| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2018: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2017: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2016: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Outline of Final Research Achievements |
By establishing an original intravital multiphoton microscopy, I have studied on 'real' cellular dynamics with immune and inflammatory systems in intact tissues and organs. Especially we first succeeded in visualizing in vivo behaviors of different cell types in bones, such as osteoclasts, which led to significant conceptual advances on dynamic bone/immune systems. Based on the cutting-edge imaging technology in our hand, in this study, we have established the novel system for analyzing in vivo pharmacological actions of different emerging drugs, which should contribute to launching an original style of immunopharmacology from Japan.
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