| Budget Amount *help |
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2019: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2017: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2016: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Outline of Final Research Achievements |
In the present study, we aimed to elucidate the full picture of alteration of host acetylation state after morbillivirus infection on changes in host gene expression and its impact on virus growth.
We performed novel quantitative longitudinal acetylome analysis with epithelial cells post morbillivirus infection, and successfully elucidated the kinetics of acetylation state.We further revealed that a host factor which implicates in expression of host housekeeping genes is cleavaged by its deacetylation after infection, and consequently causes comprehensive downregulation of the gene expressions.
In addition, we found that an inhibitor of acetylation modification enzyme suppresses growth of RNA viruses including morbillivirus. Future development of novel antivirus reagent is expected.
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