| Budget Amount *help |
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2020: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
In this study, we examined the biological functions of the phospholipase (PLA2) family, a group of lipid-metabolizing enzymes. By analyzing the phenotypes in a series of PLA2-knockout mouse strains in combination with comprehensive lipidomics, we identified several novel functions of PLA2s and their key lipid-derived metabolites whose perturbations are associated with various diseases. Particularly, we focused on the novel PLA2-driven lipid pathways in the skin and gastrointestinal tract, which are constitutively exposed to environmental stimuli, as well as their influences on distal tissues related to immunity and metabolism. Furthermore, we uncovered new regulatory mechanisms of phospholipid catabolism and turnover that are crucial for the maintenance of cell membrane homeostasis.
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