Establishment of in vivo immunopharmacology
| Project/Area Number |
16H02619
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII MASARU 大阪大学, 生命機能研究科, 教授 (10324758)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2018: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2017: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Keywords | 医療・福祉 / 免疫学 / 薬理学 |
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| Outline of Final Research Achievements |
By establishing an original intravital multiphoton microscopy, I have studied on 'real' cellular dynamics with immune and inflammatory systems in intact tissues and organs. Especially we first succeeded in visualizing in vivo behaviors of different cell types in bones, such as osteoclasts, which led to significant conceptual advances on dynamic bone/immune systems. Based on the cutting-edge imaging technology in our hand, in this study, we have established the novel system for analyzing in vivo pharmacological actions of different emerging drugs, which should contribute to launching an original style of immunopharmacology from Japan.
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| Academic Significance and Societal Importance of the Research Achievements |
元来、本邦で強みのある薬理学・免疫学分野の基礎研究に加え、やはり強みのある光学イメージング技術開発を学際的に融合させることで、実際に薬効を目で見るという、in vivoイメージング免疫薬理学を構築できたことは、国際的にも独自性が高く、学術的に大きな意義がある。現在、本評価系を用いた薬効評価・創薬研究に関する共同研究の依頼が国内外から殺到しており、その社会的意義も極めて大きい。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2017
Author(s)
Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
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Journal Title
Journal of Allergy and Clinical Immunology
Volume: S0091-6749
Issue: 2
Pages: 32949-32944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction.2016
Author(s)
3.Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Itoi-Ochi S, Penninger JM, Katayama I, Inohara H and Ishii M
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Journal Title
Molecular and Cellular Biology
Volume: 36
Issue: 11
Pages: 1610-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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