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Comprehensive analysis of acetylation network post morbillivirus infection using novel analysis method

Research Project

Project/Area Number 16H02587
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Kai Chieko  東京大学, 生産技術研究所, 特任教授 (10167330)

Co-Investigator(Kenkyū-buntansha) 佐藤 宏樹  東京大学, 医科学研究所, 助教 (50418654)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2019: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2017: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2016: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywordsモービリウイルス / 翻訳後修飾 / アセチル化 / 遺伝子発現制御 / 麻疹ウイルス / ウイルス / 発現制御 / 脱アセチル化
Outline of Final Research Achievements

In the present study, we aimed to elucidate the full picture of alteration of host acetylation state after morbillivirus infection on changes in host gene expression and its impact on virus growth.
We performed novel quantitative longitudinal acetylome analysis with epithelial cells post morbillivirus infection, and successfully elucidated the kinetics of acetylation state.We further revealed that a host factor which implicates in expression of host housekeeping genes is cleavaged by its deacetylation after infection, and consequently causes comprehensive downregulation of the gene expressions.
In addition, we found that an inhibitor of acetylation modification enzyme suppresses growth of RNA viruses including morbillivirus. Future development of novel antivirus reagent is expected.

Academic Significance and Societal Importance of the Research Achievements

これまでウイルス感染後の細胞の翻訳後修飾についてはリン酸化修飾の変化と抗ウイルス応答についての解析が主であり、本研究課題で感染後の細胞のアセチル化の変動を網羅的・定量的に解析した学術的意義は高いと考えられる。また、モービリウイルス感染後にみられるハウスキーピング遺伝子群の発現低下とアセチル化変動の関わりを明らかにし、モービリウイルスの病原性との関与を示唆した。
副次的な発見としてアセチル化修飾酵素の阻害剤の一つが広くRNAウイルスの増殖を抑制することを見いだし、阻害剤結合因子を同定した。今後この因子のウイルス増殖への関与を詳細に調べることで、新たな抗ウイルス薬開発への展開が期待される。

Report

(5 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (86 results)

All 2020 2019 2018 2017 2016

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 18 results,  Open Access: 10 results) Presentation (67 results) (of which Int'l Joint Research: 26 results,  Invited: 12 results) Book (1 results)

  • [Journal Article] Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew)2020

    • Author(s)
      Chi Hai-Ying, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamu Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara
    • Journal Title

      PLoS One

      Volume: 15(5) Issue: 5 Pages: e0233232-e0233232

    • DOI

      10.1371/journal.pone.0233232

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PIM 3 kinase, a proto-oncogene product, regulates phosphorylation of the measles virus nucleoprotein tail domain at Ser 479 and Ser 5102020

    • Author(s)
      Sugai Akihiro、Sato Hiroki、Yoneda Misako、Kai Chieko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 531 Issue: 3 Pages: 267-274

    • DOI

      10.1016/j.bbrc.2020.06.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant SLAMblind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy2020

    • Author(s)
      Fujiyuki Tomoko、Amagai Yosuke、Shoji Koichiro、Kuraishi Takeshi、Sugai Akihiro、Awano Mutsumi、Sato Hiroki、Hattori Shosaku、Yoneda Misako、Kai Chieko
    • Journal Title

      Molecular Therapy - Oncolytics

      Volume: 19 Pages: 127-135

    • DOI

      10.1016/j.omto.2020.09.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor activity of an oncolytic measles virus against canine urinary bladder transitional cell carcinoma cells2020

    • Author(s)
      Iizuka Keigo、Shoji Koichiro、Fujiyuki Tomoko、Moritoh Kanako、Tamura Kei、Yoshida Asuka、Sato Hiroki、Yoneda Misako、Asano Kazushi、Kai Chieko
    • Journal Title

      Research in Veterinary Science

      Volume: 133 Pages: 313-317

    • DOI

      10.1016/j.rvsc.2020.10.016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible role of the Nipah virus V protein in the regulation of the interferon beta induction by interacting with UBX domain-containing protein12018

    • Author(s)
      Uchida Shotaro、Horie Ryo、Sato Hiroki、Kai Chieko、Yoneda Misako
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 7682-7682

    • DOI

      10.1038/s41598-018-25815-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FANTOM5 CAGE profiles of human and mouse samples2017

    • Author(s)
      Noguchi Shuhei、Arakawa Takahiro、Ogishima Soichi、ほか
    • Journal Title

      Sci Data

      Volume: 4 Issue: 1 Pages: 170112-170112

    • DOI

      10.1038/sdata.2017.112

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The P gene of rodent brain-adapted measles virus plays a critical role in neurovirulence.2017

    • Author(s)
      Arai T., Terao-Muto Y., Uchida S., Lin C., Honda T., Takenaka A., Ikeda F., Sato H., Yoneda M., Kai C.
    • Journal Title

      Journal of General Virology

      Volume: 98(7) Issue: 7 Pages: 1620-1629

    • DOI

      10.1099/jgv.0.000842

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene end-like sequences within the 3′ non-coding region of the Nipah virus genome attenuate viral gene transcription2017

    • Author(s)
      Sugai Akihiro、Sato Hiroki、Yoneda Misako、Kai Chieko
    • Journal Title

      Virology

      Volume: 508 Pages: 36-44

    • DOI

      10.1016/j.virol.2017.05.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys2017

    • Author(s)
      Fujiyuki Tomoko、Horie Ryo、Yoneda Misako、Kuraishi Takeshi、Yasui Fumihiko、Kwon Hyun-jeong、Munekata Keisuke、Ikeda Fusako、Hoshi Miho、Kiso Yuri、Omi Mio、Sato Hiroki、Kida Hiroshi、Hattori Shosaku、Kohara Michinori、Kai Chieko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12017-12017

    • DOI

      10.1038/s41598-017-08326-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nipah and Hendra Virus Nucleoproteins Inhibit Nuclear Accumulation of STAT1 and STAT2 by Interfering with Their Complex Formation.2017

    • Author(s)
      Sugai A, Sato H, Takayama I, Yoneda M and Kai C.
    • Journal Title

      Journal of Virology

      Volume: 91 (21) Issue: 21

    • DOI

      10.1128/jvi.01136-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An integrated expression atlas of miRNAs and their promoters in human and mouse2017

    • Author(s)
      de Rie D., et al.
    • Journal Title

      Nature Biotechnology

      Volume: 35 Issue: 9 Pages: 872-878

    • DOI

      10.1038/nbt.3947

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of new therapy for canine mammary cancer with recombinant measles virus2016

    • Author(s)
      Shoji Koichiro、Yoneda Misako、Fujiyuki Tomoko、Amagai Yosuke、Tanaka Akane、Matsuda Akira、Ogihara Kikumi、Naya Yuko、Ikeda Fusako、Matsuda Hiroshi、Sato Hiroki、Kai Chieko
    • Journal Title

      Molecular Therapy Oncolytics

      Volume: 3 Pages: 15022-15022

    • DOI

      10.1038/mto.2015.22

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncolytic activity of a recombinant measles virus, blind to signaling lymphocyte activation molecule, against colorectal cancer cells.2016

    • Author(s)
      Amagai Y, Fujiyuki T, Yoneda M, Shoji K, Furukawa Y, Sato H, Kai C
    • Journal Title

      Sci Rep

      Volume: - Issue: 1 Pages: 24572-24572

    • DOI

      10.1038/srep24572

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eukaryotic elongation factor 1-beta interacts with the 5′ untranslated region of the M gene of Nipah virus to promote mRNA translation2016

    • Author(s)
      Uchida Shotaro、Sato Hiroki、Yoneda Misako、Kai Chieko
    • Journal Title

      Arch. Virol.

      Volume: 161 Issue: 9 Pages: 2361-2368

    • DOI

      10.1007/s00705-016-2903-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Region of Nipah virus C protein responsible for shuttling between the cytoplasm and nucleus2016

    • Author(s)
      Horie Ryo、Yoneda Misako、Uchida Shotaro、Sato Hiroki、Kai Chieko
    • Journal Title

      Virology

      Volume: 497 Pages: 294-304

    • DOI

      10.1016/j.virol.2016.07.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infectious Progression of Canine Distemper Virus in Circulating Cerebrospinal Fluid to the Central Nervous System.2016

    • Author(s)
      Takenaka A., Sato H., Ikeda F., Yoneda M., Kai C.
    • Journal Title

      J. Virol.

      Volume: 90 Pages: 9285-9292

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measles virus selectively blind to SLAM has oncolytic efficacy against nectin-4-expressing pancreatic cancer cells.2016

    • Author(s)
      Awano M, Fujiyuki T, Shoji K, Amagai Y, Murakami Y, Furukawa Y, Sato H, Yoneda M, Kai C
    • Journal Title

      Cancer Sci

      Volume: 11 Issue: 11 Pages: 1647-1652

    • DOI

      10.1111/cas.13064

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measles virus induces persistent infection by autoregulation of viral replication.2016

    • Author(s)
      Doi T, Kwon HJ, Honda T, Sato H, Yoneda M, Kai C.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 37163-37163

    • DOI

      10.1038/srep37163

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 致死性ニパウイルス感染症との闘い2019

    • Author(s)
      甲斐知惠子
    • Organizer
      女性・若手研究者国際シンポジウムin鹿児島
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Antitumor effects of a recombinant SLAM-blind measles virus in immunocompetent murine model.2018

    • Author(s)
      Shoji K, Fujiyuki T, Amagai Y, Yoneda M, Sato H, Kai C.
    • Organizer
      11th, International Oncolytic Virus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] For a veterinary clinical study of a recombinant measles virus in dog cancer patients.2018

    • Author(s)
      Sato H, Fujiyuki T, Shoji K, Amagai Y, Iizuka K, Horikirizono Y, Asano K, Yoneda M, Kai C.
    • Organizer
      11th, International Oncolytic Virus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A recombinant SLAMblind measles virus is applicable for breast cancer treatment2018

    • Author(s)
      Yoneda M, Fujiyuki T, Sato H< Daigo Y, Kai C.
    • Organizer
      11th, International Oncolytic Virus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A recombinant SLAM-blidn measles virus is a promising candidate for scirrhous gastric cancer treatment.2018

    • Author(s)
      Kai C, Shoji K, Kwon HJ, Sugai A, Yanagihaya K, Yamaguchi H, Sato H, Fujiyuki T, Yoneda M.
    • Organizer
      11th, International Oncolytic Virus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍溶解性麻疹ウイルスを用いた新たな癌治療法の開発2018

    • Author(s)
      甲斐知惠子
    • Organizer
      TOBIRA第7回研究交流フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Measles virus infection triggers cGAS-dependent antiviral responses.2018

    • Author(s)
      Sato H, Ikeda F, Hoshi M, Yoneda M, Kai C.
    • Organizer
      XIX International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measles virus V protein contributes to the transport of nucleoprotein complexes and efficient viral assembly in neuronal cells2018

    • Author(s)
      Uchida S, Sato H, Arai T, Ikeda F, Kai C, Yoneda M.
    • Organizer
      XIX International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A recombinant measles virus blind to SLAM is a promising candidate for scirrhous gastric cancer therapy.2018

    • Author(s)
      Kai C, Shoji K, Kwon HJ, Sugai A, Yanagihara K, Yamaguchi H, Nakanishi T, Sato H, Fujiyuki T, Yoneda M.
    • Organizer
      XIX International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nipah virus C protein inhibits inflammatory cytokine induction by interaction with phosphatase 2A inhibitor.2018

    • Author(s)
      Horie R, Yoneda M, Uchida S, Yoshida A, Sato H, Kai C.
    • Organizer
      XIX International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Invesitgation of a protein kinase responsible for the phosphorylation of measles virus nucleoprotein.2018

    • Author(s)
      Sugai A, Sato H, Yoneda M, Kai C.
    • Organizer
      XIX International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イヌ腫瘍に対する組換え麻疹ウイルス療法の適用可能性に関する検討2018

    • Author(s)
      庄司紘一郎、藤幸知子、飯塚恵悟、堀切園裕、佐藤宏樹、浅野和之、米田美佐子、甲斐知惠子
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イヌ由来膀胱移行上皮癌細胞に対する組換え麻疹ウイルスの抗腫瘍効果の検討2018

    • Author(s)
      飯塚恵悟、庄司紘一郎、藤幸知子、森藤可南子、佐藤宏樹、米田美佐子、浅野和之、甲斐知惠子
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 組換えSLAM-blind麻疹ウイルス療法の乳癌治療に対する適用性2018

    • Author(s)
      甲斐知惠子、藤幸知子、佐藤宏樹、醍醐弥太郎、米田美佐子
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イヌ腫瘍症例における組換え麻疹ウイルス療法の適用可能性に関する検討2018

    • Author(s)
      藤幸知子、庄司紘一郎、佐藤宏樹、浅野和之、米田美佐子、甲斐知惠子
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Measles virus V protein is required for the efficient viral propagation in neuronal cells.2018

    • Author(s)
      内田翔太郎、佐藤宏樹、新井哲郎、池田房子、甲斐知惠子、米田美佐子
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腫瘍溶解性組換え麻疹ウイルスrMV-SLAMblindのスキルス胃癌細胞に対する抗腫瘍効果2018

    • Author(s)
      甲斐知惠子、庄司紘一郎、権賢貞、菅井亮宏、柳原五吉、山口英樹、中西友子、佐藤宏樹、藤幸知子、米田美佐子
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 正常免疫マウス腫瘍モデルを用いた組換え麻疹ウイルス療法における抗麻疹ウイルス免疫の影響2018

    • Author(s)
      庄司紘一郎、森藤可南子、雨貝陽介、藤幸知子、佐藤宏樹、米田美佐子、甲斐知惠子
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 麻疹ウイルスNタンパク質のリン酸化就職に対する阻害薬の探索2018

    • Author(s)
      菅井亮宏、佐藤宏樹、米田美佐子、甲斐知惠子
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 未成熟雌リスザル卵胞内卵子の体外成熟とICSIによる胚盤胞作出2017

    • Author(s)
      渡辺真一、三浦恵、西萌香、横田伸一、服部正策、松本浩道、福井えみ子、日下部健、桑波田暁子、越知正憲、中潟直己、木曾康郎、甲斐知惠子、吉澤緑
    • Organizer
      第58回日本卵子学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 免疫系ヒト化マウスを用いた麻疹ウイルスの小動物感染モデル2017

    • Author(s)
      中西友子、米田美佐子、藤幸知子、雨貝陽介、斉藤泉、甲斐知惠子
    • Organizer
      第64回日本実験動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 東京大学医科学研究所実験動物センターにおける胚操作・生物遺伝資源バンクの活動状況2017

    • Author(s)
      星美穂、峯岸容子、宮川敦士、金子哲也、米田美佐子、甲斐知惠子
    • Organizer
      第64回日本実験動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] An oncolytic measles virus as a novel promising tool for cancer therapy.2017

    • Author(s)
      Kai C
    • Organizer
      Global Summit on Oncology & Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nipah virus V protein is important for virus replication in porcine myeloid cells.2017

    • Author(s)
      Casey G., Yoneda M., Kai C and Weingartl H
    • Organizer
      American Society for Virology-2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A recombinant measles virus blind to SLAM shows anti-tumor activity against triple negative breast cancer cell lines.2017

    • Author(s)
      Fujiyuki T., Amagai Y., Shoji K., Sugai A., Awano M., Sato H., Yoneda, M. and Kai C.
    • Organizer
      International Union of Microbiological Societies (IUMS) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of transcriptional regulatory network triggered by morbillivirus infection.2017

    • Author(s)
      Sato H., Yoneda M.,Nakamura T., Ikeda F., Kawai J., Hayashizaki Y. and Kai C.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle atrophy and stress responses in skeletal muscle expressing measles virus nucleocapsid protein.2017

    • Author(s)
      Kwon H-J., Watanabe Y., Nakanishi T., Honda T., Sato H., Nakae S., Ogonuki N., Ogura A., Yoneda M. and Kai C.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nucleocapsid protein of Nipah virus downregulates interferon stimulated genes by inhibiting the nuclea accumulation of STATs.2017

    • Author(s)
      Sugai A., Sato H., Takayama I., Yoneda M. and Kai C.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nipah virus C protein inhibits inflammatory cytokine induction by interacting with protein phosphatase 2A inhibitor.2017

    • Author(s)
      Horie R., Uchida S., Sato H., Kai C. and Yoneda M.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The highly conserved tryptophan residue in V ptorein plays a critical role in neurovirulence of meales virus.2017

    • Author(s)
      Uchida S., Arai T., Sato H., Kai C. and Yoneda M.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utilization of humanized mice as a small animal model for measles virus infection.2017

    • Author(s)
      Nakanishi T., Yoneda M., Fujiyuki T., Amagai Y., Saito I. and Kai C.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 正常免疫腫瘍移植モデルを用いた組換え麻疹ウイルスの治療効果および免疫の影響2017

    • Author(s)
      庄司紘一郎、藤幸知子、雨貝陽介、佐藤宏樹、米田美佐子、○甲斐知惠子
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Raf1/MAPK経路の活性化は腫瘍溶解性麻疹ウイルスrMV-SLAMblindのイヌ細胞での増殖を促進する2017

    • Author(s)
      庄司紘一郎、藤幸知子、佐藤宏樹、米田美佐子、甲斐知惠子
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oncolytic measles virus, rMV-SLAMblind is efficient in tumor grafted immunocompitent mouse model.2017

    • Author(s)
      Kai C.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 組換え麻疹ウイルスのスキルス胃癌細胞株に対する抗腫瘍効果2017

    • Author(s)
      Fujiyuki T, Shoji K, Sugai A, Yamaguchi H, Yanagihara K, Sato H, Yoneda M, Kai C.
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 正常免疫マウス腫瘍モデルを用いた組換え麻疹ウイルスの抗腫瘍効果に対する抗体の影響2017

    • Author(s)
      庄司紘一郎、雨貝陽介、藤幸知子、米田美佐子、甲斐知惠子
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Conparison of photoreceptor cells of the squirrel monkey and owl monkey.2017

    • Author(s)
      Yonetsu S., Kusakabe T., Yoshida Y., Yokota S., Hattori S., Kai C., Kano K. and Kiso Y.
    • Organizer
      6th Asian Conference of Veterinary Anatomy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of oncolytic measles virus, rMV-SLAMblind.2017

    • Author(s)
      Kai C, ○Fujiyuki T, Shoji K, Sato H, Yoneda M.
    • Organizer
      XXVth European Society of Gene & Cell Therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An oncolytic recombinant measles virus is a candidate of a novel therapeutic agent for triple negative breast cancer.2017

    • Author(s)
      Fujiyuki T, Amagai Y, Shoji K, Sugai A, Awano M, Sato H, Yoneda M, ○Kai C.
    • Organizer
      XXVth European Society of Gene & Cell Therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍溶解性麻疹ウイルスのイヌ細胞での増殖に対するRaf/MAPK経路の活性化の寄与2017

    • Author(s)
      庄司紘一郎、藤幸知子、佐藤宏樹、米田美佐子、甲斐知惠子
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Role of UBXN1, a novel host protein interacting with measles virus V tprotein, in neuropathogenicity.2017

    • Author(s)
      内田翔太郎、新井哲郎、佐藤宏樹、甲斐知惠子、米田美佐子
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nucleocapsid protein of Nipah virus suppresses host interferon responses by interfering with STAT complex formation.2017

    • Author(s)
      菅井亮宏、佐藤宏樹、高山郁代、米田美佐子、甲斐知惠子
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Immune inducibility of recombinant measles virus vaccines against Nipah virus infection in hamsters.2017

    • Author(s)
      林策、甲斐知惠子、米田美佐子
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oncolytic virotherapy with a recombinant measles virus for refractory breast cancer.2017

    • Author(s)
      Fujiyuki T, Amagai Y, Shoji K, Sugai A, Awano M, Sato H, Yoneda M, Kai C.
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of an oncolytic modified measles virus as a novel tool for cancer treatment.2017

    • Author(s)
      甲斐知惠子
    • Organizer
      IARIシンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 麻疹ウイルスベクターを利用した高病原性インフルエンザワクチンの霊長類感染モデルにおける防御効果2016

    • Author(s)
      藤幸知子、堀江亮、米田美佐子、倉石武、安井文彦、権賢貞、池田房子、宗片圭祐、石井美穂、木曽有里、小見美央、佐藤宏樹、服部正策、喜田宏、小原道法、甲斐知惠子
    • Organizer
      第61回日本実験動物学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 麻疹ウイルスNタンパク質(MV-N)発現による筋萎縮の機序解析2016

    • Author(s)
      権賢貞、渡邉悠太、中西友子、佐藤宏樹、内田翔太郎、越後貫成美、小倉淳郎、米田美佐子、甲斐知惠子
    • Organizer
      第61回日本実験動物学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 免疫ヒト化マウスを利用した麻疹ウイルス感染モデルの構築2016

    • Author(s)
      中西友子、米田美佐子、藤幸知子、雨貝陽介、斎藤泉、甲斐知惠子
    • Organizer
      第61回日本実験動物学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトと動物の感染症―人間社会への影響―2016

    • Author(s)
      甲斐知惠子
    • Organizer
      日本学術会議市民公開シンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Immunocompetent animal model to examine influence of immunity on oncolytic virotherapy with a recombinant measles virus.2016

    • Author(s)
      Shoji K., Fujiyuki T., Amagai Y., Sato H., Yoneda M. and Kai C.
    • Organizer
      International Veterinary Immunology Symposium
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nipah virus nucleoprotein inhibits nuclear transport of STATs2016

    • Author(s)
      Sugai A., Sato H., Takayama I., Yoneda M., and Kai C.
    • Organizer
      第15回淡路島感染症・免疫フォーラム
    • Related Report
      2016 Annual Research Report
  • [Presentation] An oncolytic modified measles virus is a novel tool for cancer treatment.2016

    • Author(s)
      Kai C.
    • Organizer
      第75回日本癌学会学術集会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Efficacy of a recombinant SLAM-blind measles virus via intravenous route and safety of the virus in dogs and monkeys.2016

    • Author(s)
      Fujiyuki T., Amagai Y., Shoji K., Yoneda M. and Kai C.
    • Organizer
      第75回日本癌学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Antitumor effect of oncolytic recombinant measles virus against side population of cancer cell lines.2016

    • Author(s)
      Awano M., Fujiyuki T., Shoji K., Yoneda M. and Kai C.
    • Organizer
      第75回日本癌学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] A genetically modified measles virus is a novel promising candidate for cancer thrapy.2016

    • Author(s)
      Kai C.
    • Organizer
      The 12th Annual Conference of Chinese Association for Laboratory Animal Science (CALAS).
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel oncolytic modified measles virus is a promising candidate for cancer therapy.2016

    • Author(s)
      Kai C.
    • Organizer
      13th Asia-Pacific Oncologists Annual Meeting
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Behavioral squirrel monkeys (Saimiri boliviensis) in Amami Oshima, Japan.2016

    • Author(s)
      Suzuki J., Kanta S.S., Kuraishi T., Hattori S., Kiso Y. and Kai C.
    • Organizer
      9th International Meeting of Asia Society of Conservation Medicine
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of measles virus infection model utilizing humanized mouse.2016

    • Author(s)
      Nakanishi T., Yoneda M., Fujiyuki T., Amagai Y., Saito I. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulatory activities of Nipah virus 5’ untranslated regions on viral gene expression.2016

    • Author(s)
      Uchida S., Sato H., Yoneda M. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Recombinant SLAM-blind measles virus is a promising candidate for triple negative breast cancer therapy.2016

    • Author(s)
      Fujiyuki T., Amagai Y., Shoji K., Kuraishi T., Sugai A., Awano M., Sato H., Hattori S., Yoneda M. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Therapeutic effects of oncolytic virotherapy with a recombinant measles virus in immunocompetent animal model.2016

    • Author(s)
      Shoji K., Fujiyuki T., Amagai Y., Sato H., Yoneda M. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Induction of stress responses in mouse skeletal muscles expressing measles virus nucleocapsid protein (MV-N).2016

    • Author(s)
      Kwon H-J., Watanabe Y., Nakanishi T., Honda T., Sato H., Sugai A., Uchida S., Nakae S., Ogonuki N., Ogura A., Yoneda M. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Efficacy of recombinant measles virus vaccine expressing the Nipah virus glycoprotein in hamsters previously vaccinated with measles vaccine.2016

    • Author(s)
      Lin C., Yoneda M. and Kai C.
    • Organizer
      第64回日本ウイルス学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] キーノートセッション「つくろう、科学とともにある社会」―「人獣共通感染症へのチャレンジ」2016

    • Author(s)
      甲斐知惠子
    • Organizer
      日本学術会議科学力増進分科会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 腫瘍溶解性組換え麻疹ウイルスの難治性乳癌細胞に対する抗腫瘍効果2016

    • Author(s)
      藤幸知子、雨貝陽介、庄司紘一郎、菅井亮宏、粟野睦美、佐藤宏樹、米田美佐子、甲斐知惠子
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] BSL-4施設におけるニパウイルス感染症研究2016

    • Author(s)
      米田美佐子
    • Organizer
      第16回日本バイオセーフティ学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] エマージングウイルス感染症:現状と化学の最先端2016

    • Author(s)
      甲斐知惠子
    • Organizer
      第15回自然科学講演会、大学女性協会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 実験医学:新薬認可で治療革命の幕開け がんのウイルス療法2016

    • Author(s)
      甲斐知恵子
    • Total Pages
      161
    • Publisher
      羊土社
    • ISBN
      9784758101479
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-01-27  

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