposium toward the Future of Advanced Researches in Shizuoka University 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study on efficient purification of recombinant protein from the silkworm larval haemolymph targeting pharmaceutical grade2018

    • Author(s)
      Robert Minkner, Enoch Y Park
    • Organizer
      International symposium on bio-fusion food technology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of recombinant Neospora caninum profilin in Bombyx mori2018

    • Author(s)
      Hamizah Suhaimi, Rikito Hiramatsu, Tatsuya Kato, Enoch Y Park
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト由来糖転移酵素の共発現によるカイコ発現ヒトエリスロポエチンのN型糖鎖構造改変2017

    • Author(s)
      堀場早紀, 加子夏未, 宮崎剛亜, 加藤竜也, 朴 龍洙
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都市東山区今熊野北日吉町35)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] カイコ-BmNPV バクミド系で発現させた熱帯熱マラリア原虫抗原の解析2017

    • Author(s)
      稲垣 裕, 宮崎剛亜, 加藤竜也, 朴 龍洙
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都市東山区今熊野北日吉町35)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] カイコ-BmNPVバクミド発現系によるMERS-CoVの組換えSタンパクの発現と精製2017

    • Author(s)
      高見佳宏, Vipin Kumar Deo, 加藤竜也, 朴 龍洙
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都市東山区今熊野北日吉町35)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bombyx mori nucleopolyhedrovirusを用いた哺乳動物細胞への外来遺伝子導入2017

    • Author(s)
      杉岡沙紀, 板垣滉平, 加藤竜也, 朴 龍洙
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都市東山区今熊野北日吉町35)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression and Purification of Neospora caninum Profilin in silkworm2017

    • Author(s)
      Hamizah Suhaimi, Tatsuya Kato, Enoch Y. Park
    • Organizer
      International postgraduate Symposium in Biotechnology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Potential application of virus-like particles on vaccine preparation2016

    • Author(s)
      朴 龍洙
    • Organizer
      Seminar National Biotechnology IV University Gadjah Mada
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Silkworm Biofactory - Silk to Biology2019

    • Author(s)
      Enoch Y. Park and K. Maenaka
    • Total Pages
      300
    • Publisher
      CRC Press Taylor & Francis Group
    • ISBN
      9781138328129
    • Related Report
      2018 Annual Research Report
  • [Book] 別冊BIO Clinica慢性炎症と疾患2017

    • Author(s)
      朴 龍洙
    • Total Pages
      6
    • Publisher
      北隆館
    • Related Report
      2016 Annual Research Report
  • [Book] Short Views on Insect Genomics and Proteomics Insect Proteomics, Vol. 22016

    • Author(s)
      朴 龍洙, 加藤竜也
    • Total Pages
      19
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] 静岡大学グリーン科学技術研究所生物工学研究室

    • URL

      http://www.agr.shizuoka.ac.jp/c/biotech/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 静岡大学生物工学研究室

    • URL

      http://www.agr.shizuoka.ac.jp/c/biotech/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 静岡大学グリーン科学技術研究所

    • URL

      http://www.green.shizuoka.ac.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] 静岡大学生物工学研究室ホームページ

    • URL

      http://www.agr.shizuoka.ac.jp/c/biotech/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 静岡大学グリーン科学技術研究所ホームページ

    • URL

      http://www.green.shizuoka.ac.jp

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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