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Study for the development of Ebola hemorrhagic fever treatment

Research Project

Project/Area Number 16H02627
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionHokkaido University

Principal Investigator

Takada Ayato  北海道大学, 人獣共通感染症国際共同研究所, 教授 (10292062)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2020: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords人獣共通感染症 / エボラウイルス / マールブルグウイルス / フィロウイルス / 抗体 / 治療法 / 細胞侵入阻害 / ウイルス / 細胞侵入 / 化合物 / 治療薬 / 細胞進入
Outline of Final Research Achievements

Mouse monoclonal antibodies with cross-neutralizing activity against multiple ebolavirus species were generated. Detailed analyses of the epitopes recognized by the antibodies suggested that that some of the antibodies bind to the side region of the viral surface glycoprotein (GP) molecule and inhibit the membrane fusion between the cellular membrane and the virus envelope. Electron microscopic structural analysis of the complex of the GP molecule and Mab 6D6, one of the cross-reactive antibodies, revealed that this antibody recognizes the fusion loop region of GP. In addition, a novel compound having the ability to reduce the infectivity of all known ebolaviruses were obtained from an existing compound library. It was suggested that this compound binds to the side surface region of the GP molecule and inhibits the membrane fusion.

Academic Significance and Societal Importance of the Research Achievements

エボラウイルスは、ヒトに致死率の高い感染症(エボラ出血熱)をひき起こす。近年のアフリカでの大流行と他国への拡散によって、予防・治療法開発が急務となった。抗体医薬および既存の化合物が緊急的に用いられたが、大きな課題が残されている。これまでの抗体医薬は全て1種のエボラウイルス特異的であり他の種のエボラウイルスには効果が無い。また、投与された化合物の有効性が確認されておらず、さらに副作用が大きい。本研究では全てのエボラウイルス種を中和するモノクローナル抗体を作出するとともに、エボラウイルスの細胞侵入を阻害する新規化合物を発見した。これらの成果によって、エボラ出血熱治療薬の開発に資すると思われる。

Report

(6 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (68 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (9 results) Journal Article (31 results) (of which Int'l Joint Research: 23 results,  Peer Reviewed: 25 results,  Open Access: 17 results,  Acknowledgement Compliant: 1 results) Presentation (26 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Book (2 results)

  • [Int'l Joint Research] RML, NIH/UTMB(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Rocky Mountain Laboratories, NIH/The Scripps Research Institute(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Rocky Mountain Laboratories, NIH/The Scripps Research Institute(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Public Health Agency of Canada(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] National Institute of Health/The Scripps Research Institute/University of Wisconsin(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Public Health Agency of Canada(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] NIH(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study2021

    • Author(s)
      Igarashi Manabu、Hirokawa Takatsugu、Takadate Yoshihiro、Takada Ayato
    • Journal Title

      Viruses

      Volume: 13 Issue: 5 Pages: 913-913

    • DOI

      10.3390/v13050913

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A potential role of non-neutralizing IgA antibodies in cross-protective immunity against influenza A viruses of multiple hemagglutinin subtypes2020

    • Author(s)
      Okuya K, Yoshida R, Manzoor R, Saito S, Suzuki T, Sasaki M, Saito T, Kida Y, Mori-Kajihara A, Kondoh T, Sato M, Kajihara M, Miyamoto H, Ichii O, Higashi H, Takada A
    • Journal Title

      J Virol

      Volume: - Issue: 12 Pages: 408-420

    • DOI

      10.1128/jvi.00408-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative Analyses of the Antiviral Activities of IgG and IgA Antibodies to Influenza A Virus M2 Protein2020

    • Author(s)
      Okuya Kosuke、Eguchi Nao、Manzoor Rashid、Yoshida Reiko、Saito Shinji、Suzuki Tadaki、Sasaki Michihito、Saito Takeshi、Kida Yurie、Mori-Kajihara Akina、Miyamoto Hiroko、Ichii Osamu、Kajihara Masahiro、Higashi Hideaki、Takada Ayato
    • Journal Title

      Viruses

      Volume: 12 Issue: 7 Pages: 780-780

    • DOI

      10.3390/v12070780

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection2020

    • Author(s)
      Furuyama W, Nanbo A, Maruyama J, Marzi A, Takada A
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 14 Issue: 9 Pages: e0008602-e0008602

    • DOI

      10.1371/journal.pntd.0008602

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A biaryl sulfonamide derivative as a novel inhibitor of filovirus infection.2020

    • Author(s)
      Isono M, Furuyama W, Kuroda M, Kondoh T, Igarashi M, Kajihara M, Yoshida R, Manzoor R, Okuya K, Miyamoto H, Feldmann H, Marzi A, Sakaitani M, Nanbo A, Takada A
    • Journal Title

      Antiviral Res

      Volume: 183 Pages: 104932-104932

    • DOI

      10.1016/j.antiviral.2020.104932

    • NAID

      120007173916

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Receptor-Mediated Host Cell Preference of a Bat-Derived Filovirus, Lloviu Virus2020

    • Author(s)
      Takadate Yoshihiro、Manzoor Rashid、Saito Takeshi、Kida Yurie、Maruyama Junki、Kondoh Tatsunari、Miyamoto Hiroko、Ogawa Hirohito、Kajihara Masahiro、Igarashi Manabu、Takada Ayato
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 10 Pages: 1530-1530

    • DOI

      10.3390/microorganisms8101530

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Mechanism Underlying Antiviral Activity of an Influenza Virus M2-Specific Antibody2020

    • Author(s)
      Manzoor Rashid、Eguchi Nao、Yoshida Reiko、Ozaki Hiroichi、Kondoh Tatsunari、Okuya Kosuke、Miyamoto Hiroko、Takada Ayato
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 1

    • DOI

      10.1128/jvi.01277-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Surrogate Animal Model for Screening of Ebola and Marburg Glycoprotein-Targeting Drugs Using Pseudotyped Vesicular Stomatitis Viruses2020

    • Author(s)
      Saito Takeshi、Maruyama Junki、Nagata Noriyo、Isono Mao、Okuya Kosuke、Takadate Yoshihiro、Kida Yurie、Miyamoto Hiroko、Mori-Kajihara Akina、Hattori Takanari、Furuyama Wakako、Ogawa Shinya、Iida Shigeru、Takada Ayato
    • Journal Title

      Viruses

      Volume: 12 Issue: 9 Pages: 923-923

    • DOI

      10.3390/v12090923

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Niemann-Pick C1 heterogeneity of bat cells controls filovirus tropism2020

    • Author(s)
      Takadate Y, Kondoh T, Igarashi M, Maruyama J, Manzoor R, Ogawa H, Kajihara M, Furuyama W, Sato M, Miyamoto H, Yoshida R, Hill TE, Freiberg AN, Feldmann H, Marzi A, Takada A
    • Journal Title

      Cell Rep.

      Volume: 30(2): Issue: 2 Pages: 308-319

    • DOI

      10.1016/j.celrep.2019.12.042

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Taxonomy of the order Mononegavirales: second update 20182019

    • Author(s)
      Maes P, Amarasinghe GK, Ayllon MA, Takada A, et al.
    • Journal Title

      Arch. Virol.

      Volume: 164 Issue: 4 Pages: 1233-1244

    • DOI

      10.1007/s00705-018-04126-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Therapeutic monoclonal antibodies for Ebola virus infection derived from vaccinated humans2019

    • Author(s)
      Rijal P, Elias SC, Machado SR, Takada A, et al.
    • Journal Title

      Cell Rep.

      Volume: 27 Issue: 1 Pages: 172-186

    • DOI

      10.1016/j.celrep.2019.03.020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Taxonomy of the order Mononegavirales: update 20192019

    • Author(s)
      Amarasinghe GK, Ayllon MA, Bao Y, Takada A, et al.
    • Journal Title

      Arch. Virol.

      Volume: 164 Issue: 7 Pages: 1967-1980

    • DOI

      10.1007/s00705-019-04247-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical evaluation of QuickNaviTM-Ebola in the 2018 outbreak of Ebola virus disease in the Democratic Republic of the Congo2019

    • Author(s)
      Makiala S, Mukadi D, De Weggheleire A, Muramatsu S, Kato D, Inano K, Gondaira F, Kajihara M, Yoshida R, Changula K, Mweene A, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Masumu J, Ahuka S, Takada A
    • Journal Title

      Viruses

      Volume: 11 Issue: 7 Pages: 589-589

    • DOI

      10.3390/v11070589

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector2019

    • Author(s)
      Ohtsuka J, Fukumura M, Furuyama W, Wang S, Hara K, Maeda M, Tsurudome M, Miyamoto H, Kaito A, Tsuda N, Kataoka Y, Mizoguchi A, Takada A, Nosaka T.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-019-49579-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection2018

    • Author(s)
      Saphire EO, Takada A, et al.
    • Journal Title

      Cell

      Volume: 174(4) Issue: 4 Pages: 938-952.e13

    • DOI

      10.1016/j.cell.2018.07.033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein2018

    • Author(s)
      Milligan Jacob C、Parekh Diptiben V、Fuller Katherine M、Igarashi Manabu、Takada Ayato、Saphire Erica Ollmann
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 219 Issue: 3 Pages: 415-419

    • DOI

      10.1093/infdis/jiy532

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monoclonal Antibody Cocktail Protects Hamsters From Lethal Marburg Virus Infection2018

    • Author(s)
      Marzi A, Haddock E, Kajihara M, Feldmann H, Takada A
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 218 Issue: suppl_5 Pages: S662-S665

    • DOI

      10.1093/infdis/jiy235

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity2018

    • Author(s)
      Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 5495-5495

    • DOI

      10.1038/s41598-018-23357-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia2018

    • Author(s)
      Changula K, Kajihara M, Mori-Kajihara A, Eto Y, Miyamoto H, Yoshida R, Shigeno A, Hang'ombe B, Qiu Y, Mwizabi D, Squarre D, Ndebe J, Ogawa H, Harima H, Simulundu E, Moonga L, Kapila P, Furuyama W, Kondoh T, Sato M, Takadate Y, Kaneko C, Nakao R, Mukonka V, Mweene A, Takada A
    • Journal Title

      J Infect Dis

      Volume: 218(Suppl 5)

    • DOI

      10.1093/infdis/jiy266

    • NAID

      120006771013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles2018

    • Author(s)
      Nanbo Asuka、Maruyama Junki、Imai Masaki、Ujie Michiko、Fujioka Yoichiro、Nishide Shinya、Takada Ayato、Ohba Yusuke、Kawaoka Yoshihiro
    • Journal Title

      PLoS Pathog

      Volume: 14 Issue: 1 Pages: e1006848-e1006848

    • DOI

      10.1371/journal.ppat.1006848

    • NAID

      120006416019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor2017

    • Author(s)
      Kondoh Tatsunari、Manzoor Rashid、Nao Naganori、Maruyama Junki、Furuyama Wakako、Miyamoto Hiroko、Shigeno Asako、Kuroda Makoto、Matsuno Keita、Fujikura Daisuke、Kajihara Masahiro、Yoshida Reiko、Igarashi Manabu、Takada Ayato
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 10 Pages: e0186450-e0186450

    • DOI

      10.1371/journal.pone.0186450

    • NAID

      120006366507

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses2017

    • Author(s)
      Bao Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Smither SJ, Takada A, Towner JS, Volchkov VE, Wahl-Jensen V, Kuhn JH
    • Journal Title

      Viruses

      Volume: 9 (5) Issue: 5 Pages: 106-106

    • DOI

      10.3390/v9050106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials2017

    • Author(s)
      Postler TS, Takada A, et al.
    • Journal Title

      Syst. Biol.

      Volume: 66 (3) Pages: 463-473

    • DOI

      10.1093/sysbio/syw096

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Taxonomy of the order Mononegavirales: update 20172017

    • Author(s)
      Amarasinghe GK, Takada A, et al.
    • Journal Title

      Arch. Virol.

      Volume: 162 (8) Issue: 8 Pages: 2493-2504

    • DOI

      10.1007/s00705-017-3311-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] エボラ出血熱に対する治療法および診断法の開発2017

    • Author(s)
      古山若呼、吉田玲子、五十嵐学、高田礼人
    • Journal Title

      化学療法の領域

      Volume: 33 (5) Pages: 148-155

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Quantification of Filovirus Glycoprotein-Specific Antibodies2017

    • Author(s)
      Furuyama W, Miyamoto H, Yoshida R, Takada A
    • Journal Title

      Methods Mol. Biol.

      Volume: 1628 Pages: 309-320

    • DOI

      10.1007/978-1-4939-7116-9_25

    • ISBN
      9781493971152, 9781493971169
    • Related Report
      2017 Annual Research Report
  • [Journal Article] エボラ出血熱2017

    • Author(s)
      高田礼人
    • Journal Title

      小児科臨床

      Volume: 70(増刊号) Pages: 2308-2317

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 感染症 現状の問題点と未来への展望 エボラ出血熱2017

    • Author(s)
      高田礼人
    • Journal Title

      臨床と微生物

      Volume: 45(2) Pages: 165-169

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Fcγ-receptor IIa-mediated Src signaling pathway is essential for the antibody-dependent enhancement of Ebola virus infection2016

    • Author(s)
      Furuyama W, Marzi A, Carmody AB, Maruyama J, Kuroda M, Miyamoto H, Nanbo A, Manzoor R, Yoshida R, Igarashi M, Feldmann H, Takada A
    • Journal Title

      PLoS Pathog.

      Volume: 12 Issue: 12 Pages: e1006139-e1006139

    • DOI

      10.1371/journal.ppat.1006139

    • NAID

      120005981447

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] エボラ出血熱の予防・治療・診断法開発の現状2016

    • Author(s)
      古山若呼、高田礼人
    • Journal Title

      ウイルス

      Volume: 66 Pages: 63-72

    • NAID

      130006882831

    • Related Report
      2016 Annual Research Report
  • [Journal Article] エボラ出血熱の診断・治療法開発 ―モノクローナル抗体の活用―2016

    • Author(s)
      高田礼人
    • Journal Title

      日本臨床

      Volume: 74 Pages: 2080-2085

    • Related Report
      2016 Annual Research Report
  • [Presentation] A型インフルエンザウイルス亜型間交差感染防御免疫における非中和IgA抗体の役割2021

    • Author(s)
      奥谷 公亮、吉田 玲子、マンズール ラシッド、齊藤 慎二、鈴木 忠樹、市居 修、東 秀明、高田 礼人
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2020 Annual Research Report
  • [Presentation] フィロウイルスに対するコウモリ由来細胞の感受性を決定する分子機構の解析2021

    • Author(s)
      高舘佳弘、近藤達成、五十嵐学、丸山隼輝、Rashid MANZOOR、小川寛人、梶原将大、古山若呼、佐藤匡治、宮本洋子、吉田玲子、Terence HILL、Alexander N. FREIBERG、Heinz FELDMANN、Andrea MARZI、高田礼人
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2020 Annual Research Report
  • [Presentation] Molecular mechanisms underlying the cellular entry and host range restriction of Lujo virus2021

    • Author(s)
      齋藤健、奥谷公亮、服部貴成、梶原将大、高田礼人
    • Organizer
      日本ウイルス学会北海道支部第54回夏季シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Single nucleotide polymorphisms in human angiotensin-converting enzyme 2 receptor and cell susceptibility to SARS-CoV-22021

    • Author(s)
      服部 貴成、斎藤 健、高館 佳弘、奥谷 公亮、笠島 和、梶原亜紀奈、宮本 洋子、梶原 将大、高田 礼人
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inhibition of filovirus entry by cyclic peptides derived from the Niemann-Pick C1 loop structure2021

    • Author(s)
      髙橋 侑嗣、高舘 佳弘、宮本 洋子、梶原 将大、五十嵐 学、髙田 礼人
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ウイルス性新興感染症の制御を目指して2021

    • Author(s)
      高田礼人
    • Organizer
      第16回北海道HIV/AIDS歯科医療研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] エボラおよびマールブルグ出血熱2019

    • Author(s)
      高田礼人
    • Organizer
      第8回日本精神科医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] フィロウイルス研究における最近の知見2019

    • Author(s)
      高田礼人
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] エボラウイルスの細胞侵入阻害薬の探索2019

    • Author(s)
      磯野 真央、古山 若呼、黒田 誠、近藤 達成、五十嵐 学、梶原 将大、吉田 玲子、マンズール ラシッド、奥谷 公亮、宮本 洋子、フェルドマン ハインツ、マルジ アンドレア、堺谷 政弘、高田 礼人
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A型インフルエンザウイルスに対する交差感染防御免疫への非中和 IgA抗体の役割2019

    • Author(s)
      奥谷 公亮、吉田 玲子、マンズール ラシッド、齊藤 慎二、鈴木 忠樹、市居 修、東 秀明、高田 礼人
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シュードタイプ水胞性口炎ウイルスを用いたフィロウイルス感染代替動物モデル2019

    • Author(s)
      齋藤 健、磯野 真央、木田 祐里恵、丸山 隼輝、高田 礼人
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Seroprevalence of filovirus infection of Rousettus aegyptiacus bats in Zambia2018

    • Author(s)
      Masahiro Kajihara,Katendi Changula,Ayato Takada, et al.
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Single nucleotide polymorphisms in human Niemann-Pick C1 influence entry of filoviruses into cells2018

    • Author(s)
      Tatsunari Kondoh, Ayato Takada, et al.
    • Organizer
      Seventeenth International Conference on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エボラウイルス研究最前線2018

    • Author(s)
      高田礼人
    • Organizer
      第20回日本医療マネジメント学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Toward the Control of Zoonoses2018

    • Author(s)
      Ayato Takada
    • Organizer
      Nagasaki University WISE Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エボラウイルス研究の最前線2017

    • Author(s)
      高田礼人
    • Organizer
      第32回日本環境感染学会総会学術集会
    • Place of Presentation
      神戸国際展示場(神戸市、日本)
    • Year and Date
      2017-02-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Antibodies against Ebola, Marburg and Lassa - a global collaboration and structural illumination2017

    • Author(s)
      Saphire E, Takada A, et al.
    • Organizer
      9th Internatinal Symposium on Filoviruses
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analyses of endogenous Ebolavirus-like element2017

    • Author(s)
      Tatsunari Kondoh, Rashid Manzoor, Junki Maruyama, Nao Nao, Hiroko Miyamoto, Keita Matsuno, Daisuke Fujikura, Manabu Igarashi, Ayato Takada
    • Organizer
      9th Internatinal Symposium on Filoviruses
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ebolavirus requires a host scramblase for its efficient entry2017

    • Author(s)
      Asuka Nanbo,Haruka Komatsu,Junki Maruyama,Tadashi Watanabe,Masahiro Fujimuro,Ayato Takada,Yusuke Ohba,Yoshihiro Kawaoka
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analyses of endogenous ebolavirus VP35-like element2017

    • Author(s)
      Tatsunari Kondoh,Rashid Manzoor,Naganori Nao,Junki Maruyama,Wakako Furuyama,Hiroko Miyamoto,Asako Shigeno,Makoto Kuroda,Keita Matsuno,Daisuke Fujikura,Masahiro Kajihara,Reiko Yoshida,Manabu Igarashi,Ayato Takada
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ebolavirus --Ecology and antiviral strategies--2017

    • Author(s)
      Ayato Takada
    • Organizer
      11th Annual Meeting of Korean Society of Zoonosis
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エボラウイルス感染症における新知見2017

    • Author(s)
      高田礼人
    • Organizer
      第66回日本感染症学会東日本地方会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neutralization and Antibody-Dependent Enhancement of Ebolavirus2016

    • Author(s)
      Ayato Takada
    • Organizer
      8th International Global Virus Network Meeting
    • Place of Presentation
      札幌コンベンションセンター(札幌市、日本)
    • Year and Date
      2016-10-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation of a cross-neutralizing monoclonal antibody against all known ebolavirus species/全てのエボラウイルス種に対する交差中和モノクローナル抗体の作出2016

    • Author(s)
      Wakako Furuyama, Andrea Marzi, Asuka Nanbo, Elaine Haddock, Junki Maruyama, Hiroko Miyamoto, Manabu Igarashi, Reiko Yoshida, Osamu Noyori, Heinz Feldmann, Ayato Takada
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌市、日本)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Antibody-dependent enhancement of Ebola virus infection is induced by the Fc gamma receptor IIa-dependent signaling pathway through Src family protein tyrosine kinases2016

    • Author(s)
      Wakako Furuyama, Andrea Marzi, Aaron B. Carmody, Junki Maruyama, Makoto Kuroda, Hiroko Miyamoto, Asuka Nanbo, Rashid Manzoor, Reiko Yoshida, Manabu Igarashi, Heinz Feldmann, Ayato Takada
    • Organizer
      8th Internatinal Symposium on Filoviruses
    • Place of Presentation
      BNP Paribas Fortis auditorium (Antwerp, Belgium)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ebolavirus Entry into Cells --- Neutralization and Antibody-Dependent Enhancement---2016

    • Author(s)
      Ayato Takada
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市、日本)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021

    • Author(s)
      髙田礼人他101名
    • Total Pages
      602
    • Publisher
      技術情報協会
    • ISBN
      9784861048555
    • Related Report
      2020 Annual Research Report
  • [Book] ウイルスは悪者か お侍先生のウイルス学講義2018

    • Author(s)
      高田礼人
    • Total Pages
      358
    • Publisher
      亜紀書房
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2023-01-30  

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