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Positive selection of T cells in the thymic cortex

Research Project

Project/Area Number 16H02630
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHAMA Yousuke  徳島大学, 先端酵素学研究所(プロテオ), 特命教授 (20183858)

Co-Investigator(Kenkyū-buntansha) 大東 いずみ  徳島大学, 先端酵素学研究所(プロテオ), 准教授 (00596588)
高田 健介  北海道大学, 大学院獣医学研究科, 准教授 (40570073)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2019: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2017: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywords免疫学 / Tリンパ球 / 胸腺 / 正の選択 / レパトア
Outline of Final Research Achievements

The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、生命の頑強性と適応性を裏付ける獲得免疫システムを特徴づける本質の理解、とりわけ免疫学の中核的重要課題「正の選択とは何か」に関して従来の理解を大きく超えた進展をもたらし、学術の進展に寄与した。その結果、新たな免疫制御方法の可能性を示唆することによって、T細胞の分化制御に基づく新規の疾患治療法の更なる開発に向けて従来にない新技術を与える可能性を提示した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (82 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (9 results) Journal Article (21 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 21 results,  Open Access: 20 results,  Acknowledgement Compliant: 5 results) Presentation (48 results) (of which Int'l Joint Research: 18 results,  Invited: 10 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] 国立衛生研究所(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] バーミンガム大学(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 国立衛生研究所/メリーランド大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ジョージア大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ヤルシ大学(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] バーミンガム大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health/University of Minnesota(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Oxford/University of Birmingham(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Basel(スイス)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] PITHD1 is a proteasome-interacting protein essential for male fertilization2020

    • Author(s)
      Kondo Hiroyuki、Matsumura Takafumi、Kaneko Mari、Inoue Kenichi、Kosako Hidetaka、Ikawa Masahito、Takahama Yousuke、Ohigashi Izumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 6 Pages: 1658-1672

    • DOI

      10.1074/jbc.ra119.011144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells2019

    • Author(s)
      Khanom Umme Shahina、Ohigashi Izumi、Fujimori Sayumi、Kondo Kenta、Takada Kensuke、Takahama Yousuke
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 4 Pages: 881-887

    • DOI

      10.4049/jimmunol.1900097

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells.2019

    • Author(s)
      Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 9 Pages: 2901-2916

    • DOI

      10.1016/j.celrep.2019.10.079

    • NAID

      120006894616

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth2019

    • Author(s)
      Cowan Jennifer E.、Malin Justin、Zhao Yongge、Seedhom Mina O.、Harly Christelle、Ohigashi Izumi、Kelly Michael、Takahama Yousuke、Yewdell Jonathan W.、Cam Maggie、Bhandoola Avinash
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5498-5498

    • DOI

      10.1038/s41467-019-13465-y

    • NAID

      120006949467

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thymoproteasome and peptidic self2019

    • Author(s)
      Takahama Y, Ohigashi I, Murata S, Tanaka K.
    • Journal Title

      Immunogenetics

      Volume: 71 Issue: 3 Pages: 217-221

    • DOI

      10.1007/s00251-018-1081-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biology, evolution, and history of antigen processing and presentation: Immunogenetics special issue 20192019

    • Author(s)
      Kasahara Masanori, Flajnik Martin F., Takahama Yousuke
    • Journal Title

      Immunogenetics

      Volume: 71 Issue: 3 Pages: 137-139

    • DOI

      10.1007/s00251-019-01107-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thymus machinery for T-cell selection2019

    • Author(s)
      Kondo K, Ohigashi I, Takahama Y
    • Journal Title

      International Immunology

      Volume: 31 Issue: 3 Pages: 119-125

    • DOI

      10.1093/intimm/dxy081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A distinct subset of fibroblastic stromal cells constitutes the cortex-medulla boundary subcompartment of the lymph node2018

    • Author(s)
      Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman MA, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B, Takahama Y, Nagasawa T, Katakai T.
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 2196-2196

    • DOI

      10.3389/fimmu.2018.02196

    • NAID

      120006937683

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The immunoproteasome and thymoproteasome: functions, evolution and human disease2018

    • Author(s)
      Murata S, Takahama Y, Kasahara M, Tanaka K
    • Journal Title

      Nature Immunol.

      Volume: 19 Issue: 9 Pages: 923-931

    • DOI

      10.1038/s41590-018-0186-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7+ progenitors to the thymus2018

    • Author(s)
      Cosway EJ, Ohigashi I, Schauble K, Parnell SM, Jenkinson WE, Luther S, Takahama Y, Anderson G.
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 2 Pages: 516-523

    • DOI

      10.4049/jimmunol.1800348

    • NAID

      120006937667

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cellularity of thymic epithelial cells in the postnatal mouse.2018

    • Author(s)
      Sakata M, Ohigashi I, Takahama Y.
    • Journal Title

      J Immunol.

      Volume: 200 Issue: 4 Pages: 1382-1388

    • DOI

      10.4049/jimmunol.1701235

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential role of CCL21 in establishment of central self-tolerance in T cells.2017

    • Author(s)
      Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
    • Journal Title

      Journal of Experimental Medicine

      Volume: 214 Issue: 7 Pages: 1925-1935

    • DOI

      10.1084/jem.20161864

    • NAID

      120006312717

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017

    • Author(s)
      Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 10 Pages: 1-14

    • DOI

      10.1172/jci.insight.93664

    • NAID

      120006733720

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MiCASA is a new method for quantifying cellular organization.2017

    • Author(s)
      Sornborger A, Li J, Timmons C, Lupu F, Eggenschwiler J, Takahama Y, Manley NR.
    • Journal Title

      Nature Commun.

      Volume: 8 Issue: 1 Pages: 15619-15619

    • DOI

      10.1038/ncomms15619

    • NAID

      120006941135

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of diversity in thymic epithelial cells.2017

    • Author(s)
      Takahama Y, Ohigashi I, Baik S, Anderson G.
    • Journal Title

      Nat Rev Immunol

      Volume: 印刷中 Issue: 5 Pages: 295-305

    • DOI

      10.1038/nri.2017.12

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Antigen processing and presentation in the thymus: implications for T cell repertoire selection2017

    • Author(s)
      Kondo Kenta、Takada Kensuke、Takahama Yousuke
    • Journal Title

      Current Opinion in Immunology

      Volume: 46 Pages: 53-57

    • DOI

      10.1016/j.coi.2017.03.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus.2017

    • Author(s)
      Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 14419-14419

    • DOI

      10.1038/ncomms14419

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Generation of peptides that promote positive selection in the thymus.2017

    • Author(s)
      Takada K, Kondo K, Takahama Y.
    • Journal Title

      J Immunol

      Volume: 198 Issue: 6 Pages: 2215-2222

    • DOI

      10.4049/jimmunol.1601862

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic spatio-temporal contribution of single b5t+ cortical epithelial precursors to the thymus medulla2016

    • Author(s)
      Mayer CE, Zuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Hollander GA.
    • Journal Title

      European Journal of Immunology

      Volume: 46 Issue: 4 Pages: 846-856

    • DOI

      10.1002/eji.201545995

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development and developmental potential of cortical thymic epithelial cells.2016

    • Author(s)
      Ohigashi I, Kozai M, Takahama Y.
    • Journal Title

      Immunol Rev

      Volume: 271 Issue: 1 Pages: 10-22

    • DOI

      10.1111/imr.12404

    • NAID

      120006727049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Flow cytometry analysis of thymic epithelial cells and their subpopulation2016

    • Author(s)
      Ohigashi I, Takahama Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 1323 Pages: 65-73

    • DOI

      10.1007/978-1-4939-2809-5_5

    • ISBN
      9781493928088, 9781493928095
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Thymoproteasome-dependent positive selection of CD8 T cells is exclusively mediated by cortical thymic epithelial cells without additional thymic antigen-presenting cells2019

    • Author(s)
      高濱洋介
    • Organizer
      EMBO Workshop ThymE: T cell and thymus biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Trans-omics impact of thymoproteasome in cortical thymic epithelial cells2019

    • Author(s)
      大東いずみ、田中優、近藤健太、藤森さゆ美、Amy Palin、近藤博之、 小迫英尊、高濱洋介
    • Organizer
      EMBO Workshop ThymE: T cell and thymus biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of β-catenin in thymic epithelial progenies of β5t positive progenitors2019

    • Author(s)
      藤森さゆ美、大東いずみ、高濱洋介、高田慎治
    • Organizer
      EMBO Workshop ThymE: T cell and thymus biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第29回 Kyoto T Cell Conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] CD8T細胞の正の選択におけるペプチドスイッチ仮説の検証2019

    • Author(s)
      村松直美、大東いずみ、高濱洋介
    • Organizer
      第29回 Kyoto T Cell Conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胸腺上皮細胞特異的なWnt/β-cateninシグナル経路活性制御の影響2019

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、高濱洋介
    • Organizer
      第18回四国免疫フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胸腺上皮細胞のオミクスプロファイリング2019

    • Author(s)
      大東いずみ、小迫英尊、高濱洋介
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス胸腺上皮細胞の分化にはβ-catenin依存性経路の精緻な制御が必要である2019

    • Author(s)
      藤森さゆ美、大東いずみ、高濱洋介、高田慎治
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規プロテアソーム会合因子PITHD1は精子形成を制御する2019

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、高濱洋介、大東いずみ
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The role of the thymus cortex In T cell development and selection.2018

    • Author(s)
      高濱洋介
    • Organizer
      Symposium on Lymphoid Tissue Microenvironment and Immune Cell Trafficking.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Thymus machinery for T cell production and selection.2018

    • Author(s)
      高濱洋介
    • Organizer
      FIMSA 2018 Congress.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プロテアソームに会合する新規分子 PITHD1 の機能解析2018

    • Author(s)
      近藤博之、松村貴史、小迫英尊、伊川正人、高濱洋介、大東いずみ
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Enforced activation of β-catenin signaling in mouse thymic epithelial cells induces thymic dysplasia2018

    • Author(s)
      藤森さゆ美、大東いずみ、高田慎治、高濱洋介
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of thymic cortical epithelial cells in positive selection of CD8 T cells2018

    • Author(s)
      高濱洋介
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Peptide-induced positive selection of CD8+ T cells in vivo2018

    • Author(s)
      Umme Shahina Khanom、近藤健太、高田健介、大東いずみ、高濱洋介
    • Organizer
      第17回四国免疫フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胸腺皮質上皮細胞で高発現する新規分子の機能解析2018

    • Author(s)
      近藤博之、高濱洋介、大東いずみ
    • Organizer
      第28回 Kyoto T Cell Conference
    • Related Report
      2018 Annual Research Report
  • [Presentation] Generation of diversity in thymic epithelial cells2018

    • Author(s)
      高濱洋介
    • Organizer
      KEY Forum 2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] T細胞の自己寛容性確立におけるCCL21の役割2018

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第37回日本胸腺研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胸腺を用いた胸腺上皮細胞の解析2018

    • Author(s)
      松井尚子、大東いずみ、山本遥平、中川英刀、近藤和也、高濱洋介
    • Organizer
      第37回日本胸腺研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Human PSMB11 polymorphisms that affect thymoproteasome processing and CD8+ T cell generation2018

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      ThymOz-8
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cellularity of thymic epithelial cells in postnatal mouse2018

    • Author(s)
      高濱洋介
    • Organizer
      ThymOz-8
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] cTEC-dependent positive selection of CD8+ T cells2017

    • Author(s)
      高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of Wnt/β-catenin signaling in thymic epithelial progenitors2017

    • Author(s)
      藤森さゆ美、大東いずみ、竹本龍也、高浜洋介、高田慎治
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A human Psmb11 polymorphism affects molecular processing of thymoproteasome and thymic production of CD8+ T cells2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Essential role of CCL21 in establishment of central self-tolerance in T cells2017

    • Author(s)
      近藤博之、大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸腺髄質上皮細胞の再生におけるβ5t陽性上皮前駆細胞の寄与2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      日本胸腺研究会
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] CCL21 regulates T-cell self-tolerance in thymic medulla2017

    • Author(s)
      香西美奈、大東いずみ、高濱洋介
    • Organizer
      11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences”
    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2017

    • Author(s)
      大東いずみ、Uddin Myn、竹本龍也、高濱洋介
    • Organizer
      11th International Symposium of The Institute Network “Frontiers in Biomedical Sciences”
    • Place of Presentation
      徳島大学(徳島県・徳島市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms for positive selection of CD8+ T cells2017

    • Author(s)
      高濱洋介
    • Organizer
      2017 FIMSA Advanced Course
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus2017

    • Author(s)
      Myn Uddin、大東いずみ、高濱洋介
    • Organizer
      IMMUNOLOGY 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CCL21Ser欠損マウスにおけるT細胞異常2017

    • Author(s)
      近藤博之、大東いずみ、高濱洋介
    • Organizer
      第16回四国免疫フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] メラノーマ組織に形成される高内皮細静脈様血管の検出2017

    • Author(s)
      藤原翔、森空悟、大東いずみ、高浜洋介、早坂晴子
    • Organizer
      第26回日本がん転移学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 免疫ステルス獲得における異種細胞間相互作用2017

    • Author(s)
      大東いずみ、高濱洋介
    • Organizer
      第1回免疫ステルス公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 免疫システムのかなめ「胸腺」の形成と機能2017

    • Author(s)
      高濱洋介
    • Organizer
      日本比較免疫学会 第29回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト胸腺を用いた胸腺上皮細胞の解析2017

    • Author(s)
      松井尚子、大東いずみ、Uddin Muhammad Myn、佐坂開人、山本遥平、古川貴大、近藤和也、中川英刀、梶 龍兒、高浜洋介
    • Organizer
      第29回日本神経免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胸腺微小環境形成の分子機構2017

    • Author(s)
      高濱洋介
    • Organizer
      第3回群馬大学生体調節研究所 内分泌代謝シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thymic epithelial cells that govern T cell production and selection2017

    • Author(s)
      高濱洋介
    • Organizer
      10th FAIS-African Immunology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス胸腺皮質上皮細胞亜集団におけるWnt/β-cateninシグナル経路の活性化2017

    • Author(s)
      藤森さゆ美、大東いずみ、竹本龍也、高浜洋介、高田慎治
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] T細胞の自己寛容性確立におけるCCL21の役割2017

    • Author(s)
      大東いずみ、石丸直澄、片貝智哉、高濱洋介
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thymoproteasome-dependent positive selection conditions in vivo immune responses in CD8+ T cells2017

    • Author(s)
      近藤健太、高田健介、高濱洋介
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thymus epithelium governs immune system2017

    • Author(s)
      高濱洋介
    • Organizer
      日本研究皮膚科学会 第42回年次学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] How the thymic medulla attracts thymocytes for the establishment of self-tolerance2016

    • Author(s)
      高濱洋介
    • Organizer
      NCI Thymus Symposium
    • Place of Presentation
      ベセスダ(アメリカ)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Myn UDDIN、大東いずみ、高濱洋介
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県・宜野湾市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胸腺におけるCD8+ T細胞生成を制御するFoxn1結合シス制御領域の同定2016

    • Author(s)
      大東いずみ、竹本龍也、高濱洋介
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] CCL21欠損マウスの自己寛容確立異常2016

    • Author(s)
      香西美奈、大東いずみ、高濱洋介
    • Organizer
      四国免疫フォーラム
    • Place of Presentation
      高知大学(高知県・高知市)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 次世代シーケーンサを用いた胸腺プロテアソーム欠損マウスCD8T細胞のレパトア解析2016

    • Author(s)
      高田健介、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      延暦寺会館(滋賀県・大津市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Foxn1-binding cis-regulatry element for optimal CD8+ T cell production in the thymus2016

    • Author(s)
      Myn Uddin、大東いずみ、高濱洋介
    • Organizer
      Kyoto T Cell Conference
    • Place of Presentation
      延暦寺会館(滋賀県・大津市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Thymoproteasome-depedent positive selection of CD8 T cells.2016

    • Author(s)
      高田健介
    • Organizer
      IMMUNOLOGY 2016
    • Place of Presentation
      シアトル(アメリカ)
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] Synthetic Immunology2016

    • Author(s)
      渡邊武、高濱洋介
    • Total Pages
      200
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] 徳島大学 先端酵素学研究所 免疫系発生学分野

    • URL

      http://www.genome.tokushima-u.ac.jp/dei/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 徳島大学先端酵素学研究所免疫系発生学分野

    • URL

      http://www.genome.tokushima-u.ac.jp/dei/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 徳島大学 先端酵素学研究所 免疫系発生学分野

    • URL

      http://www.genome.tokushima-u.ac.jp/dei/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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